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81. 发明申请

US20150274647A1 POLYMERIZABLE COMPOUND, POLYMERIZABLE COMPOSITION, POLYMER, AND OPTICALLY ANISOTROPIC SUBSTANCE 有权
标题翻译：可聚合化合物，聚合物，聚合物和光学非均质物质
公开(公告)号：US20150274647A1
公开(公告)日：2015-10-01
申请号：US14436526
申请日：2013-10-16
申请人： ZEON CORPORATION
发明人： Kei Sakamoto , Satoshi Kiriki , Kumi Okuyama
IPC分类号： C07C251/86 , C08F22/22 , G02B1/04 , C07D295/30
CPC分类号： C07C251/86 , C07C251/88 , C07D295/22 , C07D295/30 , C08F22/22 , C08F222/1006 , G02B1/04 , G02B5/3016 , G02B5/3083 , G02F2001/133637 , G02F2001/133638
摘要： The present invention relates to: a polymerizable compound represented by a formula (I); a polymerizable composition comprising the polymerizable compound and an initiator; a polymer obtained by polymerizing the polymerizable compound or the polymerizable composition; and an optically anisotropic article comprising the polymer [in the formula, Y1 to Y8 are a chemical single bond, —O—, —O—C(═O)—, —C(═O)—O—, or the like; G1 and G2 are a divalent aliphatic group having 1 to 20 carbon atoms, or the like; Z1 and Z2 are an alkenyl group having 2 to 10 carbon atoms, or the like; A1 is a tetravalent aromatic group, or the like; A2 and A3 are a divalent alicyclic hydrocarbon group having 3 to 30 carbon atoms, or the like; A4 and A5 are a divalent aromatic group having 4 to 30 carbon atoms, or the like; Ax1 and Ax2 are an organic group having 2 to 30 carbon atoms that includes an aromatic ring, or the like; Ay1 and Ay2 are a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or the like; Q1 and Q2 are a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or the like; and m and n are 0 or 1]. According to the present invention, a polymerizable compound, a polymerizable composition, and a polymer that have a practical low melting point, exhibit excellent solubility in a general-purpose solvent, can be produced at low cost, and can produce an optical film that achieves uniform conversion of polarized light over a wide wavelength band, and also provide an optically anisotropic article.
摘要翻译：本发明涉及：由式（I）表示的可聚合化合物; 包含可聚合化合物和引发剂的可聚合组合物; 通过聚合可聚合化合物或可聚合组合物而获得的聚合物; 和含有该聚合物[式中Y1至Y8的光学各向异性物品为化学单键，-O - ， - O-C（= O） - ， - C（= O）-O-等） G1和G2是碳原子数1〜20的二价脂肪族基团等。 Z 1和Z 2是具有2至10个碳原子的烯基等; A1是四价芳族基团等; A2和A3是具有3至30个碳原子的二价脂环族烃基等; A4和A5是具有4-30个碳原子的二价芳族基团等; Ax1和Ax2是含有芳香环等的碳原子数2〜30的有机基团， Ay1和Ay2是氢原子，具有1至6个碳原子的烷基等; Q1和Q2是氢原子，具有1至6个碳原子的烷基等; m和n为0或1]。根据本发明，可以以低成本制造具有实用低熔点，在通用溶剂中表现出优异溶解性的可聚合化合物，可聚合组合物和聚合物，并且可以制备实现在宽波长带上的偏振光的均匀转换，并且还提供光学各向异性制品。

82. 发明申请

US20150266812A1 PYRAZOLOPYRIDAZINES AND METHODS FOR TREATING RETINAL DEGENERATIVE DISEASES AND HEARING LOSS ASSOCIATED WITH USHER SYNDROME 有权
标题翻译：吡咯并吡啶并用于治疗衰老性疾病和听力损失的方法
公开(公告)号：US20150266812A1
公开(公告)日：2015-09-24
申请号：US14730994
申请日：2015-06-04
申请人： Usher Ill Initiative, Inc.
发明人： Roland Werner BÜRLI , William Rameshchandra Krishna ESMIEU , Christopher James LOCK , Karine Fabienne MALAGU , Andrew Pate OWENS , William E. HARTE
IPC分类号： C07C243/28
CPC分类号： A61K31/5025 , A61K31/165 , A61K31/167 , A61K31/40 , C07C243/28 , C07C251/86 , C07C2602/08 , C07D487/04 , C07D495/04 , C07D519/00 , G01N33/502 , G01N33/6848 , G01N33/6893 , G01N2333/4703 , G01N2400/40 , G01N2500/04 , G01N2500/10
摘要： Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.
摘要翻译：本文描述了用于治疗视网膜退行性疾病的化合物，组合物和方法，例如色素性视网膜炎，Leber先天性黑素瘤，综合性视网膜变性，年龄相关性黄斑变性和Usher综合征，以及与Usher综合征相关的听力损失。

83. 发明申请

US20150252043A1 HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES 有权
标题翻译： HEMATOPOIETIC GROWTH FACTOR MIMETIC小分子化合物及其用途
公开(公告)号：US20150252043A1
公开(公告)日：2015-09-10
申请号：US14713930
申请日：2015-05-15
申请人： LIGAND PHARMACEUTICALS INC.
发明人： Lin Zhi , Andrew R. Hudson , Cornelis A. Van Oeveren , Steven L. Roach , Bijan Pedram , Yixing Shen , Lino J. Valdez , Jillian Basinger , Virginia Heather Sharron Grant , Jason C. Pickens
IPC分类号： C07D471/04 , C07D401/14 , C07D409/14 , C07D403/12 , C07D239/28 , C07D417/14 , C07D413/14 , C07D333/38 , C07D209/08 , C07D409/12 , C07D417/12
CPC分类号： A61K31/15 , A61K31/167 , A61K31/18 , A61K31/245 , A61K31/343 , A61K31/36 , A61K31/381 , A61K31/4015 , A61K31/402 , A61K31/4025 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/41 , A61K31/415 , A61K31/4155 , A61K31/416 , A61K31/4164 , A61K31/4184 , A61K31/4192 , A61K31/421 , A61K31/423 , A61K31/4245 , A61K31/437 , A61K31/438 , A61K31/4409 , A61K31/4418 , A61K31/4439 , A61K31/4468 , A61K31/4535 , A61K31/454 , A61K31/4747 , A61K31/495 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61K31/541 , C07C233/78 , C07C233/80 , C07C235/56 , C07C237/40 , C07C237/42 , C07C243/38 , C07C247/18 , C07C251/48 , C07C251/66 , C07C251/68 , C07C251/86 , C07C271/28 , C07C311/08 , C07D207/12 , C07D207/27 , C07D207/273 , C07D207/32 , C07D207/327 , C07D207/34 , C07D207/416 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/16 , C07D209/24 , C07D209/34 , C07D209/42 , C07D211/46 , C07D211/58 , C07D213/12 , C07D213/53 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D231/14 , C07D231/26 , C07D231/40 , C07D231/56 , C07D233/60 , C07D233/61 , C07D233/90 , C07D235/06 , C07D235/14 , C07D235/20 , C07D235/24 , C07D235/30 , C07D237/24 , C07D239/28 , C07D241/04 , C07D241/24 , C07D249/04 , C07D261/18 , C07D263/04 , C07D263/16 , C07D263/57 , C07D265/36 , C07D277/56 , C07D285/06 , C07D295/135 , C07D295/155 , C07D295/185 , C07D307/68 , C07D317/62 , C07D317/68 , C07D333/24 , C07D333/38 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/10 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/113
摘要： The present embodiments relate to compounds with physiological effects, such as the activation of hematopoietic growth factor receptors. The present embodiments also relate to use of the compounds to treat a variety of conditions, diseases and ailments such as hematopoietic conditions and disorders.
摘要翻译：本实施方案涉及具有生理作用的化合物，例如造血生长因子受体的活化。本实施方案还涉及该化合物用于治疗多种病症，疾病和疾病如造血条件和病症的用途。

84. 发明申请

US20150239825A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT 有权
标题翻译：用于疾病治疗的ALKOXY化合物
公开(公告)号：US20150239825A1
公开(公告)日：2015-08-27
申请号：US14631763
申请日：2015-02-25
申请人： Acucela Inc.
发明人： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas L. Little, JR. , Anna Gall , Feng Hong
IPC分类号： C07C217/20
CPC分类号： A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06
摘要： The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
摘要翻译：本发明一般涉及用于治疗神经变性疾病和病症，特别是眼科疾病和病症的组合物和方法。本文提供的是烷氧基衍生物化合物和包含这些化合物的药物组合物。主题组合物可用于治疗和预防眼科疾病和病症，包括年龄相关性黄斑变性（AMD）和斯塔尔加氏病。

85. 发明授权

US09085550B2 Ligands for estrogen related receptors and methods for synthesis of said ligands 有权
公开(公告)号：US09085550B2
公开(公告)日：2015-07-21
申请号：US13237605
申请日：2011-09-20
申请人： Barry Forman , Donna Yu
发明人： Barry Forman , Donna Yu
IPC分类号： C07D333/22 , A61K31/381 , C07D333/44 , C07C249/16 , C07D207/335 , C07D207/34 , C07D251/46 , C07D307/52
CPC分类号： C07D333/44 , C07C249/16 , C07D207/335 , C07D207/34 , C07D251/46 , C07D307/52 , C07D333/22 , C07C251/86
摘要： Estrogen-Related Receptor (ERR) modulating compounds and methods for synthesis of said compounds are described.

86. 发明授权

US08993807B2 Alkoxy compounds for disease treatment 有权
公开(公告)号：US08993807B2
公开(公告)日：2015-03-31
申请号：US13291932
申请日：2011-11-08
申请人： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Feng Hong
发明人： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Feng Hong
IPC分类号： C09B11/02 , C07C211/00 , A01N33/02 , A61K31/135 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C317/28 , C07C323/25 , C07D277/24 , C07D309/06
CPC分类号： A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06
摘要： The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

87. 发明授权

US08872422B2 Dinaphthyl ethylene derivativce, process for preparing it, film prepared from it, and OLED including the film 有权
标题翻译：二萘基乙烯衍生物，其制备方法，由其制备的膜和包括该膜的OLED
公开(公告)号：US08872422B2
公开(公告)日：2014-10-28
申请号：US12011897
申请日：2008-01-30
申请人： Yong Qiu , Han Chen , Yinkui Li
发明人： Yong Qiu , Han Chen , Yinkui Li
IPC分类号： C09K11/06 , H01L51/54 , C07D333/24 , C07C15/58 , C07C13/567 , C07D309/34 , C07C255/09 , C07C211/54 , C07C45/46 , C07C15/62 , C07C45/68 , C07D233/96 , C07D413/14 , C07D219/06 , C07C15/38 , C07D209/08 , C07C15/60 , C07D403/10 , C07D209/44 , C07D333/08 , C07D213/68 , C07C251/86 , C07D209/86 , C07D207/323 , C07C211/58 , C07C43/285 , C07D213/74 , H01L51/00 , C07C17/10 , C07D251/24 , C07D309/32 , C07C245/10 , C07C17/16 , C07D271/107 , C07C25/22 , C07D215/06 , C07D277/66 , C07D307/54 , C07D471/22 , C07D221/14 , C07C22/08 , C07C17/263 , C07C43/225 , C07D307/91 , C07C13/465 , C07D401/04 , C07C13/72 , C07C45/29 , C07C255/52 , C07D471/06 , C07D235/20 , C07C45/00 , C07D307/66 , C07C13/15 , H01L51/50
CPC分类号： C07D333/08 , C07C13/15 , C07C13/465 , C07C13/567 , C07C13/72 , C07C15/38 , C07C15/58 , C07C15/60 , C07C15/62 , C07C17/10 , C07C17/16 , C07C17/2635 , C07C22/08 , C07C25/22 , C07C43/225 , C07C43/285 , C07C45/00 , C07C45/292 , C07C45/46 , C07C45/68 , C07C211/54 , C07C211/58 , C07C245/10 , C07C251/86 , C07C255/09 , C07C255/52 , C07C2601/10 , C07C2602/08 , C07C2603/18 , C07C2603/24 , C07C2603/26 , C07C2603/50 , C07C2603/90 , C07C2603/97 , C07D207/323 , C07D209/08 , C07D209/44 , C07D209/86 , C07D213/68 , C07D213/74 , C07D215/06 , C07D219/06 , C07D221/14 , C07D233/96 , C07D235/20 , C07D251/24 , C07D271/107 , C07D277/66 , C07D307/54 , C07D307/66 , C07D307/91 , C07D309/32 , C07D309/34 , C07D333/24 , C07D401/04 , C07D403/10 , C07D413/14 , C07D471/06 , C07D471/22 , H01L51/0052 , H01L51/5012 , Y10S428/917 , C07C22/04 , C07C25/24 , C07C47/548 , C07C47/55 , C07C49/813 , C07C49/788 , C07C47/546
摘要： The present invention relates to a dinaphthyl ethylene derivative of formula (I), a process for preparing it, a film prepared from it useful in the manufacture of an organic light emitting device (OLED), an OLED including the film, and the use of the dinaphthyl ethylene derivative in the manufacture of an OLED. Wherein R1 to R16 are defined as in the specification.
摘要翻译：本发明涉及式（I）的二萘乙烯衍生物，其制备方法，由其制备的可用于制造有机发光器件（OLED）的膜，包含该膜的OLED以及使用二萘基乙烯衍生物在OLED的制造中。其中R1至R16如说明书中所定义。

88. 发明授权

US08865901B2 Gain-of-function Bcl-2 inhibitors 有权
标题翻译：增加功能的Bcl-2抑制剂
公开(公告)号：US08865901B2
公开(公告)日：2014-10-21
申请号：US13437795
申请日：2012-04-02
申请人： David Hockenbery , Julian Simon
发明人： David Hockenbery , Julian Simon
IPC分类号： A61K31/47 , C07D217/22 , C07D401/12 , C07C251/86 , C07D271/08 , C07D213/77 , C07C323/20 , C07C235/60
CPC分类号： C07D401/12 , C07C235/60 , C07C251/86 , C07C323/20 , C07D213/77 , C07D217/22 , C07D271/08
摘要： Compounds are described that are useful for treating an apoptosis-associated disease, which are specifically cytotoxic to tumor cells that are overexpressing Bcl-xL, and are much less cytotoxic in isogenic cells that are not overexpressing Bcl-xL. Also described is a method for treating an apoptosis-associated disease in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of an active compound that is specifically cytotoxic to tumor cells that are overexpressing Bcl-xL, and are much less cytotoxic in isogenic cells that are not overexpressing Bcl-xL. Several scaffolds of active compounds are described.
摘要翻译：描述了可用于治疗细胞凋亡相关疾病的化合物，其对过表达Bcl-xL的肿瘤细胞特异性细胞毒性，并且在不过表达Bcl-xL的同基因细胞中细胞毒性小得多。还描述了在有需要的受试者中治疗凋亡相关疾病的方法，其包括向受试者施用治疗有效量的对过表达Bcl-xL的肿瘤细胞特异性细胞毒性的活性化合物，并且少得多不是过表达Bcl-xL的等基因细胞中的细胞毒性。描述了活性化合物的几种支架。

89. 发明授权

US08846876B2 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides 有权
标题翻译：含有，涉及非天然氨基酸和多肽的方法和使用的组合物
公开(公告)号：US08846876B2
公开(公告)日：2014-09-30
申请号：US13528723
申请日：2012-06-20
申请人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
发明人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
IPC分类号： C07K1/107 , C07K16/00 , A61K31/198 , C07C251/54 , C07C251/60 , C07C251/28 , C07D333/72 , G01N33/68 , C07D307/89 , C07C251/86 , A61K38/17 , C07C229/36 , C07D317/30 , G01N33/50 , C07D317/28 , C12P21/02 , C07C237/32 , C07D317/26 , C07C323/63 , C07D307/88 , C07D307/83 , C07D317/22 , C07D209/38
CPC分类号： C07C225/10 , A61K31/198 , A61K38/17 , A61K47/08 , A61K47/10 , A61K47/34 , A61K47/60 , C07C229/36 , C07C237/32 , C07C251/28 , C07C251/54 , C07C251/60 , C07C251/86 , C07C323/63 , C07C2601/08 , C07D209/38 , C07D209/46 , C07D307/83 , C07D307/88 , C07D307/89 , C07D317/22 , C07D317/26 , C07D317/28 , C07D317/30 , C07D333/72 , C07K14/61 , C12P21/02 , G01N33/5008 , G01N33/68 , G01N33/6848 , G01N2500/00 , Y02A50/473 , Y02P20/55
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译：本文公开了包含至少一种非天然氨基酸的非天然氨基酸和多肽，以及制备这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可以包括广泛的可能的官能团，但典型的具有至少一个肟，羰基，二羰基和/或羟胺基团。本文还公开了在翻译后进一步修饰的非天然氨基酸多肽，用于实现这种修饰的方法，以及纯化这些多肽的方法。通常，修饰的非天然氨基酸多肽包括至少一个肟，羰基，二羰基和/或羟胺基团。进一步披露的是使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。

90. 发明授权

US08846280B2 Compound, charge transporting film, photoelectric conversion device, electrophotographic photoreceptor, process cartridge, and image forming apparatus 有权
标题翻译：化合物，电荷输送膜，光电转换装置，电子照相感光体，处理盒和成像装置
公开(公告)号：US08846280B2
公开(公告)日：2014-09-30
申请号：US13398061
申请日：2012-02-16
申请人： Wataru Yamada , Katsumi Nukada , Yuko Iwadate , Tomoya Sasaki , Kenji Kajiwara
发明人： Wataru Yamada , Katsumi Nukada , Yuko Iwadate , Tomoya Sasaki , Kenji Kajiwara
IPC分类号： G03G5/04 , H01L51/00 , G03G15/00 , G03G5/05 , C07C237/20 , G03G5/06 , G03G5/07 , G03G5/147 , C07C229/44 , C07C217/76 , C07C229/42 , C07C327/22 , H01L51/50 , C07C251/86 , C07C217/92
CPC分类号： G03G15/75 , C07C217/76 , C07C217/92 , C07C229/42 , C07C229/44 , C07C237/20 , C07C251/86 , C07C327/22 , C07C2601/14 , C07C2603/18 , G03G5/0503 , G03G5/0532 , G03G5/0592 , G03G5/0596 , G03G5/0614 , G03G5/071 , G03G5/14717 , G03G5/14791 , G03G5/14795 , H01L51/0038 , H01L51/0059 , H01L51/0081 , H01L51/5056
摘要： Provided is a compound represented by the following General Formula (I): wherein in General Formula (I), F represents a charge transporting subunit, L represents a linking group having a valency of (n+1) that is formed by combining two or more kinds selected from a group consisting of an alkylene group, —C═C— (an alkenylene group), —C(═O)—, —N(R)—, —O—, and —S—, and R represents a hydrogen atom, an alkyl group, an aryl group, or an aralkyl group, m represents an integer of from 1 to 6, and n represents an integer of from 2 to 3.
摘要翻译：提供由以下通式（I）表示的化合物：其中，在通式（I）中，F表示电荷输送亚单元，L表示通过将两个或多个的化合物组合而形成的化合价为（n + 1）的连接基团选自亚烷基，-C≡C-（亚烯基），-C（= O） - ， - N（R） - ， - O-和-S-中的更多种，R表示氢原子，烷基，芳基或芳烷基，m表示1〜6的整数，n表示2〜3的整数。

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