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1. 发明申请

US20110015547A1 METHOD AND A DUAL-ARRAY TRANSDUCER PROBE FOR REAL TIME MECHANICAL IMAGING OF PROSTATE 审中-公开
标题翻译：用于实时机械成像的方法和双阵列传感器探测
公开(公告)号：US20110015547A1
公开(公告)日：2011-01-20
申请号：US12885688
申请日：2010-09-20
申请人： Armen P. Sarvazyan , Vladimir Egorov , Suren Ayrapetyan
发明人： Armen P. Sarvazyan , Vladimir Egorov , Suren Ayrapetyan
IPC分类号： A61B5/103
CPC分类号： A61B5/103 , A61B5/0053 , A61B5/4381 , A61B5/6885 , A61B8/4254 , A61B2562/0247 , A61B2562/046
摘要： The present invention relates to a transrectal probe and method for real time mechanical imaging of a prostate. The probe is equipped with dual-array pressure sensors—one on the probe head and another on the shaft of the probe spaced away from the head with an angular and linear offset forming an S-shaped transition between the shaft and the head of the probe. The addition of the shaft pressure sensor array together with orientation tracking sensors allows precise calculation of the current head position throughout the examination of the prostate. Display means are used to guide the user in the proper manipulation of the probe in order to reduce the forces on surrounding tissues and organs and to minimize patient's discomfort.
摘要翻译：本发明涉及一种用于前列腺实时机械成像的经直肠探针和方法。探头配有双阵列压力传感器 - 一个在探针头上，另一个位于探头的轴上，与头部间隔开，并具有角度和线性偏移，在轴和探头头部之间形成S形过渡。轴压力传感器阵列与定向跟踪传感器的添加允许在整个前列腺检查期间精确计算当前的头部位置。显示装置用于引导用户适当地操纵探针，以减少对周围组织和器官的力并且最小化患者的不适。

2. 发明申请

US20090005707A1 Method and device for real time mechanical imaging of prostate 有权
标题翻译：前列腺实时机械成像的方法和装置
公开(公告)号：US20090005707A1
公开(公告)日：2009-01-01
申请号：US11123999
申请日：2005-05-06
申请人： Armen P. Sarvazyan , Vladimir Egorov , Sergiv Kanilo , Suren Ayrapetyan
发明人： Armen P. Sarvazyan , Vladimir Egorov , Sergiv Kanilo , Suren Ayrapetyan
IPC分类号： A61B5/117
CPC分类号： A61B5/1077 , A61B5/11 , A61B5/4381 , A61B5/6847 , A61B5/72 , A61B5/7425 , A61B2562/0247 , A61B2562/046
摘要： The present invention relates to a method for real time mechanical imaging of a prostate with a transrectal probe. In the method, generating a composite two- and three-dimensional prostate mechanical image from a plurality of partial mechanical images extracted from pressure response data and a probe orientation data starts with examining the prostate by pressing a probe head pressure sensor array against it at various overlapping locations. Merging of partial mechanical images together is accomplished by analyzing an overlap between each subsequent and previous partial mechanical image. Finding the prostate is assisted with a supplemental pressure response data indicating the location of a sphincter known to be about 4-5 cm away from the prostate. Data processing is improved by including probe orientation data to further increase the accuracy and sensitivity of the method. The probe is equipped with a two-dimensional head pressure sensor array, a supplemental shaft sensor array and orientation tracking sensors including a three-axis magnetic sensor and a two-axis accelerometer sensor for calculating elevation, rotation and azimuth angles of the probe.
摘要翻译：本发明涉及一种具有经直肠探针的前列腺实时机械成像的方法。在该方法中，从从压力响应数据和探针取向数据提取的多个部分机械图像中生成复合二维和三维前列腺机械图像开始于通过以各种方式按压探针头压力传感器阵列来抵抗前列腺重叠位置。通过分析每个后续和之前的部分机械图像之间的重叠来实现将部分机械图像合并在一起。通过补充压力响应数据来辅助前列腺，指示已知距离前列腺约4-5cm的括约肌的位置。通过包括探针取向数据来进一步提高该方法的准确度和灵敏度来改进数据处理。探头配备有二维头部压力传感器阵列，补充轴传感器阵列和定向跟踪传感器，其包括用于计算探头的仰角，旋转和方位角的三轴磁传感器和双轴加速度传感器。

3. 发明申请

US20110130685A1 METHOD AND DEVICE FOR REAL TIME MECHANICAL IMAGING OF PROSTATE 审中-公开
标题翻译：用于实时机械成像的方法和装置
公开(公告)号：US20110130685A1
公开(公告)日：2011-06-02
申请号：US13005401
申请日：2011-01-12
申请人： Armen P. Sarvazyan , Vladimir Egorov , Sergiy Kanilo , Suren Ayrapetyan
发明人： Armen P. Sarvazyan , Vladimir Egorov , Sergiy Kanilo , Suren Ayrapetyan
IPC分类号： A61B5/103
CPC分类号： A61B5/1077 , A61B5/11 , A61B5/4381 , A61B5/6847 , A61B5/72 , A61B5/7425 , A61B2562/0247 , A61B2562/046
摘要： The present invention relates to a method for real time mechanical imaging of a prostate with a transrectal probe. In the method, generating a composite two- and three-dimensional prostate mechanical image from a plurality of partial mechanical images extracted from pressure response data and a probe orientation data starts with examining the prostate by pressing a probe head pressure sensor array against it at various overlapping locations. Merging of partial mechanical images together is accomplished by analyzing an overlap between each subsequent and previous partial mechanical image. Finding the prostate is assisted with a supplemental pressure response data indicating the location of a sphincter known to be about 4-5 cm away from the prostate. Data processing is improved by including probe orientation data to further increase the accuracy and sensitivity of the method. The probe is equipped with a two-dimensional head pressure sensor array, a supplemental shaft sensor array and orientation tracking sensors including a three-axis magnetic sensor and a two-axis accelerometer sensor for calculating elevation, rotation and azimuth angles of the probe.
摘要翻译：本发明涉及一种具有经直肠探针的前列腺实时机械成像的方法。在该方法中，从从压力响应数据和探针取向数据提取的多个部分机械图像中生成复合二维和三维前列腺机械图像开始于通过以各种方式按压探针头压力传感器阵列来抵抗前列腺重叠位置。通过分析每个后续和之前的部分机械图像之间的重叠来实现将部分机械图像合并在一起。通过补充压力响应数据来辅助前列腺，指示已知距离前列腺约4-5cm的括约肌的位置。通过包括探针取向数据来进一步提高该方法的准确度和灵敏度来改进数据处理。探头配备有二维头部压力传感器阵列，补充轴传感器阵列和定向跟踪传感器，其包括用于计算探头的仰角，旋转和方位角的三轴磁传感器和双轴加速度传感器。

4. 发明授权

US07819824B2 Method and a dual-array transducer probe for real time mechanical imaging of prostate 有权
标题翻译：方法和双阵列换能器探针，用于前列腺的实时机械成像
公开(公告)号：US07819824B2
公开(公告)日：2010-10-26
申请号：US11146367
申请日：2005-06-06
申请人： Armen P. Sarvazyan , Vladimir Egorov , Suren Ayrapetyan
发明人： Armen P. Sarvazyan , Vladimir Egorov , Suren Ayrapetyan
IPC分类号： A61B5/103
CPC分类号： A61B5/103 , A61B5/0053 , A61B5/4381 , A61B5/6885 , A61B8/4254 , A61B2562/0247 , A61B2562/046
摘要： The present invention relates to a transrectal probe and method for real time mechanical imaging of a prostate. The probe is equipped with dual-array pressure sensors—one on the probe head and another on the shaft of the probe spaced away from the head with an angular and linear offset forming an S-shaped transition between the shaft and the head of the probe. The addition of the shaft pressure sensor array together with orientation tracking sensors allows precise calculation of the current head position throughout the examination of the prostate. Display means are used to guide the user in the proper manipulation of the probe in order to reduce the forces on surrounding tissues and organs and to minimize patient's discomfort.
摘要翻译：本发明涉及一种用于前列腺实时机械成像的经直肠探针和方法。探头配有双阵列压力传感器 - 一个在探针头上，另一个位于探头的轴上，与头部间隔开，并具有角度和线性偏移，在轴和探头头部之间形成S形过渡。轴压力传感器阵列与定向跟踪传感器的添加允许在整个前列腺检查期间精确计算当前的头部位置。显示装置用于引导用户适当地操纵探针，以减少对周围组织和器官的力并且最小化患者的不适。

5. 发明授权

US07922674B2 Method and device for real time mechanical imaging of prostate 有权
标题翻译：前列腺实时机械成像的方法和装置
公开(公告)号：US07922674B2
公开(公告)日：2011-04-12
申请号：US11123999
申请日：2005-05-06
申请人： Armen P. Sarvazyan , Vladimir Egorov , Sergiv Kanilo , Suren Ayrapetyan
发明人： Armen P. Sarvazyan , Vladimir Egorov , Sergiv Kanilo , Suren Ayrapetyan
IPC分类号： A61B5/103
CPC分类号： A61B5/1077 , A61B5/11 , A61B5/4381 , A61B5/6847 , A61B5/72 , A61B5/7425 , A61B2562/0247 , A61B2562/046
摘要： The present invention relates to a method for real time mechanical imaging of a prostate with a transrectal probe. In the method, generating a composite two- and three-dimensional prostate mechanical image from a plurality of partial mechanical images extracted from pressure response data and a probe orientation data starts with examining the prostate by pressing a probe head pressure sensor array against it at various overlapping locations. Merging of partial mechanical images together is accomplished by analyzing an overlap between each subsequent and previous partial mechanical image. Finding the prostate is assisted with a supplemental pressure response data indicating the location of a sphincter known to be about 4-5 cm away from the prostate. Data processing is improved by including probe orientation data to further increase the accuracy and sensitivity of the method. The probe is equipped with a two-dimensional head pressure sensor array, a supplemental shaft sensor array and orientation tracking sensors including a three-axis magnetic sensor and a two-axis accelerometer sensor for calculating elevation, rotation and azimuth angles of the probe.
摘要翻译：本发明涉及一种具有经直肠探针的前列腺实时机械成像的方法。在该方法中，从从压力响应数据和探针取向数据提取的多个部分机械图像中生成复合二维和三维前列腺机械图像开始于通过以各种方式按压探针头压力传感器阵列来抵抗前列腺重叠位置。通过分析每个后续和之前的部分机械图像之间的重叠来实现将部分机械图像合并在一起。通过补充压力响应数据来辅助前列腺，指示已知距离前列腺约4-5cm的括约肌的位置。通过包括探针取向数据来进一步提高该方法的准确度和灵敏度来改进数据处理。探头配备有二维头部压力传感器阵列，补充轴传感器阵列和定向跟踪传感器，其包括用于计算探头的仰角，旋转和方位角的三轴磁传感器和双轴加速度传感器。

6. 发明申请

US20080221484A1 Method and a dual-array transducer probe for real time mechanical imaging of prostate 有权
标题翻译：方法和双阵列换能器探针，用于前列腺的实时机械成像
公开(公告)号：US20080221484A1
公开(公告)日：2008-09-11
申请号：US11146367
申请日：2005-06-06
申请人： Armen P. Sarvazyan , Vladimir Egorov , Suren Ayrapetyan
发明人： Armen P. Sarvazyan , Vladimir Egorov , Suren Ayrapetyan
IPC分类号： A61B5/103
CPC分类号： A61B5/103 , A61B5/0053 , A61B5/4381 , A61B5/6885 , A61B8/4254 , A61B2562/0247 , A61B2562/046
摘要： The present invention relates to a transrectal probe and method for real time mechanical imaging of a prostate. The probe is equipped with dual-array pressure sensors—one on the probe head and another on the shaft of the probe spaced away from the head with an angular and linear offset forming an S-shaped transition between the shaft and the head of the probe. The addition of the shaft pressure sensor array together with orientation tracking sensors allows precise calculation of the current head position throughout the examination of the prostate. Display means are used to guide the user in the proper manipulation of the probe in order to reduce the forces on surrounding tissues and organs and to minimize patient's discomfort.
摘要翻译：本发明涉及一种用于前列腺实时机械成像的经直肠探针和方法。探头配有双阵列压力传感器 - 一个在探针头上，另一个位于探头的轴上，与头部间隔开，并具有角度和线性偏移，在轴和探头头部之间形成S形过渡。轴压力传感器阵列与定向跟踪传感器的添加允许在整个前列腺检查期间精确计算当前的头部位置。显示装置用于引导用户适当地操纵探针，以减少对周围组织和器官的力并且最小化患者的不适。

7. 发明申请

US20120259247A1 METHODS FOR ASSESSMENT OF IMPROVEMENTS IN PELVIC ORGAN CONDITIONS AFTER AN INTERVENTIONAL PROCEDURE 有权
标题翻译：传统程序之后评估有关条件改进措施的方法
公开(公告)号：US20120259247A1
公开(公告)日：2012-10-11
申请号：US13439165
申请日：2012-04-04
申请人： Vladimir Egorov , Heather van Raalte , Armen P. Sarvazyan
发明人： Vladimir Egorov , Heather van Raalte , Armen P. Sarvazyan
IPC分类号： A61B5/103
CPC分类号： A61B5/103 , A61B5/4337 , A61B5/6847
摘要： Methods for assessment of pelvic floor conditions based on tactile imaging are described. The vaginal wall is deformed before and after an interventional procedure using a transvaginal probe equipped with tactile pressure sensors and a motion tracking sensor. The vaginal wall coordinates and pressure patterns are obtained during the examination and used to build 3-D tactile image of the vagina and to calculate elasticity modulus profiles and spacing profiles along selected lines inside 3-D tactile image. The “before” and “after” profile values at specified locations are then compared to each other and to thresholds or profiles for normal conditions of vagina and its support structures. Methods of the invention may be used in estimating an improvement after an interventional procedure such as pelvic tissue regeneration, muscle repair or implantation of a supporting structure.
摘要翻译：描述了基于触觉成像评估盆底状况的方法。在使用装有触觉压力传感器和运动跟踪传感器的经阴道探针的介入手术之前和之后，阴道壁变形。在检查期间获得阴道壁坐标和压力图，并用于构建阴道的3-D触觉图像，并计算3-D触觉图像内选定线的弹性模量分布和间距分布。然后将指定位置处的前后分析值彼此进行比较，并将其与阴道及其支持结构的正常条件的阈值或分布进行比较。本发明的方法可用于估计介入手术如骨盆组织再生，肌肉修复或植入支撑结构之后的改善。

8. 发明授权

US08052622B2 Methods for characterizing vaginal tissue elasticity 有权
标题翻译：表征阴道组织弹性的方法
公开(公告)号：US08052622B2
公开(公告)日：2011-11-08
申请号：US12874583
申请日：2010-09-02
申请人： Vladimir Egorov , Armen P. Sarvazyan
发明人： Vladimir Egorov , Armen P. Sarvazyan
IPC分类号： A61B5/117 , A61B5/103
CPC分类号： A61B5/4337 , A61B5/0053 , A61B5/065 , A61B5/6847 , A61B5/6885 , A61B2562/0247 , A61B2562/0261 , A61B2562/046
摘要： Methods for characterizing elasticity of vaginal tissue are provided. A transvaginal probe is used to deform vaginal tissue during examination. The probe is equipped with pressure sensors and a motion tracking sensor. Stress and strain data is recorded during examination. Elasticity of vaginal tissue is then characterized by calculating a stress gradient defined as a ratio of stress over strain for each point of measurement. Vaginal tactile image may also be compiled to include a family of surfaces representing locations of measurement points at predefined constant levels of stress. Pelvic organ abnormality condition may be detected if the stress gradient is below either a predetermined threshold or a normal stress gradient obtained from clinical data.
摘要翻译：提供了表征阴道组织弹性的方法。经阴道探针用于在检查期间使阴道组织变形。探头配有压力传感器和运动跟踪传感器。在检查期间记录应力和应变数据。然后通过计算应力梯度来定义阴道组织的弹性，该应力梯度定义为每个测量点的应力与应变之比。阴道触觉图像也可以被编译成包括表示测量点的位置的表面系列，其具有预定的不变应力水平。如果应力梯度低于从临床数据获得的预定阈值或正常应力梯度，则可以检测到骨盆器官异常状况。

9. 发明申请

US20110196263A1 METHODS FOR ASSESSMENT OF PELVIC ORGAN CONDITIONS AFFECTING THE VAGINA 有权
标题翻译：评估影响VAGINA的皮肤器官条件的方法
公开(公告)号：US20110196263A1
公开(公告)日：2011-08-11
申请号：US13083494
申请日：2011-04-08
申请人： Vladimir Egorov , Heather van Raalte , Armen P. Sarvazyan
发明人： Vladimir Egorov , Heather van Raalte , Armen P. Sarvazyan
IPC分类号： A61B5/103 , A61F2/00
CPC分类号： A61B5/103 , A61B5/4337 , A61B5/6847
摘要： Methods for assessment of pelvic floor conditions based on tactile imaging are described. The vaginal wall is deformed using a transvaginal probe equipped with tactile pressure sensors and a motion tracking sensor. The vaginal wall coordinates and pressure patterns are obtained during the examination and used to build 3-D tactile image of the vagina and to calculate elasticity modulus profiles and spacing profiles along selected lines inside 3-D tactile image. The profile values at specified locations are then compared with thresholds or profiles for normal conditions of vagina and its support structures. Methods of the invention are disclosed to be used in assessing a risk of pelvic organ prolapse development, estimating an extent of pelvic floor organ traumatic damage after childbirth and estimating an improvement after an interventional procedure.
摘要翻译：描述了基于触觉成像评估盆底状况的方法。使用配有触觉压力传感器和运动跟踪传感器的经阴道探针使阴道壁变形。在检查期间获得阴道壁坐标和压力图，并用于构建阴道的3-D触觉图像，并计算3-D触觉图像内选定线的弹性模量分布和间距分布。然后将特定位置的轮廓值与阴道及其支撑结构的正常条件的阈值或轮廓进行比较。公开了本发明的方法来评估盆腔器官脱垂发展的风险，估计分娩后盆底器官创伤性损伤的程度并估计介入手术后的改善。

10. 外观设计

USD609801S1 Calibration chamber for prostate mechanical imaging probe 有权
标题翻译：前列腺机械成像探头校准室
公开(公告)号：USD609801S1
公开(公告)日：2010-02-09
申请号：US29320474
申请日：2008-06-27
申请人： Vladimir Egorov , Armen P. Sarvazyan
设计人： Vladimir Egorov , Armen P. Sarvazyan

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