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1. 发明申请

US20010044524A1 Method for preparing dual virally inactivated immune globulin for intravenous administration 失效
标题翻译：用于静脉内给药的双病毒灭活免疫球蛋白的制备方法
公开(公告)号：US20010044524A1
公开(公告)日：2001-11-22
申请号：US09861713
申请日：2001-05-22
申请人： ALPHA THERAPEUTIC CORPORATION
发明人： Raja R. Mamidi , Andranik Bagdasarian , Gorgonio Canaveral , Kazuo Takechi
IPC分类号： C07K016/44 , C07K016/00 , A61K039/395
CPC分类号： C07K16/065
摘要： A process for producing an intravenously-administrable gamma globulin solution substantially free of contaminating viruses by fractionating an impure gamma globulin solution and then treating the purified gamma globulin, in any order, with a solvent-detergent for viral inactivation and a heat treating for viral inactivation. Thereafter, denatured impurities, residual solvent and aggregate generated by the heat treatment are removed from the gamma globulin.
摘要翻译：通过分级分离不纯的γ球蛋白溶液，然后以任何顺序用溶剂洗涤剂，用于病毒灭活和用于病毒灭活的热处理来生产静脉内施用的γ球蛋白溶液基本上不含污染病毒的方法。此后，从γ-球蛋白中除去变性杂质，残留溶剂和通过热处理产生的骨料。

2. 发明授权

US6037452A Poly(alkylene oxide)-Factor VIII or Factor IX conjugate 失效
标题翻译：聚（环氧烷） - 活化剂VIII或因子IX缀合物
公开(公告)号：US6037452A
公开(公告)日：2000-03-14
申请号：US866518
申请日：1992-04-10
申请人： Hitoshi Minamino , Edward H. Mealey
发明人： Hitoshi Minamino , Edward H. Mealey
IPC分类号： A61K47/48 , C07K14/755 , C07K14/745
CPC分类号： A61K47/48215
摘要： Factor VIIIC:vWF, Factor VIII C, Factor IX or Factor IX or the activated co-factors thereof are covalently linked to a poly(alkylene oxide).
摘要翻译：因子VIIIC：vWF，因子VIIIC，因子IX或因子IX或其活化的辅因子与聚（环氧烷）共价连接。

3. 发明授权

US5744586A Manufacturing process for the production of purified transferrin 失效
标题翻译：生产纯化转铁蛋白的制造工艺
公开(公告)号：US5744586A
公开(公告)日：1998-04-28
申请号：US668351
申请日：1996-06-26
申请人： John M. Rolf , Akimasa Ohmizu , Shawn D. Latham , Prabir Bhattacharya
发明人： John M. Rolf , Akimasa Ohmizu , Shawn D. Latham , Prabir Bhattacharya
IPC分类号： A61K38/16 , A61P43/00 , C07K1/18 , C07K1/34 , C07K14/00 , C07K14/79 , A61K38/00 , C07K5/00 , C07K7/00 , C07K16/00
CPC分类号： C07K14/79
摘要： Method for obtaining highly purified transferrin from a partially purified plasma fraction containing transferrin in which the starting fraction is concentrated. Its ionic strength is reduced and then transferrin is adsorbed onto a chromatographic column. Following elution, the transferrin can be further processed through to packaging in final containers. The final purified transferrin product is sterile, at least 95% pure and is substantially free of enveloped and non-enveloped viruses.
摘要翻译：从含有起始级分浓缩的转铁蛋白的部分纯化血浆级分中获得高度纯化的转铁蛋白的方法。其离子强度降低，然后将转铁蛋白吸附到色谱柱上。洗脱后，可以将转铁蛋白进一步加工成包装在最终的容器中。最终纯化的转铁蛋白产物是无菌的，至少95％纯，并且基本上没有包膜和非包膜病毒。

4. 发明授权

US5591573A Method and system for testing blood samples 失效
标题翻译：检测血样的方法和系统
公开(公告)号：US5591573A
公开(公告)日：1997-01-07
申请号：US419620
申请日：1995-04-10
申请人： John J. Whalen , Michael E. Chlebowski , Charles M. Heldebrant , H. Edward Matveld
发明人： John J. Whalen , Michael E. Chlebowski , Charles M. Heldebrant , H. Edward Matveld
IPC分类号： B01L3/00 , G01N33/483 , C12Q1/70 , C12N7/00 , C12P19/34
CPC分类号： B01L3/505
摘要： Systems, processes and devices are provided which are useful for testing blood or plasma donations to detect those specific donations which are contaminated by virus above a predetermined level. An apparatus and process is described which forms individual, separately sealed, and connected sample-containing pouches from a flexible hollow tubing segment connected to a fluid donation container. The tubing segment is sealed at spaced-apart intervals along its length, with tubing segment portions in the intervals between the seals defining pouches, each of which contains a portion of a plasma sample. The contents of the pouches are formed into pools which are subsequently tested for virus contamination by a high sensitivity test such as PCR. When a pool tests positive, indicating it is contaminated by a virus, a further pouch is removed from each of the tubing segments used to form the initial pool. Subsequent pouches are divided into approximately equal sized subgroups and their contents separately formed into subpools. A selected one of the subgroup pools is then tested for virus contamination. The test process is iterated, with each pool that tests positive being further subdivided into two successively smaller subgroups, until two final subgroups are formed, each comprising a single pouch corresponding to a single plasma donation. The final two pouches are subsequently PCR tested in order to determine and uniquely identify the corresponding contaminated donation.
摘要翻译：提供了用于测试血液或血浆捐赠以检测被预定水平以上的病毒污染的特定捐赠的系统，过程和装置。描述了一种从连接到流体供应容器的柔性中空管段形成单独的，单独密封的和连接的含样品袋的装置和方法。管段沿着其长度以间隔间隔密封，密封件之间的间隔中的管段部分限定袋，每个袋包含一部分等离子体样品。将小袋的内容物形成池，随后通过高灵敏度试验如PCR检测病毒污染。当池测试为阳性时，表明其被病毒污染，从用于形成初始池的每个管段中移除另外的袋。随后的小袋被分成大致相等大小的亚组，其内容分别形成子笔。然后对选定的一个亚组池进行病毒感染。测试过程被迭代，每个测试阳性的池被进一步细分为两个连续较小的亚组，直到形成两个最终子组，每个子组包含与单个血浆捐赠相对应的单个小袋。随后对最后两个小袋进行PCR测试，以确定和唯一识别相应的受污染的捐赠。

5. 发明授权

US5399670A Solubilization and stabilization of factor VIII complex 失效
标题翻译：因子VIII复合物的溶解和稳定
公开(公告)号：US5399670A
公开(公告)日：1995-03-21
申请号：US54903
申请日：1993-04-29
申请人： Prabir Bhattacharya , Toshiharu Motokubota
发明人： Prabir Bhattacharya , Toshiharu Motokubota
IPC分类号： A61K38/37 , C07K14/755 , A61K37/02 , A61K37/06 , C07K3/20 , C07K13/00
CPC分类号： C07K14/755 , A61K38/37
摘要： A process for facilitating the reconstitution of lyophilized Factor VIII complex compositions, and compositions of Factor VIII complex, which are readily reconstituted. The process of the present invention comprises providing a purified Factor VIII complex preparations; adding a stabilization agent comprising arginine; lyophilizing the stabilization agent-Factor VIII complex solutions; and reconstituting the lyophilized stabilization agent-Factor VIII complex by contacting it with solvent for less than one minute.
摘要翻译：促进重组冻干因子VIII复合物组合物的方法，以及易于重构的因子VIII复合物的组合物。本发明的方法包括提供纯化的因子VIII复合物制剂; 加入包含精氨酸的稳定剂; 冻干稳定剂 - 因子VIII复合物溶液; 并通过使其与溶剂接触少于1分钟来重构冻干稳定剂 - 因子VIII络合物。

6. 发明授权

US5374243A Oxygen permeable bag containing oxygen-transporting perfluorochemical for providing oxygen internally to mammals 失效
标题翻译：含氧输送全氟化学物质的透氧袋，用于向哺乳动物内部提供氧气
公开(公告)号：US5374243A
公开(公告)日：1994-12-20
申请号：US85920
申请日：1993-07-06
申请人： John J. Whalen , Charles M. Heldebrandt
发明人： John J. Whalen , Charles M. Heldebrandt
IPC分类号： A61M1/16 , A61M37/00
CPC分类号： A61M37/00 , A61M1/1678 , A61M1/1698 , A61M2202/0208 , A61M2202/0476 , A61M2210/1017
摘要： A method for providing oxygen to an internal body cavity by providing an oxygenated oxygen-transporting perfluorochemical enclosed within an oxygen permeable/perfluorochemical impermeable membrane within said body cavity.
摘要翻译：通过提供包封在所述体腔内的透氧/全氟化学不可渗透膜内的氧化氧输送全氟化合物来向内部体腔提供氧气的方法。

7. 发明授权

US5286849A Purification of factor IX 失效
标题翻译：因子IX的纯化
公开(公告)号：US5286849A
公开(公告)日：1994-02-15
申请号：US913666
申请日：1992-07-14
申请人： Steven W. Herring
发明人： Steven W. Herring
IPC分类号： A61K38/43 , A61P7/02 , C07K1/14 , C07K1/16 , C07K14/745 , C12N9/64 , A61K35/16 , A61K37/02 , C07K3/20
CPC分类号： C12N9/644 , C12Y304/21022
摘要： The present invention relates to a process for purifying Factor IX from an impure protein fraction containing Factor IX. The purification process comprises the steps of adding a solvent and a detergent to an impure protein fraction and incubating the solvent/detergent protein solution to inactivate any viral contaminants. Factor IX is purified from the solvent/detergent protein solution by chromatography on a sulfated polysaccharide resin without first removing the solvent and detergent prior to the purification on the sulfated polysaccharide resin. The Factor IX, purified by the process has a specific activity of at least 85 units/mg.
摘要翻译：本发明涉及从含有因子IX的不纯蛋白质级分中纯化因子IX的方法。纯化方法包括以下步骤：向不纯的蛋白质级分中加入溶剂和洗涤剂，并培养溶剂/洗涤剂蛋白溶液以灭活任何病毒污染物。通过色谱法在硫酸化多糖树脂上从溶剂/洗涤剂蛋白溶液中纯化因子IX，而无需首先在硫酸化多糖树脂上纯化之前除去溶剂和洗涤剂。通过该方法纯化的因子IX具有至少85单位/ mg的比活性。

8. 发明授权

US5250662A Albumin purification 失效
标题翻译：白蛋白净化
公开(公告)号：US5250662A
公开(公告)日：1993-10-05
申请号：US842749
申请日：1992-02-27
申请人： Chong E. Chang
发明人： Chong E. Chang
IPC分类号： A61K38/00 , C07K14/765 , C07K3/22 , C07K15/06
CPC分类号： C07K14/765 , A61K38/00
摘要： There is provided in accordance with the practice of this invention a process for separating albumin from an impure protein fraction containing albumin. Contaminants, in an aqueous solution of the impure protein fraction containing albumin, are precipitated from the solution at a pH of from about 4.5 to about 4.7. Additional contaminants that remain soluble are bound to an anion-exchange resin. After the precipitated and anion-exchange-bound contaminants are removed from the albumin-containing solution, the pH of the solution is adjusted to from about 4.7 to about 6.1, and additional contaminants are precipitated. Further contaminants are then bound to an anion-exchange resin, and these precipitated and anion-exchange-bound contaminants are removed from the albumin-containing solution.
摘要翻译：根据本发明的实践提供了用于从含有白蛋白的不纯蛋白质级分中分离白蛋白的方法。在含有白蛋白的不纯蛋白质级分的水溶液中的污染物在约4.5至约4.7的pH下从溶液中沉淀出来。仍然可溶的附加污染物与阴离子交换树脂结合。在从含白蛋白的溶液中除去沉淀和阴离子交换结合的污染物后，将溶液的pH调节至约4.7至约6.1，并且附加的污染物沉淀。然后将其它污染物与阴离子交换树脂结合，并从含白蛋白的溶液中除去这些沉淀和阴离子交换结合的污染物。

9. 发明授权

US5262442A Process for rapid thawing and storage of frozen fluorocarbon emulsion, and resultant product 失效
标题翻译：快速解冻和储存冷冻碳氟化合物乳液及其产物的方法
公开(公告)号：US5262442A
公开(公告)日：1993-11-16
申请号：US812937
申请日：1991-12-24
申请人： Charles M. Heldebrandt , Charles H. Davis, Jr.
发明人： Charles M. Heldebrandt , Charles H. Davis, Jr.
IPC分类号： A61J3/00 , A61K9/00 , A61K47/00
CPC分类号： A61K9/0026 , Y10S514/832 , Y10S514/833 , Y10S514/937
摘要： A method for rapidly preparing a frozen fluorocarbon emulsion for administration without degradation and having an extended shelf life is disclosed.

10. 发明授权

US5219995A Plasma fraction purification 失效
$Plasma fraction purification$
标题翻译：血浆级分纯化
公开(公告)号：US5219995A
公开(公告)日：1993-06-15
申请号：US913590
申请日：1992-07-14
申请人： Steven W. Herring , Yahiro Uemura , Munehiro Noda , Kenneth T. Shitanishi
发明人： Steven W. Herring , Yahiro Uemura , Munehiro Noda , Kenneth T. Shitanishi
IPC分类号： A61K38/43 , C07K1/18 , C07K1/22 , C07K1/30 , C07K14/435 , C07K14/745 , C12N9/64 , C12N9/74
CPC分类号： C12N9/6429 , C07K14/745 , C12N9/6432 , C12Y304/21005 , C12Y304/21006
摘要： The present invention describes a process for activating Factor II to Factor II.sub.a by incubating Factor II in the presence of Factor V, Factor X.sub.a, phospholipids, and calcium ions. Each of the factors is prepared from a single impure protein fraction which includes Factors II, V and X. The Factor II, V and X purification procedure comprises the steps of DEAE ligand chromatography and precipitation by the addition of barium chloride. Factor V is recovered from the barium chloride supernatant, and Factors II and X are contained in the barium chloride precipitate. The barium chloride precipitate is dissolved in an aqueous solution and is applied to a chromatographic resin coupled with a ligand which binds Factor X and Factor II weakly or not at all. Factor II is recovered from the fraction, which remains unbound or weakly bound to the Factor X binding ligand. Factor X.sub.a is prepared by recovering Factor X from the ligand during the Factor II preparation procedure and activating the Factor X to Factor X.sub.a by specific proteolytic cleavage.
摘要翻译：本发明描述了通过在因子V，因子Xa，磷脂和钙离子的存在下孵育因子II来激活因子II至因子IIa的方法。因子II，V和X的纯化程序包括DEAE配体层析和加入氯化钡沉淀的步骤。因子V从氯化钡上清液中回收，因子II和X包含在氯化钡沉淀中。将氯化钡沉淀物溶解在水溶液中，并施加到与限制因子X和因子II的配体偶联的色谱树脂上或完全不结合。因子II从部分回收，其保持未结合或弱结合于因子X结合配体。因子Xa通过在因子II制备过程中从配体中回收因子X并通过特异性蛋白水解切割活化因子X至因子Xa来制备。

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