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    • 81. 发明申请
    • Method for Triggering Dependent Spectra for Data Acquisition
    • 用于触发依赖光谱数据采集的方法
    • US20130289894A1
    • 2013-10-31
    • US13995816
    • 2011-12-22
    • David M. CoxStephen A. TateMatthias Glueckmann
    • David M. CoxStephen A. TateMatthias Glueckmann
    • G01N23/00H01J49/02
    • G01N23/00H01J49/0031H01J49/0045H01J49/025
    • Methods and systems are provided for triggering an information dependent mass spectrometry scan in real time. A mass spectrometry scan of a separating sample mixture is performed by a mass spectrometer at each time interval of a time period. The mass spectrometer receives the separating sample mixture from a separation device. It is determined at a certain time interval that a received mass spectrometry scan at the time interval and one or more preceding received mass spectrometry scans include two or more time-varying ion signals that represent two or more fragment ion transitions of a known compound. If a characteristic of the two or more time-varying ion signals meets a selection criterion, the mass spectrometer is instructed to perform a dependent mass spectrometry scan of the separating sample mixture for a precursor ion of the known compound at the time interval.
    • 提供了实时触发信息依赖质谱扫描的方法和系统。 分离样品混合物的质谱扫描由质谱仪在每个时间段的每个时间间隔进行。 质谱仪从分离装置接收分离样品混合物。 在一定时间间隔确定在时间间隔和一个或多个先前接收质谱扫描的接收质谱扫描包括表示已知化合物的两个或更多个片段离子转变的两个或更多个时变离子信号。 如果两个或更多个时变离子信号的特征满足选择标准,则指示质谱仪以时间间隔对已知化合物的前体离子进行分离样品混合物的依赖性质谱扫描。
    • 85. 发明申请
    • DRIVING TYPE PATIENT PLATFORM, CONTROL DEVICE FOR DRIVING TYPE PATIENT PLATFORM, CONTROL PROGRAM FOR DRIVING TYPE PATIENT PLATFORM, AND PARTICLE BEAM THERAPY SYSTEM UTILIZING THESE ITEMS
    • 驾驶型患者平台,用于驾驶型患者平台的控制装置,用于驾驶型患者平台的控制程序和使用这些物品的颗粒束治疗系统
    • US20120248331A1
    • 2012-10-04
    • US13494371
    • 2012-06-12
    • Takaaki IWATA
    • Takaaki IWATA
    • A61N5/10A61G13/04
    • G01N23/00
    • A patient platform for making the position and posture of a diseased site coincide with those established by a treatment plan. Translation units translate a top board in the X, Y and Z directions respectively, in a fixed coordinate system. Rotation units rotate the top board in the θ, φ, and ξ directions respectively. A controller controls the translation units and rotation units, based on desired rotation center point and desired rotation angle. The controller has a rotation drive signal generation unit that generates a signal for moving the top board in a rotating manner from the reference state “a” of the translation units and the rotation units to a desired rotation angle; and a translation drive signal generation unit that generates a signal for translating the translation units so the amount of translation movement, of the desired rotation center point, caused by the rotation movement is a predetermined value.
    • 用于使病变位置和姿势的患者平台与治疗计划确定的平台相符。 翻译单位在固定坐标系中分别在X,Y和Z方向翻译顶板。 旋转单元旋转顶板,&phgr;和&xgr; 方向。 控制器根据期望的旋转中心点和期望的旋转角度来控制平移单元和旋转单元。 控制器具有旋转驱动信号生成单元,该旋转驱动信号生成单元从旋转方向生成用于使顶板从转动单元和旋转单元的基准状态a移动到希望的旋转角度的信号; 以及翻译驱动信号生成单元,其生成用于平移平移单元的信号,使得由旋转运动引起的期望的旋转中心点的平移运动量为预定值。
    • 89. 发明申请
    • DRIVING TYPE PATIENT PLATFORM, CONTROL DEVICE FOR DRIVING TYPE PATIENT PLATFORM, CONTROL PROGRAM FOR DRIVING TYPE PATIENT PLATFORM, AND PARTICLE BEAM THERAPY SYSTEM UTILIZING THESE ITEMS
    • 驾驶型患者平台,用于驾驶型患者平台的控制装置,用于驾驶型患者平台的控制程序和使用这些物品的颗粒束治疗系统
    • US20110215259A1
    • 2011-09-08
    • US13009359
    • 2011-01-19
    • Takaaki IWATA
    • Takaaki IWATA
    • G01N23/00
    • G01N23/00
    • The objective is to obtain a driving type patient platform that can efficiently perform positioning work for making the position and the posture of a diseased site coincide with those established when a treatment plan is generated. There are provided translation units that translate a top board in the X direction, the Y direction, and the Z direction, respectively, in a fixed coordinate system; rotation units that rotate the top board in the θ direction around the X axis, the φ direction around the Y axis, and the ξ direction around the Z axis, respectively; and a control device that controls the translation units and the rotation units, based on an inputted desired rotation center point and an inputted desired rotation angle. The control device is provided with a rotation drive signal generation unit that generates a rotation drive signal for moving the top board in a rotating manner from the reference state “a” of the translation units and the rotation units to a desired rotation angle; and a translation drive signal generation unit that generates a translation drive signal for translating the translation units in such a way that the amount of translation movement, of the desired rotation center point, that is caused by the rotation movement becomes the same as or smaller than a predetermined value.
    • 目的是获得能够有效地执行定位工作的驾驶型患者平台,以使得患病部位的位置和姿势与产生治疗计划时建立的位置和姿势一致。 在固定坐标系中,分别提供了在X方向,Y方向和Z方向上分别翻译顶板的翻译单元; 在顶部旋转顶板的旋转单元; 方向围绕X轴,&phgr; Y轴方向,&xgr; 分别绕Z轴方向; 以及基于输入的期望旋转中心点和输入的期望旋转角度来控制平移单元和旋转单元的控制装置。 控制装置设置有旋转驱动信号生成单元,该旋转驱动信号生成单元生成用于将顶板以旋转的方式从平移单元和旋转单元的基准状态“a”移动到期望的旋转角度的旋转驱动信号; 以及翻译驱动信号生成单元,其生成用于平移平移单元的平移驱动信号,使得由旋转运动引起的期望的旋转中心点的平移运动的量变为等于或小于 预定值。
    • 90. 发明授权
    • Instruments for measuring nanoparticle exposure
    • 用于测量纳米颗粒暴露的仪器
    • US07812306B2
    • 2010-10-12
    • US11439451
    • 2006-05-23
    • Heinz FissanAndreas TrampeDavid Y. H. PuiStanley L. Kaufman
    • Heinz FissanAndreas TrampeDavid Y. H. PuiStanley L. Kaufman
    • H01J49/00
    • G01N27/622B03C3/017B03C3/09B03C3/12B03C3/38B03C3/41B03C3/47G01N15/0266G01N23/00G01N2015/0038
    • An instrument for non-invasively measuring nanoparticle exposure includes a corona discharge element generating ions to effect unipolar diffusion charging of an aerosol, followed by an ion trap for removing excess ions and a portion of the charged particles with electrical mobilities above a threshold. Downstream, an electrically conductive HEPA filter or other collecting element accumulates the charged particles and provides the resultant current to an electrometer amplifier. The instrument is tunable to alter the electrometer amplifier output toward closer correspondence with a selected function describing particle behavior, e.g. nanoparticle deposition in a selected region of the respiratory system. Tuning entails adjusting voltages applied to one or more of the ion trap, the corona discharge element and the collecting element. Alternatively, tuning involves adjusting the aerosol flow rate, either directly or in comparison to the flow rate of a gas conducting the ions toward merger with the aerosol.
    • 用于非侵入性地测量纳米颗粒暴露的仪器包括产生离子以实现气溶胶的单极扩散充电的电晕放电元件,随后是用于去除过量离子的离子阱和一部分电荷迁移率高于阈值的带电粒子。 下游,导电HEPA过滤器或其他收集元件累积带电粒子并将合成电流提供给静电计放大器。 该仪器是可调谐的,以改变静电计放大器输出,使其与所选择的描述粒子行为的函数更接近地对应,例如。 在呼吸系统的选定区域中的纳米颗粒沉积。 调谐需要调整施加到一个或多个离子阱,电晕放电元件和收集元件的电压。 或者,调整包括直接或与将离子导向与气溶胶合并的气体的流速相比调节气溶胶流速。