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81. 发明申请

US20160251302A1 PROCESS FOR ACIDIC SCRUBBING OF DINITROTOLUENE IN THE PRESENCE OF HYDROCYANIC ACID 有权
标题翻译：氨基酸在酸性酸存在下的酸洗过程
公开(公告)号：US20160251302A1
公开(公告)日：2016-09-01
申请号：US15031100
申请日：2014-10-22
申请人： BASF SE , JOSEF MEISSNER GMBH & CO. KG
发明人： SAMUEL NETO , Rüdiger FRITZ , Renate HEMPEL , Holger ALLARDT , Yuan Shen DAI , Barbara BECKER , Sebastian AHRENS , Julia LESCHINSKI , Henrich HERMANN , Mirko HAENDEL , Jürgen PÖHLMANN
IPC分类号： C07C201/16 , C02F1/26 , C02F1/20 , B01D11/04 , C02F3/00
CPC分类号： C07C201/16 , B01D11/0488 , B01D11/0492 , B01D2011/002 , C02F1/20 , C02F1/26 , C02F3/00 , C02F2101/18 , C02F2103/36 , C07C205/06
摘要： Process for scrubbing a crude mixture which is obtained in the nitration of toluene after separating off the nitrating acid and comprises dinitrotoluene, nitric acid, nitrogen oxides and sulfuric acid, which comprises two scrubbing steps (WS-I) and (WS-II), wherein i) in a first scrubbing step (WS-I), the crude mixture is extracted with a scrubbing acid I comprising nitric acid, nitrogen oxides and sulfuric acid in a scrub comprising at least one extraction stage, where the scrubbing acid discharged from the first extraction stage (WS-I-1) of the first scrubbing step (WS-I) has a total acid content of from 10 to 40% by weight and a content of from 80 to 350 ppm of hydrocyanic acid, giving a prescrubbed crude mixture, ii) in a second scrubbing step (WS-II), the prescrubbed crude mixture comprising dinitrotoluene is extracted with a scrubbing acid II in a scrub comprising at least one, preferably at least 2, extraction stage(s), where the scrubbing acid discharged from the first extraction stage (WS-II-1) of the second scrubbing step (WS-II) has a pH of less than or equal to 4, giving a dinitrotoluene-comprising mixture which is essentially free of nitric acid, sulfuric acid, nitrogen oxides and hydrocyanic acid and has a content of not more than 300 ppm of nitric acid and nitrogen oxides, not more than 3 ppm of sulfate and not more than 50 ppm of hydrocyanic acid.
摘要翻译：在分离出硝酸后，除去硝化硝酸甲苯后得到的粗混合物的方法，包括二硝基甲苯，硝酸，氮氧化物和硫酸，其包括两个洗涤步骤（WS-I）和（WS-II）其中i）在第一洗涤步骤（WS-1）中，所述粗混合物用包含硝酸，氮氧化物和硫酸的洗涤酸I在包含至少一个萃取阶段的洗涤中萃取，其中所述洗涤酸从第一洗涤步骤（WS-1）的第一提取阶段（WS-I-1）的总酸含量为10至40重量％，含量为80至350ppm的氢氰酸，得到预先粗制的粗品混合物，ii）在第二次洗涤步骤（WS-II）中，包含二硝基甲苯的预先混合的粗混合物用洗涤酸II在洗涤中提取，所述洗涤包括至少一个，优选至少2个萃取阶段，其中洗涤酸从第一次提取出来在第二洗涤步骤（WS-II）的阶段（WS-II-1）上具有小于或等于4的pH，得到基本上不含硝酸，硫酸，氮氧化物的二硝基甲苯混合物，氢氰酸，硝酸和氮氧化物含量不超过300ppm，硫酸盐不超过3ppm，氢氰酸不大于50ppm。

82. 发明授权

US09302978B1 Process for the preparation of nitrobenzene by adiabatic nitration 有权
标题翻译：通过绝热硝化制备硝基苯的方法
公开(公告)号：US09302978B1
公开(公告)日：2016-04-05
申请号：US14785763
申请日：2014-04-24
申请人： Covestro Deutschland AG
发明人： Antoni Mairata , Thomas Knauf
IPC分类号： C07C205/00 , C07C201/08 , C07C201/16
CPC分类号： C07C201/08 , C07C201/16 , C07C205/06
摘要： The present invention relates to a continuously operated adiabatic process for the preparation of nitrobenzene by nitration of benzene with nitric acid and sulfuric acid, in which the dilute sulfuric acid obtained after the nitration has taken place and the crude nitrobenzene has been separated off from the aqueous phase is concentrated for the purpose of re-use in the nitration, and after its concentration, at least one minute before it comes into contact with fresh nitric acid again an oxidizing agent is added such that a concentration of the oxidizing agent of from 10 ppm to 5,000 ppm, based on the total weight of the concentrated sulfuric acid to be recycled into the nitration, is established.
摘要翻译：本发明涉及用硝酸和硫酸硝化苯来制备硝基苯的连续操作的绝热方法，其中在硝化发生后获得的稀硫酸和粗硝基苯已从水溶液中分离出来浓缩的浓度是为了在硝化中重复使用，并且在其浓缩之后，再次与新鲜硝酸接触至少一分钟，加入氧化剂使得氧化剂的浓度为10ppm 至5,000ppm，基于要再循环到硝化中的浓硫酸的总重量。

83. 发明授权

US09284256B2 Process for the production of nitrobenzene by adiabatic nitration 有权
标题翻译：通过绝热硝化生产硝基苯的方法
公开(公告)号：US09284256B2
公开(公告)日：2016-03-15
申请号：US14415794
申请日：2013-07-23
申请人： Bayer MaterialScience AG
发明人： Thomas Knauf , Michael Merkel
IPC分类号： C07C201/00 , C07C201/08 , C07C201/16
CPC分类号： C07C201/08 , C07C201/16 , C07C205/06
摘要： The present invention provides a continuous process for the production of nitrobenzene by nitration of benzene with mixtures of sulfuric and nitric acid using a stoichiometric excess of benzene, in which the content of aliphatic organic compounds in the feed benzene during the start-up period of the production plant is always maintained at less than 1.5 wt. %, based on the total mass of the feed benzene. This is achieved either by mixing the feed benzene comprising recycled unreacted benzene (recycled benzene) and benzene newly supplied to the reaction (fresh benzene) in appropriate quantitative ratios during the start-up period, depending on the purity of the two streams, or by completely omitting the recycling of unreacted benzene during the start-up period, i.e. the feed benzene consists only of benzene newly supplied to the reaction.
摘要翻译：本发明提供了一种使用化学计量过量的苯硝化苯与硫酸和硝酸的混合物来生产硝基苯的连续方法，其中在起始时期的进料苯中的脂族有机化合物的含量生产厂总是维持在1.5重量％以下。％，基于进料苯的总质量。这可以通过在启动期间将包含再循环的未反应苯（再循环苯）和新提供给反应的苯（新鲜苯）的进料苯与合适的定量比例混合，取决于两个流的纯度，或者通过在启动期间完全省略未反应苯的再循环，即进料苯仅由新提供给反应的苯组成。

84. 发明申请

US20150368173A1 PHARMACEUTICAL COMPOSITIONS COMPRISING MONOTERPENES 有权
标题翻译：包含单体的药物组合物
公开(公告)号：US20150368173A1
公开(公告)日：2015-12-24
申请号：US14817286
申请日：2015-08-04
申请人： NEONC Technologies, Inc.
发明人： Thomas CHEN , DANIEL LEVIN , SATISH PUPPALI
IPC分类号： C07C29/88 , C07C201/12 , C07C67/14 , C07C201/16
CPC分类号： C07C29/92 , A61K31/045 , A61K31/4188 , A61K45/06 , A61N5/10 , C07B2200/07 , C07C29/78 , C07C29/86 , C07C29/88 , C07C67/14 , C07C201/12 , C07C201/16 , C07C2601/16 , C07C33/14 , C07C205/57 , C07C69/76 , C07C69/92
摘要： The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.
摘要翻译：本发明提供纯化大于约98.5％（w / w）的单萜或倍半萜的方法。该方法包括衍生单萜（或倍半萜烯）以产生单萜（或倍半萜烯）衍生物，分离单萜（或倍半萜烯）衍生物和从衍生物中释放单萜（或倍半萜烯）的步骤。包括本发明范围的药物组合物是包含纯度大于约98.5％（w / w）的单萜（或倍半萜烯）的药物组合物。纯化的单萜可用于治疗癌症等疾病。本单萜（或倍半萜烯）可以单独施用，或者可以与辐射或其它治疗剂如化学治疗剂共同施用。

85. 发明授权

US09192877B2 Apparatus and process for using a nitroalkane as an entrainer for azeotropic removal of water from aqueous acid solution 有权
标题翻译：使用硝基烷烃作为夹带剂从酸性水溶液中共沸去除水的装置和方法
公开(公告)号：US09192877B2
公开(公告)日：2015-11-24
申请号：US13990352
申请日：2011-12-07
申请人： Mahesh Ratnakar Sawant , Daniel M. Trauth , John G. Pendergast
发明人： Mahesh Ratnakar Sawant , Daniel M. Trauth , John G. Pendergast
IPC分类号： B01D3/34 , C07C205/00 , B01D3/36 , C07C201/08 , C07C201/16
CPC分类号： B01D3/36 , C07C201/08 , C07C201/16 , C07C205/02
摘要： Disclosed are a process and an apparatus for concentrating an organic acid by using a nitroalkane as an entrainer for the azeotropic removal of water from an aqueous organic acid solution. The nitroalkane may be the same as a nitroalkane that is the product of a high pressure nitration process that produces nitroalkanes and aqueous organic acid.
摘要翻译：公开了一种通过使用硝基烷烃作为夹带剂浓缩有机酸的方法和装置，用于从有机酸水溶液中共沸除去水。硝基烷烃可以与硝基烷烃相同，硝基烷烃是产生硝基烷烃和含水有机酸的高压硝化方法的产物。

86. 发明授权

US09133094B2 Apparatus and process for nitration selectivity flexibility enabled by azeotropic distillation 有权
标题翻译：通过共沸蒸馏实现硝化选择性灵活性的装置和方法
公开(公告)号：US09133094B2
公开(公告)日：2015-09-15
申请号：US14007531
申请日：2012-04-05
申请人： Mahesh Sawant , Daniel M. Trauth , John G. Pendergast, Jr.
发明人： Mahesh Sawant , Daniel M. Trauth , John G. Pendergast, Jr.
IPC分类号： C07C205/02 , C07C201/08 , C07C201/16
CPC分类号： C07C205/02 , C07C201/08 , C07C201/16
摘要： Disclosed are processes and apparatuses for concentrating at least one organic acid using an alkyl acetate as an entrainer. The processes and apparatuses may use the same alkyl acetate as an entrainer to concentrate a mixture of organic acids.
摘要翻译：公开了使用乙酸烷基酯作为夹带剂浓缩至少一种有机酸的方法和装置。方法和装置可以使用相同的乙酸烷基酯作为夹带剂来浓缩有机酸的混合物。

87. 发明授权

US09040758B2 Washing system for nitroaromatic compounds 有权
标题翻译：硝基芳族化合物洗涤系统
公开(公告)号：US09040758B2
公开(公告)日：2015-05-26
申请号：US13388836
申请日：2009-08-18
申请人： Sergio Berretta
发明人： Sergio Berretta
IPC分类号： C07C27/26 , C07C201/16 , C02F1/04 , C02F1/20 , C02F101/38
CPC分类号： C07C201/16 , C02F1/04 , C02F1/20 , C02F2101/38 , C02F2209/06 , C07C205/06
摘要： A method of removing alkalinity and salt from a nitroaromatic product downstream of water washing to remove mineral acids and alkaline washing to remove salts of organic acids, comprises washing the product stream with an acidic aqueous solution, prior to the step of removing excess organic reactant, by steam stripping or distillation. Acid removed from the stripper or column is recycled back for use in the acidic washing. The acidic washing is done instead of the neutral washing step of the prior art. It removes residual salt and decreases the level of entrained colloidal water in the nitroaromatic product.
摘要翻译：一种从水洗下游的硝基芳族化合物产物中去除碱度和盐的方法，以除去无机酸和碱洗涤以除去有机酸的盐，包括在除去过量有机反应物的步骤之前用酸性水溶液洗涤产物流，通过汽提或蒸馏。从汽提塔或塔中除去的酸被循环使用，用于酸洗。进行酸性洗涤代替现有技术的中性洗涤步骤。它去除残留的盐并降低硝基芳族产物中夹带的胶体水的含量。

88. 发明授权

US09012701B2 Washing system for nitroaromatic compounds 有权
公开(公告)号：US09012701B2
公开(公告)日：2015-04-21
申请号：US13388836
申请日：2009-08-18
申请人： Sergio Berretta
发明人： Sergio Berretta
IPC分类号： C07C27/26 , C07C201/16 , C02F1/04 , C02F1/20 , C02F101/38
摘要： A method of removing alkalinity and salt from a nitroaromatic product downstream of water washing to remove mineral acids and alkaline washing to remove salts of organic acids, comprises washing the product stream with an acidic aqueous solution, prior to the step of removing excess organic reactant, by steam stripping or distillation. Acid removed from the stripper or column is recycled back for use in the acidic washing. The acidic washing is done instead of the neutral washing step of the prior art. It removes residual salt and decreases the level of entrained colloidal water in the nitroaromatic product.

89. 发明申请

US20140209464A1 Separation and Manipulation of a Chiral Object 审中-公开
标题翻译：手性物体的分离和操作
公开(公告)号：US20140209464A1
公开(公告)日：2014-07-31
申请号：US14229011
申请日：2014-03-28
申请人： Dynamic Connections, LLC
发明人： Osman Kibar , Mirianas Chachisvilis , Eugene Tu , Thomas H. Marsilje
IPC分类号： C07C303/44 , C07C201/16 , C07B57/00
CPC分类号： C07C303/44 , B03C1/24 , B03C7/026 , C07B57/00 , C07C201/16 , Y10T436/143333 , Y10T436/25375
摘要： Among other things, for use in directional motion of chiral objects in a mixture, a field is applied across the chamber and is rotating relative to the chamber to cause rotation of the chiral objects. The rotation of the objects causes them to move directionally based on their chirality. The method applies to sugars, proteins, and peptides, among other things, and can be used in a wide variety of applications.
摘要翻译：除其他之外，为了在混合物中的手性物体的定向运动中使用场，跨过腔室施加场并相对于腔室旋转以引起手性物体的旋转。物体的旋转导致它们基于手性方向移动。该方法适用于糖，蛋白质和肽等，并可用于各种应用。

90. 发明申请

US20130150608A1 Production of Alkylaromatic Compounds 有权
标题翻译：烷基芳族化合物的生产
公开(公告)号：US20130150608A1
公开(公告)日：2013-06-13
申请号：US13324176
申请日：2011-12-13
申请人： Beth A. Winsett , James I. Arnett, II , Kenwyn M. Leger , Brady A. Compton
发明人： Beth A. Winsett , James I. Arnett, II , Kenwyn M. Leger , Brady A. Compton
IPC分类号： C07C7/04 , C07C45/82 , C07C68/08 , C07C41/42 , C07C209/84 , C07C67/54 , C07C319/28 , C07C201/16 , C07C37/76 , C07C17/383
CPC分类号： C07C7/04 , C07C2/66 , C07C7/05 , C07C17/383 , C07C37/14 , C07C201/12 , C07C201/16 , C07C209/68 , C07C209/84 , C07C319/28 , C07C205/06 , C07C211/45 , C07C39/06 , C07C321/30 , C07C15/24
摘要： This invention is directed to an improvement in the process for the production of alkylaromatic compounds that results in lower levels of residual unreacted materials in the final product. This invention comprises: 1) alkylation of an aromatic compound with an alkylating agent and a catalyst to produce an effluent stream comprising an alkylaromatic compound and unreacted materials; 2) heating the effluent stream; 3) stripping the effluent stream in a stripping device in the presence of steam; 4) separating a stripping stream from the stripping device, the stripping stream rich in unreacted materials; and 5) separating a product stream from the stripping device, the product stream rich in alkylated aromatic compound.
摘要翻译：本发明涉及生产烷基芳族化合物的方法的改进，其导致最终产物中残留未反应物质的较低水平。本发明包括：1）用烷基化剂和催化剂烷基化芳族化合物以产生包含烷基芳族化合物和未反应物质的流出料流; 2）加热流出物流; 3）在蒸汽存在下，在汽提装置中汽提流出物流; 4）从汽提装置中分离汽提物流，富含未反应物质的汽提流; 和5）从汽提装置中分离产物流，产物流富含烷基化芳族化合物。

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