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81. 发明授权

US6422431B2 Microvolume liquid handling system 有权
标题翻译：微体积液体处理系统
公开(公告)号：US6422431B2
公开(公告)日：2002-07-23
申请号：US77522901
申请日：2001-02-01
申请人： PACKARD INSTRUMENT CO INC
发明人： PELC RICHARD E , CHIBUCOS NICHOLAS S , PAPEN ROELAND F , MEYER WILHELM
IPC分类号： B01L3/02 , C40B60/14 , G01F1/48 , G01F3/00 , G01N35/00 , G01N35/10
CPC分类号： G01F1/48 , B01J2219/00378 , B01L3/0265 , B01L3/0268 , C40B60/14 , G01F3/00 , G01N35/1065 , G01N2035/00237 , G01N2035/1018 , G01N2035/1025 , G01N2035/1039 , G01N2035/1041 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： In one embodiment, a microvolume liquid handling system includes a microdispenser employing a piezoelectric transducer attached to a glass capillary, a positive displacement pump for priming and aspiring transfer liquid into the microdispenser, controlling the pressure of the liquid system and washing the microdispenser between liquid transfers, and a pressure sensor to measure the liquid system pressure and produce a corresponding electrical signal. The pressure signal is used to verify and quantify the microvolume of transfer liquid dispensed and is used to perform automated calibration and diagnostics on the microdispenser. In another embodiment of the microvolume liquid handling system, a system reservoir is connected with tubing to a pressure control system for controlling the liquid system pressure in the system reservoir. The system reservoir is coupled to one or more microdispenser through a distribution tube having a branched section for each microdispenser. In this embodiment, each microdispenser is coupled to its own flow sensor and which enables a system controller to respectively measure and control the flow of liquid in each dispenser.
摘要翻译：在一个实施例中，微体积液体处理系统包括使用连接到玻璃毛细管的压电换能器的微型分配器，用于将液体引入和分散到微型分配器中的正位移泵，控制液体系统的压力并在液体转移之间洗涤微分液器以及用于测量液体系统压力并产生相应的电信号的压力传感器。压力信号用于验证和量化分配的转移液体的微量，并用于对微型分配器执行自动校准和诊断。在微体积液体处理系统的另一个实施例中，系统储存器与管道连接到用于控制系统储存器中的液体系统压力的压力控制系统。系统储存器通过具有用于每个微分配器的分支部分的分配管耦合到一个或多个微分配器。在该实施例中，每个微型分配器连接到其自身的流量传感器，并且使得系统控制器能够分别测量和控制每个分配器中的液体的流动。

82. 发明申请

US20010032505A1 Liquid-level detection method and device thereof 失效
标题翻译：液面检测方法及其装置
公开(公告)号：US20010032505A1
公开(公告)日：2001-10-25
申请号：US09836277
申请日：2001-04-18
申请人： ARKRAY, INC.
发明人： Toshikazu Iwao
IPC分类号： G01F023/00
CPC分类号： G01N35/1009 , G01F23/14 , G01N2035/1025
摘要： An ALC circuit is turned on (S1), a nozzle is shifted to a sampling position (S2), and after the ALC circuit has been turned off (S3), the nozzle is allowed to start discharging air from its tip (S4). While the nozzle is being lowered, the inner pressure of the nozzle is monitored (S5, S6), and upon detection of an increase in the pressure, the discharging process of air and the nozzle lowering process are stopped (S7), while the monitoring of the magnitude of the pressure is continued (S8). When the magnitude of the pressure is being maintained within a permissible range of the change for a predetermined time, it is judged that the tip of the nozzle has come into contact with the true liquid level, and after a suction operation of a sample (S9), the nozzle is raised (S10). When the magnitude of the pressure has dropped below the permissible range of the change within the predetermined time, it is judged that the tip of the nozzle has not come into contact with the true liquid level, the nozzle is again lowered (S11).
摘要翻译： ALC电路接通（S1），喷嘴移动到采样位置（S2），在ALC电路断开（S3）之后，允许喷嘴从其顶端开始排出空气（S4）。在喷嘴降低的同时，监视喷嘴的内部压力（S5，S6），并且在检测到压力增加时，停止排出空气和喷嘴降低过程（S7），同时监视压力的大小继续（S8）。当压力的大小保持在允许的变化范围内达预定时间时，判断喷嘴的尖端已经与真实液面接触，并且在抽样操作之后（S9 ），喷嘴升高（S10）。当压力的大小降低到在预定时间内允许的变化范围之外时，判断出喷嘴的尖端未与真实液面接触，喷嘴再次降低（S11）。

83. 发明授权

US06190617B1 Sample container segment assembly 失效
标题翻译：样品容器段装配
公开(公告)号：US06190617B1
公开(公告)日：2001-02-20
申请号：US08956939
申请日：1997-10-23
申请人： Frederick L. Clark , Larry W. Moore , Donny Ray Walker , John M Clemens , William J. Kanewske, III , B. Jane Smith
发明人： Frederick L. Clark , Larry W. Moore , Donny Ray Walker , John M Clemens , William J. Kanewske, III , B. Jane Smith
IPC分类号： G01N3500
CPC分类号： G01N35/0092 , B01F11/0022 , B01L3/08 , B01L3/5025 , B01L3/5085 , B01L3/50853 , B01L9/06 , B01L2200/142 , B01L2300/042 , B01L2300/043 , B29C45/00 , B29K2995/0032 , B29L2023/22 , G01N21/03 , G01N21/6428 , G01N21/6452 , G01N21/76 , G01N33/53 , G01N33/5302 , G01N33/537 , G01N33/538 , G01N33/542 , G01N33/54313 , G01N35/0099 , G01N35/025 , G01N35/1004 , G01N35/1065 , G01N2001/007 , G01N2021/6482 , G01N2035/00168 , G01N2035/00287 , G01N2035/00356 , G01N2035/00386 , G01N2035/00455 , G01N2035/00475 , G01N2035/00495 , G01N2035/00524 , G01N2035/00752 , G01N2035/0093 , G01N2035/0405 , G01N2035/0436 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2035/0446 , G01N2035/0448 , G01N2035/0453 , G01N2035/0465 , G01N2035/1025 , G01N2035/1076 , G01N2035/1086 , H01J49/04 , Y10T436/11 , Y10T436/113332
摘要： A sample container segment assembly for use in an automated, continuous, and random access analytical system is disclosed. The assembly includes a sample container which is received by a sample container segment, and the sample container segment is received on a carousel of the automated analytical instrument. The test sample container includes an upper skirt and a body having a reservoir for receipt of the test sample. The segment includes a base, a frame, and a handle. The frame has a shelf for which the upper skirt of the test sample container rests on, and has openings for receipt of the body of the sample container. The carousel has a carousel trough for receipt of the base of the sample container segment, and has a plurality of alignment pins disposed in the carousel trough. The base of the sample container segment has a circular slot and an elongated slot for receiving the alignment pins and positioning the sample container segment relative to the carousel. The sample container segment can include a liquid level sensing sleeve which is made of a conductive material and surrounds the reservoir of the test sample container inserted therein. Alternatively, the test sample container can have a conductive core which surrounds the reservoir and extends therebelow. The container sample segment can also include various sleeves, or springs and arms, for securing and positioning the test sample container within the sample container segment.
摘要翻译：公开了一种用于自动，连续和随机存取分析系统的样品容器段组件。组件包括由样品容器段接收的样品容器，并且样品容器段被接收在自动分析仪器的转盘上。测试样本容器包括上裙部和具有用于接收测试样品的容器的主体。该段包括基座，框架和手柄。框架具有搁置测试样本容器的上裙部的搁架，并且具有容纳样本容器的主体的开口。转盘具有用于接收样品容器段的底部的转盘槽，并且具有设置在转盘槽中的多个对准销。样品容器段的底部具有圆形狭槽和用于接收对准销并且相对于转盘定位样品容器段的细长槽。样品容器段可包括由导电材料制成并围绕插入其中的测试样品容器的储存器的液位感测套筒。或者，测试样本容器可以具有包围储存器并在其下方延伸的导电芯。容器样品片段还可以包括各种套筒或弹簧和臂，用于将测试样品容器固定并定位在样品容器段内。

84. 发明授权

US6074615A Reagent container for an automated analyzer 有权
标题翻译：用于自动分析仪的试剂容器
公开(公告)号：US6074615A
公开(公告)日：2000-06-13
申请号：US238309
申请日：1999-01-28
申请人： Scott C. Lewis , Mary Beth Whitesel
发明人： Scott C. Lewis , Mary Beth Whitesel
IPC分类号： G01N21/78 , B01L3/00 , G01N21/03 , G01N21/76 , G01N33/53 , G01N33/543 , G01N33/553 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10
CPC分类号： B01L3/508 , G01N21/76 , G01N35/021 , G01N35/025 , G01N35/1002 , B01L2300/0854 , G01N2035/00386 , G01N2035/00396 , G01N2035/00524 , G01N2035/00752 , G01N2035/0441 , G01N2035/0443 , G01N2035/0465 , G01N2035/0484 , G01N2035/0486 , G01N2035/1025 , G01N35/0098 , G01N35/1065 , Y10S215/01 , Y10S215/03 , Y10S215/08 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
摘要： An analyzer for performing automated assay testing. The analyzer includes a storage and conveyor system for conveying cuvettes to an incubation or processing conveyor, a storage and selection system for test sample containers, a storage and selection system for reagent containers, sample and reagent aspirating and dispensing probes, a separation system for separating bound from unbound tracer or labeled reagent, a detection system and date collection/processing system. All of the sub-units of the machine are controlled by a central processing unit to coordinate the activity of all of the subunits of the analyzer. The analyzer is specificallysuited for performing heterogeneous binding assay protocols, particularly immunoassays.
摘要翻译：用于进行自动化测定测试的分析仪。分析仪包括用于将比色皿输送到孵育或加工输送机的储存和输送系统，用于测试样品容器的储存和选择系统，用于试剂容器的储存和选择系统，样品和试剂抽吸和分配探针，用于分离的分离系统绑定来自未结合的示踪剂或标记试剂，检测系统和日期收集/处理系统。机器的所有子单元由中央处理单元控制，以协调分析仪的所有子单元的活动。该分析仪特别用于进行异质结合测定方案，特别是免疫测定。

85. 发明授权

US5915282A Fluid handler and method of handling a fluid 失效
标题翻译：流体处理器和处理流体的方法
公开(公告)号：US5915282A
公开(公告)日：1999-06-22
申请号：US861670
申请日：1997-05-22
申请人： Richard Merriam , Theresa M. Donahoe , Gregory O. Ford , James C. Kolterman , Kevin C. Warnke
发明人： Richard Merriam , Theresa M. Donahoe , Gregory O. Ford , James C. Kolterman , Kevin C. Warnke
IPC分类号： B67D7/08 , B67D99/00 , G01F11/00 , G01F11/02 , G01N1/00 , G01N1/14 , G01N35/10
CPC分类号： G01N35/1009 , G01F11/00 , G01F11/029 , G01N35/1016 , G01N2035/102 , G01N2035/1025 , Y10T137/0318
摘要： Methods of fluid handling are disclosed. In one method, a pump fluidly associated with a nozzle is energized to move a first fluid with respect to the nozzle. Pressure fluidly associated with the nozzle is substantially continuously monitored with a pressure transducer fluidly associated with the nozzle during movement of the first fluid. An average of the pressure substantially continuously monitored is calculated. The calculated average is used to determine a threshold. The pump fluidly associated with the nozzle is energized to move a second fluid with respect to the nozzle. Pressure fluidly associated with the nozzle is substantially continuously monitored with a pressure transducer fluidly associated with the nozzle during movement of the second fluid. The substantially continuously monitored pressure is integrated. The threshold is compared with the integrated pressure to determine whether movement of the second fluid was intended or unintended.
摘要翻译：公开了流体处理方法。在一种方法中，与喷嘴流体相关联的泵被激励以相对于喷嘴移动第一流体。在第一流体运动期间，利用与喷嘴流体相关联的压力传感器基本上连续地监测与喷嘴流体相关的压力。计算基本上连续监测的压力的平均值。计算的平均值用于确定阈值。与喷嘴流体相关的泵被激励以相对于喷嘴移动第二流体。在第二流体运动期间，与喷嘴流体相关的压力基本上连续地用与喷嘴流体相关联的压力传感器监测。基本上连续监测的压力是一体的。将阈值与积分压力进行比较，以确定第二流体的运动是意图还是意外。

86. 发明授权

US5880364A Non-contact ultrasonic micromeasurement system 失效
标题翻译：非接触超声波测微系统
公开(公告)号：US5880364A
公开(公告)日：1999-03-09
申请号：US961607
申请日：1997-10-31
申请人： Naim Dam
发明人： Naim Dam
IPC分类号： G01F23/296 , G01N35/02 , G01N35/10 , G01F23/28
CPC分类号： G01F23/2962 , G01N2035/1025 , G01N35/028
摘要： A non-contact ultrasonic system for measuring the volume of liquid in a container in which an ultrasonic sensor is disposed opposite the top of the container. A circuit provides pulses of ultrasonic energy for transmission through the air to the air-liquid interface of liquid in the container and for measuring the round trip transit time from the sensor to the interface and back to the sensor. A computer is programmed with dimensional data of the container internal volume and computes the volume of liquid in the container based on the dimensional data and the round trip transit time. The computed volume data is stored. The system can measure the volume of a plurality of containers using a plurality of sensors that are operated in sequence or at the same time or single sensor in which the plurality of sensors are moved relative to the single sensor for the volume of each of the sensors to be sequentially measured.
摘要翻译：一种非接触超声波系统，用于测量容器中的液体的体积，其中超声波传感器与容器的顶部相对设置。电路提供超声能量的脉冲，用于通过空气传输到容器中的液体的气液界面，并用于测量从传感器到界面返回传感器的往返行程。计算机被编程为容器内部体积的尺寸数据，并且基于尺寸数据和往返渡越时间来计算容器中的液体体积。计算的体积数据被存储。该系统可以使用多个传感器来测量多个容器的体积，这些传感器按顺序或同时操作或单个传感器，其中多个传感器相对于单个传感器移动，用于每个传感器的体积依次测量。

87. 发明授权

US5846491A Device for automatic chemical analysis 失效
标题翻译：自动化学分析装置
公开(公告)号：US5846491A
公开(公告)日：1998-12-08
申请号：US370910
申请日：1995-01-10
申请人： Alfredo Choperena , Ross Krogh , Venkatesh Prasad , Gershon Giter
发明人： Alfredo Choperena , Ross Krogh , Venkatesh Prasad , Gershon Giter
IPC分类号： G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10
CPC分类号： G01N35/0092 , G01N35/021 , G01N2035/0467 , G01N2035/1025 , G01N35/0098 , G01N35/1004 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/115831 , Y10T436/2575
摘要： This invention provides an automated chemical analyzer capable of automatically analyzing a plurality of samples for at least two different analytes. The analyzer includes a plurality of assay resource stations and an analyzer control means. Each assay resource station includes an assay resource capable of performing a predetermined operation upon a sample-containing reaction vessel within a fixed indexing time. The analyzer control means includes scheduling means for allocating assay resources to one of the reaction vessels as a function of that time cycle and a transfer control means for controlling transfer of reaction vessels directly from one assay resource station to another according to a chronology selected from a plurality of different predetermined chronologies.
摘要翻译：本发明提供一种能够自动分析至少两种不同分析物的多个样品的自动化学分析仪。分析仪包括多个测定资源站和分析仪控制装置。每个测定资源站包括能够在固定的分度时间内对含有样品的反应容器执行预定操作的测定资源。分析仪控制装置包括调度装置，用于根据该时间周期将测定资源分配给一个反应容器;以及转移控制装置，用于根据选自以下的时间顺序控制从一个测定资源站到另一个测定资源站的反应容器的转移多个不同的预定年表。

88. 发明授权

US5843378A Method of producing a probe for aspirating and dispensing probe having surface sensing capability 失效
标题翻译：用于产生具有表面感测能力的吸引和分配探针的探针的方法
公开(公告)号：US5843378A
公开(公告)日：1998-12-01
申请号：US790096
申请日：1997-01-29
申请人： Amer El-Hage , Rick V. Stellmacher
发明人： Amer El-Hage , Rick V. Stellmacher
IPC分类号： G01F23/24 , G01N35/10 , B01L3/02
CPC分类号： G01N35/1009 , G01F23/24 , G01F23/245 , G01N2035/1025 , Y10T436/2575
摘要： A method of producing a probe for aspirating and dispensing liquid. A fluid conduit and rod are positioned in the central bore of a tube so that an inlet end of the conduit and a contact end of the rod protrude from an upper end of the tube and a discharge end of the conduit and a sensing end of the rod protrude from a lower end of the tube. The tube has a heat-shrinkable outer layer and a meltable inner layer. The tube is heated so that its outer layer shrinks and its inner layer melts to encapsulate middle portions of the conduit and rod. A circuit board having first and second traces and first and second holes is placed on the upper end of the tube so that the inlet end of the conduit is inserted through the first hole and the contact end of the rod is inserted through the second hole. The conduit and rod are attached to the board so that the conduit is electrically connected to the first trace and the rod is electrically connected to the second trace. First and second conducting pins are also attached to the board. The conducting pins electrically connect the traces to a voltage sensing circuit when the probe is attached to a probe positioning device.
摘要翻译：一种生产用于吸入和分配液体的探针的方法。流体导管和杆定位在管的中心孔中，使得导管的入口端和杆的接触端从管的上端突出并且管的排出端和导管的感测端杆从管的下端突出。该管具有可热收缩的外层和可熔融的内层。加热管，使其外层收缩，其内层熔化以封装导管和棒的中间部分。具有第一和第二迹线和第一和第二孔的电路板被放置在管的上端，使得导管的入口端插入穿过第一孔，并且杆的接触端插入穿过第二孔。管道和杆被附接到板，使得导管电连接到第一迹线，并且杆电连接到第二迹线。第一和第二导电引脚也连接到电路板。当探针附接到探针定位装置时，导电引脚将迹线电连接到电压感测电路。

89. 发明授权

US5648727A Capacitive level sensing pipette probe 失效
标题翻译：电容式感应吸管探针
公开(公告)号：US5648727A
公开(公告)日：1997-07-15
申请号：US547553
申请日：1995-10-24
申请人： William T. Tyberg , John W. Jones
发明人： William T. Tyberg , John W. Jones
IPC分类号： G01F23/26 , G01N35/10 , B01L3/02 , G01F23/24
CPC分类号： G01N35/1009 , G01F23/26 , G01F23/263 , G01N2035/1025
摘要： A capacitive fluid level sensing pipette probe adapted to be used in an automated random access immunoassay analyzer is provided. The pipette probe comprises an elongated shaft having a conductive tip. An integrated circuit chip containing capacitive sensing circuitry is positioned on the pipette probe itself, or in very close proximity. With this arrangement, the sensing circuitry moves with the pipette probe as it is raised and lowered into and out of a vessel containing a liquid. Thus, errors associated with capacitance caused by flexing connector cables is eliminated. Flex tape wiring may be used to carry data from the capacitive sensing circuitry on the pipette probe to the processing board of the automated immunoassay analyzer.
摘要翻译：提供了一种适用于自动化随机存取免疫测定分析仪的电容式液位检测移液管探头。移液管探头包括具有导电尖端的细长轴。包含电容式感测电路的集成电路芯片位于移液管探针本身上，或非常接近。利用这种布置，感测电路随着移液管探针的升高和降低进入和流出含有液体的容器而移动。因此，消除了由弯曲连接器电缆引起的与电容相关联的错误。 Flex带接线可用于将数据从移液器探头上的电容感测电路传送到自动化免疫分析仪的处理板。

90. 发明授权

US5597733A Automatic multiple-sample multiple-reagent dispensing method in chemical analyzer 失效
标题翻译：化学分析仪自动多样品多试剂分配方法
公开(公告)号：US5597733A
公开(公告)日：1997-01-28
申请号：US404168
申请日：1995-03-14
申请人： Charles A. Bell , Warren J. Heath , Norman M. Kleinman
发明人： Charles A. Bell , Warren J. Heath , Norman M. Kleinman
IPC分类号： G01N35/00 , G01N35/10
CPC分类号： G01N35/1004 , G01N2035/00425 , G01N2035/00435 , G01N2035/00752 , G01N2035/1025 , G01N2035/1086 , Y10T436/11 , Y10T436/113332 , Y10T436/114998 , Y10T436/115831 , Y10T436/119163 , Y10T436/2575
摘要： An analyzer for chemical assays includes a turntable which supports sample containers and reagent containers within a cooled volume and test cells about the periphery of the cooled volume. A probe is carried by a rotating arm for withdrawing liquid from the containers and dispensing the liquid. Fixed stations are also provided in the path of the probe. One such station serves to both wash the tip of the probe and to receive samples for flow-through analysis. Heaters associated with the probe and with the test cells increase the rate of reaction. Curved walls of test cell segments match the optics of an optical analyzer so that light from the analyzer lamp is generally orthogonal to the curved surfaces. The light voltage of the lamp may be controlled as a function of lamp wavelength required for particular assays. The system provides multiple-point calibration and automatic dilution of samples. Multiple aliquots of reagent may be drawn into the probe and then be dispensed into separate test cells. Individual aliquots of sample may be drawn and dispensed with the reagent.
摘要翻译：用于化学测定的分析仪包括在冷却体积内支持样品容器和试剂容器的转台，并且围绕冷却体积的周边测试细胞。探针由旋转臂承载，用于从容器中取出液体并分配液体。探头的路径上也设有固定站。一个这样的站用于洗涤探针的尖端并接收用于流通分析的样品。与探针和测试细胞相关的加热器增加反应速率。测试单元段的弯曲壁与光学分析仪的光学器件匹配，使得来自分析器灯的光通常与弯曲表面正交。可以根据特定测定所需的灯波长来控制灯的光电压。该系统提供多点校准和样品的自动稀释。可以将多个等份的试剂吸入探针中，然后分配到单独的测试细胞中。可以抽出样品的各个等分试样并分配试剂。

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