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1. 发明申请

US20210332092A1 ARTICLES COMPRISING A SILK POLYPEPTIDE FOR ANTIGEN DELIVERY 有权
公开(公告)号：US20210332092A1
公开(公告)日：2021-10-28
申请号：US17245818
申请日：2021-04-30
申请人： AMSILK GmbH , Ludwig-Maximilians-Universitat Munchen , Universitat Bayreuth
发明人： Lin ROMER , Ute SLOTTA , Julia ENGERT , Gerhard WINTER , Matthias LUCKE , Thomas SCHEIBEL
IPC分类号： C07K14/435 , A61K39/385 , A61K47/64 , A61K47/65 , A61P35/00 , A61K47/42 , C12N15/62
摘要： The present invention relates to a polypeptide comprising a silk polypeptide and an antigen. Further, the present invention relates to an article comprising the polypeptide. Furthermore, the present invention relates to a pharmaceutical composition comprising the article. In addition, the present invention relates to the article or pharmaceutical composition for use as a pharmaceutical, for inducing an immune response and/or for use in a prophylactic and/or therapeutic treatment of a disease.

2. 发明申请

US20130225476A1 NOVEL BIOPOLYMER HAVING EXCELLENT TENSILE STRENGTH, EXTENSIBILITY AND TOUGHNESS 有权
标题翻译：具有优异的拉伸强度，可伸缩性和韧性的新型生物聚合物
公开(公告)号：US20130225476A1
公开(公告)日：2013-08-29
申请号：US13742636
申请日：2013-01-16
申请人： AMSilk GmbH
发明人： Thomas Scheibel , Felix Bauer
IPC分类号： C07K14/00
CPC分类号： C07K14/00 , A61K38/00 , C07K14/43563
摘要： The present invention relates to a biopolymer having excellent tensile strength, extensibility and toughness. The present invention further relates to a nucleic acid molecule encoding the biopolymer of the invention, a vector comprising the nucleic acid molecule of the invention and a non-human host transformed with the vector of the invention. Furthermore, the present invention relates to methods for producing a biopolymer of the invention and to foams, films, gels, coatings, particles, capsules, springs or nonwoven mats as well as fibres comprising or consisting of the biopolymer of the invention. The present invention also relates to a method of producing fibres and the biopolymer of the invention for use in medicine, agriculture, cosmetics as well as surface, paper, leather and/or textile processing.
摘要翻译：本发明涉及具有优异的拉伸强度，伸长性和韧性的生物聚合物。本发明还涉及编码本发明的生物聚合物的核酸分子，包含本发明的核酸分子的载体和用本发明的载体转化的非人宿主。此外，本发明涉及制备本发明的生物聚合物和泡沫，薄膜，凝胶，涂层，颗粒，胶囊，弹簧或非织造垫以及由本发明的生物聚合物组成或由其组成的纤维的方法。本发明还涉及用于医药，农业，化妆品以及表面，纸，皮革和/或纺织品加工的本发明的纤维和生物聚合物的生产方法。

3. 发明申请

US20130172478A1 METHOD FOR PRODUCTION OF POLYMER CONTAINING FIBRES 审中-公开
标题翻译：生产聚合物纤维的方法
公开(公告)号：US20130172478A1
公开(公告)日：2013-07-04
申请号：US13634484
申请日：2011-03-16
申请人： Andreas Bausch , Sebastian Rammensee
发明人： Andreas Bausch , Sebastian Rammensee
IPC分类号： D01F1/02 , D01F6/68
CPC分类号： D01F1/02 , C07K7/06 , C07K14/43563 , D01D5/00 , D01F4/00 , D01F6/68 , Y10T442/30 , Y10T442/60
摘要： The present invention relates to a method of spinning a polypeptide polymer containing fibre. It further relates to a polymer fibre obtainable by said method and to uses thereof. The invention also relates to products comprising said polymer fibre.
摘要翻译：本发明涉及纺丝含有纤维的多肽聚合物的方法。它还涉及通过所述方法获得的聚合物纤维及其用途。本发明还涉及包含所述聚合物纤维的产品。

4. 发明申请

US20130109762A1 SILK PARTICLES FOR CONTROLLED AND SUSTAINED DELIVERY OF COMPOUNDS 有权
标题翻译：用于控制和持续输送化合物的丝状颗粒
公开(公告)号：US20130109762A1
公开(公告)日：2013-05-02
申请号：US13512789
申请日：2010-11-30
申请人： Andreas Lammel , Thomas Scheibel , Martin Schwab , Gerhard Winter , Markus Hofer , Julia Myschik
发明人： Andreas Lammel , Thomas Scheibel , Martin Schwab , Gerhard Winter , Markus Hofer , Julia Myschik
IPC分类号： A61K9/00
CPC分类号： A61K9/0002 , A61K31/137 , A61K31/138 , A61K31/245 , A61K31/285 , A61K31/40 , A61K31/485 , A61K38/00 , C07K14/43518
摘要： The present invention relates to a method of producing and loading silk particles, preferably spider silk particles, with a compound. In particular, the present invention provides a novel two step method for loading silk particles, preferably spider silk particles, with small and water-soluble compounds. Also disclosed are silk particles, preferably spider silk particles, loaded with at least one compound which are eminently suited as carriers for controlled and sustained delivery applications. Furthermore, the invention relates to pharmaceutical or cosmetic compositions comprising said silk particles, preferably spider silk particles, and a pharmaceutically active compound or cosmetic compound for controlled and sustained release. The present invention is also directed to silk particles, preferably spider silk particles, loaded with a compound obtainable by the method according to the invention.
摘要翻译：本发明涉及一种用化合物生产和加载丝粒子，优选蜘蛛丝粒子的方法。特别地，本发明提供了一种用于将丝状颗粒，优选蜘蛛丝颗粒加载到小的和水溶性化合物的新颖的两步法。还公开了装载有至少一种非常适合用作控制和持续递送应用的载体的化合物的丝粒子，优选蜘蛛丝粒子。此外，本发明涉及包含所述丝粒，优选蜘蛛丝颗粒的药物或化妆品组合物，以及用于受控和持续释放的药学活性化合物或化妆品化合物。本发明还涉及装有可通过本发明方法获得的化合物的丝粒子，优选蜘蛛丝粒子。

5. 发明申请

US20110230911A1 RECOMBINANT SPIDER SILK PROTEINS 有权
标题翻译：重组天丝蛋白蛋白
公开(公告)号：US20110230911A1
公开(公告)日：2011-09-22
申请号：US13117274
申请日：2011-05-27
申请人： Thomas Scheibel , Daniel Huemmerich , Christian Ackerschott
发明人： Thomas Scheibel , Daniel Huemmerich , Christian Ackerschott
IPC分类号： A61B17/04 , C07K14/435 , D02G1/20
CPC分类号： A61L27/227 , A61L27/52 , C07K14/43518 , D01F4/02
摘要： The present invention is directed to recombinant spider silk proteins, nucleic acids, coding for these recombinant spider silk proteins, as well as hosts suitable for expressing those nucleic acids. Furthermore, the present invention is directed to a method of aggregation of spider silk proteins and the use of the proteins in the field of biotechnology and/or medicine and other industrial fields, in particular in the manufacture of automotive parts, in the aircraft construction, in the processing of textiles and leather, as well as in the manufacture and processing of paper and the like.
摘要翻译：本发明涉及编码这些重组蜘蛛丝蛋白的重组蜘蛛丝蛋白，核酸，以及适于表达这些核酸的宿主。此外，本发明涉及一种聚集蜘蛛丝蛋白的方法以及在生物技术和/或医药领域以及其它工业领域，特别是在制造汽车部件领域中的蛋白质在飞机结构中的应用，在加工纺织品和皮革以及纸张的制造和加工等方面。

6. 发明公开

US20240301015A1 SILK POLYPEPTIDE FORMULATION COMPRISING FORMATE 审中-公开
公开(公告)号：US20240301015A1
公开(公告)日：2024-09-12
申请号：US18568183
申请日：2022-06-02
申请人： AMSILK GMBH
发明人： Jens Klein , Lin Romer , Andreas Schmideder
IPC分类号： C07K14/435
CPC分类号： C07K14/43518
摘要： The present invention relates to an acidic formulation comprising a silk polypeptide and formate. The present invention further relates to a method for producing said formulation. The present invention also relates to the uses of said formulation.

7. 发明授权

US11324852B2 Coated silk films, methods for the production thereof and uses thereof 有权
公开(公告)号：US11324852B2
公开(公告)日：2022-05-10
申请号：US15115215
申请日：2015-01-29
申请人： AMSILK GMBH , LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN
发明人： Gerhard Winter , Elisa Agostini , Julia Engert , Lin Romer , Ute Slotta
IPC分类号： A61L15/32 , A61K8/64 , A61L15/44 , A61Q19/00 , A61K8/02 , A61L15/40 , A61K9/70 , A61K8/98
摘要： The present invention relates to coated silk films. Further, the present invention relates to pharmaceutical or cosmetic compositions comprising the coated silk films. Furthermore, the present invention relates to coated silk films or pharmaceutical compositions comprising the coated silk films for use in medicine. In addition, the present invention relates to methods of producing the coated silk films.

8. 发明申请

US20210347832A1 ARTICLES COMPRISING A SILK POLYPEPTIDE FOR ANTIGEN DELIVERY 有权
公开(公告)号：US20210347832A1
公开(公告)日：2021-11-11
申请号：US17383926
申请日：2021-07-23
申请人： AMSILK GmbH , Ludwig-Maximilians-Universitat Munchen , Universitat Bayreuth
发明人： Lin Romer , Ute Slotta , Julia Engert , Gerhard Winter , Matthias Lucke , Thomas Scheibel
IPC分类号： C07K14/435 , A61K39/385 , A61K47/64 , A61K47/65 , A61P35/00 , A61K47/42 , C12N15/62
摘要： The present invention relates to a polypeptide comprising a silk polypeptide and an antigen. Further, the present invention relates to an article comprising the polypeptide. Furthermore, the present invention relates to a pharmaceutical composition comprising the article. In addition, the present invention relates to the article or pharmaceutical composition for use as a pharmaceutical, for inducing an immune response and/or for use in a prophylactic and/or therapeutic treatment of a disease.

9. 发明授权

US10253213B2 Silk protein coatings 有权
公开(公告)号：US10253213B2
公开(公告)日：2019-04-09
申请号：US14958775
申请日：2015-12-03
申请人： AMSILK GMBH
发明人： Axel H. Leimer , Lin Romer
IPC分类号： C07K14/435 , C09D189/00 , D06M15/15 , D06M23/10 , C03C17/28 , C04B41/48 , C08J7/04 , C23C2/04
摘要： The present invention relates to a method for coating an inert or naturally occurring material with a silk polypeptide. It further relates to a coated inert or naturally occurring material obtainable by said method and to uses thereof. It also relates to products comprising said coated material.

10. 发明授权

US10072152B2 Methods for producing high toughness silk fibres 有权
公开(公告)号：US10072152B2
公开(公告)日：2018-09-11
申请号：US14426316
申请日：2013-09-05
申请人： Amsilk GmbH
发明人： Thomas Scheibel , Axel Leimer , Lin Römer , Lukas Eisoldt , Aniela Heidebrecht , Martha Geffers
IPC分类号： C08L89/00 , C07K14/435 , B29C47/00 , C08L1/02 , C08L5/02 , C08L23/12 , C08L33/08 , C08L67/00 , C08L67/04 , C08L75/04 , C08L77/06 , C08L89/04 , B29L31/00
CPC分类号： C08L89/00 , B29C48/022 , B29K2089/00 , B29L2031/731 , C07K14/43518 , C07K14/43586 , C08L1/02 , C08L5/02 , C08L23/12 , C08L33/08 , C08L67/00 , C08L67/04 , C08L75/04 , C08L77/06 , C08L89/04
摘要： The present invention provides methods for producing a silk protein spinning dope solution suitable for producing high toughness fibers, the thus produced silk protein spinning dope solution, methods for producing fibers using said silk protein spinning dope solution.

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