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81. 发明授权

US4855407A Solid phase process for synthesizing peptides 失效
标题翻译：用于合成肽的固相方法
公开(公告)号：US4855407A
公开(公告)日：1989-08-08
申请号：US849835
申请日：1986-04-09
申请人： Su S. Wang
发明人： Su S. Wang
IPC分类号： C07K1/04 , C07K1/08 , C07K1/113 , C07K7/23 , C07K14/00 , C07K14/575
CPC分类号： C07K14/57581 , C07K1/04 , Y02P20/55 , Y10S930/18
摘要： Thymosin .alpha.1 and other peptide amides are synthesized in the solid phase using methylbenzhydrylamine resin as the support and hydrogen bromide as the deprotecting and cleaving agents. The N-terminal 14 amino acid partial sequence of thymosin .alpha.1, Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-OH is synthesized on benzyl ester resin. Using a mixture of hydrogen bromide, anisole and thioanisole as the cleavage and deprotection composition, the yields of the cleaved peptide and the selectivity of the deprotection is highly improved. For example, yields of thymosin .alpha.1 have been increased by about 90% as compared to the use of hydrogen bromide alone. By using hydrogen bromide rather than hydrogen fluoride, the synthesis can use conventional laboratory glassware and the synthesis can be easily scaled up to commercial production.
摘要翻译：使用甲基二苯甲基胺树脂作为载体和溴化氢作为脱保护和切割剂，在固相中合成了胸腺素α1和其他肽酰胺。在苄酯上合成胸腺素α1，Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-OH的N-末端14个氨基酸部分序列树脂。使用溴化氢，苯甲醚和硫代苯甲醚的混合物作为切割和去保护组合物，裂解肽的产率和脱保护的选择性得到很大改善。例如，与单独使用溴化氢相比，胸腺素α1的产量已增加约90％。通过使用溴化氢而不是氟化氢，该合成可以使用常规的实验室玻璃器皿，并且可以将合成容易地扩大到商业生产。

82. 发明授权

US4659694A Prothymosin alpha 失效
标题翻译：孕激素α
公开(公告)号：US4659694A
公开(公告)日：1987-04-21
申请号：US639757
申请日：1984-08-13
申请人： Bernard L. Horecker
发明人： Bernard L. Horecker
IPC分类号： A61K38/00 , C07K14/575 , C07K7/48 , C07K13/00
CPC分类号： C07K14/57581 , A61K38/00 , Y10S930/18
摘要： A new biological polypeptide hormone has been isolated from mammalian thymus and has been given the designation prothymosin alpha. This peptide contains approximately 107 to 113 amino acid residues depending on species and is distinguished by having the thymosin alpha.sub.1 sequence at its amino-terminus. Prothymosin alpha appears to represent the native polypeptide from which thymosin alpha.sub.1, thymosin alpha.sub.11 and other fragments are generated during the isolation of thymosin fraction 5. Prothymosin alpha is one of several peptides isolated from thymic tissue which participate in the regulation, differentiation and function of thymic dependent lymphocytes (T cells). The new peptide appears to be more potent on a weight basis than thymosin alpha.sub.1 in the protection of subject animals against opportunistic infections.
摘要翻译：已经从哺乳动物胸腺中分离出一种新的生物多肽激素，并被赋予了称为胸腺素α。该肽根据物种含有约107至113个氨基酸残基，其特征在于在其氨基末端具有胸腺素α1序列。胸腺素α似乎代表在分离胸腺素级分5期间产生胸腺素α1，胸腺素α11和其他片段的天然多肽。胸腺素α是从参与胸腺调节，分化和功能的胸腺组织分离的几种肽之一依赖淋巴细胞（T细胞）。在保护受试动物免受机会性感染的情况下，新肽在重量方面似乎比胸腺素α1更有效。

83. 发明授权

US4650761A Method for stabilizing and selecting recombinant DNA containing host cell 失效
标题翻译：用于稳定和选择含有宿主细胞的重组DNA的方法
公开(公告)号：US4650761A
公开(公告)日：1987-03-17
申请号：US550167
申请日：1983-11-09
申请人： Charles L. Hershberger , Paul R. Rosteck, Jr.
发明人： Charles L. Hershberger , Paul R. Rosteck, Jr.
IPC分类号： C07K14/575 , C07K14/62 , C12N15/63 , C12N15/70 , C12N15/00 , C07H21/04 , C12N1/00 , C12N1/20 , C12P19/34 , C12P21/00 , C12P21/02 , C12P21/04 , C12R1/19
CPC分类号： C12N15/635 , C07K14/57581 , C07K14/62 , C12N15/70 , Y10S435/849 , Y10S930/18
摘要： The present invention is an improvement in the method for stabilizing and selecting host cells containing recombinant DNA. The method involves transforming a host cell with a recombinant DNA cloning vector which contains the .about.2.5 kb BglII cI repressor gene-containing restriction fragment of bacteriophage .lambda. and then lysogenizing the transformed host cell with a lysogenic organism which contains a marker which is lethal or conditionally lethal in the host cell but which is repressed in the transformed host cell by the repressor gene contained in the recombinant DNA cloning vector. The vector additionally contains a gene which codes for the expression of human proinsulin. The invention further comprises related recombinant DNA cloning vectors, transformed host cells and lysogenized transformed host cells.
摘要翻译：本发明是用于稳定和选择含有重组DNA的宿主细胞的方法的改进。该方法包括用含有含噬菌体λ的DIFFERENCE 2.5kb BglII cI阻遏物基因限制性片段的重组DNA克隆载体转化宿主细胞，然后用含有致死或有条件的标记物的溶原性生物溶解转化的宿主细胞在宿主细胞中致死，但是通过重组DNA克隆载体中包含的阻遏物基因在转化的宿主细胞中被抑制。该载体还含有编码人胰岛素原表达的基因。本发明还包括相关的重组DNA克隆载体，转化的宿主细胞和溶解的转化的宿主细胞。

84. 发明授权

US4517119A Synthesis of thymosin .alpha..sub.1 失效
标题翻译：胸腺素α的合成1
公开(公告)号：US4517119A
公开(公告)日：1985-05-14
申请号：US482113
申请日：1983-04-04
申请人： Arthur M. Felix , Dieter Gillessen , William Lergier , Johannes A. Meienhofer , Arnold Trzeciak
发明人： Arthur M. Felix , Dieter Gillessen , William Lergier , Johannes A. Meienhofer , Arnold Trzeciak
IPC分类号： A61K38/22 , A61P5/00 , A61P43/00 , C07K5/113 , C07K14/00 , C07K14/575 , C07C103/52
CPC分类号： C07K5/1021 , C07K14/57581 , Y10S930/18
摘要： An improved solution phase synthesis of thymosin .alpha..sub.1 and proceeding through novel intermediates is disclosed.
摘要翻译：公开了改进的胸腺素α1的溶液相合成并进行新的中间体。

85. 发明授权

US4504415A Synthesis of thymosin .alpha..sub.1 and desacetyl thymosin .alpha..sub.1 失效
标题翻译：胸腺素α1和去乙酰基胸腺素α1的合成
公开(公告)号：US4504415A
公开(公告)日：1985-03-12
申请号：US482114
申请日：1983-04-04
申请人： Arthur M. Felix , Dieter Gillessen , Rolf Studer , Johannes A. Meienhofer , Arnold Trzeciak
发明人： Arthur M. Felix , Dieter Gillessen , Rolf Studer , Johannes A. Meienhofer , Arnold Trzeciak
IPC分类号： A61K38/22 , A61P5/00 , A61P43/00 , C07K7/06 , C07K14/575 , C07C103/52
CPC分类号： C07K14/57581 , Y10S930/18
摘要： An improved solution phase synthesis of thymosin .alpha..sub.1 and desacetyl thymosin .alpha..sub.1 with t-Boc side chain protection and proceeding through novel intermediates is disclosed.
摘要翻译：公开了改进的溶液相合成胸腺素α1和去乙酰基胸腺素α1与t-Boc侧链保护并通过新型中间体进行。

86. 发明授权

US4444757A Use of thymosin as an anti-diabetes and anti-hypertensive disease agent 失效
标题翻译：使用胸腺素作为抗糖尿病和抗高血压药物
公开(公告)号：US4444757A
公开(公告)日：1984-04-24
申请号：US321783
申请日：1981-11-16
申请人： Helen R. Strausser
发明人： Helen R. Strausser
IPC分类号： A61K38/00 , C07K14/575 , A61K37/00
CPC分类号： C07K14/57581 , A61K38/00 , Y10S514/866
摘要： Methods are provided for the use of Thymus gland extracts, such as Thymosin, fraction 5, as an anti-autoimmune disease agent, useful in treating autoimmune diseases such as hypertension, lupus and diabetes. Thymosin, fraction 5, administration stimulated the development of a specific subclass of Thymus derived cells called Thymus suppressor cells which reduced the autoimmune state, thereby reducing hypertension, lupus, diabetes, and other autoimmune diseases.
摘要翻译：提供了用于使用胸腺素提取物（例如Thymosin，5级）作为抗自身免疫性疾病剂的方法，其可用于治疗自身免疫性疾病如高血压，狼疮和糖尿病。胸腺素，级分5，给药刺激称为胸腺抑制细胞的称为胸腺抑制细胞的特异性亚类的特异性亚类的发展，其降低自身免疫状态，从而降低高血压，狼疮，糖尿病和其他自身免疫性疾病。

87. 发明授权

US2642426A Method of producing ihygopbotein 失效
公开(公告)号：US2642426A
公开(公告)日：1953-06-16
申请号：US2642426D
CPC分类号： A23J3/10 , C07K14/57581

88. 发明授权

US09775883B2 Methods, systems, and compositions for promoting recovery of peripheral neuropathy 有权
公开(公告)号：US09775883B2
公开(公告)日：2017-10-03
申请号：US14367800
申请日：2012-12-21
申请人： HENRY FORD HEALTH SYSTEM
发明人： Michael Chopp , Zhenggang Zhang , Daniel C. Morris , Lei Wang
IPC分类号： A61K38/00 , A61K38/28 , A61K38/22 , C07K14/575
CPC分类号： A61K38/2292 , C07K14/57581
摘要： Without limitation, some embodiments comprise a method of treatment for promoting recovery of peripheral neuropathy in a subject, including administering to a subject in need of such treatment a therapeutically effective amount of a composition comprised of thymosin beta 4, amino acid sequences LKKTET or LKKTNT, and/or any conservative variants thereof, or an agent that stimulates production of any of those materials, or a conservative variant thereof.

89. 发明申请

US20160176918A1 COUPLING METHOD FOR PEPTIDE SYNTHESIS AT ELEVATED TEMPERATURES 审中-公开
标题翻译：在高温下肽合成的联合方法
公开(公告)号：US20160176918A1
公开(公告)日：2016-06-23
申请号：US14969004
申请日：2015-12-15
申请人： CEM CORPORATION
发明人： JONATHAN M. COLLINS , SANDEEP KUMAR SINGH
IPC分类号： C07K1/10 , C07K7/08 , C07K7/06 , C07K14/575 , C07K14/00
CPC分类号： C07K1/10 , C07K1/04 , C07K1/084 , C07K14/57581
摘要： An improved method for coupling carboxylic acids and amines is disclosed that includes the steps of combining a hyper-acid sensitive linker connecting an amine and a resin, a carboxylic acid, a carbodiimide, an activator additive, and a base, and carrying out the activation and coupling at a temperature greater than 30° C.
摘要翻译：公开了一种用于偶联羧酸和胺的改进方法，其包括连接连接胺和树脂的高酸敏感性连接体，羧酸，碳二亚胺，活化剂添加剂和碱的步骤，并进行活化并在大于30℃的温度下进行偶联。

90. 发明授权

US09259487B2 Transgenic non-human animal model of neurodegenerative disease 有权
标题翻译：转基因非人动物模型的神经变性疾病
公开(公告)号：US09259487B2
公开(公告)日：2016-02-16
申请号：US14122522
申请日：2012-05-18
申请人： Hiroshi Ueda
发明人： Hiroshi Ueda
IPC分类号： A01K67/00 , A01K67/027 , C07H21/04 , G01N33/00 , A61K49/00 , C07K14/575 , C12N15/85
CPC分类号： A61K49/0008 , A01K67/027 , A01K67/0276 , A01K2217/075 , A01K2217/206 , A01K2227/105 , A01K2267/0318 , C07H21/04 , C07K14/57581 , C12N15/8509 , C12N2800/30
摘要： The present invention provides a non-human mammal deficient in the expression of prothymosin α gene in the striatum and a screening method for a prophylactic/therapeutic drug for Huntington's disease and the like, which uses the animal.
摘要翻译：本发明提供了缺乏纹状体中胸腺素α基因表达的非人哺乳动物，以及使用该动物的亨廷顿氏病等的预防/治疗药物的筛选方法。

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