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81. 发明授权

US07468119B2 Separation of 6-aminocapronitrile and hexamethylenediamine from a mixture comprising hexamethylenediamine, 6-aminocapronitrile and tetrahydroazepine 失效
标题翻译：从包含六亚甲基二胺，6-氨基己腈和四氢氮杂的混合物中分离6-氨基己腈和六亚甲基二胺
公开(公告)号：US07468119B2
公开(公告)日：2008-12-23
申请号：US10938831
申请日：2004-09-10
申请人： John Joseph Ostermaier
发明人： John Joseph Ostermaier
IPC分类号： B01D3/10 , B01D3/42 , C07C209/86 , C07C253/34
CPC分类号： C07C209/86 , C07C253/34 , C07C211/12 , C07C255/24
摘要： The invention relates to the field of separation by distillation of 6-aminocapronitrile (ACN) and hexamethylenediamine (HMD) from a mixture containing ACN, HMD, tetrahydrozaepine (THA), adiponitrile (ADN) and low boilers (LB). A method for producing a distillate stream comprising HMD is disclosed, which is suitable for the production of Nylon-6,6. The tails stream from the distillation of the mixture can be further distilled to produce a distillate containing ACN and THA, which is particularly suitable for use in the production of caprolactam and Nylon-6 from the caprolactam. Process conditions of the method of the invention disfavor the production of 2-cyanocyclopentylideneirnine (CPI).
摘要翻译：本发明涉及从含有ACN，HMD，四氢氮杂（THA），己二腈（ADN）和低锅炉（LB）的混合物中蒸馏出6-氨基己腈（ACN）和六亚甲基二胺（HMD）的分离领域。公开了一种用于生产包含HMD的馏出物流的方法，其适用于生产尼龙-6,6。来自混合物蒸馏的尾巴料可以进一步蒸馏，以产生含有ACN和THA的馏出物，其特别适用于从己内酰胺制备己内酰胺和尼龙-6。本发明方法的工艺条件不利于2-氰基环戊二烯基（CPI）的生产。

82. 发明授权

US07301044B2 Preparation of chiral amino-nitriles 失效
标题翻译：手性氨基腈的制备
公开(公告)号：US07301044B2
公开(公告)日：2007-11-27
申请号：US10946167
申请日：2004-09-21
申请人： David Robert Allen , Crystal A Achenbach-McCarthy
发明人： David Robert Allen , Crystal A Achenbach-McCarthy
IPC分类号： C07C255/03
CPC分类号： C07C253/30 , C07B2200/07 , C07C255/24
摘要： A process and intermediates for producing 3-amino nitrites. The process involves resolving an enantiomeric mixture of chiral 3-amino nitrites in the presence of a chiral acid in a solvent system to produce a chiral 3-amino nitrile salt. The process may further comprise a recrystalizing step, wherein an enantiomerically enriched 3-amino nitrile salt is produced. The process may further comprise a salt exchanging step, wherein another acid is added to the chiral 3-amino nitrile salt or the enantiomerically enriched 3-amino nitrile salt to produce another 3-amino nitrile salt.
摘要翻译：一种生产3-氨基亚硝酸盐的方法和中间体。该方法包括在溶剂体系中在手性酸存在下拆分手性3-氨基亚硝酸盐的对映异构体混合物以产生手性3-氨基腈盐。该方法还可以包含重结晶步骤，其中产生对映异构体富集的3-氨基腈盐。该方法还可以包括盐交换步骤，其中将另一种酸加入到手性3-氨基腈盐或对映体富集的3-氨基腈盐中以产生另外的3-氨基腈盐。

83. 发明授权

US07208632B2 Separation of 6-aminocapronitrile and hexamethylenediamine from a mixture comprising hexamethylenediamine, 6-aminocapronitrile and tetrahydroazepine 有权
标题翻译：从包含六亚甲基二胺，6-氨基己腈和四氢氮杂的混合物中分离6-氨基己腈和六亚甲基二胺
公开(公告)号：US07208632B2
公开(公告)日：2007-04-24
申请号：US10939144
申请日：2004-09-10
申请人： John Joseph Ostermaier
发明人： John Joseph Ostermaier
IPC分类号： C07C209/86
CPC分类号： C07C209/86 , C07C253/34 , C07C211/12 , C07C255/24
摘要： The invention relates to the field of separation by distillation of 6-aminocapronitrile (ACN) and hexamethylenediamine (HMD) from a mixture comprising ACN, HMD, tetrahydroazepine (THA), adiponitrile (ADN) and low boilers (LB). Also disclosed is a method for producing a distillate stream comprising HMD; a side draw stream comprising ACN, THA and low levels of dimers of ACN and HMD; and a tails stream comprising ACN, THA and substantially higher levels of dimers of ACN and HMD than found in the side draw stream. The side draw stream is particularly suitable for use in the production of caprolactam since the low levels of dimers of ACN and HMD do not greatly affect the catalyst life in the caprolactam production process. The tails stream can be further distilled to produce a tails distillate stream comprising ACN and THA, which can be recycled back to the first distillation column, further increasing recovery of ACN from the feed stream. Process conditions of the method of the invention disfavor the production of 2-cyanocyclopentylideneimine (CPI).
摘要翻译：本发明涉及从包含ACN，HMD，四氮氮平（THA），己二腈（ADN）和低锅炉（LB））的混合物中蒸馏出6-氨基己腈（ACN）和六亚甲基二胺（HMD）的分离领域。还公开了一种生产包含HMD的馏出液流的方法; 包含ACN，THA和ACN和HMD的低水平二聚体的侧引流; 以及包含ACN，THA和比侧馏分流中发现的ACN和HMD的显着更高水平的二聚体的尾料流。由于ACN和HMD的低水平二聚体不会极大地影响己内酰胺生产过程中的催化剂寿命，所以侧引流特别适用于生产己内酰胺。可以进一步蒸馏尾巴料流以产生包含ACN和THA的尾馏馏料流，其可再循环回第一蒸馏塔，进一步增加ACN从进料流中的回收。本发明方法的工艺条件不利于2-氰基环戊烯亚胺（CPI）的生产。

84. 发明申请

US20060287402A1 Cathepsin inhibitors 审中-公开
标题翻译：组织蛋白酶抑制剂
公开(公告)号：US20060287402A1
公开(公告)日：2006-12-21
申请号：US10569351
申请日：2004-08-23
申请人： Christopher Bayly , Cameron Black , Daniel McKay
发明人： Christopher Bayly , Cameron Black , Daniel McKay
IPC分类号： A61K31/13 , C07C211/01
CPC分类号： C07D295/108 , C07C255/24 , C07C255/29 , C07C255/46 , C07C323/41 , C07C2601/02 , C07D223/08 , C07D295/135 , C07D307/33 , C07D333/20 , C07D333/24 , C07D401/12 , C07K5/06191
摘要： This invention relates to a novel class of compounds, represented by the formula (I) below, wherein the meanings of R1, R2, R3 and R4 are indicated therein, which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis, osteoarthritis and rheumatoid arthritis.
摘要翻译：本发明涉及由下式（I）表示的新一类化合物，其中R 1，R 2，R 3，R 3， SUB>和R 4，其中是半胱氨酸蛋白酶抑制剂，包括但不限于组织蛋白酶K，L，S和B的抑制剂。这些化合物可用于治疗其中抑制骨吸收表现为骨质疏松症，骨关节炎和类风湿性关节炎。

85. 发明授权

US07091153B2 Hydrogenation catalyst 有权
标题翻译：氢化催化剂
公开(公告)号：US07091153B2
公开(公告)日：2006-08-15
申请号：US10776544
申请日：2004-02-12
申请人： Guido Voit , Rolf Fischer , Peter Bassler , Andreas Ansmann , Hermann Luyken , Martin Merger , Frank Ohlbach , Alwin Rehfinger
发明人： Guido Voit , Rolf Fischer , Peter Bassler , Andreas Ansmann , Hermann Luyken , Martin Merger , Frank Ohlbach , Alwin Rehfinger
IPC分类号： B01J23/34 , B01J21/14
CPC分类号： C07C253/30 , B01J23/8892 , C07C209/48 , C07C211/12 , C07C255/24
摘要： A material useful as catalyst for the hydrogenation of alpha, omega-dinitriles comprises (a) iron or a compound based on iron or mixtures thereof, (b) from 0.001 to 0.3% by weight based on (a) of a promoter based on 2, 3, 4 or 5 elements selected from the group consisting of aluminum, silicon, zirconium, titanium and vanadium, (c) from 0 to 0.3% by weight based on (a) of a compound based on an alkali and/or alkaline earth metal, and also (d) from 0.001 to 1% by weight based on (a) of manganese.
摘要翻译：可用作α，ω-二腈的氢化催化剂的材料包括（a）铁或基于铁或其混合物的铁或其混合物，（b）基于（a）基于2的促进剂的0.001至0.3重量％，选自铝，硅，锆，钛和钒的3,4或5种元素，（c）基于（a）基于碱和/或碱土金属的化合物，0至0.3重量％金属，以及（d）以（a）锰计为0.001〜1重量％。

86. 发明申请

US20060057194A1 Cationic liposomes for gene transfer 失效
公开(公告)号：US20060057194A1
公开(公告)日：2006-03-16
申请号：US11201496
申请日：2005-08-11
申请人： Xiang Gao
发明人： Xiang Gao
IPC分类号： A61K48/00 , A61K9/127 , C12N15/88
CPC分类号： C07D295/088 , A61K9/1272 , A61K48/0025 , C07C211/09 , C07C211/14 , C07C211/21 , C07C211/63 , C07C217/08 , C07C217/28 , C07C219/06 , C07C219/08 , C07C229/12 , C07C229/16 , C07C233/36 , C07C233/38 , C07C237/06 , C07C237/10 , C07C237/12 , C07C237/20 , C07C255/24 , C07C271/22 , C07C275/16 , C07C279/24 , C07D295/13 , C07D295/24 , C07D295/30 , C07D295/32 , C12N15/88 , Y10S977/907 , Y10S977/923
摘要： The present invention relates to synthetic cationic lipids, liposome formulations and the use of such compounds to introduce functional bioactive agents into cultured cells.

87. 发明申请

US20050222449A1 Method for reducing the content of an unsaturated amine in a mixture containing an amino nitrile, a diamine, a dinitrile or mixtures thereof 有权
标题翻译：降低含氨基腈，二胺，二腈或其混合物的混合物中不饱和胺含量的方法
公开(公告)号：US20050222449A1
公开(公告)日：2005-10-06
申请号：US10515281
申请日：2003-05-21
申请人： Stefan Maixner , Christoph Benisch , Hermann Luyken , Peter Bassler , Rolf-Hartmuth Fischer , Johann-Peter Melder , Andreas Ansmann
发明人： Stefan Maixner , Christoph Benisch , Hermann Luyken , Peter Bassler , Rolf-Hartmuth Fischer , Johann-Peter Melder , Andreas Ansmann
IPC分类号： C07C209/84 , C07C211/09 , C07C211/12 , C07C253/34 , C07C255/09 , C07C255/24
CPC分类号： C07C253/34 , C07C255/24
摘要： A process for reducing the level of an aliphatic monounsaturated amine (IV) in a mixture (V) containing an aminonitrile (I) or a diamine (II) or a dinitrile (III) or mixtures thereof as well as said amine (IV) by a) reacting said mixture (V) with an anionic nucleophile (VI) which contains a nucleophilic atom selected from the group consisting of oxygen, nitrogen and sulfur, which is capable of taking up an H+ ion to form an acid having a pKa value in the range from 7 to 11, as measured in water at 25° C., and which has a relative nucleophilicity, as measured in methyl perchlorate/methanol at 25° C., in the range from 3.4 to 4.7 when said nucleophilic atom is oxygen, in the range from 4.5 to 5.8 when said nucleophilic atom is nitrogen, and in the range from 5.5 to 6.8 when said nucleophilic atom is sulfur, in an amount in the range from 0.01 to 10 mol per mole of said amine (IV) in said mixture (V) at a temperature in the range from 50 to 200° C. to obtain a mixture (VII), b) distilling said aminonitrile (I) or said diamine (II) or said dinitrile (III) or mixtures thereof from said mixture (VII) at a temperature in the range from 50 to 200° C. and at a pressure in the range from 0.1 to 100 kPa to obtain a bottom product (VIII), which comprises c) distilling an aminonitrile (I) or diamine (II) or dinitrile (III) or mixtures thereof from said bottom product (VIII) at a temperature which is lower than that chosen in step b).
摘要翻译：含有氨基腈（I）或二胺（II）或二腈（III）或其混合物以及所述胺（IV）的混合物（V）中的脂肪族单不饱和胺（IV）的水平以及所述胺（IV） a）使所述混合物（V）与含有选自氧，氮和硫的亲核原子的阴离子亲核试剂（VI）反应，其能够吸收H + 形成在25℃下在水中测量的具有7至11的pK值的酸，其在25℃下在高氯酸甲酯/甲醇中测得的具有相对亲核性当所述亲核原子为氧时，在3.4至4.7的范围内，当所述亲核原子为氮时，在4.5至5.8的范围内，当所述亲核原子为硫时在5.5至6.8的范围内，其量为在所述混合物（V）中，在50至200℃的温度范围内每摩尔所述胺（IV）为0.01至10摩尔的范围，以获得混合物（VII）中，b）在50至200℃的温度下，从所述混合物（VII）中蒸馏所述氨基腈（I）或所述二胺（II）或所述二腈（III）或其混合物，压力为0.1至100kPa，以获得底部产物（VIII），其包括c）在所述底部产物（VIII）中蒸馏氨基腈（I）或二胺（II）或二腈（III）或其混合物，温度低于步骤b）中选择的温度。

88. 发明申请

US20050107453A1 Resolution of 3-amino alkylnitriles 失效
标题翻译：分解3-氨基烷基腈
公开(公告)号：US20050107453A1
公开(公告)日：2005-05-19
申请号：US10942985
申请日：2004-09-17
申请人： Juan Colberg , Samuela Franz , Riccardo Motterle , Mariano Stivanello
发明人： Juan Colberg , Samuela Franz , Riccardo Motterle , Mariano Stivanello
IPC分类号： A61K31/277 , A61K31/401 , A61K31/405 , A61K31/4172 , C07B57/00 , C07C253/32 , C07C255/24 , C07C255/29 , C07D233/90
CPC分类号： C07C253/34 , C07B2200/07 , C07C255/24
摘要： The present invention relates to chiral N-acetyl-alpha-amino acid salts of optically active β-amino alkylnitriles, and also to a process for preparing optically active β-amino alkylnitriles by resolving racemic β-amino alkylnitriles using chiral N-acetyl-alpha-amino acids as resolving agent.
摘要翻译：本发明涉及光学活性β-氨基烷基腈的手性N-乙酰基-α-氨基酸盐，还涉及通过使用手性N-乙酰基-α分解外消旋的β-氨基烷基腈制备光学活性β-氨基烷基腈的方法 - 氨基酸作为拆分剂。

89. 发明申请

US20040254059A1 Iron-containing material suitable for use as hydrogenation catalyst 失效
标题翻译：适用于氢化催化剂的含铁材料
公开(公告)号：US20040254059A1
公开(公告)日：2004-12-16
申请号：US10493419
申请日：2004-04-22
发明人： Andreas Ansmann , Christoph Benisch , Peter Bassler , Rolf-Hartmuth Fischer , Stefan Maixner , Johann-Peter Melder , Hermann Luyken
IPC分类号： B01J029/04
CPC分类号： C07C253/30 , B01J23/745 , B01J23/8892 , C07C209/48 , C07C211/12 , C07C255/24
摘要： The iron-containing catalyst suitable for use as a catalyst contains a) iron or a mixture containing iron and an iron-based compound. The iron has an average crystallite size ranging from 1-35 nm measured by X-ray diffraction.
摘要翻译：适合用作催化剂的含铁催化剂含有a）铁或含有铁和铁基化合物的混合物。铁通过X射线衍射测得的平均微晶尺寸为1-35nm。

90. 发明申请

US20040147503A1 Novel compounds and compositions as cathepsin inhibitors 审中-公开
标题翻译：新型化合物和组合物作为组织蛋白酶抑制剂
公开(公告)号：US20040147503A1
公开(公告)日：2004-07-29
申请号：US10478632
申请日：2003-11-24
发明人： Sheila Zipfeil
IPC分类号： A61K031/397 , C07D211/06 , A61K031/445
CPC分类号： C07D213/40 , C07C255/24 , C07C2601/14 , C07D209/08 , C07D213/64 , C07D213/75 , C07D215/06 , C07D215/12 , C07D217/02 , C07D217/06 , C07D235/14 , C07D263/32 , C07D263/56 , C07D295/185 , C07D307/16 , C07D333/20
摘要： The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
摘要翻译：本发明涉及新的选择性组织蛋白酶S抑制剂，其药学上可接受的盐和N-氧化物，它们作为治疗剂的用途及其制备方法。

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