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81. 发明授权

US2140713A Addition products of acetylene and alcohol and process of producing them 失效
标题翻译：乙炔和酒精的添加产物及其生产工艺
公开(公告)号：US2140713A
公开(公告)日：1938-12-20
申请号：US7011036
申请日：1936-03-21
申请人： DU PONT
发明人： NIEUWLAND JULIUS A , HENNION GEORGE F , KILLIAN DONALD B
IPC分类号： C07C41/08
CPC分类号： C07C41/54 , C07C43/303 , C07C43/315

82. 发明授权

US2036304A Formals of aliphatic partial ethers 失效
公开(公告)号：US2036304A
公开(公告)日：1936-04-07
申请号：US2036304D
CPC分类号： C07C43/315 , C07C41/56 , C07C45/54

83. 发明授权

US11944623B2 Modulators of Kv3 channels to treat pain 有权
公开(公告)号：US11944623B2
公开(公告)日：2024-04-02
申请号：US17472493
申请日：2021-09-10
申请人： Autifony Therapeutics Limited
发明人： Charles Large , Giuseppe Alvaro
IPC分类号： A61K31/506 , A61K31/4196 , A61K31/4439 , A61K45/06 , A61P29/02 , C07C43/315 , C07D307/94 , C07D401/14 , C07D403/04 , C07D405/14
CPC分类号： A61K31/506 , A61K31/4196 , A61K31/4439 , A61K45/06 , A61P29/02 , C07C43/315 , C07D307/94 , C07D401/14 , C07D403/04 , C07D405/14
摘要： The present invention provides a modulator of Kv3.1 and/or Kv3.2 and/or Kv3.3 channels for use in the prophylaxis or treatment of pain. Modulators for use in the prophylaxis or treatment of pain include compounds of formula (I) or a pharmaceutically acceptable salt and/or solvate thereof and/or derivative thereof:

84. 发明申请

US20190248725A1 PROCESS FOR THE PREPARATION OF TREPROSTINIL 审中-公开
公开(公告)号：US20190248725A1
公开(公告)日：2019-08-15
申请号：US16397139
申请日：2019-04-29
申请人： CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.
发明人： Imre JUHÁSZ , Irén HORTOBÁGYI , Tamás ALTSACH , István LÁSZLÓFI , Ágnes NAGYNÉ BORKÓ , Imre ROZSUMBERSZKI , Gábor HAVASI , Zsuzsanna KARDOS , Péter BUZDER-LANTOS
IPC分类号： C07C51/347 , C07C59/72 , C07C67/14 , C07C13/547 , C07C35/37 , C07C51/41 , C07C51/09 , C07C45/65 , C07C45/30 , C07C41/26 , C07C43/315 , C07C41/48 , C07C41/30 , C07C69/76 , C07C67/293 , C07C67/29
CPC分类号： C07C51/347 , C07C13/547 , C07C35/37 , C07C41/26 , C07C41/30 , C07C41/48 , C07C43/315 , C07C45/30 , C07C45/305 , C07C45/65 , C07C51/09 , C07C51/412 , C07C59/72 , C07C67/14 , C07C67/29 , C07C67/293 , C07C69/76 , C07C2603/14 , C07C49/84 , C07C49/755 , C07C59/70
摘要： Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anhydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. Also disclosed are treprostinil intermediates and the preparation of the intermediates.

85. 发明授权

US09975830B2 Compound containing modified phenolic hydroxy group, method for producing compound containing modified phenolic hydroxy group, photosensitive composition, resist material, and resist coating film 有权
公开(公告)号：US09975830B2
公开(公告)日：2018-05-22
申请号：US15307959
申请日：2015-04-16
申请人： DIC Corporation
发明人： Tomoyuki Imada
IPC分类号： G03F7/004 , G03F7/039 , C08G8/04 , C08G8/24 , C09D161/12 , C09D161/06 , C07C39/14 , C07C43/23 , C07C43/315 , C08G8/12
CPC分类号： C07C39/14 , C07C37/20 , C07C43/23 , C07C43/315 , C07C2603/92 , C08G8/04 , C08G8/12 , C08G8/24 , C09D161/06 , C09D161/12 , G03F7/0045 , G03F7/039 , G03F7/0392 , G03F7/162 , G03F7/168 , G03F7/2002 , G03F7/322 , G03F7/40
摘要： The present invention provides a compound containing a modified phenolic hydroxy group, which has a molecular structure represented by General Formula (1) except for a molecular structure represented by the following General Formula (2). In the formulas, R1 represents a tertiary alkyl group, an alkoxyalkyl group, an aryloxyalkyl group, an acyl group, an alkoxycarbonyl group, an aryloxycarbonyl group, a cyclic aliphatic hydrocarbon group containing a hetero atom, or a trialkylsilyl group; R2 represents a hydrogen atom, an alkyl group, an alkoxy group, an aryl group which may have a substituent, an aralkyl group which may have a substituent, or a halogen atom; and R3 represents an alkyl group which may have a substituent or an aryl group which may have a substituent.

86. 发明申请

US20170066703A1 COMPOUND CONTAINING MODIFIED PHENOLIC HYDROXY GROUP, METHOD FOR PRODUCING COMPOUND CONTAINING MODIFIED PHENOLIC HYDROXY GROUP, PHOTOSENSITIVE COMPOSITION, RESIST MATERIAL, AND RESIST COATING FILM 有权
标题翻译：含有改性酚羟基的化合物，含有改性苯酚羟基的化合物的生产方法，感光性组合物，耐腐蚀材料和耐腐蚀涂膜
公开(公告)号：US20170066703A1
公开(公告)日：2017-03-09
申请号：US15307959
申请日：2015-04-16
申请人： DIC Corporation
发明人： Tomoyuki Imada
IPC分类号： C07C39/14 , G03F7/004 , G03F7/20 , G03F7/039 , C08G8/12 , G03F7/16 , G03F7/40 , C07C37/20 , G03F7/32
CPC分类号： C07C39/14 , C07C37/20 , C07C43/23 , C07C43/315 , C07C2603/92 , C08G8/04 , C08G8/12 , C08G8/24 , C09D161/06 , C09D161/12 , G03F7/0045 , G03F7/039 , G03F7/0392 , G03F7/162 , G03F7/168 , G03F7/2002 , G03F7/322 , G03F7/40
摘要： The present invention provides a compound containing a modified phenolic hydroxy group, which has a molecular structure represented by General Formula (1) except for a molecular structure represented by the following General Formula (2). In the formulas, R1 represents a tertiary alkyl group, an alkoxyalkyl group, an aryloxyalkyl group, an acyl group, an alkoxycarbonyl group, an aryloxycarbonyl group, a cyclic aliphatic hydrocarbon group containing a hetero atom, or a trialkylsilyl group; R2 represents a hydrogen atom, an alkyl group, an alkoxy group, an aryl group which may have a substituent, an aralkyl group which may have a substituent, or a halogen atom; and R3 represents an alkyl group which may have a substituent or an aryl group which may have a substituent.
摘要翻译：式中，R1表示叔烷基，烷氧基烷基，芳氧基烷基，酰基，烷氧基羰基，芳氧基羰基，含有杂原子的环状脂族烃基或三烷基甲硅烷基。 R 2表示氢原子，烷基，烷氧基，可以具有取代基的芳基，可以具有取代基的芳烷基或卤素原子; 并且R 3表示可以具有取代基的烷基或可以具有取代基的芳基。

87. 发明授权

US08742176B2 Process for producing optically active 4-chloro-3-hydroxybutanal compound 有权
标题翻译：光学活性4-氯-3-羟基丁醛化合物的制备方法
公开(公告)号：US08742176B2
公开(公告)日：2014-06-03
申请号：US13880640
申请日：2011-10-19
申请人： Yujiro Hayashi
发明人： Yujiro Hayashi
IPC分类号： C07C47/02
CPC分类号： C07C45/00 , C07B53/00 , C07B2200/07 , C07C41/01 , C07C41/56 , C07C45/72 , C07C67/00 , C07C67/343 , C07D301/26 , C07D303/12 , C07D303/16 , C07C69/732 , C07C47/195 , C07C43/315 , C07C47/273
摘要： The invention relates to a method of producing optically active 4-chloro-3-hydroxybutanal compound (2) by reacting chloroacetaldehyde with aldehyde compound (1) in the presence of optically active pyrrolidine compound (5). wherein each symbol is as defined in the specification.
摘要翻译：本发明涉及通过在光学活性吡咯烷化合物（5）的存在下使氯乙醛与醛化合物（1）反应制备光学活性的4-氯-3-羟基丁醛化合物（2）的方法。其中每个符号如说明书中所定义。

88. 发明申请

US20130004896A1 COMPOUND FOR RESIST AND RADIATION-SENSITIVE COMPOSITION SPECIFICATION 有权
标题翻译：抗敏化合物和辐射敏感性组合物规格
公开(公告)号：US20130004896A1
公开(公告)日：2013-01-03
申请号：US13614976
申请日：2012-09-13
申请人： Masatoshi ECHIGO , Dai Oguro
发明人： Masatoshi ECHIGO , Dai Oguro
IPC分类号： G03F7/004 , G03F7/20
CPC分类号： G03F7/0045 , C07C39/15 , C07C43/164 , C07C43/18 , C07C43/196 , C07C43/2055 , C07C43/225 , C07C43/315 , C07C49/747 , C07C69/96 , C07C2601/14 , C07C2603/74 , G03F7/0392 , Y10S430/106
摘要： A radiation-sensitive composition containing 1 to 80% by weight of a solid component and 20 to 99% by weight of a solvent. The solid component contains a compound B which has (a) a structure derived from a polyphenol compound A by introducing an acid-dissociating group to at least one phenolic hydroxyl group of the polyphenol compound A which is synthesized by a condensation between a di- to tetrafunctional aromatic ketone or aromatic aldehyde each having 5 to 36 carbon atoms with a compound having 1 to 3 phenolic hydroxyl groups and 6 to 15 carbon atoms, and (b) a molecular weight of 400 to 2000. The composition containing the compound B is useful as an acid-amplified, non-polymeric resist material, because it is highly sensitive to radiation such as KrF excimer lasers, extreme ultraviolet rays, electron beams, and X-rays, and provides resist patterns with a high resolution, high heat resistance, and high etching resistance.
摘要翻译：含有1至80重量％固体组分和20至99重量％溶剂的辐射敏感组合物。固体成分含有化合物B，该化合物B具有（a）由多酚化合物A导入的结构，该酸结合基通过将多元酚化合物A中的至少一个酚羟基引入到通过二 - 具有5至36个碳原子的四官能芳族酮或芳族醛与具有1至3个酚羟基和6至15个碳原子的化合物，和（b）分子量为400至2000.含有化合物B的组合物是有用的作为酸性扩增的非聚合抗蚀剂材料，因为它对诸如KrF准分子激光器，极紫外线，电子束和X射线的辐射高度敏感，并且提供具有高分辨率，高耐热性的抗蚀剂图案，耐腐蚀性高。

89. 发明申请

US20120277477A1 Method For Manufacturing Hydroxyl Group-containing Acetal Compound 有权
标题翻译：制备含羟基的缩醛化合物的方法
公开(公告)号：US20120277477A1
公开(公告)日：2012-11-01
申请号：US13428671
申请日：2012-03-23
申请人： Takashi Ichikawa , Shuichi Yoshimura , Ken-ichiro Nakamoto
发明人： Takashi Ichikawa , Shuichi Yoshimura , Ken-ichiro Nakamoto
IPC分类号： C07C41/58 , C07C43/315
CPC分类号： C07C41/58 , C07C43/315
摘要： A method for manufacturing an acetal compound represented by the formula [1] in which the steps (A) to (D) as defined herein are performed sequentially, and an acetal compound of the formula [1] which is produced by the method: wherein n is 0 or 1 provided that R1 groups may be bonded or may not be bonded to each other when n is 0; R1 is an alkyl group having 1 or 2 carbon atoms or an alkylene group having 1 or 2 carbon atoms and the R1 groups may be same or different from each other; and R2 is an alkylene group having 1 or 6 carbon atoms.
摘要翻译：由式[1]表示的缩醛化合物的制造方法，其中本文定义的步骤（A）至（D）依次进行，以及通过以下方法制备的式[1]的缩醛化合物：其中 n为0或1，条件是当n为0时，R 1基团可以键合或不相互结合; R1是具有1或2个碳原子的烷基或具有1或2个碳原子的亚烷基，并且R 1基团可以相同或不同; 并且R 2是具有1或6个碳原子的亚烷基。

90. 发明申请

US20110034737A1 Water-Soluble Polymer Alkanals 有权
标题翻译：水溶性聚合物碱
公开(公告)号：US20110034737A1
公开(公告)日：2011-02-10
申请号：US12908266
申请日：2010-10-20
申请人： Antoni Kozlowski
发明人： Antoni Kozlowski
IPC分类号： C07C45/61
CPC分类号： A61K47/48215 , A61K47/60 , C07C43/315 , C07C45/30 , C07C47/198 , C08G65/2603 , C08G65/329 , C08L2203/02 , C07C47/14
摘要： The present invention is directed to alkanal derivatives of water-soluble polymers such as poly(ethylene glycol), their corresponding hydrates and acetals, and to methods for preparing and using such polymer alkanals. The polymer alkanals of the invention are prepared in high purity and exhibit storage stability.
摘要翻译：本发明涉及水溶性聚合物如聚（乙二醇），它们相应的水合物和缩醛的链烷醛衍生物，以及制备和使用这种聚合物链烷醛的方法。本发明的聚合物链烷可以高纯度制备并显示储存稳定性。

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