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    • 1. 发明申请
    • Method and apparatus for automatic image orientation normalization
    • 用于自动图像定向归一化的方法和装置
    • US20060061599A1
    • 2006-03-23
    • US10944683
    • 2004-09-17
    • Hong YuPrabir Bhattacharya
    • Hong YuPrabir Bhattacharya
    • G09G5/00G06K9/32G06K9/00
    • H04N1/32101H04N1/32128H04N2201/3242H04N2201/3254
    • In some embodiments, systems and methods for visually rendering images rotate images at time of display based on annotations indicating needed rotations. In other embodiments, systems and methods for visually rendering images rotate images at time of display by determining a needed rotation for an image based on automatic orientation recognition. In further embodiments, systems and methods for visually rendering images rotate images at time of display by utilizing fuzzy logic to determine a best rotation angle for an image based on a none precise marking generated by computer vision or signal processing applied to the image. In yet further embodiments, systems and methods for annotating images annotate images at time of image capture, time of image display, or any time in between by using one or more of automatic image orientation recognition, user input specifying a needed rotation, and sensed orientation of an image capture mechanism.
    • 在一些实施例中,用于视觉呈现图像的系统和方法基于指示所需旋转的注释在显示时旋转图像。 在其他实施例中,用于视觉呈现图像的系统和方法通过基于自动方位识别来确定图像所需的旋转来在显示时旋转图像。 在另外的实施例中,用于视觉渲染图像的系统和方法通过利用模糊逻辑在显示时旋转图像,以基于由计算机视觉或应用于图像的信号处理产生的无精确标记来确定图像的最佳旋转角度。 在另外的实施例中,用于注释图像的系统和方法通过使用自动图像定向识别,指定所需旋转的用户输入和感测到的方向来识别图像捕获时间,图像显示时间或其间的任何时间来注释图像 的图像捕获机制。
    • 6. 发明授权
    • Anion exchange process for the purification of Factor VIII
    • 阴离子交换过程用于纯化因子VIII
    • US5659017A
    • 1997-08-19
    • US554724
    • 1995-11-07
    • Prabir BhattacharyaToshiharu MotokubotaNorman M. Fedalizo
    • Prabir BhattacharyaToshiharu MotokubotaNorman M. Fedalizo
    • C07K14/755
    • C07K14/755
    • A new method for purifying Factor VIII complex from an impure protein fraction, usually cryoprecipitate, is disclosed. The cryoprecipitate is dissolved in a heparin solution. Then Factor VIII complex is initially purified by polyethylene glycol precipitation. The Factor VIII containing supernatant collected after the precipitation is loaded into an anion exchange column that has a quaternary amino ethyl group. The Factor VIII complex is then eluted from the column with a buffer comprising from about 0.14M to about 0.20M CaCl.sub.2. The final step in the purification is to precipitate the Factor VIII complex in the presence of glycine and sodium chloride. The precipitated Factor VIII complex is then reconstituted and stabilized. The reconstituted Factor VIII complex can then be lyophilized and dry heated to obtain a final Factor VIII product.
    • 公开了一种从不纯的蛋白质级分(通常是冷沉淀物)中纯化因子VIII复合物的新方法。 将该沉淀物溶于肝素溶液。 然后,因子VIII复合物最初通过聚乙二醇沉淀来纯化。 将沉淀后收集的含有因子VIII的上清液负载到具有季氨基乙基的阴离子交换柱中。 然后用包含约0.14M至约0.20M CaCl 2的缓冲液从柱中洗脱因子VIII复合物。 纯化的最后一步是在甘氨酸和氯化钠存在下沉淀因子VIII配合物。 然后沉淀的因子VIII复合物被重构并稳定。 然后将重构的因子VIII复合物冻干并干燥加热以获得最终因子VIII产物。