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81. 发明申请

US20160237235A1 Dendritic Macroporous Hydrogels Prepared By Crystal Templating 有权
公开(公告)号：US20160237235A1
公开(公告)日：2016-08-18
申请号：US15135978
申请日：2016-04-22
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： Scott Zawko , Christine Schmidt
IPC分类号： C08J9/26 , A61L27/56 , A61L27/26 , C08J5/18 , C08J3/24 , C08J5/10 , C08J3/28 , C08K5/21 , A61L27/52 , C08J3/075
CPC分类号： C08J9/26 , A61L26/0023 , A61L26/0095 , A61L27/52 , B01J13/0065 , C08B37/0015 , C08B37/003 , C08B37/0045 , C08B37/0072 , C08B37/0075 , C08B37/0084 , C08H1/06 , C08J3/075 , C08J3/24 , C08J3/242 , C08J3/26 , C08J3/28 , C08J5/10 , C08J5/18 , C08J2201/0424 , C08J2205/022 , C08J2205/04 , C08J2207/10 , C08J2305/00 , C08J2305/04 , C08J2305/08 , C08K5/0025 , C08K5/0083 , C08K5/21 , C08L5/00 , C08L5/04 , C08L5/10 , C08L5/16 , C08L89/06 , C08L5/06 , C08L5/08
摘要： The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel.

82. 发明授权

US09359591B2 Glucomannan scaffolding for three-dimensional tissue culture and engineering 有权
标题翻译：葡甘聚糖支架用于三维组织培养和工程
公开(公告)号：US09359591B2
公开(公告)日：2016-06-07
申请号：US14360910
申请日：2012-11-29
申请人： The Regents of the University of California
发明人： C. Chang I. Lee
IPC分类号： C12N5/074 , C12N5/00 , C12N5/0775 , C08B37/00 , C08L5/00 , C08J9/28 , C08J9/36
CPC分类号： C12N5/0068 , C08B37/0087 , C08J9/28 , C08J9/36 , C08J2201/0484 , C08J2207/10 , C08J2305/00 , C08L5/00 , C12N5/0607 , C12N5/0663 , C12N2513/00 , C12N2533/70 , C08L89/06 , C08L89/00 , C08L77/04
摘要： The present invention provides a neutralized glucomannan scaffold capable of promoting cell growth and suitable for three-dimensional tissue culture and engineering. The present invention also provides methods for making and degrading the neutralized glucomannan scaffold. The present invention further provides a method of growing cells on a neutralized glucomannan scaffold.
摘要翻译：本发明提供能够促进细胞生长并适用于三维组织培养和工程的中和葡萄糖甘露聚糖支架。本发明还提供了制备和降解中和的葡甘聚糖骨架的方法。本发明还提供了在中和的葡甘聚糖骨架上培养细胞的方法。

83. 发明申请

US20160030625A1 POROUS POLYMER COMPOSITES 审中-公开
标题翻译：多孔聚合物复合材料
公开(公告)号：US20160030625A1
公开(公告)日：2016-02-04
申请号：US14445089
申请日：2014-07-29
申请人： U.S. Army Research Laboratory ATTN: RDRL-LOC-I
发明人： Randy A. Mrozek , Joseph L. Lenhart , Michael C. Berg , Eric J. Robinette
IPC分类号： A61L24/00 , C08J9/26 , C08J9/28
CPC分类号： A61L24/0036 , A61L24/0015 , A61L2300/418 , A61L2400/04 , A61L2400/08 , C08J9/26 , C08J9/28 , C08J2201/0543 , C08J2207/10 , C08J2207/12 , C08J2353/02
摘要： Porous polymer composites and methods of preparing porous polymer composites are provided herein. In some embodiments, a method for preparing porous polymer composites may include mixing a first polymer with a solvent and a particulate filler to form a first polymer composition, wherein the amount of particulate filler in the first polymer composition is below a mechanical percolation threshold; and removing the solvent from the first polymer composition to concentrate the first polymer and particulate filler into a second polymer composition having a porous structure, wherein the particulate filler concentration in the second polymer composition is increased above the mechanical percolation threshold during solvent removal.
摘要翻译：多孔聚合物复合材料和多孔聚合物复合材料的制备方法。在一些实施方案中，制备多孔聚合物复合材料的方法可包括将第一聚合物与溶剂和颗粒填料混合以形成第一聚合物组合物，其中第一聚合物组合物中颗粒填料的量低于机械渗滤阈值; 以及从所述第一聚合物组合物中除去溶剂以将所述第一聚合物和颗粒填料浓缩成具有多孔结构的第二聚合物组合物，其中在除去溶剂期间所述第二聚合物组合物中的颗粒填料浓度高于机械渗透阈值。

84. 发明申请

US20160024285A1 RESILIENT FOAMS AND USES THEREOF 审中-公开
标题翻译：灵活的手段及其用途
公开(公告)号：US20160024285A1
公开(公告)日：2016-01-28
申请号：US14734684
申请日：2015-06-09
申请人： ArthroCare Corporation
发明人： George T. Delli-Santi , Helawe Betre
IPC分类号： C08L1/28 , A61L15/28 , A61L31/04 , A61L31/14 , A61L15/42
CPC分类号： C08L1/286 , A61L15/28 , A61L15/425 , A61L15/60 , A61L27/20 , A61L27/52 , A61L27/56 , A61L31/042 , A61L31/145 , A61L31/146 , A61L2400/04 , A61L2400/16 , C08J9/28 , C08J9/40 , C08J2201/0484 , C08J2205/022 , C08J2205/06 , C08J2207/10 , C08J2301/08
摘要： Disclosed is a resilient foam and methods of making the foam. The resilient foam includes a derivatized polyanionic polysaccharide and has an open-cell structure. When the resilient foam is contacted with water, the foam forms a thixotropic hydrogel.
摘要翻译：公开了弹性泡沫和制造泡沫的方法。弹性泡沫包括衍生的聚阴离子多糖并具有开孔结构。当弹性泡沫与水接触时，泡沫形成触变性水凝胶。

85. 发明申请

US20150328154A1 METHOD FOR INCORPORATING ACTIVE AGENTS INTO A HYDROPHILIC POLYMER FOAM 有权
标题翻译：将活性成分掺入水解聚合物泡沫的方法
公开(公告)号：US20150328154A1
公开(公告)日：2015-11-19
申请号：US14653217
申请日：2013-12-17
申请人： LABORATOIRES URGO
发明人： Jean-Marc Henri Maurice PERNOT , Anne-Laure RAVENET
IPC分类号： A61K9/12 , A61K31/7016 , A61K47/34 , A61K31/17 , A61K8/04 , A61K8/87
CPC分类号： A61K9/122 , A61F13/00991 , A61F13/84 , A61K8/046 , A61K8/87 , A61K31/17 , A61K31/7016 , A61K47/34 , A61K2800/10 , A61K2800/56 , A61L15/44 , B29C44/12 , C08J9/28 , C08J2201/0504 , C08J2207/10 , C08J2375/04
摘要： The present invention consists of a novel process for the incorporation of one or more water-soluble active agents in a hydrophilic polymer foam. Said process makes it possible in particular to obtain a hydrophilic polyurethane foam exhibiting a gradient of active agents. This process is of particular use when manufacturing hydrophilic polyurethane foams intended for medical, cosmetic and dermocosmetic purposes.
摘要翻译：本发明包括在亲水聚合物泡沫中掺入一种或多种水溶性活性剂的新方法。所述方法特别可以获得表现出活性剂梯度的亲水性聚氨酯泡沫。当制造用于医疗，化妆和皮肤用途的亲水性聚氨酯泡沫时，该方法特别有用。

86. 发明申请

US20150240046A1 PROCESS FOR PREPARING A POROUS LAYER 审中-公开
标题翻译：制备多孔层的方法
公开(公告)号：US20150240046A1
公开(公告)日：2015-08-27
申请号：US14423150
申请日：2013-09-26
申请人： Sofradim Production
发明人： Sébastien Ladet , Nicolas Prost
IPC分类号： C08J9/28 , A61L31/14 , A61L31/04
CPC分类号： C08J9/28 , A61L27/20 , A61L31/042 , A61L31/146 , A61L2400/18 , C08J5/18 , C08J2201/048 , C08J2207/10 , C08J2305/04 , C08J2305/08 , C08L5/04 , C08L5/08
摘要： The present invention relates to a process for preparing a porous layer of biocompatible polymer, having a uniform density and porosity, comprising the following steps: —a) a quantity Qp of solution of the said polymer, having a viscosity Vp, is poured into a mould in order to form a first sublayer, the surface of the first sublayer being left to the open air; —b) a quantity Qs of solvent, having a viscosity Vs, lower than Vp, is spread uniformly over the surface of the first sublayer so as to form a second sublayer; —c) the first and second sublayers are subjected to a step of lyophilisation, in which the said polymer is a polysaccharide chosen from hyaluronic acid, alginic acid and chitosan, salts thereof and mixtures thereof.
摘要翻译：本发明涉及制备具有均匀密度和孔隙率的生物相容性聚合物多孔层的方法，包括以下步骤：a）将具有粘度Vp的所述聚合物溶液的量Qp倒入模具以形成第一子层，第一子层的表面留在露天; -b），粘度Vs低于Vp的溶剂量Qs均匀地分散在第一子层的表面上，形成第二子层; -c）第一和第二子层进行冻干的步骤，其中所述聚合物是选自透明质酸，藻酸和壳聚糖的多糖，其盐及其混合物。

87. 发明申请

US20150203650A1 AEROGELS, CALCINED AND CRYSTALLINE ARTICLES AND METHODS OF MAKING THE SAME 有权
标题翻译： AEROGELS，CALCINED AND CRYSTALLINE ARTICLES AND METHODS OF MAKING THE SAME
公开(公告)号：US20150203650A1
公开(公告)日：2015-07-23
申请号：US14347382
申请日：2012-08-03
申请人： Brant U. Kolb , Bryan C. Feisel , Martin Goetzinger , Philip S. Hall , Holger Hauptmann , Mark J. Hendrickson , Kathleen M. Humpal , John W. Longabach , James P. Mathers , Roberta R. Naujok , Paul D. Pennington , Gallus Schechner
发明人： Brant U. Kolb , Bryan C. Feisel , Martin Goetzinger , Philip S. Hall , Holger Hauptmann , Mark J. Hendrickson , Kathleen M. Humpal , John W. Longabach , James P. Mathers , Roberta R. Naujok , Paul D. Pennington , Gallus Schechner
IPC分类号： C08J9/28 , A61K6/02 , C08J9/00 , A61K6/083 , A61C13/00 , A61C5/10
CPC分类号： A61K6/024 , A61C5/20 , A61C5/77 , A61C7/282 , A61C8/0001 , A61C8/0012 , A61C8/0048 , A61C13/0006 , A61C13/0022 , A61C13/082 , A61K6/0002 , A61K6/0008 , A61K6/025 , A61K6/0255 , A61K6/083 , B82Y30/00 , C01G25/00 , C01G25/006 , C01G25/02 , C01P2002/50 , C01P2002/52 , C01P2002/60 , C01P2002/84 , C01P2004/62 , C01P2004/64 , C01P2006/10 , C04B35/486 , C04B35/488 , C04B35/624 , C04B35/64 , C04B38/00 , C04B38/0045 , C04B2111/00836 , C04B2235/3217 , C04B2235/3225 , C04B2235/3227 , C04B2235/3244 , C04B2235/549 , C04B2235/6562 , C04B2235/6565 , C04B2235/6567 , C04B2235/661 , C04B2235/77 , C04B2235/781 , C04B2235/785 , C04B2235/80 , C04B2235/96 , C04B2235/9646 , C04B2235/9661 , C08J9/008 , C08J9/28 , C08J2201/038 , C08J2201/04 , C08J2201/0502 , C08J2203/08 , C08J2205/026 , C08J2205/042 , C08J2207/10 , C08J2333/02 , C08J2333/10 , C08J2333/14 , Y02P20/544 , C04B38/0054 , C04B38/0058 , C04B38/0074
摘要： Aerogel, calcined articles, and crystalline articles comprising ZrO2. Exemplary uses of the crystalline metal oxide articles include dental articles (e.g., restoratives, replacements, inlays, onlays, veneers, full and partial crowns, bridges, implants, implant abutments, copings, anterior fillings, posterior fillings, and cavity liner, and bridge frameworks) and orthodontic appliances (e.g., brackets, buccal tubes, cleats, and buttons).
摘要翻译：气凝胶，煅烧制品和包含ZrO 2的结晶制品。结晶金属氧化物制品的示例性用途包括牙科制品（例如修复剂，替代物，镶嵌物，镶嵌物，单板，全冠和部分牙冠，桥梁，植入物，植入物邻接物，突起物，前部填充物，后部填充物和空腔衬垫，以及桥梁框架）和正畸器具（例如，支架，口腔管，夹板和按钮）。

88. 发明申请

US20150099817A1 MOULDED PARTS MADE OF PMMA POWDER AS SIMPLE DOSING AID IN THE MANUFACTURE OF DENTAL PROSTHESES 审中-公开
标题翻译： PMMA粉末的模制部件作为简单的剂量在牙齿制造中的作用
公开(公告)号：US20150099817A1
公开(公告)日：2015-04-09
申请号：US14299362
申请日：2014-06-09
申请人： HERAEUS KULZER GMBH
发明人： Klaus RUPPERT , Kevin KERSCHER , Stephan DEKERT
IPC分类号： A61K6/083 , B29C69/02 , A61L24/06
CPC分类号： A61K6/083 , A61L24/06 , A61L27/16 , A61L2430/12 , B29C69/02 , B29L2031/7722 , B29L2031/7739 , C08J9/24 , C08J2207/10 , C08J2333/06 , C08L33/12
摘要： The invention relates to three-dimensional dimensionally-stable moulded parts made of polymeric particles whose particles are connected firmly to each other, at least in part, at the contact sites of the particles, whereby the particles are preferably glued to each other, at least in part, at the contact sites. The pre-packaged moulded parts made of polymeric, powdery particles made of PMMA can take up acrylate or MMA into the porous three-dimensional structure and form a pasty or creamy dough that can be cast, pressed or injected and can be cured by common techniques after the forming. Also subject matters of the invention are the use of and a kit for producing said pasty dough. Said pre-packaged moulded parts are used in methods for producing prostheses, such as dental prostheses, bone cements, investment compounds, in particular of porous substrates, as investment compound in metallography.
摘要翻译：本发明涉及由聚合物颗粒制成的三维尺寸稳定的模制部件，其颗粒至少部分地彼此牢固地连接在颗粒的接触部位，由此颗粒优选彼此粘合，至少部分地在联系地点。由PMMA制成的聚合物，粉末颗粒制成的预先包装的模制件可以将丙烯酸酯或MMA吸收到多孔三维结构中并形成可以铸造，压制或注射的糊状或乳状面团，并且可以通过常规技术固化成型后。本发明的主题还涉及生产所述糊状生面团的用途和试剂盒。所述预包装的模制件用于生产假体的方法，例如牙科假体，骨水泥，投资化合物，特别是多孔底物，作为金相中的投资化合物。

89. 发明授权

US08993537B2 Forming porous scaffold from cellulose derivatives 有权
标题翻译：从纤维素衍生物形成多孔支架
公开(公告)号：US08993537B2
公开(公告)日：2015-03-31
申请号：US13611339
申请日：2012-09-12
申请人： Zhilian Yue , Feng Wen , Hanry Yu
发明人： Zhilian Yue , Feng Wen , Hanry Yu
IPC分类号： A61K31/717 , A61L27/20 , A61L27/56 , C08B11/20 , C08J9/28 , C08L1/14
CPC分类号： B32B3/26 , A61L27/20 , A61L27/56 , C08B11/20 , C08J9/28 , C08J2201/024 , C08J2201/026 , C08J2201/0484 , C08J2201/0524 , C08J2205/044 , C08J2207/10 , C08J2301/28 , C08L1/14 , Y10T428/249921 , Y10T428/249978 , Y10T428/249979 , C08L1/28
摘要： Scaffold comprises a polymer defining macropores and comprising hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, which is crosslinked through the self-crosslinkable group. The macropores have an average pore size larger than 50 microns and are at least partially interconnected. In one method, bicontinuous emulsion comprising a continuous aqueous phase and a continuous polymer phase is formed. The polymer phase comprises hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, and is crosslinked through the self-crosslinkable group to form a polymer defining at least partially interconnected pores. In another method, phase separation is induced in a solution comprising a polymer precursor and water to form a bicontinuous emulsion comprising a continuous polymer phase and a continuous aqueous phase. The polymer precursor comprises a self-crosslinkable group and is crosslinked through the self-crosslinkable group in the emulsion to form a polymer defining at least partially interconnected macropores.
摘要翻译：脚手架包含限定大孔的聚合物，并且包含部分由包含自交联基团的取代基取代的羟丙基纤维素，所述取代基通过自交联基团交联。大孔具有大于50微米的平均孔径并且至少部分互连。在一种方法中，形成包含连续水相和连续聚合物相的双连续乳液。聚合物相包含部分由包含自交联基团的取代基取代的羟丙基纤维素，并且通过自交联基团交联以形成限定至少部分互连的孔的聚合物。在另一种方法中，在包含聚合物前体和水的溶液中诱导相分离以形成包含连续聚合物相和连续水相的双连续乳液。聚合物前体包含自交联基团，并且通过乳液中的自交联基团交联以形成限定至少部分互连的大孔的聚合物。

90. 发明申请

US20150057381A1 POROGEN COMPOSITIONS, METHODS OF MAKING AND USES 有权
标题翻译：多孔组合物，制备方法和用途
公开(公告)号：US20150057381A1
公开(公告)日：2015-02-26
申请号：US14504329
申请日：2014-10-01
申请人： Allergan, Inc.
发明人： Futian Liu , Nicholas J. Manesis , Xiaojie Yu , Athene Wan Chie Chan
IPC分类号： C08J9/26 , B05D1/38 , B05D3/00 , B05D5/00
CPC分类号： C08J9/26 , A61L27/56 , A61L31/06 , A61L31/146 , A61L2400/08 , B01D39/1692 , B01D2239/1208 , B01D2239/1216 , B05D1/38 , B05D3/007 , B05D5/00 , C08J2201/04 , C08J2201/042 , C08J2201/0422 , C08J2201/0462 , C08J2201/0464 , C08J2201/05 , C08J2205/05 , C08J2207/10 , C08J2207/12 , C08J2325/10 , C08J2353/02 , C08J2375/04 , C08J2383/04 , C09D167/04 , C09D171/02
摘要： Provided are porogen compositions and methods of using such porogen compositions in the manufacture of porous materials, for example, porous silicone elastomers. The porogens generally include comprising a core material and shell material different from the core material. The porogens can be used to form a scaffold for making a resulting porous elastomer when the scaffold is removed.
摘要翻译：提供的是致孔剂组合物和在制造多孔材料例如多孔硅橡胶中使用这种致孔剂组合物的方法。致孔剂通常包括芯材和与芯材不同的壳材料。当去除支架时，致孔剂可用于形成用于制备所得多孔弹性体的支架。

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