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81. 发明授权

US09434752B2 Dinuclear metallocene compound, and a method for preparing the same 有权
标题翻译：双核茂金属化合物及其制备方法
公开(公告)号：US09434752B2
公开(公告)日：2016-09-06
申请号：US14895875
申请日：2013-12-27
申请人： LG CHEM, LTD.
发明人： Young Shil Do , Choong Hoon Lee , Seung Hwan Jung , Ji Joong Moon , Yoon Hee Cho , Sang Eun Park
IPC分类号： C07F7/28 , C07F7/00 , C07F17/00 , C08F4/76
CPC分类号： C07F7/28 , C07F17/00 , C08F4/76
摘要： The present invention relates to a dinuclear metallocene compound with a new structure which can manufacture polyolefin having high molecular weight and to a method for preparing the same. The dinuclear metallocene compound according to the present invention is a dinuclear metallocene compound with a new structure, and, unlike a single-site catalyst, has high accessibility to a substrate, and thus, can provide a multi-site catalyst with high activity.
摘要翻译：本发明涉及具有可制造高分子量聚烯烃的新结构的双核金属茂化合物及其制备方法。根据本发明的双核茂金属化合物是具有新结构的双核金属茂化合物，并且与单中心催化剂不同，对基材的可及性高，因此可提供高活性的多位点催化剂。

82. 发明申请

US20160207951A1 ORGANOMETALLIC COMPOUNDS FOR USE AS ANTHELMINTICS 审中-公开
标题翻译：有机化合物作为ANTHELMINTICS使用
公开(公告)号：US20160207951A1
公开(公告)日：2016-07-21
申请号：US15023414
申请日：2014-09-26
申请人： UNIVERSITÄT ZÜRICH , THE UNIVERSITY OF MELBOURNE
发明人： Gilles GASSER , Robin B. GASSER , Jeannine HESS , Abdul JABBAR , Malay PATRA
IPC分类号： C07F17/02 , C07F15/06 , A01N55/02 , C07F17/00
CPC分类号： C07F17/02 , A01N31/04 , A01N33/08 , A01N35/04 , A01N35/10 , A01N37/14 , A01N37/40 , A01N37/44 , A01N47/02 , A01N47/48 , A01N55/02 , A01N59/16 , C07F13/00 , C07F15/06 , C07F17/00
摘要： The Invention comprises a compound characterized by a general formula (1), RL—OM-RR (1) wherein OM is an organometallic compound independently selected from the group of an unsubstituted or substituted metal sandwich compound, an unsubstituted or substituted half metal sandwich compound or a metal carbonyl compound, and wherein at least one of RL and RR is selected from and their use for in a method of treatment of disease, in particular their use against helminths.
摘要翻译：本发明包括由通式（1）表示的化合物，RL-OM-RR（1），其中OM是独立地选自未取代或取代的金属夹心化合物，未取代或取代的半金属夹心化合物的有机金属化合物或金属羰基化合物，并且其中RL和RR中的至少一个选自它们在治疗疾病的方法中的用途，特别是其用于抗蠕虫的用途。

83. 发明申请

US20150374858A1 CONJUGATES DERIVED FROM NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND METHODS OF USE THEREOF IN IMAGING 有权
标题翻译：非甾体抗炎药物衍生的结合物及其在成像中的使用方法
公开(公告)号：US20150374858A1
公开(公告)日：2015-12-31
申请号：US14746349
申请日：2015-06-22
申请人： Reiley Pharmaceuticals, Inc.
发明人： Mark A. REILEY , B. Michael SILBER , Julio MEDINA , Frank KAYSER , William D. SHRADER
IPC分类号： A61K51/04 , C07F17/00 , C07B59/00 , C07F13/00 , A61K51/08
CPC分类号： C07B59/004 , A61K51/0402 , A61K51/0478 , A61K51/0487 , A61K51/0497 , C07F13/00 , C07F13/005
摘要： Conjugates derived from non-steroidal anti-inflammatory drugs (NSAIDs) and methods of use thereof are disclosed, useful for, inter alia, identifying and localizing the site of pathology and/or inflammation responsible for the sensation of pain in a patient; for identifying the sites of primary, secondary, benign, or malignant tumors; and for diagnosing infection or confirming or ruling out suspected infection. The NSAID-based conjugates contain an imaging moiety. The conjugates concentrate at sites of increased cyclooxygenase expression, thus revealing the sites of increased prostaglandin production, which is correlated with pain and inflammation, and correlated with tumor presence and/or location. Identifying areas of increased COX expressing can also aid in screening for infections.
摘要翻译：公开了衍生自非甾体抗炎药（NSAID）的缀合物及其使用方法，用于特别是鉴定和定位病人和/或炎症部位，该部位负责患者的疼痛感觉; 用于鉴定原发性，继发性，良性或恶性肿瘤的部位; 并用于诊断感染或确认或排除疑似感染。基于NSAID的缀合物含有成像部分。缀合物集中在增加的环加氧酶表达的位点，从而揭示了与疼痛和炎症相关的前列腺素产生增加的位点，并且与肿瘤存在和/或位置相关。识别增加的COX表达的区域也可以帮助筛查感染。

84. 发明授权

US09200092B2 η5:η1-cyclopentadienylidene-phosphorane constrained geometry complexes of rare earth metals 有权
标题翻译：＆eegr; 5：稀土金属的1-环戊二烯基 - 正膦面约束几何复合物
公开(公告)号：US09200092B2
公开(公告)日：2015-12-01
申请号：US14235259
申请日：2012-08-02
申请人： Nina Hillesheim , Jörg Sundermeyer
发明人： Nina Hillesheim , Jörg Sundermeyer
IPC分类号： C07F17/00 , C07F9/54 , C08F4/52 , C08F10/00 , B01J31/02 , B01J31/22 , C07F9/535 , C08F36/08 , C08G63/84 , C08G63/82
CPC分类号： C08F4/52 , B01J31/0235 , B01J31/2265 , B01J31/2295 , B01J2531/0205 , B01J2531/36 , B01J2531/37 , B01J2531/38 , C07F9/5352 , C07F9/54 , C07F17/00 , C08F36/08 , C08F2420/02 , C08G63/823 , C08G63/84 , C08F136/08 , C08F4/545
摘要： The invention relates to η5:η1-cyclopentadienylidene-phosphorane constrained geometry complexes of rare earth metals, abbreviated to η5:η1-CpPC-CGC, method for production and use of same. The η5:η1-CpPC-CGCs correspond to the general formula (1), wherein SE=Sc, Y, La, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb or Lu; X=independently of one another, a mono-anionic diorganoamido-, bistrimethylsilylamido-, halogenido-, alkyl-, aryl-, alkoxo-, aryloxo- or alkylaluminate (AlR4−) substituent; L=neutral ligand (PR3, NR3, pyridine), solvent molecule (THF, ether, DMF, DMSO, HMPT, tetrahydropyran THP, tetrahydrothiofuran THT); R=alkyl with up to 1-10 C atoms or mono- or polycyclical aryl with 6 to 20 C atoms; R1, R4=independently of one another H or methyl; R2, R3=independently of one another, H or methyl or tertiary butyl or together a substituted cycloalkyl group; R5, R6=methyl, n-butyl, tertiary butyl or phenyl; R7, R8=independently of one another H, trimethylsilyl, alkyl with 1-10 C atoms or mono- or polycyclical aryl with 6 to 20 C atoms, and m=0, 1, 2 or 3.
摘要翻译：本发明涉及＆amp; 5＆gt;稀土金属的1-环戊二烯基 - 正磷烷约束几何配合物，缩写为＆amp; e＆gt; 1-CpPC-CGC，其生产和使用方法。其中SE = Sc，Y，La，Ce，Pr，Nd，Pm，Sm，Eu，Gd，Tb，Dy，Ho等于通式（1） Er，Tm，Yb或Lu; X =彼此独立，单阴离子二有机基酰胺基，双三甲基甲硅烷基氨基 - ，卤代 - ，烷基 - ，芳基 - ，烷氧基 - ，芳氧基 - 或烷基铝酸盐（AlR 4 - ）取代基; L =中性配体（PR3，NR3，吡啶），溶剂分子（THF，醚，DMF，DMSO，HMPT，四氢吡喃THP，四氢噻呋喃THT）; R =具有至多1-10个C原子的烷基或具有6至20个C原子的单环或多环芳基; R1，R4 =彼此独立地为H或甲基; R2，R3彼此独立地为H或甲基或叔丁基或一起取代的环烷基; R5，R6 =甲基，正丁基，叔丁基或苯基; R 7，R 8彼此独立地为H，三甲基甲硅烷基，具有1-10个C原子的烷基或具有6至20个C原子的单环或多环芳基，m = 0,1,2或3。

85. 发明授权

US09185914B2 Substituted 5-(cyclohex-2-en-1-yl)-penta-2,4-dienes and 5-(cyclohex-2-en-1-yl)-pent-2-en-4-ines as active agents against abiotic stress in plants 有权
标题翻译：取代的5-（环己-2-烯-1-基） - 戊-2,4-二烯和5-（环己-2-烯-1-基） - 戊-2-烯-4-酮作为活性剂，植物中的非生物胁迫
公开(公告)号：US09185914B2
公开(公告)日：2015-11-17
申请号：US14111741
申请日：2012-03-28
申请人： Jens Frackenpohl , Thomas Müller , Ines Heinemann , Pascal Von Koskull-Döring , Christopher Hugh Rosinger , Isolde Häuser-Hahn , Martin Jeffrey Hills
发明人： Jens Frackenpohl , Thomas Müller , Ines Heinemann , Pascal Von Koskull-Döring , Christopher Hugh Rosinger , Isolde Häuser-Hahn , Martin Jeffrey Hills
IPC分类号： A01N43/40 , A01N35/06 , A01N33/24 , A01N55/00 , A01N37/42 , A01N43/30 , C07C403/20 , C07D317/72 , C07F7/22 , C07F7/18 , C07F17/00 , C07F7/30
CPC分类号： A01N55/00 , A01N33/24 , A01N35/06 , A01N37/42 , A01N43/30 , C07C403/20 , C07C2601/02 , C07C2601/16 , C07D317/72 , C07F7/1804 , C07F7/2208 , C07F7/30 , C07F17/00
摘要： Substituted 5-(cyclohex-2-en-1-yl)-penta-2,4-dienes and 5-(cyclohex-2-en-1-yl)-pent-2-en-4-ynes as active agents against abiotic stress in plantsThe invention relates to substituted 5-(cyclohex-2-en-1-yl)penta-2,4-dienes and 5-(cyclohex-2-en-1-yl)pent-2-en-4-ynes of the formula (I) and their salts where the radicals R1, R2, R3, R4, [X—Y] and Q are each as defined in the description, to processes for preparation thereof and to the use thereof for enhancing stress tolerance in plants with respect to abiotic stress, and/or for increasing plant yield.
摘要翻译：取代5-（环己-2-烯-1-基） - 戊-2,4-二烯和5-（环己-2-烯-1-基） - 戊-2-烯-4-炔，作为活性剂，植物中的非生物胁迫本发明涉及取代的5-（环己-2-烯-1-基）五2,4-二烯和5-（环己-2-烯-1-基）戊-2-烯-4 式（I）的炔及其盐，其中基团R 1，R 2，R 3，R 4，[X-Y]和Q各自如说明书中所定义，其制备方法及其用于增强应激的用途植物对非生物胁迫的耐受性和/或增加植物产量。

86. 发明申请

US20150284490A1 SUBSTITUTED ZIRCONOCENES CATALYSTS AND METHODS OF USE IN POLYMERIZATION REACTIONS 有权
标题翻译：取代的ZIRCONOCENES催化剂及其在聚合反应中的使用方法
公开(公告)号：US20150284490A1
公开(公告)日：2015-10-08
申请号：US14677690
申请日：2015-04-02
申请人： Equistar Chemicals, LP
发明人： Sandor Nagy , Shahram Mihan , Linda N. Winslow , Ilya E. Nifant’ev , Pavel V. Ivchenko , Vladimir V. Bagrov , Igor A. Kashulin
IPC分类号： C08F210/16 , C07F17/00
CPC分类号： C08F210/16 , C07F17/00 , C08F4/65912 , C08F4/65925
摘要： The present disclosure relates to metallocene catalysts for use in polymerization processes. Such catalysis may be used to generate long chain polymers with low long chain branching and high molecular weights. Additionally, the size of the polymers produced can be controlled by modifying the ratio of MAO or other activator to metallocene catalyst.
摘要翻译：本公开涉及用于聚合方法的茂金属催化剂。这种催化可用于产生具有低长链支化和高分子量的长链聚合物。另外，可以通过改变MAO或其它活化剂与茂金属催化剂的比例来控制所生产的聚合物的尺寸。

87. 发明申请

US20150284489A1 NON-BRIDGED METALLOCENE COMPLEXES FOR THE POLYMERIZATION OF OLEFINS 有权
标题翻译：用于烯烃聚合的非桥联金属络合物
公开(公告)号：US20150284489A1
公开(公告)日：2015-10-08
申请号：US14677668
申请日：2015-04-02
申请人： Equistar Chemicals, LP
发明人： Sandor Nagy , Shahram Mihan , Ilya E. Nifant'ev , Pavel V. Ivchenko , Vladimir V. Bagrov , Igor A. Kashulin
IPC分类号： C08F210/16 , C07F17/00
CPC分类号： C08F210/16 , C07F17/00 , C08F4/65912 , C08F4/65916 , C08F4/65925 , C08F10/00 , C08F210/08 , C08F2500/09 , C08F2500/03
摘要： The present disclosure relates to metallocene catalyst and the use thereof to make polyolefins. In particular, the present disclosure relates to silyl-functionalized metallocene catalyst and the use of the silyl-functionalized metallocene catalyst to polymerize olefins and yield a polyolefin. Also, the present disclosure relates to a method for producing a polyolefin comprising at least the step of contacting an olefin with a metallocene catalyst to produce a polyolefin. In particular, the present disclosure provides a method for producing a polyolefin comprising the step of contacting an olefin with a silyl-functionalized metallocene catalyst.
摘要翻译：本发明涉及茂金属催化剂及其制备聚烯烃的用途。特别地，本公开涉及甲硅烷基官能化的茂金属催化剂和甲硅烷基官能化的茂金属催化剂用于聚合烯烃并产生聚烯烃的用途。此外，本公开涉及一种生产聚烯烃的方法，至少包括使烯烃与茂金属催化剂接触以制备聚烯烃的步骤。特别地，本公开提供了一种生产聚烯烃的方法，其包括使烯烃与甲硅烷基官能化的茂金属催化剂接触的步骤。

88. 发明授权

US09062134B2 Half-metallocene compounds and catalyst compositions 有权
标题翻译：半茂金属化合物和催化剂组合物
公开(公告)号：US09062134B2
公开(公告)日：2015-06-23
申请号：US14277140
申请日：2014-05-14
申请人： Chevron Phillips Chemical Company LP
发明人： Errun Ding , Joel L. Martin , Albert P. Masino , Qing Yang , Youlu Yu
IPC分类号： C08F4/6592 , C08F4/642 , C08F10/00 , C08F210/16 , C08F4/76 , C07F17/00 , C08F4/659
CPC分类号： C08F4/76 , C07F17/00 , C08F4/65912 , C08F4/65916 , C08F4/6592 , C08F10/00 , C08F210/16 , C08F210/14 , C08F2500/04 , C08F2500/07 , C08F2500/12
摘要： The present invention provides polymerization catalyst compositions employing half-metallocene compounds with a heteroatom-containing ligand bound to the transition metal. Methods for making these hybrid metallocene compounds and for using such compounds in catalyst compositions for the polymerization of olefins also are provided.
摘要翻译：本发明提供了采用具有与过渡金属结合的含杂原子的配体的半茂金属化合物的聚合催化剂组合物。还提供了制备这些杂化茂金属化合物和在用于烯烃聚合的催化剂组合物中使用这些化合物的方法。

89. 发明授权

US09023402B2 Method for treating a mammal by administration of a compound having the ability to release CO 有权
标题翻译：通过给予具有释放CO能力的化合物来治疗哺乳动物的方法
公开(公告)号：US09023402B2
公开(公告)日：2015-05-05
申请号：US13078735
申请日：2011-04-01
申请人： Werner E. Haas , Carlos C. Romao , Beatriz Royo , Ana Cristina Fernandes , Isabel Goncalves
发明人： Werner E. Haas , Carlos C. Romao , Beatriz Royo , Ana Cristina Fernandes , Isabel Goncalves
IPC分类号： A61K33/00 , A61K33/24 , A61K31/28 , A61K31/665 , A61K31/67 , A61K31/675 , C07F17/00 , A61K31/00 , A61K31/555 , A61K31/60 , A61K31/603 , A61K31/616 , A61K31/695 , A61K31/7048 , A61K31/7135 , A61K33/14 , A61K33/32 , A61K45/06 , A61K47/48 , C07F11/00 , C07F13/00 , C07F15/02
CPC分类号： C07F17/00 , A61K31/00 , A61K31/28 , A61K31/555 , A61K31/60 , A61K31/603 , A61K31/616 , A61K31/695 , A61K31/7048 , A61K31/7135 , A61K33/00 , A61K33/14 , A61K33/32 , A61K45/06 , A61K47/52 , C07F11/005 , C07F13/005 , C07F15/02 , Y10S514/824 , Y10S514/825 , Y10S514/826 , Y10S514/879 , Y10S514/886 , Y10S514/887 , Y10S514/894 , Y10S514/903 , Y10S514/921 , Y10S514/929 , Y10S514/95 , Y10S514/958 , Y10S514/959 , Y10S514/964 , A61K2300/00
摘要： Several classes of in vivo carbon monoxide-releasing compounds are useful for the treatment and/or prevention of diseases, such as chronic inflammatory, e.g., rheumatoid arthritis, and of diseases with a strong inflammatory component, such as atherosclerosis, stroke, coronary disease, and Alzheimers disease. The in vivo carbon monoxide-releasing compounds can be attached to known drug vectors and/or known anti-inflammatory drugs, such as aspirin.
摘要翻译：几类体内释放一氧化碳的化合物可用于治疗和/或预防疾病，例如慢性炎症，例如类风湿性关节炎，以及具有强烈炎症成分的疾病，例如动脉粥样硬化，中风，冠状动脉疾病，和阿尔茨海默病。体内释放一氧化碳的化合物可以连接到已知的药物载体和/或已知的抗炎药物，例如阿司匹林。

90. 发明授权

US09018387B2 Complexes of imidazole ligands 有权
标题翻译：咪唑配体的配合物
公开(公告)号：US09018387B2
公开(公告)日：2015-04-28
申请号：US13152885
申请日：2011-06-03
申请人： John Anthony Thomas Norman , Melanie K. Perez , Xinjian Lei , Daniel P. Spence , Sergei Vladimirovich Ivanov , Wade Hampton Bailey, III
发明人： John Anthony Thomas Norman , Melanie K. Perez , Xinjian Lei , Daniel P. Spence , Sergei Vladimirovich Ivanov , Wade Hampton Bailey, III
IPC分类号： C07F5/00 , C07F7/28 , C07F15/00 , C07F17/02 , C07F15/02 , C07F15/04 , C07F15/06 , C07F17/00 , C07F7/00
CPC分类号： C07F17/02 , C07F5/00 , C07F5/003 , C07F7/003 , C07F7/28 , C07F15/02 , C07F15/04 , C07F15/06 , C07F17/00
摘要： Metal imidazolate complexes are described where imidazoles ligands functionalized with bulky groups and their anionic counterpart, i.e., imidazolates are described. Compounds comprising one or more such polyalkylated imidazolate anions coordinated to a metal or more than one metal, selected from the group consisting of alkali metals, transition metals, lanthanide metals, actinide metals, main group metals, including the chalcogenides, are contemplated. Alternatively, multiple different imidazole anions, in addition to other different anions, can be coordinated to metals to make new complexes. The synthesis of novel compounds and their use to form thin metal containing films is also contemplated.
摘要翻译：描述了金属咪唑盐络合物，其中描述了用大体积基团官能化的咪唑配体及其阴离子配对物，即咪唑盐。包括一种或多种这样的多烷基化咪唑酸盐阴离子配位到金属或一种以上选自碱金属，过渡金属，镧系元素金属，锕系金属，主要金属（包括硫族化物）的金属中。或者，除了其它不同的阴离子之外，多种不同的咪唑阴离子可以与金属配位以制备新的络合物。还考虑了新化合物的合成及其用于形成含薄金属膜的用途。

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