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1. 发明公开

US20240131239A1 ABSOLUTE BLOOD VOLUME ESTIMATION DEVICE AND METHOD 审中-公开
公开(公告)号：US20240131239A1
公开(公告)日：2024-04-25
申请号：US18400507
申请日：2023-12-29
申请人： University of Massachusetts , Analiza, Inc. , Medical University of Graz
发明人： Yossi Chait , Joseph Horowitz , Christopher V. Hollot , Hamed Samandari , Michael J. Germain , Daniel Schneditz
IPC分类号： A61M1/16 , A61B5/00 , A61B5/02 , A61B5/0275 , A61B5/145 , A61M1/26 , A61M1/36
CPC分类号： A61M1/1613 , A61B5/02028 , A61B5/0275 , A61B5/14535 , A61B5/6866 , A61M1/267 , A61M1/361 , A61M2205/3389 , A61M2205/50 , A61M2205/52 , A61M2230/20 , A61M2230/207
摘要： Absolute blood volume in dialysis patients is a useful patient attribute to know for dialysis treatment, diagnosis, adjustments, etc. In some cases, it is difficult or impossible to directly determine absolute blood volume. Estimating absolute blood volume may be used to overcome the inability to directly determine the absolute blood volume. Estimating absolute blood volume may include obtaining a series of measurements of hemoconcentration of a patient over a time period, and estimating parameters for a physiological model based on the series of measurements. The absolute blood volume of the patient may be determined using the physiological model.

2. 发明授权

US10928405B2 Devices and methods for determining and/or isolating cells such as circulating cancer or fetal cells 有权
公开(公告)号：US10928405B2
公开(公告)日：2021-02-23
申请号：US16208671
申请日：2018-12-04
申请人： Analiza, Inc.
发明人： Pavel Idelevich , Arnon Chait , Alan Bauer , Paul David Jackson
IPC分类号： G01N33/84 , G01N33/569 , G01N33/574 , G01N33/50 , C12Q1/6806
摘要： Some embodiments of the present invention generally relate to devices and methods for determining and/or isolating cells. For example, one aspect is generally directed to methods and devices for detecting, identifying, counting, and/or potentially sorting cells of interest in blood or other biological sample. In some embodiments, blood samples (or other biological fluids) may be treated with signaling entities, such as pH-sensitive entities, that change color or otherwise produce a signal in suitable internal environments. For example, certain cells, such as cancer or fetal cells, may have differences in intracellular pH compared to other cells, which can be detected using pH-sensitive entities. In certain embodiments, the cells may be sorted based on such signaling entities; for example, illumination of cells in a suitable machine for sorting cells (e.g., using fluorescent light) may allow determination of the cells, which may also be recovered or isolated for further manipulation in some cases.

3. 发明授权

US09678076B2 Methods and devices for determining a disease state 有权
公开(公告)号：US09678076B2
公开(公告)日：2017-06-13
申请号：US14312907
申请日：2014-06-24
申请人： Analiza, Inc.
发明人： Arnon Chait , Boris Y. Zaslavsky
IPC分类号： G01N33/574 , G01N33/68
CPC分类号： G01N33/57488 , G01N33/54366 , G01N33/57415 , G01N33/68 , G01N33/6893 , G01N2333/765 , G01N2800/085 , G01N2800/56
摘要： The present invention, in some embodiments thereof, relates to methods and devices for determining a disease state in a patient. In some embodiments, human serum albumin may be analyzed for associated molecules, wherein the associated molecules are related to a disease such as cancer. Certain aspects of the invention are generally directed to devices and methods for determining a disease state as a function of the three-dimensional structure of a blood protein, human serum albumin (HSA) or its complex with other ligands, e.g., due to binding to disease-specific ligands. HSA interacts with biomolecules associated with a disease presence, and liganded HSA may differentially partition between aqueous phases of a predetermined partitioning system, wherein the partitioning behavior differs between HSA from healthy individuals and HSA from people harboring the predetermined disease, such as breast cancer.

4. 发明授权

US09063127B1 Devices and methods for determining and/or isolating cells such as circulating cancer or fetal cells 有权
标题翻译：用于确定和/或分离细胞如循环癌症或胎儿细胞的装置和方法
公开(公告)号：US09063127B1
公开(公告)日：2015-06-23
申请号：US14312875
申请日：2014-06-24
申请人： Analiza, Inc.
发明人： Pavel Idelevich , Arnon Chait , Alan Bauer
IPC分类号： G01N33/50
CPC分类号： G01N33/5094 , G01N33/5005 , G01N33/5091 , G01N33/57492 , G01N2333/70514 , G01N2333/70517
摘要： The present invention generally relates to devices and methods for determining and/or isolating cells. One aspect is generally directed to methods and devices for detecting, identifying, counting, and/or potentially sorting cells of interest in blood or other biological sample. In some embodiments, blood samples (or other biological fluids) may be treated with signaling entities, such as pH-sensitive entities, that change color or otherwise produce a signal in suitable internal environments. For example, certain cells, such as cancer or fetal cells, may have differences in intracellular pH compared to other cells, which can be detected using pH-sensitive entities. In certain embodiments, the cells may be sorted based on such signaling entities; for example, illumination of cells in a suitable machine for sorting cells (e.g., using fluorescent light) may allow determination of the cells, which may also be recovered or isolated for further manipulation in some cases.
摘要翻译：本发明一般涉及用于确定和/或分离细胞的装置和方法。一方面通常涉及用于检测，识别，计数和/或潜在地分选血液或其他生物样品中感兴趣的细胞的方法和装置。在一些实施方案中，血液样品（或其他生物流体）可以用信号实体（例如pH敏感实体）来处理，其在适当的内部环境中改变颜色或以其它方式产生信号。例如，某些细胞，如癌症或胎儿细胞，与其他细胞相比，细胞内的pH可能有差异，其可以使用pH敏感的实体来检测。在某些实施方案中，可以基于这种信令实体对细胞进行分类; 例如，在用于分选细胞的合适的机器中照射细胞（例如，使用荧光）可以允许确定细胞，其在一些情况下也可以被回收或分离用于进一步的操作。

5. 发明申请

US20120088692A1 SYSTEMS AND METHODS FOR CHARACTERIZATION OF MOLECULES 审中-公开
标题翻译：用于表征分子的系统和方法
公开(公告)号：US20120088692A1
公开(公告)日：2012-04-12
申请号：US13316625
申请日：2011-12-12
申请人： Arnon Chait , Boris Y. Zaslavsky
发明人： Arnon Chait , Boris Y. Zaslavsky
IPC分类号： C40B30/10 , G01N33/566
CPC分类号： G01N33/57434 , G01N33/53 , G01N33/543 , G01N33/68 , G01N33/6803 , G01N33/6842 , G01N33/6845 , G01N2333/96441 , G01N2333/96455 , G16B5/00 , G16B20/00 , G16C20/30 , G16H50/50
摘要： The present invention generally provides systems and methods for the detection, identification, or characterization of differences between properties or behavior of corresponding species in two or more mixtures comprised of molecules, including biomolecules and/or molecules able to interact with biomolecules, using techniques such as partitioning. The experimental conditions established as distinguishing between the mixtures of the molecules using the systems and methods of the invention can also be used, in some cases, for further fractionation and/or characterization of the biomolecules and/or other molecules, using techniques such as single-step or multiple-step extraction, and/or by liquid-liquid partition chromatography. The methods could also be used for discovering and identifying markers associated with specific diagnostics, and can be used for screening for such markers once discovered and identified during diagnostics screening.
摘要翻译：本发明通常提供用于检测，鉴定或表征两种或更多种由分子组成的混合物的性质或行为之间的差异的系统和方法，包括生物分子和/或能够与生物分子相互作用的分子，使用诸如分区使用本发明的系统和方法区分分子的混合物所建立的实验条件也可以在某些情况下用于进一步分级和/或表征生物分子和/或其他分子，使用诸如单一 - 步骤或多步萃取，和/或通过液 - 液分配色谱法。该方法还可用于发现和识别与特定诊断相关的标记，并且可以在诊断筛选期间发现和鉴定后用于筛选此类标记物。

6. 发明授权

US08099242B2 Systems and methods for characterization of molecules 有权
标题翻译：表征分子的系统和方法
公开(公告)号：US08099242B2
公开(公告)日：2012-01-17
申请号：US11818911
申请日：2007-06-15
申请人： Arnon Chait , Boris Y. Zaslavsky
发明人： Arnon Chait , Boris Y. Zaslavsky
IPC分类号： G01N33/48 , G01N31/00 , C12Q1/00
CPC分类号： G01N33/57434 , G01N33/53 , G01N33/543 , G01N33/68 , G01N33/6803 , G01N33/6842 , G01N33/6845 , G01N2333/96441 , G01N2333/96455 , G06F19/00 , G06F19/12 , G06F19/18 , G06F19/704 , G16H50/50
摘要： The present invention generally provides systems and methods for the detection, identification, or characterization of differences between properties or behavior of corresponding species in two or more mixtures comprised of molecules, including biomolecules and/or molecules able to interact with biomolecules, using techniques such as partitioning. The experimental conditions established as distinguishing between the mixtures of the molecules using the systems and methods of the invention can also be used, in some cases, for further fractionation and/or characterization of the biomolecules and/or other molecules, using techniques such as single-step or multiple-step extraction, and/or by liquid-liquid partition chromatography. The methods could also be used for discovering and identifying markers associated with specific diagnostics, and can be used for screening for such markers once discovered and identified during diagnostics screening.
摘要翻译：本发明通常提供用于检测，鉴定或表征两种或更多种由分子组成的混合物的性质或行为之间的差异的系统和方法，包括生物分子和/或能够与生物分子相互作用的分子，使用诸如分区使用本发明的系统和方法区分分子的混合物所建立的实验条件也可以在某些情况下用于进一步分级和/或表征生物分子和/或其他分子，使用诸如单一 - 步骤或多步萃取，和/或通过液 - 液分配色谱法。该方法还可用于发现和识别与特定诊断相关的标记，并且可以在诊断筛选期间发现和鉴定后用于筛选此类标记物。

7. 发明申请

US20070198194A1 Systems and methods involving data patterns such as spectral biomarkers 有权
标题翻译：涉及数据模式如光谱生物标志物的系统和方法
公开(公告)号：US20070198194A1
公开(公告)日：2007-08-23
申请号：US11641611
申请日：2006-12-19
申请人： Arnon Chait , Boris Zaslavsky
发明人： Arnon Chait , Boris Zaslavsky
IPC分类号： G06F19/00 , G01N33/48
CPC分类号： G01N33/6848
摘要： The present invention is generally related to the separation, fractionation, and/or characterization of molecules and/or biomolecules in one or more mixtures. After fractionation, different phases of a partitioning system can be analyzed via an analytical technique such as spectral analysis, chromatography, or the like, to produce a spectrum or other symbolic representation of the species after fractionation, and the spectra of the various fractions/phases compared to define a comparative spectrum as a marker or otherwise providing information about the sample, including such information that is independent of the original level of abundance of the molecules in the mixture. Comparative spectra of various samples can be compared to each other and/or to controls or reference spectra and/or comparative spectra to determine a variety of information. In some embodiments, the methods can be used for discovering and/or identifying patterns in a mixture of species and/or corresponding patterns of species in a second mixture, where each mixture of species originates from biological systems with different physiological conditions as markers associated with specific diagnostics, and can be used for screening for such markers once discovered and identified during diagnostics screening.
摘要翻译：本发明通常涉及一种或多种混合物中分子和/或生物分子的分离，分级和/或表征。分馏后，分析系统的不同阶段可以通过分析技术（如光谱分析，色谱法等）进行分析，以产生分级后的物种的光谱或其他符号表示，以及各种馏分/相的光谱比较将比较光谱定义为标记物或以其他方式提供关于样品的信息，包括独立于混合物中分子丰度的原始水平的信息。可以将各种样品的比较光谱彼此进行比较和/或控制或参考光谱和/或比较光谱以确定各种信息。在一些实施方案中，所述方法可用于在第二混合物中发现和/或识别物种和/或物种的相应模式的混合物中的模式，其中每种物质混合物源自具有不同生理条件的生物系统作为与特异性诊断，并且可以用于在诊断筛选期间发现和鉴定后筛选这些标记物。

8. 发明申请

US20070128618A1 Systems and methods for characterization of molecules 审中-公开
标题翻译：表征分子的系统和方法
公开(公告)号：US20070128618A1
公开(公告)日：2007-06-07
申请号：US11440222
申请日：2006-05-24
申请人： Arnon Chait , Boris Zaslavsky
发明人： Arnon Chait , Boris Zaslavsky
IPC分类号： C12Q1/68 , G01N33/53 , G06F19/00
CPC分类号： G01N33/6842 , G01N33/53 , G01N33/68 , G01N33/6803 , G01N33/6845 , G16C20/20
摘要： The present invention generally provides systems and methods for the detection, identification, or characterization of differences between properties or behavior of corresponding species in two or more mixtures comprised of molecules, including biomolecules and/or molecules able to interact with biomolecules, using techniques such as partitioning. The experimental conditions established as distinguishing between the mixtures of the molecules using the systems and methods of the invention can also be used, in some cases, for further fractionation and/or characterization of the biomolecules and/or other molecules, using techniques such as single-step or multiple-step extraction, and/or by liquid-liquid partition chromatography. The methods could also be used for discovering and identifying markers associated with specific diagnostics, and can be used for screening for such markers once discovered and identified during diagnostics screening.
摘要翻译：本发明通常提供用于检测，鉴定或表征两种或更多种由分子组成的混合物的性质或行为之间的差异的系统和方法，包括生物分子和/或能够与生物分子相互作用的分子，使用诸如分区使用本发明的系统和方法区分分子的混合物所建立的实验条件也可以在某些情况下用于进一步分级和/或表征生物分子和/或其他分子，使用诸如单一 - 步骤或多步萃取，和/或通过液 - 液分配色谱法。该方法还可用于发现和识别与特定诊断相关的标记，并且可以在诊断筛选期间发现和鉴定后用于筛选此类标记物。

9. 发明公开

US20240241123A1 SYSTEMS AND METHODS FOR DETERMINING VIRUSES SUCH AS CORONAVIRUSES 审中-公开
公开(公告)号：US20240241123A1
公开(公告)日：2024-07-18
申请号：US18618944
申请日：2024-03-27
申请人： Analiza, Inc.
发明人： Arnon Chait , Boris Y. Zaslavsky
IPC分类号： G01N33/569 , C12Q1/6888 , C12Q1/70 , G01N33/49
CPC分类号： G01N33/56983 , C12Q1/6888 , C12Q1/70 , G01N33/491 , G01N2333/11 , G01N2333/165
摘要： Certain aspects of the present disclosure generally relate to systems and methods for determining viruses. For instance, some aspects are directed to systems and methods for determining viruses using a partitioning system. Within the partitioning system, the virus may partition into one or more phases. In some cases, a virus-binding moiety facilitates partitioning of the virus. The phases may be assayed to determine the virus based on, e.g., quantitative or qualitative assessments of the distribution of virus-binding and/or signaling moieties. The virus-binding moiety may be attached to particles that may form a complex around a virus. The complex may be detectable without a signaling moiety (e.g., as a color change) in some embodiments. In some cases, more than one virus may be determined. For example, a virus-binding moiety may substantially alter the partitioning behavior of one virus or complex, relative to another, by being selective for the first virus.

10. 发明授权

US11988665B2 Systems and methods for determining viruses such as coronaviruses 有权
公开(公告)号：US11988665B2
公开(公告)日：2024-05-21
申请号：US17800296
申请日：2021-02-26
申请人： Analiza, Inc.
发明人： Arnon Chait , Boris Y. Zaslavsky
IPC分类号： G01N33/569 , C12Q1/6888 , C12Q1/70 , G01N33/49
CPC分类号： G01N33/56983 , C12Q1/6888 , C12Q1/70 , G01N33/491 , G01N2333/11 , G01N2333/165
摘要： Certain aspects of the present disclosure generally relate to systems and methods for determining viruses. For instance, some aspects are directed to systems and methods for determining viruses using a partitioning system. Within the partitioning system, the virus may partition into one or more phases. In some cases, a virus-binding moiety facilitates partitioning of the virus. The phases may be assayed to determine the virus based on, e.g., quantitative or qualitative assessments of the distribution of virus-binding and/or signaling moieties. The virus-binding moiety may be attached to particles that may form a complex around a virus. The complex may be detectable without a signaling moiety (e.g., as a color change) in some embodiments. In some cases, more than one virus may be determined. For example, a virus-binding moiety may substantially alter the partitioning behavior of one virus or complex, relative to another, by being selective for the first virus.

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