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81. 发明授权

US09506942B2 Automatic analyzer and method for detecting measurement value abnormalities 有权
标题翻译：自动分析仪和检测测量值异常的方法
公开(公告)号：US09506942B2
公开(公告)日：2016-11-29
申请号：US14367066
申请日：2012-11-22
申请人： HITACHI HIGH-TECHNOLOGIES CORPORATION
发明人： Akihisa Makino , Masahiko Iijima , Akiko Watanabe
IPC分类号： G01N35/10 , G01N35/00 , G01N21/53
CPC分类号： G01N35/1002 , G01N21/532 , G01N35/00603 , G01N35/00663 , G01N35/00693 , G01N2035/00702 , Y10T436/11
摘要： An automatic analyzer detects measurement value abnormalities stemming from reaction process anomalies caused by the presence of foreign matter or bubbles. It is determined whether the results of concentration calculation based on light quantity data from multiple target detectors each fall within an applicable determination range. If the results fall within the determination range, an average value of the results of concentration calculation with the target detectors is calculated, and if not, an out-of-determination-range flag is given. A default fluctuation range is retrieved regarding the average value of the results of concentration calculation. The fluctuation range of the results of concentration calculation with the multiple target detectors is calculated. If the fluctuation range is found to fall within the default range, the results of concentration calculation are output to a display; and if outside the default range, a reexamination request is displayed with an added measurement value abnormality alarm.
摘要翻译：自动分析仪检测由异物或气泡的存在引起的反应过程异常引起的测量值异常。确定基于来自多个目标检测器的光量数据的浓度计算的结果是否落入适用的确定范围内。如果结果落在确定范围内，则计算与目标检测器的浓度计算结果的平均值，如果不是，则给出超出判定范围的标志。检索浓度计算结果的平均值的默认波动范围。计算多个目标检测器的浓度计算结果的波动范围。如果发现波动范围在默认范围内，则将浓度计算的结果输出到显示器; 如果超出默认范围，将显示一个复查请求，并附加一个测量值异常报警。

82. 发明申请

US20160327586A1 AUTOMATIC ANALYZER 有权
标题翻译：自动分析仪
公开(公告)号：US20160327586A1
公开(公告)日：2016-11-10
申请号：US15109824
申请日：2015-01-16
申请人： HITACHI HIGH-TECHNOLOGIES CORPORATION
发明人： Gorou YOSHIDA
IPC分类号： G01N35/10 , G01N35/00
CPC分类号： G01N35/1004 , G01N27/06 , G01N33/18 , G01N35/00613 , G01N35/00623 , G01N35/1002 , G01N35/1009 , G01N35/1016 , G01N2035/00277 , G01N2035/1025 , G01N2035/1032
摘要： Dilution of a sample occurring in a sample dispensing operation is a problem in terms of analysis accuracy. Although the dilution amount is alleviated to some extent by a technique of sucking the sample excessively, the problem may emerge along with a requirement for reducing the sample dispensing amount, an increase of sucking and discharging speed in response to improvement of a processing capability, and an increase of the number of items to be analyzed simultaneously. Provided is an automatic analyzer including a mechanism monitoring conductivity of system water filled in a nozzle and an electro-physical amount such as voltage and capacitance of a probe to enable detection of mixture of the sample and a reagent into the system water and dilution of the sample and the reagent.
摘要翻译：在样品分配操作中发生的样品的稀释在分析精度方面是一个问题。尽管通过过度吸取样品的技术可以减轻稀释量，但随着对提高加工能力的提高，抽样分配量的减少，吸取和排出速度的提高也可能出现问题，以及同时增加要分析的项目数量。提供了一种自动分析仪，其包括监测填充在喷嘴中的系统水的电导率的机构和诸如探针的电 - 电容的电物理量，以便能够将样品和试剂的混合物检测到系统水中并稀释样品和试剂。

83. 发明申请

US20160289729A1 INSTRUMENT AND SYSTEM FOR RAPID MICROORGANISM IDENTIFICATION AND ANTIMICROBIAL AGENT SUSCEPTIBILITY TESTING 有权
标题翻译：用于快速微生物鉴定和抗微生物试剂检测的仪器和系统
公开(公告)号：US20160289729A1
公开(公告)日：2016-10-06
申请号：US15085953
申请日：2016-03-30
申请人： Accelerate Diagnostics, Inc.
发明人： William L. Richards , Austin Ashby , Matthew Ketterer , Kevin Marshall , Josh Harrison , Matthew Mette , Paul Richards , Wayne Showalter , Jasmin Cote , Phillip C. Halbert , Solene Bourgeois , Steven W. Metzger , Ken Hance , Meghan Mensack , Carlos Michel , Elke Allers , Dulini Gamage , Landon Prisbrey , Oleg Gusyatin , Alena Shamsheyeva , Ben Turng , Andrew Ghusson , Kurt Reinhardt
IPC分类号： C12Q1/02 , G01N35/02 , H04N5/232 , C12Q1/04 , B01L3/00 , G01N35/10 , G01N1/38
CPC分类号： C12Q1/025 , B01L3/527 , B01L2300/0893 , C12Q1/04 , G01N1/38 , G01N15/06 , G01N21/6458 , G01N35/025 , G01N35/1002 , G01N2015/0693 , G01N2021/6419 , G01N2035/00346 , G01N2035/0443 , G01N2035/0444 , G01N2035/0446 , G01N2035/0455 , G01N2035/1032 , G02B7/28 , H04N5/23212
摘要： A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing.
摘要翻译：公开了一种用于自动化微生物鉴定和抗生素敏感性测试的系统，其包括试剂盒，试剂台，盒式磁带，载物台，移液器组件，光学检测系统和控制器。该系统旨在动态调整电机怠速转矩以控制热负荷，并采用快速聚焦过程来确定单个微生物的真实聚焦位置。该系统还可以使用动态稀释来量化样品中活的微生物的相对丰度，并促进微生物在定制培养基中的生长以用于快速，准确的抗微生物敏感性测试。

84. 发明授权

US09459270B2 In-vitro diagnostic analysis method and system 有权
标题翻译：体外诊断分析方法和系统
公开(公告)号：US09459270B2
公开(公告)日：2016-10-04
申请号：US14732132
申请日：2015-06-05
申请人： Roche Diagnostics Operations, Inc.
发明人： Thomas Meyer , Gottlieb Schacher , Rolf Sigrist , Christian Guzek
IPC分类号： G01N35/02 , G01N35/10 , G01N35/00
CPC分类号： G01N35/0092 , G01N33/86 , G01N35/026 , G01N35/1002 , G01N35/1065 , G01N2035/00356 , G01N2035/00524 , G01N2035/0094 , Y10T436/113332 , Y10T436/114165 , Y10T436/115831 , Y10T436/2575
摘要： A method and system for automatic in-vitro diagnostic analysis are described. The method includes adding a first reagent type and a second reagent type to a first test liquid during a first and second cycle times respectively. The addition of the first reagent type to the first test liquid includes parallel addition of a second reagent type to a second test liquid during the first cycle time. The addition of the second reagent type to the first test liquid includes parallel addition of a first reagent type to a third test liquid during the second cycle time, respectively.
摘要翻译：描述了用于自动体外诊断分析的方法和系统。该方法包括在第一和第二循环时间期间将第一试剂类型和第二试剂类型添加到第一测试液体。将第一试剂类型添加到第一测试液体包括在第一循环时间期间将第二试剂类型平行添加到第二测试液体。向第一测试液体添加第二试剂类型包括分别在第二循环时间期间向第三测试液体平行添加第一试剂类型。

85. 发明申请

US20160282373A1 APPARATUS FOR PARALLEL PROCESSING OF SLIDE SPECIMENS IN RECEPTACLES 审中-公开
标题翻译：用于并口处理插入样品的装置
公开(公告)号：US20160282373A1
公开(公告)日：2016-09-29
申请号：US15079011
申请日：2016-03-23
申请人： SYFR, INC.
发明人： Shazi S. Iqbal , Michael Mayo , Paul Parks , Alexander Greis
IPC分类号： G01N35/00 , G01N35/10
CPC分类号： G01N35/00029 , G01N1/312 , G01N35/1002 , G01N35/1065
摘要： A test instrument includes multiple receptacle bays for testing specimens contained in specimen receptacles. The test instrument processes different specimens in different specimen receptacles in the respective receptacle bays in parallel. Different tests may be conducted in the receptacle bays at the same time. Each receptacle bay couples to one or more common bulk reagent stores and to one or more small volume reagent stores. This arrangement may provide a dramatic increase in specimen processing efficiency by enabling different tests to be conducted in each receptacle bay at the same time.
摘要翻译：测试仪器包括多个插座，用于测试样品容器中包含的样品。测试仪器在相应的插座隔间中的不同样品容器中并行处理不同的样品。同时可以在插座间进行不同的测试。每个插座隔间耦合到一个或多个常见的散装试剂储存器和一个或多个小体积试剂储存器。这种布置可以通过在每个插座隔间同时进行不同的测试来提高样品处理效率。

86. 发明申请

US20160266161A1 ANALYSIS DEVICE AND REAGENT CONTAINER 审中-公开
标题翻译：分析装置和试剂容器
公开(公告)号：US20160266161A1
公开(公告)日：2016-09-15
申请号：US15164105
申请日：2016-05-25
申请人： SYSMEX CORPORATION
发明人： Takaaki Nagai , Yuichi Hamada , Nobuhiro Kitagawa
IPC分类号： G01N35/10 , G01N35/00
CPC分类号： G01N35/1009 , G01N35/00663 , G01N35/0099 , G01N35/026 , G01N35/04 , G01N35/1002 , G01N35/1079 , G01N2035/00673 , G01N2035/0412
摘要： An analysis device for particle analysis, configured in such a manner that a reagent container is set in the device by inserting the reagent container from a side surface of the device toward the inside thereof, the reagent container having, near the forward end thereof, a suction pipe entrance portion into which a suction pipe can enter. The analysis device is provided with: a reagent container holding portion which holds the reagent container inserted from the suction pipe entrance portion side; and the suction pipe which enters, from above, the suction pipe entrance portion of the reagent container held by the reagent container holding portion and which sucks a reagent within the reagent container. The reagent container holding portion includes a guide member for guiding the insertion of the reagent container, which is inserted from the suction pipe entrance portion side, into the reagent container holding portion.
摘要翻译：一种用于粒子分析的分析装置，其特征在于，通过将试剂容器从所述装置的侧面插入其内部而将试剂容器设置在所述装置中，所述试剂容器在其前端附近具有吸入管入口部分，吸入管可以进入其中。分析装置具备：试剂容器保持部，其保持从吸入管入口部侧插入的试剂容器; 以及吸入管，其从上方进入由试剂容器保持部保持的试剂容器的吸入口入口部分，并且吸入试剂容器内的试剂。试剂容器保持部包括用于将从吸入管入口部侧插入的试剂容器的插入引导到试剂容器保持部的引导部件。

87. 发明申请

US20160231344A1 CARTRIDGE FOR DISPENSING A FLUID 审中-公开
公开(公告)号：US20160231344A1
公开(公告)日：2016-08-11
申请号：US15132915
申请日：2016-04-19
申请人： Roche Diagnostics Operations, Inc.
发明人： Christoph Boehm , Peter Kupser , Norbert Oranth , Juergen Spinke , Thorsten Brueckner , Timo Klein
IPC分类号： G01N35/10 , B01L3/00 , G01N35/00
CPC分类号： G01N35/1002 , A61M5/14216 , A61M5/16809 , B01L3/0217 , B01L3/0224 , B01L3/502 , B01L2200/025 , B01L2200/0605 , B01L2200/0684 , B01L2200/16 , B01L2300/0627 , B01L2300/0681 , B01L2400/0478 , B01L2400/0644 , B01L2400/065 , G01F11/021 , G01N35/00871 , G01N35/1016 , G01N35/1097 , G01N2035/1025 , Y10T436/119163 , Y10T436/2575
摘要： A cartridge for dispensing fluid is presented. The cartridge comprises a valve. The valve comprises a pumping chamber for pumping the fluid. The valve positions a pumping chamber conduit. The pumping chamber conduit is connected to the pumping chamber. The cartridge further comprises a plunger for changing the volume of the pumping chamber. The cartridge further comprises a reservoir conduit for connecting the reservoir with the valve. The valve positions the pumping chamber conduit to connect with the reservoir conduit. The cartridge further comprises an outlet conduit for dispensing the fluid. The valve further rotates the pumping chamber conduit to connect with the outlet conduit.

88. 发明申请

US20160202280A1 Methods and Systems for Automated Pipette Tracking 审中-公开
标题翻译：自动移液器跟踪的方法和系统
公开(公告)号：US20160202280A1
公开(公告)日：2016-07-14
申请号：US15072434
申请日：2016-03-17
申请人： Actrace, LLC
发明人： Lei Zeng
IPC分类号： G01N35/10 , G01N35/00
CPC分类号： G01N35/00584 , B01L3/0237 , B01L3/527 , B01L2200/025 , B01L2200/143 , B01L2200/148 , B01L2300/027 , B01L2300/0654 , B01L2300/0829 , G01N35/00722 , G01N35/1002 , G01N35/1011 , G01N2035/0091
摘要： Described are pipetting systems that automatically track the dispensing and extracting of reagents to and from arrays of well locations. The systems track the position of a pipette with respect to the well locations, and selectively illuminate those locations to indicate the progress of pipetting operations. Control logic can shepherd pipetting processes, indicating errors and guiding the user.
摘要翻译：描述了移液系统，其自动跟踪从井阵列阵列排出和提取试剂。系统跟踪移液器相对于井位置的位置，并且选择性地照亮那些位置以指示移液操作的进展。控制逻辑可以吸取移液过程，指示错误并引导用户。

89. 发明授权

US09372156B2 System for processing contents of a receptacle to detect an optical signal emitted by the contents 有权
标题翻译：用于处理插座的内容以检测由内容发射的光信号的系统
公开(公告)号：US09372156B2
公开(公告)日：2016-06-21
申请号：US13031889
申请日：2011-02-22
申请人： Byron J. Knight
发明人： Byron J. Knight
IPC分类号： C12Q1/00 , G01N21/00 , G01N21/64 , C12Q1/68 , G01N21/76 , G01N35/00 , G01N35/02 , B01L7/00 , G01N35/10 , G01N35/04
CPC分类号： G01N21/6428 , B01L7/52 , C12Q1/6813 , C12Q1/6851 , G01N21/6454 , G01N21/76 , G01N35/00693 , G01N35/0092 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/026 , G01N35/028 , G01N35/04 , G01N35/1002 , G01N2021/6419 , G01N2021/6421 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441 , G01N2035/00346 , G01N2035/00356 , G01N2035/00524 , G01N2035/0097 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2035/0455 , G01N2035/0491 , G01N2035/103 , G01N2201/0415 , Y10S435/808 , Y10S435/809 , Y10T436/113332 , Y10T436/25 , C12Q2537/165
摘要： A system is configured to process the contents of one or more receptacles to detect an optical signal emitted by the contents of each receptacle. Each receptacle is held within a receptacle station of a movable receptacle carrier disposed within a temperature-controlled chamber of an incubator. At least one signal detector is configured to detect an optical signal emitted by the contents of a receptacle as the receptacle carrier moves each receptacle into an operative position with respect to the signal detector. A magnet holder is attached to the receptacle carrier and holds one or more magnets adjacent to an associated receptacle station so as to expose the contents of each receptacle carried in the receptacle station to a magnetic field when the receptacle is in the operative position with respect to the signal detector.
摘要翻译：系统被配置为处理一个或多个插座的内容物以检测由每个插座的内容物发射的光信号。每个容器被保持在设置在培养箱的温度控制室内的可移动容器载体的容器台内。至少一个信号检测器被配置为当插座承载器将每个插座移动到相对于信号检测器的操作位置时，检测由插座的内容物发射的光信号。磁体保持器附接到插座托架并且将一个或多个磁体保持在与相关的插座站相邻的位置，以便当插座处于相对于插座的操作位置时将容纳站中承载的每个插座的内容物暴露于磁场信号检测器。

90. 发明申请

US20160139164A1 CARTRIDGE FOR DISPENSING A FLUID, AUTOMATIC ANALYZER AND METHOD OF ANALYZING A BIOLOGICAL SAMPLE 有权
标题翻译：液体分配盒，自动分析仪和分析生物样品的方法
公开(公告)号：US20160139164A1
公开(公告)日：2016-05-19
申请号：US15006476
申请日：2016-01-26
申请人： Roche Diagnostics Operations, Inc. , Hitachi High-Technologies Corporation
发明人： Thorsten Brueckner , Christoph Boehm , Juergen Spinke , Terumi Tamura , Taku Sakazume , Kyoko Imai
IPC分类号： G01N35/10 , B01L3/02
CPC分类号： G01N35/1002 , B01L3/0268 , B01L3/0286 , B01L2200/04 , B01L2200/0684 , B01L2300/0609 , B01L2300/0832 , B01L2300/123 , B01L2400/0481 , B01L2400/082 , G01N35/1009
摘要： A cartridge for dispensing a fluid is presented. The cartridge comprises a reservoir chamber for receiving the fluid. The reservoir chamber has a fluid outlet. The cartridge further comprises a controllable dispenser component for dispensing a dispensing volume of the fluid from the reservoir chamber. The dispenser component is connected to the fluid outlet of the reservoir. The cartridge further comprises a single compressible fluid pump with a single elastic pumping element and a conduit extending from the fluid pump towards the fluid outlet. The fluid pump discharges a mixing volume of the fluid from the conduit into the reservoir chamber upon compression of the elastic pumping element. The mixing volume depends on the degree of compression of the elastic pumping element. The fluid pump sucks in the mixing volume from the reservoir into the conduit upon decompression of the elastic pumping element.
摘要翻译：呈现用于分配流体的盒。墨盒包括用于接收流体的储存室。储存室具有流体出口。墨盒还包括可控分配器部件，用于从储存室分配流体的分配体积。分配器部件连接到储存器的流体出口。墨盒还包括具有单个弹性抽吸元件的单个可压缩流体泵和从流体泵朝向流体出口延伸的导管。当压缩弹性抽吸元件时，流体泵将流体的混合体积从管道排出到储存室中。混合体积取决于弹性泵送元件的压缩程度。当弹性抽吸元件减压时，流体泵从储存器吸入混合容积。

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