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81. 发明申请

US20130112865A1 Method of Avoiding Space Charge Saturation Effects In An Ion Trap 有权
标题翻译：在离子阱中避免空间电荷饱和效应的方法
公开(公告)号：US20130112865A1
公开(公告)日：2013-05-09
申请号：US13722301
申请日：2012-12-20
申请人： Micromass UK Limited
发明人： Martin Raymond Green , Jason Lee Wildgoose
IPC分类号： H01J49/02 , H01J49/00
CPC分类号： H01J49/02 , H01J49/0027 , H01J49/0031 , H01J49/062 , H01J49/10 , H01J49/4265
摘要： A mass spectrometer includes a first ion trap arranged upstream of an analytical second ion trap. The charge capacity of the first ion trap is set at a value such that if all the ions stored within the first ion trap up to the charge capacity limit of the first ion trap are then transferred to the second ion trap, then the analytical performance of the second ion trap is not substantially degraded due to space charge effects.
摘要翻译：质谱仪包括布置在分析第二离子阱的上游的第一离子阱。第一离子阱的充电容量被设定为使得如果存储在第一离子阱内的所有离子直到第一离子阱的充电容量极限，则转移到第二离子阱，则分析性能由于空间电荷效应，第二离子阱基本上不会劣化。

82. 发明授权

US08384027B2 Ion guide array 有权
标题翻译：离子导向阵列
公开(公告)号：US08384027B2
公开(公告)日：2013-02-26
申请号：US13119264
申请日：2009-09-17
申请人： John B. Hoyes , David Langridge
发明人： John B. Hoyes , David Langridge
IPC分类号： H01J49/42
CPC分类号： H01J49/062 , G01N27/622 , H01J49/02 , H01J49/065
摘要： An ion guide array is disclosed comprising a first ion guide section and a second ion guide section and optionally further ion guide sections. Each ion guide section may comprise a plurality of electrodes having an aperture through which ions are transmitted in use. A transfer section is arranged at the exit of the first ion guide section and ions are transmitted radially from the first ion guide section into the second ion guide section. The electrodes in the transfer section may have a radial aperture enabling ions to be transmitted radially from the first ion guide section to the second ion guide section.
摘要翻译：公开了一种离子导向阵列，其包括第一离子引导部分和第二离子引导部分以及任选的其它离子引导部分。每个离子引导部分可以包括具有孔的多个电极，在使用中离子通过该孔传播。在第一离子引导部的出口设置有转印部，离子从第一离子引导部径向地传递到第二离子引导部。转印部分中的电极可以具有使得离子能够从第一离子导向部径向地传递到第二离子引导部的径向孔。

83. 发明申请

US20110042560A1 LOW TEMPERATURE PLASMA PROBE AND METHODS OF USE THEREOF 有权
标题翻译：低温等离子体探针及其使用方法
公开(公告)号：US20110042560A1
公开(公告)日：2011-02-24
申请号：US12863801
申请日：2009-02-11
申请人： Zheng Ouyang , Jason Harper , Nicholas Charipar , Robert Graham Cooks
发明人： Zheng Ouyang , Jason Harper , Nicholas Charipar , Robert Graham Cooks
IPC分类号： H01J49/26
CPC分类号： H01J37/32009 , H01J27/022 , H01J37/00 , H01J37/32348 , H01J49/02 , H01J49/105 , H01J49/142 , H01J2237/0044 , H05H1/24 , H05H1/2406 , H05H1/30 , H05H2001/2412 , H05H2001/2443 , H05H2240/10 , H05H2240/20 , Y10T436/145555 , Y10T436/147777 , Y10T436/173076 , Y10T436/203332 , Y10T436/24
摘要： The present invention generally relates to a low temperature plasma probe for desorbing and ionizing at least one analyte in a sample material and methods of use thereof. In one embodiment, the invention generally relates to a low temperature plasma probe including: a housing having a discharge gas inlet port, a probe tip, two electrodes, and a dielectric barrier, in which the two electrodes are separated by the dielectric barrier, in which application of voltage from a power supply generates a low temperature plasma, and in which the low temperature plasma is propelled out of the discharge region by the electric field and/or the discharge gas flow.
摘要翻译：本发明一般涉及用于解吸和电离样品中至少一种分析物的低温等离子体探针及其使用方法。在一个实施方案中，本发明一般涉及一种低温等离子体探针，其包括：壳体，其具有放电气体入口端口，探针尖端，两个电极和介电屏障，其中两个电极由电介质屏障隔开，来自电源的电压的施加产生低温等离子体，其中通过电场和/或放电气体流将低温等离子体推出排出区域。

84. 发明授权

US07667193B2 Personalised mass spectrometer 失效
标题翻译：个性化质谱仪
公开(公告)号：US07667193B2
公开(公告)日：2010-02-23
申请号：US11711142
申请日：2007-02-26
申请人： Alan Finlay
发明人： Alan Finlay
IPC分类号： H01J49/00 , H01J49/02
CPC分类号： H01J49/02
摘要： A personalized mass spectrometer system is described. By fabricating analyzer components on a module and including with that module an identifier for that module, it is possible to uniquely associate a user or task with one or more modules. The module is removably receivable within a housing and can be replaced with another module if so required.
摘要翻译：描述了一种个性化的质谱仪系统。通过在模块上制造分析器组件，并且在该模块中包括该模块的标识符，可以将用户或任务与一个或多个模块唯一地相关联。模块可拆卸地接收在外壳内，如果需要，可以用其他模块更换。

85. 发明授权

US07476853B2 Ion fragmentation by reaction with neutral particles 有权
标题翻译：通过与中性粒子反应产生的离子碎片
公开(公告)号：US07476853B2
公开(公告)日：2009-01-13
申请号：US11349551
申请日：2006-02-07
申请人： Roman Zubarev , Alexander Misharin , Oleg Silivra , Frank Kjeldsen
发明人： Roman Zubarev , Alexander Misharin , Oleg Silivra , Frank Kjeldsen
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/005 , G01N33/6848 , H01J49/02 , Y10S250/91 , Y10T436/17
摘要： The invention relates to a method and apparatus for the fragmentation of large molecules, especially biopolymers. The invention consists in reacting analyte ions with excited or radical neutral particles, whereby, at least in the case of bombardment of analyte ions with helium atoms from an FAB generator, a new type of fragmentation occurs which strongly resembles fragmentation by electron capture (ECD). The reactions may be performed in magnetic ion traps (ion cyclotron resonance cells, ICR), in RF ion traps according to Wolfgang Paul, in RF ion guides, or in free beams of analyte ions or neutral particles.
摘要翻译：本发明涉及一种用于大分子，特别是生物聚合物破碎的方法和装置。本发明包括使分析物离子与激发或自由基中性颗粒反应，由此，至少在从FAB发生器轰击具有氦原子的分析物离子的情况下，发生类似于通过电子捕获（ECD）破碎的新型碎裂，。反应可以在磁离子阱（离子回旋共振池，ICR），RF离子阱中根据Wolfgang Paul，RF离子导向器或分析离子或中性粒子的自由光束进行。

86. 发明申请

US20080315080A1 Electrostatic Trap 有权
标题翻译：静电捕集阱
公开(公告)号：US20080315080A1
公开(公告)日：2008-12-25
申请号：US10587478
申请日：2006-06-05
申请人： Alexander Makarov , Eduard V. Denisov , Gerhard Jung , Wilko Balschun , Stevan Roy Horning
发明人： Alexander Makarov , Eduard V. Denisov , Gerhard Jung , Wilko Balschun , Stevan Roy Horning
IPC分类号： B01D59/46
CPC分类号： H01J49/4245 , H01J49/0027 , H01J49/02 , H01J49/282 , H01J49/406 , H01J49/425
摘要： An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′(r,φ,z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, φ,z) is the result of a perturbation W to an ideal field U(r, φ,z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, φ,z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than about 2π radians over an ion detection period Tm.
摘要翻译：公开了诸如轨道捕获器的静电捕获器，具有电极结构。产生U'（r，phi，z）形式的静电捕获场，以捕获陷阱内的离子，使它们经历同步振荡。捕获场U'（r，phi，z）是对于理想场U（r，phi，z）的扰动W的结果，其在例如轨道捕获的情况下例如是超对数的。扰动W可以以各种方式引入，例如通过使陷波器的几何形状变形，使得其不再遵循理想场U（r，phi，z）的等电位，或者通过添加失真场（电或磁性）。扰动的幅度使得至少一些捕获的离子在离子检测周期Tm之后具有大于零但小于约2pi弧度的绝对相位扩展。

87. 发明申请

US20080073510A1 Personalised mass spectrometer 失效
标题翻译：个性化质谱仪
公开(公告)号：US20080073510A1
公开(公告)日：2008-03-27
申请号：US11711142
申请日：2007-02-26
申请人： Alan Finlay
发明人： Alan Finlay
IPC分类号： H01J49/00
CPC分类号： H01J49/02
摘要： A personalised mass spectrometer system is described. By fabricating analyser components on a module and including with that module an identifier for that module, it is possible to uniquely associate a user or task with one or more modules. The module is removably receivable within a housing and can be replaced with another module if so required.
摘要翻译：描述了一种个性化的质谱仪系统。通过在模块上制造分析器组件，并且在该模块中包括该模块的标识符，可以将用户或任务与一个或多个模块唯一地相关联。模块可拆卸地接收在外壳内，如果需要，可以用其他模块更换。

88. 发明申请

US20070152149A1 SYSTEMS AND METHODS FOR CALCULATING ION FLUX IN MASS SPECTROMETRY 审中-公开
标题翻译：用于在大量光谱中计算离子通量的系统和方法
公开(公告)号：US20070152149A1
公开(公告)日：2007-07-05
申请号：US11619858
申请日：2007-01-04
申请人： Gordana Ivosev , Nic Bloomfield
发明人： Gordana Ivosev , Nic Bloomfield
IPC分类号： B01D59/44
CPC分类号： H01J49/40 , H01J49/0031 , H01J49/0036 , H01J49/02 , H01J49/025
摘要： Systems and methods for calculating ion flux. In one embodiment, a mass spectrometer includes an ion source for emitting a beam of ions from a sample through a plurality of pulses during an analysis period, and a detector positioned downstream of said ion source. A clock is provided which is configured to determine a repeatable series of bins, wherein each bin in the repeatable series will correspond to a corresponding pulse time segment in every pulse. Additionally a controller is provided which is operatively coupled to the detector and to the clock and configured to determine the total number of pulses during the analysis period. The controller is further configured to determine for at least one bin in the repeatable series, the number of corresponding pulse time segments in which no ion impact was detected during the analysis period. The controller is also configured to calculate the ion flux corresponding to the at least one bin and wherein said ion flux is calculated to be correlated to the probability of not detecting an ion impact during pulse time segments which correspond to the at least one bin in the repeatable series.
摘要翻译：用于计算离子通量的系统和方法。在一个实施例中，质谱仪包括离子源，用于在分析周期期间通过多个脉冲从样品发射离子束，以及位于所述离子源下游的检测器。提供时钟，其被配置为确定可重复的一系列存储区，其中可重复序列中的每个仓对应于每个脉冲中的相应脉冲时间段。另外，提供控制器，其可操作地耦合到检测器和时钟并且被配置为在分析周期期间确定总脉冲数。控制器还被配置为确定可重复序列中的至少一个箱，在分析周期期间没有检测到离子冲击的相应脉冲时间段的数量。控制器还被配置为计算对应于至少一个仓的离子通量，并且其中计算所述离子通量与在脉冲时间段期间不检测离子冲击的概率相关联，所述脉冲时间段对应于所述至少一个仓可重复系列。

89. 发明申请

US20070045529A1 Mass spectrometry data analysis engine 审中-公开
标题翻译：质谱数据分析引擎
公开(公告)号：US20070045529A1
公开(公告)日：2007-03-01
申请号：US11329536
申请日：2006-01-11
申请人： Libo Cao , Christopher Janko , Guoxiang Chen
发明人： Libo Cao , Christopher Janko , Guoxiang Chen
IPC分类号： H01J49/26
CPC分类号： H01J49/02 , H01J49/0009
摘要： A data processing engine for an automated mass spectrometry system is provided that identifies analyte and spike peak locations in spectral data based upon mass spectrometer tunings and solution identities. The data processing engine calculates analyte concentrations based upon spectral responses at the identified peak locations.
摘要翻译：提供了一种用于自动质谱系统的数据处理引擎，其基于质谱仪调谐和溶液特性来识别光谱数据中的分析物和尖峰位置。数据处理引擎基于所识别的峰位置处的光谱响应来计算分析物浓度。

90. 发明申请

US20060076483A1 Optical bench for a mass spectrometer system 有权
标题翻译：光谱仪系统的光学台
公开(公告)号：US20060076483A1
公开(公告)日：2006-04-13
申请号：US11205758
申请日：2005-08-16
申请人： Adi Scheidemann , Mark McGraw , Clare Long , Gottfried Kibelka
发明人： Adi Scheidemann , Mark McGraw , Clare Long , Gottfried Kibelka
IPC分类号： B01D59/44
CPC分类号： H01J49/02 , H01J49/28 , H05K1/0271 , H05K1/0284 , H05K2201/2009
摘要： Mass spectrometer systems for measuring mass/charge ratios of analytes are described. A mass spectrometer system includes a vacuum flange, a PCB base plate coupled to the vacuum flange, and an ion optic assembly coupled to the PCB base plate. The PCB base plate may include signal-processing electronics. The system may include an electrical cable coupled to the PCB base plate for supplying power, control, and I/O to the ion optic assembly and the signal processing electronics. Alternatively, a mass spectrometer system includes a PCB base plate and an ion optic assembly. The PCB base plate has a sealant portion and an electrical portion. The ion optic assembly is coupled to the electrical portion. The system may include a vacuum housing for enclosing the ion optic assembly. The vacuum housing is coupled to the sealant portion of the PCB base plate for sustaining a vacuum while the system is in operation.
摘要翻译：描述了用于测量分析物质量/电荷比的质谱仪系统。质谱仪系统包括真空法兰，联接到真空法兰的PCB基板和耦合到PCB基板的离子光学组件。 PCB基板可以包括信号处理电子器件。该系统可以包括耦合到PCB基板的电缆，用于向离子光学组件和信号处理电子器件供电，控制和I / O。或者，质谱仪系统包括PCB基板和离子光学组件。 PCB基板具有密封剂部分和电气部分。离子光学组件耦合到电气部分。该系统可以包括用于封闭离子光学组件的真空壳体。真空壳体联接到PCB基板的密封剂部分，以在系统运行时维持真空。

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