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81. 发明授权

US4554371A Phenoxyalkylcarboxylic acids 失效
标题翻译：苯氧基烷基羧酸
公开(公告)号：US4554371A
公开(公告)日：1985-11-19
申请号：US637062
申请日：1984-08-02
申请人： Bernard Majoie
发明人： Bernard Majoie
IPC分类号： C07C69/712 , A61K31/19 , A61K31/22 , A61P25/04 , A61P29/00 , C07C51/00 , C07C59/125 , C07C59/70 , C07C59/90 , C07C67/00 , C07C219/06 , C07D317/22 , C07D317/24 , A61K31/44
CPC分类号： C07D317/24 , C07C59/90
摘要： Arylcarbonylphenoxyalkylcarboxylic acids, and alkyl esters and salts thereof, are described. The compounds may be formulated into therapeutic compositions and administered to animals, including humans, for the treatment of hyperlipidaemia and related diseases.
摘要翻译：描述了芳基羰基苯氧基烷基羧酸及其烷基酯和盐。可以将化合物配制成治疗组合物并施用于包括人在内的动物用于治疗高脂血症和相关疾病。

82. 发明授权

US4518612A Naphthalene and 2-oxo-benzopyran acids and derivatives and pharamaceutical use thereof 失效
标题翻译：萘和2-氧代 - 苯并吡喃酸及其衍生物和药物用途
公开(公告)号：US4518612A
公开(公告)日：1985-05-21
申请号：US563709
申请日：1983-12-21
申请人： John R. Bantick , John Fuher , David N. Hardern , Thomas B. Lee
发明人： John R. Bantick , John Fuher , David N. Hardern , Thomas B. Lee
IPC分类号： A61K31/19 , C07C43/225 , C07C43/23 , C07C45/00 , C07C45/71 , C07C47/565 , C07C59/52 , C07C59/70 , C07C59/74 , C07C59/90 , C07C65/11 , C07C65/24 , C07C65/40 , C07D209/42 , C07D307/84 , C07D307/85 , C07D311/06 , C07D311/08 , C07D311/16 , C07D333/70 , A61K31/35 , C07D311/12
CPC分类号： C07D333/70 , C07C323/00 , C07C43/225 , C07C43/23 , C07C45/00 , C07C45/71 , C07C47/565 , C07C59/70 , C07C59/74 , C07C59/90 , C07C65/24 , C07C65/40 , C07D209/42 , C07D307/85 , C07D311/16 , Y10S514/826 , Y10S514/849
摘要： There are described compounds of formula I, ##STR1## in which Ra, Rb, Rc, Rd, Re, Rf and Rg, which may be the same or different, each represent hydrogen, amino, hydroxy, alkoxy, alkenyloxy, halogen, acyl, alkenyl, alkyl, or alkoxy substituted by phenyl,Rh is hydrogen, alkyl or --COOH.X is a hydrocarbon chain containing from 2 to 10 carbon atoms and optionally substituted by a hydroxy group,A has no significance or represents Y, OY, or SY and Y represents a C 1 to 4 hydrocarbon chain which is optionally substituted by alkyl C 1 to 4,E and G, which may be the same or different, each represent --O--, --S-- or --CH.sub.2 --, provided that at least one of E and G is --O-- or --S--,L, together with the carbon atoms to which it is attached, forms a benzene, furan, thiophene, pyrrole, or pyran-2-one ring,and pharmaceutically acceptable derivatives thereof.

83. 发明授权

US4483999A Phenoxy alkanoic acid derivatives having the ability to lower the level of fatty substances in the blood 失效
标题翻译：具有降低血液中脂肪物质水平的能力的苯氧基链烷酸衍生物
公开(公告)号：US4483999A
公开(公告)日：1984-11-20
申请号：US773148
申请日：1977-03-01
申请人： Kurt Thiele , Quazi Ahmed , Rudolf Adrian , Ulrich Jahn
发明人： Kurt Thiele , Quazi Ahmed , Rudolf Adrian , Ulrich Jahn
IPC分类号： C07C59/68 , C07C59/70 , C07C69/712 , C07D211/46 , C07D473/08 , C07C69/76
CPC分类号： C07C321/00 , C07C59/68 , C07C59/70 , C07D211/46 , C07D473/08
摘要： Novel compounds of the formula ##STR1## wherein R.sup.1 is hydrogen, halogen, or alkyl or alkoxy containing from 1 to 4 carbon atoms,R.sup.2 is hydrogen, halogen, hydroxy or alkyl of alkoxy containing from 1 to 4 carbon atoms,n and m are integers such that the sum (n+m) lies in the range from 3 to 10 inclusive and n differs from m, andx is alkyl containing from 1 to 4 carbon atoms, hydrogen or a cation which is a metal cation of main Groups 1, 2 and 3 of the Periodic System of the Elements, an organic base cation or an ammonium ion. These compounds have pharmaceutical utility by virtue of their considerable ability to reduce the level of fatty substances in the blood.
摘要翻译：式中，R 1为氢，卤素，含有1至4个碳原子的烷基或烷氧基，R2为氢，卤素，羟基或含有1至4个碳原子的烷氧基烷基，n和m的新型化合物整数，使得和（n + m）在3〜10的范围内，n与m不同，x是含有1〜4个碳原子的烷基，氢或作为主体1的金属阳离子的阳离子，元素周期系统的2和3，有机碱性离子或铵离子。这些化合物由于其相当的降低血液中脂肪物质含量的能力而具有药用效用。

84. 发明授权

US4440786A Compounds with antiinflammatory and analgesic activity, process for the preparation thereof and pharmaceutical compositio ns therefrom 失效
标题翻译：具有抗炎和止痛活性的化合物，其制备方法和药物组合物
公开(公告)号：US4440786A
公开(公告)日：1984-04-03
申请号：US380124
申请日：1982-05-20
申请人： Leonardo de Vincentiis
发明人： Leonardo de Vincentiis
IPC分类号： A61K31/19 , A61P25/04 , A61P29/00 , C07C51/00 , C07C51/367 , C07C59/125 , C07C59/70 , C07C67/00 , C07C59/52 , A01N37/12
CPC分类号： C07C59/70
摘要： The compound (2',4'-difluoro-4-biphenyl)oxyacetic acid and its pharmaceutically acceptable salts with a metal or an organic base are described. They exhibit high antiinflammatory and analgesic activity and do not cause gastric lesions.
摘要翻译：描述了化合物（2'，4'-二氟-4-联苯基）氧基乙酸及其与金属或有机碱的药学上可接受的盐。它们具有高抗炎和止痛活性，不引起胃损伤。

85. 发明授权

US4417918A Herbicidal .alpha.-[3-(2-halo-4-trifluoromethylphenoxy)-6-halophenoxy]propionic acid thio esters and acids 失效
标题翻译：除草剂α-[3-（2-卤代-4-三氟甲基苯氧基）-6-卤苯氧基]丙酸硫酯和酸
公开(公告)号：US4417918A
公开(公告)日：1983-11-29
申请号：US297299
申请日：1981-08-28
申请人： Otto Rohr , Georg Pissiotas , Beat Bohner , Kurt Burdeska
发明人： Otto Rohr , Georg Pissiotas , Beat Bohner , Kurt Burdeska
IPC分类号： C07D295/18 , A01N39/02 , A01N39/04 , A01N47/40 , C07C51/00 , C07C59/125 , C07C59/68 , C07C59/70 , C07C67/00 , C07C69/712 , C07C69/736 , C07C219/06 , C07C231/00 , C07C231/12 , C07C233/00 , C07C233/16 , C07C235/06 , C07C235/20 , C07C235/22 , C07C235/24 , C07C239/00 , C07C253/00 , C07C255/16 , C07C255/49 , C07C255/53 , C07C255/54 , C07C325/00 , C07C327/06 , C07C327/22 , C07D295/08 , C07D295/088 , C07D295/185 , A01N37/10 , C07C149/40 , C07C149/43 , C07C153/023
CPC分类号： C07D295/185 , A01N39/02 , A01N39/04 , C07C255/00 , C07C323/00 , C07C327/00 , C07C59/68 , C07D295/088
摘要： 3-Phenoxy-.alpha.-phenoxy-alkancarboxylic acid derivatives of the formula ##STR1## are disclosed as possessing a surprising selective herbicidal activity. In the formula Hal is a halogen atom, m is an integer 1, 2, or 3, Y is a hydrogen or halogen atom or the cyano group, Z is a halogen atom or the cyano group, R.sub.1 is hydrogen or C.sub.1 -C.sub.8 alkyl, and R is an acid function. Methods are disclosed for combatting weeds in mono- and dicotyledonous cultures such as cereals, corn, rice, soya and cotton, which comprise applying to the locus to be protected from weeds a dosage of from 0.1 to 10.0 kilograms per hectare of the above compounds.
摘要翻译：公开了具有令人惊奇的选择性除草活性的式（I）的3-苯氧基-α-苯氧基 - 链烷羧酸衍生物。式中Hal为卤原子，m为整数1,2或3，Y为氢或卤素原子或氰基，Z为卤素原子或氰基，R1为氢或C1-C8烷基，R为酸官能团。公开了用于防治单谷和双子叶培养物如谷物，玉米，水稻，大豆和棉花中的杂草的方法，其包括以每公顷0.1至10.0千克的上述化合物的剂量施用于要防止杂草的场所。

86. 发明授权

US4326882A Trichlorophenoxy alkanoic acid free of chlorinated dibenzo-p-dioxins 失效
标题翻译：不含氯化二苯并对二恶英的三氯苯氧基链烷酸
公开(公告)号：US4326882A
公开(公告)日：1982-04-27
申请号：US33349
申请日：1979-04-26
申请人： Sidney B. Richter , William S. Grove
发明人： Sidney B. Richter , William S. Grove
IPC分类号： C07C59/70 , C07C59/68 , A01N39/02 , A01N39/04
CPC分类号： C07C59/70
摘要： This invention provides as new compositions of matter 2,4,5-trichlorophenoxy acetic acid (2,4,5-T) and (2-2,4,5-trichlorophenoxy) propionic acid (Silvex) including the hydrolyzable salts, aliphatic esters and amides of these acids, which compositions are free of chlorinated dibenzo-p-dioxins.
摘要翻译：本发明提供了新的组合物2,4,5-三氯苯氧乙酸（2,4,5-T）和（2-2,4,5-三氯苯氧基）丙酸（Silvex），包括可水解盐，脂族酯和这些酸的酰胺，该组合物不含氯化二苯并对二恶英。

87. 发明授权

US4254262A Process for producing phenoxycarboxylic acid derivative 失效
标题翻译：生产苯氧基羧酸衍生物的方法
公开(公告)号：US4254262A
公开(公告)日：1981-03-03
申请号：US84164
申请日：1979-10-12
申请人： Wataro Koike , Tadashi Sasuga , Chihiro Yazawa
发明人： Wataro Koike , Tadashi Sasuga , Chihiro Yazawa
IPC分类号： C07C69/66 , A01N37/10 , B01J31/00 , C07B61/00 , C07C51/00 , C07C51/367 , C07C59/125 , C07C59/60 , C07C59/68 , C07C59/70 , C07C67/00 , C07C69/612 , C07C201/00 , C07C205/38 , C07C253/00 , C07C255/54 , C07D213/57 , C07C61/08 , C07C69/767
CPC分类号： C07C51/367
摘要： A phenoxycarboxylic acid derivative having the formula ##STR1## wherein R represents ##STR2## and X.sub.1 represents a hydrogen atom, a halogen atom, a lower alkyl group, trifluoromethyl group, nitro group or cyano group and X.sub.2 represents a hydrogen atom, a halogen atom, a lower alkyl group, nitro group or cyano group, R' represents ##STR3## and R.sub.1 and R.sub.2 are the same and different and respectively represent hydrogen atom or a lower alkyl group, is produced by reacting a phenol compound having the formula ##STR4## with a halogen compound havingX--R'wherein X represents a halogen atom in the presence of a base. The reaction is carried out in the presence of a quarternary ammonium salt or a quaternary phosphonium salt in a nonpolar solvent.
摘要翻译：具有下式的式（III）的苯氧基羧酸衍生物，其中R表示“IMA”，X 1表示氢原子，卤素原子，低级烷基，三氟甲基，硝基或氰基，X 2表示氢原子，卤素原子，低级烷基，硝基或氰基，R'表示“IMA”，R1和R2相同且不同，分别表示氢原子或低级烷基，是通过使苯酚具有式（I）的化合物与具有XR'的卤素化合物反应，其中X表示卤素原子。反应在非极性溶剂中在季铵盐或季鏻盐存在下进行。

88. 发明授权

US4238626A 4-Phenoxy-phenoxy-alkane-carboxylic acid derivatives and process for their manufacture 失效
标题翻译： 4-苯氧基 - 苯氧基 - 烷烃 - 羧酸衍生物及其制备方法
公开(公告)号：US4238626A
公开(公告)日：1980-12-09
申请号：US905049
申请日：1978-05-11
申请人： Helmut Nahm , Ernold Granzer
发明人： Helmut Nahm , Ernold Granzer
IPC分类号： A61K31/19 , C07C37/05 , C07C43/263 , C07C43/29 , C07C51/09 , C07C59/68 , C07C59/70 , C07C69/712 , C07C69/736
CPC分类号： C07C323/00 , C07C51/09 , C07C59/68
摘要： Novel 4-phenoxy-phenoxy-alkane-carboxylic acid derivatives of the formula I ##STR1## in which R.sub.1 stands for hydrogen, methylthio, cyclopentyl, cyclohexyl, phenyl, methylcyclohexyl, ethylcyclohexyl, or R.sub.1 and R.sub.3 together stand for a --CH.dbd.CH--CH.dbd.CH-- bridge or--unless at least one of the substituents R.sub.2 to R.sub.8 stands for hydrogen, or if R.sub.9 stands for a radical having at least 2 carbon atoms--for chlorine,R.sub.2 and R.sub.3, independent of one another, each stands for hydrogen, chlorine or alkyl of 1 to 4 carbon atoms,R.sub.4 stands for hydrogen, chlorine, alkyl of 1 to 4 carbon atoms, cyclopentyl, cyclohexyl, methylcyclohexyl or R.sub.3 and R.sub.4 together stand for a --CH.dbd.CH--CH.dbd.CH-- bridge,R.sub.5, R.sub.6 and R.sub.7, independent of one another, each stands for hydrogen or alkyl of 1 to 4 carbon atoms,R.sub.8 stands for hydrogen, alkyl of 1 to 4 carbon atoms or allyl,R.sub.9 stands for alkyl of 1 to 10 carbon atoms or phenyl andX stands for hydrogen, the cation of a physiologically acceptable inorganic or organic base of a hydrocarbon radical of 1 to 10 carbon atoms, having a strong action on the lipide and cholesterine metabolism and a process for their manufacture.
摘要翻译： R1代表氢，甲硫基，环戊基，环己基，苯基，甲基环己基，乙基环己基或R 1和R 3的新的4-苯氧基 - 苯氧基 - 烷 - 羧酸衍生物，其中R1代表氢，甲基， -CH = CH-桥或 - 除非取代基R2至R8中的至少一个代表氢，或者如果R9表示具有至少2个碳原子的基团，则对于氯，R 2和R 3彼此独立地，各自独立地对于氢，氯或1至4个碳原子的烷基，R4代表氢，氯，1至4个碳原子的烷基，环戊基，环己基，甲基环己基或R3和R4一起代表-CH = CH-CH = CH- 桥，R5，R6和R7彼此独立，各代表氢或1-4个碳原子的烷基，R8代表氢，1-4个碳原子的烷基或烯丙基，R9代表1-10个碳原子的烷基原子或苯基，X代表氢，生理上可接受的无机或有机碱的烃的阳离子具有1至10个碳原子的基团，对脂质和胆固醇代谢具有强烈的作用及其制造方法。

89. 发明授权

US4234742A Bis-(aryloxycarboxylic acid) compounds 失效
标题翻译：双（芳氧基羧酸）化合物
公开(公告)号：US4234742A
公开(公告)日：1980-11-18
申请号：US45665
申请日：1979-06-05
申请人： Jean C. Cognacq , Jean Lacrampe
发明人： Jean C. Cognacq , Jean Lacrampe
IPC分类号： A61K31/19 , A61P7/00 , C07C51/00 , C07C59/125 , C07C59/68 , C07C59/70 , C07C67/00 , C07C313/00 , C07C319/20 , C07C319/22 , C07C323/20 , C07C149/40 , A61K31/185
CPC分类号： C07C59/68 , A61K31/19
摘要： Compounds of the formula: ##STR1## in which A is a methylene group, sulphur or a disulphide bridge, R is a hydrogen atom or a methyl group, R.sub.1 is a linear or branched alkyl group having 1 to 4 carbon atoms, and R.sub.2 is an alkyl group having 1 to 4 carbon atoms, or a halogen atom, or an alkoxy group, and their pharmaceutically acceptable salts have a valuable hypocholesterolemia-inducing activity.
摘要翻译：下式的化合物：其中A是亚甲基，硫或二硫桥，R是氢原子或甲基，R1是具有1至4个碳原子的直链或支链烷基， R2为碳原子数1〜4的烷基或卤素原子或烷氧基，其药学上可接受的盐具有有价值的低胆固醇血症诱导活性。

90. 发明授权

US4153803A Cholesterol-lowering phenoxyalkanoic acid esters 失效
公开(公告)号：US4153803A
公开(公告)日：1979-05-08
申请号：US773144
申请日：1977-03-01
申请人： Kurt Thiele , Quazi Ahmed , Rudolf Adrian , Ulrich Jahn
发明人： Kurt Thiele , Quazi Ahmed , Rudolf Adrian , Ulrich Jahn
IPC分类号： A61K31/22 , C07C59/68 , C07C59/70 , C07C69/712 , C07C69/736 , C07D211/46 , C07D213/30 , C07D473/08 , C07C69/76
CPC分类号： C07C321/00 , C07C59/68 , C07C59/70 , C07D211/46 , C07D473/08
摘要： Compounds possessing pharmaceutical activity as substances able to lower the level of fatty substances in the blood possess the following general formula: ##STR1## wherein R represents hydrogen, halogen, hydroxy or alkyl or alkoxy containing from 1 to 4 carbon atoms;A.sup.1 and A.sup.2 which can be the same or different are hydrogen or alkyl containing from 1 to 9 carbon atoms such that A.sup.1 and A.sup.2 contain together not more than 10 carbon atoms,Y is oxygen, in which case X is benzyl, benzyloxy or benzylthio or benzyl, benzyloxy or benzylthio substituted by R and Z is amine, azacyclohydrocarbyloxy cycloalkoxy containing from 3 to 6 ring carbon atoms or tertiary aminoalkoxy or pivaloyloxyalkoxy in which the alkoxy group contains from 1 to 3 carbon atoms, or X is hydrogen and Z is pivaloyloxyalkoxy in which the alkoxy group contains from 1 to 3 carbon atoms, orY is oxygen, X is benzyl, benzyloxy or benzylthio or benzyl, benzyloxy or benzylthio substituted by R and Z is alkoxy containing from 1 to 4 carbon atoms, hydroxy or O.sup.- M.sup.+, M being a metal cation of Main Groups I, II or III of the Periodic System of the Elements or an organic base cation or ammonium ion, A.sup.1 and A.sup.2 being the same and being as aforesaid or being different with one of A.sup.1 and A.sup.2 being hydrogen or both being hydrogen and X being a para substituent with respect to Y in the benzene ring in the same general formula,Y is oxygen, X is hydrogen and Z is amine, azacyclohydrocarbyloxy or pivaloyloxyalkoxy in which the alkoxy group contains from 1 to 3 carbon atoms,Or Y is sulphur, in which case X is hydrogen, benzyl, benzyloxy or benzylthio or benzyl, benzyloxy or benzylthio substituted by R and Z is amine, azacyclohydrocarbyloxy, alkoxy containing from 1 to 4 carbon atoms, hydroxy, O.sup.- M.sup.+ wherein M is a metal cation of Main Groups I, II or III of the Periodic System of The Elements or an organic base cation or ammonium ion, cycloalkoxy containing from 3 to 6 ring carbon atoms or tertiaryaminoalkoxy, pivaloyloxyalkoxy or pyridyl-C-alkoxy in which the alkoxy group contains from 1 to 3 carbon atoms, and pharmacologically acceptable acid addition and quaternary ammonium salts of compounds containing basic groups, and optical isomers of said compounds when A.sup.1 and A.sup.2 are different.

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