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1. 发明授权

US08840571B2 Method and device for measuring tactile profile of vagina 有权
标题翻译：用于测量阴道触觉概况的方法和装置
公开(公告)号：US08840571B2
公开(公告)日：2014-09-23
申请号：US13756788
申请日：2013-02-01
申请人： Vladimir Egorov , Armen P. Sarvazyan
发明人： Vladimir Egorov , Armen P. Sarvazyan
IPC分类号： A61B5/117 , A61B5/103 , A61B5/00 , A61B5/22
CPC分类号： A61B5/227 , A61B5/4337 , A61B5/6847
摘要： Transvaginal probes equipped with tactile sensors are configured for placement into vagina to record tactile response during insertion, acquire static tactile pattern from vaginal wall after the insertion is complete, and acquire dynamic tactile patterns during probe motion as well as recording dynamic tactile response during contraction of vaginal muscle. The acquired and recorded tactile data are transmitted to a data processor for composing tactile profile of vagina and visually presenting thereof on a display. Elasticity profile of vaginal tissue is calculated from the tactile response recorded from different parts of the probe during its insertion, from the static pressure pattern and from the dynamic tactile pattern. Pelvic floor muscle strength is defined as a contact pressure increase detected on fixed probe surface under the muscle contraction. Tactile profile of vagina is determined using the static tactile pattern, the elasticity profile and pelvic floor muscle strength. The data processor provides a comparative analysis of the tactile profile with a variety of vaginal tactile profiles recorded for a given population with known clinical conditions so as to assist in diagnosing a disease.
摘要翻译：配置有触觉传感器的经阴道探针被配置为放置在阴道中以在插入期间记录触觉反应，在插入完成之后从阴道壁获得静态触觉图案，并且在探针运动期间获得动态触觉图案以及在收缩期间记录动态触觉反应阴道肌。获取和记录的触觉数据被传送到数据处理器，用于构成阴道的触觉概况并且在显示器上视觉呈现阴道。阴茎组织的弹性曲线是根据探针插入过程中记录的触觉反应，静态压力模式和动态触觉模式计算出来的。骨盆底肌肉强度定义为在肌肉收缩下在固定探针表面上检测到的接触压力增加。使用静态触觉模式，弹性特征和盆底肌肉力量确定阴道的触觉特征。数据处理器提供对具有已知临床条件的给定群体记录的各种阴道触觉概况的触觉概况的比较分析，以帮助诊断疾病。

2. 发明申请

US20120029286A1 SIMPLIFIED HANDGRIP FOR ASSESSMENT OF COLONOSCOPE MANIPULATION 有权
标题翻译：用于评估结肠镜手术的简化手术
公开(公告)号：US20120029286A1
公开(公告)日：2012-02-02
申请号：US13267838
申请日：2011-10-06
申请人： Armen P. Sarvazyan , Aleksandr Pasechnik , Sergey Tsyuryupa , Vladimir Egorov
发明人： Armen P. Sarvazyan , Aleksandr Pasechnik , Sergey Tsyuryupa , Vladimir Egorov
IPC分类号： A61B1/00
CPC分类号： A61B1/31 , A61B1/00006 , A61B1/00066 , A61B1/00147 , A61B1/0052 , G06F19/00
摘要： A handgrip for a colonoscope shaft is equipped with a novel compact multifunction force and torque sensor allowing for a comprehensive characterization of colonoscope manipulation during a colonoscopy procedure. A two-part hinge design of the handgrip in combination with the multifunction sensor provides for a light weight design in a compact package making using the handgrip convenient and natural. An electronic unit is provided to receive the sensor data wirelessly and calculate a variety of motion parameters guiding a medical practitioner during the procedure and aimed at making colonoscopy safer and less painful.
摘要翻译：结肠镜手柄的手柄配备有一种新颖的紧凑型多功能力和扭矩传感器，可在结肠镜检查过程中对结肠镜手术进行综合表征。手柄的两部分铰链设计与多功能传感器相结合，提供了使用手柄方便自然的紧凑型包装中的轻质设计。提供电子单元以无线地接收传感器数据，并且计算在手术期间引导医师的各种运动参数，并且旨在使结肠镜检查更安全且不那么痛苦。

3. 发明申请

US20110015547A1 METHOD AND A DUAL-ARRAY TRANSDUCER PROBE FOR REAL TIME MECHANICAL IMAGING OF PROSTATE 审中-公开
标题翻译：用于实时机械成像的方法和双阵列传感器探测
公开(公告)号：US20110015547A1
公开(公告)日：2011-01-20
申请号：US12885688
申请日：2010-09-20
申请人： Armen P. Sarvazyan , Vladimir Egorov , Suren Ayrapetyan
发明人： Armen P. Sarvazyan , Vladimir Egorov , Suren Ayrapetyan
IPC分类号： A61B5/103
CPC分类号： A61B5/103 , A61B5/0053 , A61B5/4381 , A61B5/6885 , A61B8/4254 , A61B2562/0247 , A61B2562/046
摘要： The present invention relates to a transrectal probe and method for real time mechanical imaging of a prostate. The probe is equipped with dual-array pressure sensors—one on the probe head and another on the shaft of the probe spaced away from the head with an angular and linear offset forming an S-shaped transition between the shaft and the head of the probe. The addition of the shaft pressure sensor array together with orientation tracking sensors allows precise calculation of the current head position throughout the examination of the prostate. Display means are used to guide the user in the proper manipulation of the probe in order to reduce the forces on surrounding tissues and organs and to minimize patient's discomfort.
摘要翻译：本发明涉及一种用于前列腺实时机械成像的经直肠探针和方法。探头配有双阵列压力传感器 - 一个在探针头上，另一个位于探头的轴上，与头部间隔开，并具有角度和线性偏移，在轴和探头头部之间形成S形过渡。轴压力传感器阵列与定向跟踪传感器的添加允许在整个前列腺检查期间精确计算当前的头部位置。显示装置用于引导用户适当地操纵探针，以减少对周围组织和器官的力并且最小化患者的不适。

4. 发明申请

US20100087756A1 METHOD OF CHARACTERIZATION AND DIFFERENTIATION OF TISSUE 有权
标题翻译：表征方法和组织分化
公开(公告)号：US20100087756A1
公开(公告)日：2010-04-08
申请号：US12244235
申请日：2008-10-02
申请人： Vladimir Egorov , Armen P. Sarvazvan
发明人： Vladimir Egorov , Armen P. Sarvazvan
IPC分类号： A61B5/103
CPC分类号： A61B5/4381 , A61B5/0053 , A61B5/4312 , A61B5/442 , A61B5/444 , A61B5/7264 , A61B5/7267 , G06K9/6278
摘要： A novel method for soft tissue characterization includes obtaining a sequence of surface stress patterns as a function of an increasing compression force when a probe is pressed against the tissue over the location of the lesion of interest. A number of elasticity features are then calculated to characterize the tissue and the lesion located therein including strain hardening, loading curve average slope, lesion peak signal under a predetermined load, tissue heterogeneity, lesion shape and lesion mobility. At least three elasticity features are provided as an input to a statistical Bayesian classifier trained on a clinical database to calculate the probability of the lesion being benign or malignant. Additional patient-related parameters may be further provided as inputs to the classifier to increase the accuracy of differentiation between benign and malignant lesions. These parameters include a family history of cancer disease, a patient-inherited genetic factor, a history of said tissue related diseases, patient's age, patient's weight, and patient's lifestyle and dietary factors. The method of the invention along with other non-invasive examinations of lesions may help in reducing the rate of biopsies, specifically breast tissue biopsies.
摘要翻译：用于软组织表征的新颖方法包括当探针在感兴趣的病变位置上被压靠在组织上时，获得作为增加的压缩力的函数的表面应力模式序列。然后计算出许多弹性特征来表征位于其中的组织和病变，其中包括在预定负荷下的应变硬化，负荷曲线平均斜率，病变峰值信号，组织异质性，损伤形状和损伤移动性。提供至少三个弹性特征作为在临床数据库上训练的统计贝叶斯分类器的输入，以计算病变为良性或恶性的概率。可以进一步提供额外的患者相关参数作为分类器的输入，以增加良性和恶性病变之间的分化准确性。这些参数包括癌症病史，患者遗传遗传因素，所述组织相关疾病的病史，患者年龄，患者体重以及患者的生活方式和饮食因素。本发明的方法与病变的其他非侵入性检查可能有助于降低活组织检查的比例，特别是乳腺组织活检。

5. 发明申请

US20090216128A1 Broadband Ultrasonic Probe 审中-公开
标题翻译：宽带超声波探头
公开(公告)号：US20090216128A1
公开(公告)日：2009-08-27
申请号：US12036531
申请日：2008-02-25
申请人： Armen P. Sarvazyan
发明人： Armen P. Sarvazyan
IPC分类号： A61B8/14
CPC分类号： A61B8/4483 , A61B8/4281 , G10K11/02
摘要： An ultrasound probe includes a reverberator having a randomly uneven shape preferably including a plurality of facets. Together with a rigid coupling window, it forms a closed cavity filled with reverberation medium such as water. One or more ultrasound transducers are placed inside the reverberator to generate a signal using time-reversed acoustics principles. Additional transducers increase the power output of the probe. An optional transducer design features a piezomaterial formed in a randomly uneven shape, preferably having length/thickness ratio of at least 2. The reverberator cavity further includes scatterers suspended inside and aimed at improving the focusing quality of the probe. Such scatterers can be of various sizes and in a number of shapes such as beads, cylinders and membranes. The probe can be advantageously used for focusing broadband ultrasonic waves in various industrial and medical applications such as those utilizing high intensity short ultrasonic pulses.
摘要翻译：超声波探头包括具有随机不均匀形状的混响器，优选地包括多个面。与刚性耦合窗口一起，它形成充满混响介质（如水）的封闭空腔。将一个或多个超声换能器放置在混响器内部以产生使用时间反转声学原理的信号。额外的传感器增加了探头的功率输出。可选的换能器设计具有形成为随机不均匀形状的压电材料，优选地具有至少2的长度/厚度比。混响腔还包括悬挂在其内并旨在提高探针的聚焦质量的散射体。这种散射体可以是各种尺寸和多种形状，例如珠，圆筒和膜。该探针可以有利地用于将宽带超声波聚焦在各种工业和医疗应用中，例如使用高强度短超声波脉冲的那些。

6. 发明申请

US20080154154A1 INTERNET-BASED SYSTEM AND A METHOD FOR AUTOMATED ANALYSIS OF TACTILE IMAGING DATA AND DETECTION OF LESIONS 审中-公开
标题翻译：基于互联网的系统和自动分析战术成像数据和检测LESIONS的方法
公开(公告)号：US20080154154A1
公开(公告)日：2008-06-26
申请号：US12038041
申请日：2008-02-27
申请人： Armen P. Sarvazyan , Vladimir Egorov , Sergiy Kanilo
发明人： Armen P. Sarvazyan , Vladimir Egorov , Sergiy Kanilo
IPC分类号： A61B5/103 , G06K9/00
CPC分类号： A61B5/06 , A61B5/7264
摘要： An Internet-based system is described including a number of patient terminals equipped with tactile imaging probes to allow conducting of breast examinations and collecting the 2-D digital data from the pressure arrays of the tactile imaging probes. The digital data is processed at the patient side including a step of detecting moving objects and discarding the rest of the data from further analysis. The data is then formatted into a standard form and transmitted over the Internet to the host system where it is accepted by one of several available servers. The host system includes a breast examination database and a knowledge database and is designed to further process, classify, and archive breast examination data. It also provides access to processed data from a number of physician terminals equipped with data visualization and diagnosis means. The physician terminal is adapted to present the breast examination data as a 3-D model and facilitates the comparison of the data with previous breast examination data as well as assists physicians in feature recognition and final diagnosis.
摘要翻译：描述了基于互联网的系统，其包括配备有触觉成像探针的多个患者终端，以允许进行乳房检查并从触觉成像探针的压力阵列收集2-D数字数据。在患者侧处理数字数据，包括检测移动物体的步骤，并从剩余的分析中丢弃剩余的数据。然后，将数据格式化为标准形式，并通过Internet传输到主机系统，其中几个可用服务器之一被其接受。主机系统包括乳房检查数据库和知识数据库，旨在进一步处理，分类和归档乳房检查数据。它还提供从具有数据可视化和诊断手段的许多医生终端访问经处理的数据。医师终端适用于将乳房检查数据呈现为3维模型，便于将数据与以前的乳房检查数据进行比较，并协助医师进行特征识别和最终诊断。

7. 发明申请

US20080097211A1 ULTRASONIC METHOD AND APPARATUS FOR ASSESSMENT OF BONE 有权
标题翻译：超声波检测方法及装置
公开(公告)号：US20080097211A1
公开(公告)日：2008-04-24
申请号：US11533871
申请日：2006-09-21
申请人： Armen P. Sarvazyan , Alexej Tatarinov , Vladimir Egorov
发明人： Armen P. Sarvazyan , Alexej Tatarinov , Vladimir Egorov
IPC分类号： A61B8/00
CPC分类号： A61B8/0875 , A61B8/485
摘要： Methods and apparatus are disclosed for non-invasive bone evaluation based on a broadband ultrasonic transducer emitting a train of ultrasonic wave packets of multiple carrier frequencies ranging from about 50 kHz to about 2 MHz. Receiving broadband ultrasonic transducer accepts broadband ultrasonic signal propagated through the bone. Computer processing means provide for data analysis and feature extraction allowing diagnostic evaluation of the bone, including comparing the features of the received signal to a database of known bone conditions.
摘要翻译：公开了用于非侵入式骨骼评估的方法和装置，其基于宽带超声换能器，其发射大约50kHz至大约2MHz范围的多个载波频率的超声波波段。接收宽带超声波传感器接受通过骨骼传播的宽带超声信号。计算机处理装置提供数据分析和特征提取，允许骨骼的诊断评估，包括将接收信号的特征与已知骨骼状况的数据库进行比较。

8. 发明申请

US20080076099A1 HUMAN TISSUE PHANTOMS AND METHODS FOR MANUFACTURING THEREOF 失效
标题翻译：人造革组织及其制造方法
公开(公告)号：US20080076099A1
公开(公告)日：2008-03-27
申请号：US11464238
申请日：2006-08-14
申请人： Armen P. Sarvazyan , Vladimir Egorov
发明人： Armen P. Sarvazyan , Vladimir Egorov
IPC分类号： G09B23/28
CPC分类号： G09B23/30
摘要： Disclosed are human tissue phantoms mimicking the mechanical properties of real tissue, and methods for manufacturing thereof including the steps of obtaining a computer aided three-dimensional design of a phantom mimicking the tissue in shape and size; fabrication of a mold form facilitating the production of the designed phantom; molding said phantom with the use of two-component silicon gels as a bulk tissue-mimicking material having Young's modulus in the range of 2 to 30 kPa; filling the enclosed volume of said phantom with anatomical and pathological tissue structures mimicking their respective mechanical properties and having Young's modulus in the range of about 30 to 600 kPa; covering said phantom by a protective layer having mechanical properties to a human tissue protective layer; and securing the phantom perimeter on a supporting plate by a rubber barrier. The example of used tissue-mimicking material is a two-component silicone SEMICOSIL gel with variable elastic properties and Young's modulus from 3 kPa to 600 kPa as a result of changing the silicon component ratio. As examples, the breast and prostate phantom tissue and their fabrication procedures are described.
摘要翻译：公开了模拟实际组织的机械性质的人体组织模型及其制造方法，其包括以下步骤：获得模仿组织形状和尺寸的体模的计算机辅助三维设计; 制造有助于生产设计的幻影的模具形式; 使用双组分硅凝胶将所述体模成型为具有在2至30kPa范围内的杨氏模量的块状组织模拟材料; 用解剖和病理组织结构填充所述体模的封闭体积，模拟其各自的机械性能，并且杨氏模量在约30至600kPa的范围内; 通过对人体组织保护层具有机械性能的保护层覆盖所述体模; 并通过橡胶屏障将幻影周边固定在支撑板上。使用的组织模拟材料的实例是具有可变弹性和双组分硅氧烷SEMICOSIL凝胶，由3位变化至600千帕的杨氏模量。作为例子，描述了乳房和前列腺体模组织及其制造方法。

9. 发明授权

US08419643B2 Ultrasonic method and apparatus for assessment of bone 有权
标题翻译：用于评估骨骼的超声方法和装置
公开(公告)号：US08419643B2
公开(公告)日：2013-04-16
申请号：US11533871
申请日：2006-09-21
申请人： Armen P. Sarvazyan , Alexej Tatarinov , Vladimir Egorov
发明人： Armen P. Sarvazyan , Alexej Tatarinov , Vladimir Egorov
IPC分类号： A61B8/00
CPC分类号： A61B8/0875 , A61B8/485
摘要： Methods and apparatus are disclosed for non-invasive bone evaluation based on a broadband ultrasonic transducer emitting a train of ultrasonic wave packets of multiple carrier frequencies ranging from about 50 kHz to about 2 MHz. Receiving broadband ultrasonic transducer accepts broadband ultrasonic signal propagated through the bone. Computer processor provides for data analysis and feature extraction allowing diagnostic evaluation of the bone, including comparing the features of the received signal to a database of known bone conditions.
摘要翻译：公开了用于非侵入式骨骼评估的方法和装置，其基于宽带超声换能器，其发射大约50kHz至大约2MHz范围的多个载波频率的超声波波段。接收宽带超声波传感器接受通过骨骼传播的宽带超声信号。计算机处理器提供数据分析和特征提取，允许骨骼的诊断评估，包括将接收到的信号的特征与已知骨骼状况的数据库进行比较。

10. 发明授权

US08388518B2 Simplified handgrip for assessment of colonoscope manipulation 有权
标题翻译：用于评估结肠镜手术的简化手柄
公开(公告)号：US08388518B2
公开(公告)日：2013-03-05
申请号：US13267838
申请日：2011-10-06
申请人： Armen P. Sarvazyan , Aleksandr Pasechnik , Sergey Tsyuryupa , Vladimir Egorov
发明人： Armen P. Sarvazyan , Aleksandr Pasechnik , Sergey Tsyuryupa , Vladimir Egorov
IPC分类号： A61B1/00
CPC分类号： A61B1/31 , A61B1/00006 , A61B1/00066 , A61B1/00147 , A61B1/0052 , G06F19/00
摘要： A handgrip for a colonoscope shaft is equipped with a novel compact multifunction force and torque sensor allowing for a comprehensive characterization of colonoscope manipulation during a colonoscopy procedure. A two-part hinge design of the handgrip in combination with the multifunction sensor provides for a light weight design in a compact package making using the handgrip convenient and natural. An electronic unit is provided to receive the sensor data wirelessly and calculate a variety of motion parameters guiding a medical practitioner during the procedure and aimed at making colonoscopy safer and less painful.
摘要翻译：结肠镜手柄的手柄配备有一种新颖的紧凑型多功能力和扭矩传感器，可在结肠镜检查过程中对结肠镜手术进行综合表征。手柄的两部分铰链设计与多功能传感器相结合，提供了使用手柄方便自然的紧凑型包装中的轻质设计。提供电子单元以无线地接收传感器数据，并且计算在手术期间引导医师的各种运动参数，并且旨在使结肠镜检查更安全且不那么痛苦。

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