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81. 发明授权

US07572410B2 Core sampling device intended to assemble tissue arrays 有权
标题翻译：用于组装组织阵列的核心取样装置
公开(公告)号：US07572410B2
公开(公告)日：2009-08-11
申请号：US11281537
申请日：2005-11-18
申请人： Pierre Chaumat
发明人： Pierre Chaumat
IPC分类号： B01L3/00 , A61B10/00 , G01N21/00 , G01N15/06 , A01N1/00 , A01N1/02 , C12M3/00 , C12M1/26
CPC分类号： C12M33/00
摘要： A core sampling device includes a core sampling punch, a core excision punch that makes a recess in a receiver body, and an ejector that expels a sample core into the receiver body. The core excision punch is mounted inside the core sampling punch and is substantially coaxial with the core sampling punch. Both punches are able to move in translation and/or rotation with respect to one another, and the ejector is arranged so as to expel cores from each punch.
摘要翻译：核心采样装置包括芯取样冲头，使接收器主体中的凹槽的芯切除冲头，以及将样品芯排入接收器主体的喷射器。核心切割冲头安装在芯取样冲头内部，并且与芯取样冲头基本上同轴。两个冲头能够相对于彼此平移和/或旋转移动，并且喷射器布置成从每个冲头排出芯。

82. 发明申请

US20090130221A1 DECELLULARISATION OF TISSUE MATRICES FOR BLADDER IMPLANTATION 有权
标题翻译：用于叶片植入的组织矩阵的分解
公开(公告)号：US20090130221A1
公开(公告)日：2009-05-21
申请号：US12295190
申请日：2007-03-28
申请人： Fiona Bolland , Jennifer Southgate , Sotirios Korossis , Eileen Ingham
发明人： Fiona Bolland , Jennifer Southgate , Sotirios Korossis , Eileen Ingham
IPC分类号： A61K35/22 , A01N1/00 , A61P13/10 , A61P17/02 , A61P41/00
CPC分类号： A61K35/22 , A61F2/042 , A61L27/3604 , A61L27/3679 , A61L27/3687 , A61L27/38 , A61L2430/00 , A61L2430/22 , A61L2430/40 , C12N5/0068 , C12N5/0605 , C12N2509/00 , C12N2533/92 , G01N33/5088
摘要： The invention provides an improved method of producing a natural, acellular matrix scaffold for subsequent use in tissue-engineered replacement of tissues such as the bladder. Decellularisation is carried out on an expanded or distended bladder and the product retains the strength and compliance of natural material. The invention also provides use of the matrix scaffolds as wound healing material and to investigate tissue structure and function in vitro.
摘要翻译：本发明提供了一种生产天然的无细胞基质支架的改进方法，用于随后用于组织工程化替代诸如膀胱的组织。脱细胞化在膨胀或膨胀的膀胱上进行，产品保持天然材料的强度和顺应性。本发明还提供了基质支架作为伤口愈合材料的用途，并且在体外研究组织结构和功能。

83. 发明申请

US20090123904A1 COMPOSITION FOR PRESERVING CELLS, TISSUES, OR ORGANS, PRODUCTION PROCESS AND USES 有权
标题翻译：用于保存细胞，组织或器官，生产过程和用途的组合物
公开(公告)号：US20090123904A1
公开(公告)日：2009-05-14
申请号：US11954323
申请日：2007-12-12
申请人： Yves CENATIEMPO , El Mustapha Belgsir , Manilduth Ramnath , Frederic Favreau , Michel Carretier , Gerard Mauco , Thierry Hauet
发明人： Yves CENATIEMPO , El Mustapha Belgsir , Manilduth Ramnath , Frederic Favreau , Michel Carretier , Gerard Mauco , Thierry Hauet
IPC分类号： A01N1/00 , C12N5/06
CPC分类号： A61K31/724 , A01N1/0226 , A61K31/05 , A61K31/12 , A61K2300/00
摘要： The object of the invention is a composition for protecting and/or preserving cells, tissues or organs, characterized in that it comprises at least one cyclodextrin, preferably closely combined with an antioxidant.The invention also relates to a process for producing this composition and its uses.
摘要翻译：本发明的目的是用于保护和/或保存细胞，组织或器官的组合物，其特征在于其包含至少一种环糊精，优选与抗氧化剂紧密结合。本发明还涉及制备该组合物及其用途的方法。

84. 发明申请

US20090064474A1 Bio-bones prosthetic system for tissue donor cadavers 审中-公开
标题翻译：组织供体尸体生物骨假体系统
公开(公告)号：US20090064474A1
公开(公告)日：2009-03-12
申请号：US12222195
申请日：2008-08-05
申请人： Carol Jane Dancer
发明人： Carol Jane Dancer
IPC分类号： A01N1/00 , A61F2/28
CPC分类号： A61F2/2857
摘要： The bio-bones prosthetics are designed to replace harvested bones from deceased tissue donors. Rigid bone replacement prosthetics offer structure and fill voids to provide a normal appearance to the donor. Each of the bio-bones prosthetics consist of rigid telescopic tubes, manufactured from bone colored polylactic acid, a biodegradeable material, making them ideal for both cremation and burial. They are extruded in slightly oval form, with the smaller units sliding inside the larger tubes, to provide continuous adjustment in length. A simple twist of the inner unit locks them in place. No foreign objects are need to secure them in place. This prevents any injuries to the users or cause any protrusions in the donors skin. The tubes are moldable, both prior to recovery and on-site allowing for a custom fit. Molded attachments are provided to secure the prosthetics in place.
摘要翻译：生物骨假肢被设计成从死亡组织供体取代收获的骨头。刚性骨置换假体提供结构和填充空隙以向供体提供正常外观。每个生物骨骼假肢由刚性伸缩管组成，由骨色聚乳酸制成，可生物降解材料，使其成为火化和埋葬的理想选择。它们以略椭圆形的形式挤出，较小的单元在较大的管中滑动，以提供长度的连续调节。内部单元的简单扭曲将它们锁定到位。没有任何外来物体需要将其固定到位。这可以防止使用者的任何伤害或引起供体皮肤的任何突起。管是可模制的，在恢复之前和在现场允许定制适合。提供模制附件以将假肢固定就位。

85. 发明申请

US20090047654A1 Polymer affinity matrix, a method for the production and use thereof 审中-公开
标题翻译：聚合物亲和基质，其生产和使用方法
公开(公告)号：US20090047654A1
公开(公告)日：2009-02-19
申请号：US12219356
申请日：2008-07-21
申请人： Wolfgang Rapp , Reinhold Deppisch , Hermann Gohl , Bernd Wittner , Werner Beck
发明人： Wolfgang Rapp , Reinhold Deppisch , Hermann Gohl , Bernd Wittner , Werner Beck
IPC分类号： B01D15/38 , B01D67/00 , A01N1/00 , C07C229/26 , C07K5/09 , C07K7/06 , C07K7/08 , C07K5/11 , C07K14/00 , C07K7/54 , C08G63/91 , C08F8/32
CPC分类号： B01J20/28016 , A61K31/195 , B01J20/26 , B01J20/28033 , B01J20/3219 , B01J20/3242 , B01J20/3248 , G01N33/54353
摘要： A polymer affinity matrix for the binding of one or more substances in a fluid or removing said substance(s) from the fluid and/or decreasing the amount or concentration thereof in said fluid with a view to preventing, eliminating or reducing undesired activation of components in said fluid is described, as well as a method for removing said substance(s) from the fluid and/or decreasing the amount or concentration thereof in said fluid, a method for the production of said matrix, use of said matrix and a kit comprising said matrix. The polymer affinity matrix comprises a solid support, a spacer and a ligand, containing arginine as a binding unit.
摘要翻译：用于结合流体中的一种或多种物质或从流体中除去所述物质和/或减少所述流体的量或浓度的聚合物亲和基质，以防止，消除或减少组分的不期望的活化在所述流体中描述，以及用于从流体中除去所述物质和/或减少所述流体的量或浓度的方法，用于生产所述基质的方法，所述基质的使用和试剂盒包括所述矩阵。聚合物亲和基质包含固体支持物，间隔基和配体，其含有精氨酸作为结合单元。

86. 发明授权

US07465535B2 Dehydration procedures for induction of cryptobiosis in insect larvae 失效
标题翻译：诱导昆虫幼虫隐孢子虫病的脱水程序
公开(公告)号：US07465535B2
公开(公告)日：2008-12-16
申请号：US11150268
申请日：2005-06-13
申请人： Kazuyo Watanabe, legal representative , Takashi Okuda , Takahiro Kikawada , Yasuhiko Kobayashi , Tetsuya Sakashita , Seichi Wada , Tomoo Funayama
发明人： Masahiko Watanabe
IPC分类号： A01N1/00 , A01K67/00 , G09B23/36
CPC分类号： A01N1/0294 , A01N1/02
摘要： This invention provides a method for effectively producing dehydrated larvae for educational materials without disrupting the environment. The cryptobiotic larvae for educational materials can be obtained by dehydrating larvae while gradually reducing humidity in 3 separate stages.
摘要翻译：本发明提供了一种有效地生产用于教育材料的脱水幼体而不破坏环境的方法。用于教育材料的隐窝生物幼体可以通过脱水幼虫获得，同时在三个不同的阶段逐渐降低湿度。

87. 发明申请

US20080182233A1 METHODS AND COMPOSITIONS FOR DEPLETING SPECIFIC CELL POPULATIONS FROM BLOOD TISSUES 有权
标题翻译：从血液组织中清除特定细胞群体的方法和组合
公开(公告)号：US20080182233A1
公开(公告)日：2008-07-31
申请号：US11627762
申请日：2007-01-26
申请人： Daniel P. Collins
发明人： Daniel P. Collins
IPC分类号： A01N1/00 , A61J1/05 , C07K16/00
CPC分类号： G01N33/56972 , C12N5/0087 , G01N2333/705 , Y10T436/101666 , Y10T436/107497 , Y10T436/25125 , Y10T436/25375
摘要： The invention provides compositions and methods for cell separation. These reagents and techniques specifically agglutinate cells via surface antigen recognition and can be used to recover even rare cell types in high yield.
摘要翻译：本发明提供了用于细胞分离的组合物和方法。这些试剂和技术通过表面抗原识别特异性地凝集细胞，并可用于以高产率回收甚至罕见的细胞类型。

88. 发明申请

US20080161423A1 Organ Function Maintaining or Amelorating Solution 审中-公开
标题翻译：器官功能维护或安装解决方案
公开(公告)号：US20080161423A1
公开(公告)日：2008-07-03
申请号：US11885485
申请日：2006-03-06
申请人： Atsushi Kudo , Shigeki Arii , Kenjiro Wake , Isao Sakano
发明人： Atsushi Kudo , Shigeki Arii , Kenjiro Wake , Isao Sakano
IPC分类号： A61K49/00 , A01N1/00
CPC分类号： A01N1/02 , A01N1/0226
摘要： It is intended to provide an organ function maintaining or ameliorating solution, which is effective for suppressing the depression of an organ provided for transplantation and an organ preservation method using the organ function maintaining or ameliorating solution.The present invention relates to an organ function maintaining or ameliorating solution for maintaining or ameliorating the functions of an organ provided for organ transplantation, comprising a pharmacologically active substance comprising glycyrrhizic acid, glycyrrhetinic acid or a pharmacologically acceptable salt or derivative thereof in an organ preservation solution. The present invention also relates to a method of preserving an organ for organ transplantation comprising perfusing the organ function maintaining or ameliorating solution to the organ isolated from the donor to cause ischemia and immersing the organ in the organ function maintaining or ameliorating solution during the time until the organ is transplanted into a recipient.
摘要翻译：旨在提供维持或改善溶液的器官功能，其有效抑制用于移植的器官的抑制，以及使用器官功能维持或改善溶液的器官保存方法。本发明涉及用于维持或改善器官移植器官功能的器官功能维持或改善溶液，其包括在器官保存液中含有甘草酸，甘草次酸或其药理学上可接受的盐或衍生物的药理活性物质。本发明还涉及一种保存器官移植器官的方法，其包括将所述器官功能维持或改善至所述供体分离的器官的器官功能，引起局部缺血并将所述器官浸入所述器官功能中，以维持或改善溶液的时间直至将器官移植到受体中。

89. 发明申请

US20080145833A1 ORGAN TRANSPORTATION DEVICE 有权
标题翻译：有机运输装置
公开(公告)号：US20080145833A1
公开(公告)日：2008-06-19
申请号：US11610913
申请日：2006-12-14
申请人： RAMON E. POO , Camillo Ricordi
发明人： RAMON E. POO , Camillo Ricordi
IPC分类号： A01N1/00 , A01N1/02
CPC分类号： A01N1/02 , A01N1/0273
摘要： An organ transportation device includes a fluid-tight organ container and structure within the organ container for engaging an organ within the organ container. A base assembly is provided, and structure for rotating the organ engaging structure and the organ relative to the base assembly. The base assembly can have a motor and a battery to provide for rotation of the organ container during shipping.
摘要翻译：器官输送装置包括在器官容器内的流体密封的器官容器和结构，用于与器官容器内的器官接合。提供基座组件，以及用于相对于基座组件旋转器官接合结构和器官的结构。基座组件可以具有马达和电池以在运输期间提供器官容器的旋转。

90. 发明授权

US07371513B2 Method of preserving corneal tissue using polyoxyethylene/polyoxypropylene copolymer 有权
标题翻译：使用聚氧乙烯/聚氧丙烯共聚物保存角膜组织的方法
公开(公告)号：US07371513B2
公开(公告)日：2008-05-13
申请号：US11015180
申请日：2004-12-17
申请人： Richard A. Steinhardt
发明人： Richard A. Steinhardt
IPC分类号： A01N1/00
CPC分类号： A01N1/0221 , A01N1/00 , A01N1/02 , A01N1/0226
摘要： Tissue preservation media comprising a polyoxyethylene/polyoxypropylene copolymer are used to preserve tissues and organs for storage and transplantation. In particular embodiments, the polyoxyethylene/polyoxypropylene copolymer is Pluronic F68 or FLOCOR (CRL-5861; purified poloxamer 188), and the medium is Steinhardt medium, polyoxyethylene/polyoxypropylene copolymer-supplemented Optisol GS or polyoxyethylene/polyoxypropylene copolymer-supplemented ViaSpan.
摘要翻译：包含聚氧乙烯/聚氧丙烯共聚物的组织保存介质用于保存用于储存和移植的组织和器官。在特定实施方案中，聚氧乙烯/聚氧丙烯共聚物是Pluronic F68或FLOCOR（CRL-5861;纯化泊洛沙姆188），并且培养基是Steinhardt培养基，补充的聚氧乙烯/聚氧丙烯共聚物Optisol GS或者补充了聚氧乙烯/聚氧丙烯共聚物的ViaSpan。

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