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81. 发明申请

US20110064629A1 Cytocentrifuge sample container holder and support device 有权
标题翻译：细胞离心机样品容器支架和支撑装置
公开(公告)号：US20110064629A1
公开(公告)日：2011-03-17
申请号：US12584932
申请日：2009-09-15
申请人： Christopher Stamas , Michael Faulkner
发明人： Christopher Stamas , Michael Faulkner
IPC分类号： B01L9/00
CPC分类号： B01L9/52 , A61B10/0096 , B01L3/502 , B01L3/5021 , B01L2200/025 , B01L2300/0822 , B01L2400/0409 , G01N1/2813
摘要： A support device for a cytocentrifuge sample container includes a support body including spaced edge fingers and a clip hinged to the support body. The clip has a latch for each spaced edge finger of the support body and edge members each including lugs engaging slotted ledges in the sample container.
摘要翻译：用于细胞离心机样品容器的支撑装置包括支撑体，所述支撑体包括间隔开的边缘指状物和铰接到支撑体的夹子。夹子具有用于支撑体的每个间隔开的边缘指状物的闩锁，每个边缘构件包括接合在样品容器中的开槽凸缘的凸耳。

82. 发明授权

US07901634B2 Apparatus and methods for processing biological samples and a reservoir therefor 有权
标题翻译：用于处理生物样品的装置和方法及其储存器
公开(公告)号：US07901634B2
公开(公告)日：2011-03-08
申请号：US11031514
申请日：2005-01-07
申请人： Gregory A. Testa , Tim Svenstrup Poulsen , Steen Hauge Matthiesen , Ole Feldballe Rasmussen , Lars Winther
发明人： Gregory A. Testa , Tim Svenstrup Poulsen , Steen Hauge Matthiesen , Ole Feldballe Rasmussen , Lars Winther
IPC分类号： B01L3/00 , B01L3/02
CPC分类号： C12Q1/6841 , B01L3/508 , B01L7/52 , B01L2200/142 , B01L2300/043 , B01L2300/069 , B01L2300/0822 , B01L2300/10 , B01L2300/1822 , B01L2300/1844 , C12M41/14 , C12M41/36 , G01N1/312 , Y10T436/143333
摘要： An apparatus for processing at least one biological sample accommodated on at least one carrier member (15) in a chamber includes at least one reservoir (18) able to accommodate a fluid arranged on a surface inside the chamber adjacent to and/or facing a substantial part of the at least one biological sample. The apparatus may comprise a bottom member (12) arranged to support at least one carrier member (15) carrying at least one biological sample and a lid (14) including at least one fluid reservoir (18). The reservoir filled with water provides humidity to the chamber and impedes drying out of the sample.
摘要翻译：用于处理容纳在腔室中的至少一个载体构件（15）上的至少一个生物样品的装置包括至少一个储存器（18），其能够容纳布置在室内的表面上的流体，邻近和/ 至少一种生物样品的一部分。该装置可以包括底部构件（12），该底部构件（12）被布置成支撑承载至少一个生物样品的至少一个载体构件（15）和包括至少一个流体储存器（18）的盖子（14）。充满水的储存器为室提供湿气并阻止样品干燥。

83. 发明申请

US20110031139A1 Protection, authentication, identification device for a physical object specimen 审中-公开
标题翻译：保护，认证，身体物体识别装置
公开(公告)号：US20110031139A1
公开(公告)日：2011-02-10
申请号：US12924170
申请日：2010-09-22
申请人： James Joseph Macor
发明人： James Joseph Macor
IPC分类号： B65D69/00
CPC分类号： G06K19/04 , B01L3/508 , B01L3/54 , B01L2300/022 , B01L2300/023 , B01L2300/024 , B01L2300/0822 , G09F3/0297 , G09F3/185 , G09F2003/0272
摘要： A protection, authentication, identification device for a physical object specimen is described. The device comprises a holder formed for assembly with at least one physical object specimen to provide protection and preservation of the physical object specimen. The holder is further formed with a holding area for the physical object specimen and to resist disassembly and separation with the physical object specimen, once it is assembled. The protection, authentication, identification device for a physical object specimen is further comprised of a nonvolatile electronic data storage device configured to store at least one digital image of the physical object specimen including sufficient detail to record at least one unique appearance characteristic of the physical object specimen. The data storage device is nondetachably secured to the protection, authentication, identification device. In preferred embodiments the digital image records may have, at least in part, an immutable condition to deter or prevent alteration. One or more digital images are readable and displayable by a computer system connectable by wired or wireless means to the nonvolatile electronic storage device.
摘要翻译：描述了用于物理对象样本的保护，认证，识别装置。该装置包括形成为用于与至少一个物理对象样本组装以提供物理对象样本的保护和保存的保持器。保持架进一步形成有用于物体样品的保持区域，并且一旦组装就能抵抗物理样品的拆卸和分离。用于物理对象样本的保护，认证，识别装置还包括非易失性电子数据存储装置，其被配置为存储包括足够细节的物理对象标本的至少一个数字图像，以记录物理对象的至少一个独特的外观特征标本。数据存储设备不可靠地固定到保护，认证，识别设备。在优选实施例中，数字图像记录可以至少部分地具有阻止或防止改变的不变条件。一个或多个数字图像可由可由有线或无线装置连接到计算机系统的非易失性电子存储装置读取和显示。

84. 发明申请

US20100330578A1 THERMO-OPTICAL CHARACTERISATION OF NUCLEIC ACID MOLECULES 有权
标题翻译：核酸分子的热光学特征
公开(公告)号：US20100330578A1
公开(公告)日：2010-12-30
申请号：US12865985
申请日：2009-02-06
申请人： Stefan Duhr , Philipp Baaske
发明人： Stefan Duhr , Philipp Baaske
IPC分类号： C12Q1/68 , G01N21/64 , C12M1/34
CPC分类号： G01N21/6428 , B01L3/50273 , B01L2300/0822 , B01L2300/1861 , B01L2300/1872 , B01L2400/0451 , C12Q1/6813 , G01N21/171 , G01N21/6408 , G01N21/6458 , C12Q2527/107 , C12Q2523/313
摘要： The present invention pertains to a method and a device for the determination of thermo-optical properties, particularly the size or size distribution, of fluorescently labeled biomolecules or biomolecule complexes, particularly nucleic acids, in a reaction solution. The method comprises the steps of: (i) providing a reaction solution with fluorescently labeled biomolecules or biomolecule complexes; (ii) irradiating a laser light beam into the solution to obtain a spatial temperature distribution in the solution around the irradiated laser light beam; (iii) exciting fluorescently said fluorescently labeled biomolecules and detecting the fluorescence at two or more defined regions representing different mean temperatures in said spatial temperature distribution, wherein said detection of fluorescence is performed at least once at a predetermined time after the start of the laser irradiation; and (iv) determining the thermo-optical properties, particularly the size or size distribution, of the fluorescently labeled biomolecules or biomolecule complexes from the detected fluorescence intensity or fluorescence intensity distribution.
摘要翻译：本发明涉及用于确定反应溶液中荧光标记的生物分子或生物分子复合物，特别是核酸的热光学性质，特别是尺寸或尺寸分布的方法和装置。该方法包括以下步骤：（i）提供具有荧光标记的生物分子或生物分子复合物的反应溶液; （ii）将激光束照射到溶液中以获得围绕照射的激光束的溶液中的空间温度分布; （iii）激发荧光标记的荧光标记的生物分子，并检测在所述空间温度分布中表示不同平均温度的两个或多个限定区域处的荧光，其中所述荧光检测在激光照射开始之后的预定时间至少进行一次 ; 和（iv）根据检测到的荧光强度或荧光强度分布确定荧光标记的生物分子或生物分子复合物的热 - 光学性质，特别是尺寸或尺寸分布。

85. 发明授权

US07807451B2 Apparatus for detecting cell chemotaxis 失效
标题翻译：用于检测细胞趋化性的装置
公开(公告)号：US07807451B2
公开(公告)日：2010-10-05
申请号：US10542189
申请日：2004-04-08
申请人： Shiro Kanegasaki
发明人： Shiro Kanegasaki
IPC分类号： G01N33/48 , C12M1/00 , C12M3/00 , C12M1/42 , C12M1/34
CPC分类号： B01L3/50273 , B01L3/502738 , B01L2200/0647 , B01L2300/049 , B01L2300/0816 , B01L2300/0822 , B01L2300/0864 , B01L2400/0487 , G01N15/1484 , G01N2015/1486
摘要： The present invention relates to an improvement in an apparatus for detecting chemotaxis of cells. It aims at providing a structure for detecting chemotaxis of cells at an elevated accuracy with the use of a microquantity of cells. That is to say, an object of the present invention is to provide an apparatus for detecting chemotaxis of cells by which cell injection and position control can be easily carried out while ensuring the prevention of unexpected migration of the cells definitely positioned in a well or the injected sample so that a stable concentration gradient due to the diffusion of the specimen can be maintained and which ensures further automated operation and controlling.Namely, an apparatus for detecting chemotaxis of cells with a structure wherein two wells are connected to each other via a channel having resistance to the passage of cells and each well has an opening for injecting cells or a specimen, characterized by having (1) a means of transporting a liquid and a means of stopping the transportation after the injection or the aspiration discharge of the liquid and (2) a means of sealing the opening(s) in one or both of the cell-injection side and the specimen-injection side.
摘要翻译：本发明涉及用于检测细胞趋化性的装置的改进。其目的在于提供一种以高精度检测细胞趋化性的结构，使用微量的细胞。也就是说，本发明的目的是提供一种用于检测细胞的趋化性的装置，通过该装置可以容易地进行细胞注射和位置控制，同时确保防止绝对定位在孔中的细胞的意外迁移或注入样品，从而可以保持由于样品扩散而产生的稳定的浓度梯度，并确保进一步的自动化操作和控制。也就是说，一种用于检测细胞的趋化性的装置，其中两个孔通过具有对细胞通过的通道和每个孔的通道彼此连接，具有用于注入细胞或样本的开口，其特征在于具有（1）运送液体的方法和在液体的注射或抽吸排出之后停止运输的装置和（2）在细胞注射侧和样品注射中的一个或两个中密封开口的装置侧。

86. 发明申请

US20100248295A1 ANALYTIC SUBSTRATE COATING METHOD 有权
公开(公告)号：US20100248295A1
公开(公告)日：2010-09-30
申请号：US12795528
申请日：2010-06-07
申请人： Lee H. Angros
发明人： Lee H. Angros
IPC分类号： G01N1/28 , C12Q1/24
CPC分类号： G01N1/30 , B01L3/0258 , B01L3/508 , B01L99/00 , B01L2200/12 , B01L2300/0822 , B01L2300/16 , B01L2300/161 , B05C1/025 , B05C9/06 , B05C9/14 , B05C11/028 , B05C13/02 , B05D1/02 , B05D1/20 , B05D1/28 , B05D7/5483 , B05D2252/04 , G01N2001/305 , Y10T156/179 , Y10T156/1798
摘要： An apparatus and method for producing a coated analytic substrate using a compact and portable automated instrument located in the laboratory setting at the point of use which can consistently produce one or a plurality of coated analytic substrates “on demand” for using the analytic substrate immediately after coating, preferably without a step of rinsing the coated analytic substrate before use. The apparatus preferably uses applicator cartridges having a reservoir containing the coating compositions used to form the coatings. Preferably the cartridges are removable and interchangeable to facilitate the production of individual analytic substrates having different coatings or different coating patterns. These coated analytic substrates have superior specimen adhesion characteristics due to the improved quality of the coatings applied by the coating apparatus and due to the quickness with which the coated analytic substrates can be used in the lab after production.

87. 发明申请

US20100248294A1 ANALYTIC SUBSTRATE COATING METHOD 有权
标题翻译：分析基板涂层方法
公开(公告)号：US20100248294A1
公开(公告)日：2010-09-30
申请号：US12795509
申请日：2010-06-07
申请人： Lee H. Angros
发明人： Lee H. Angros
IPC分类号： G01N1/28 , C12Q1/24
CPC分类号： G01N1/30 , B01L3/0258 , B01L3/508 , B01L99/00 , B01L2200/12 , B01L2300/0822 , B01L2300/16 , B01L2300/161 , B05C1/025 , B05C9/06 , B05C9/14 , B05C11/028 , B05C13/02 , B05D1/02 , B05D1/20 , B05D1/28 , B05D7/5483 , B05D2252/04 , G01N2001/305 , Y10T156/179 , Y10T156/1798
摘要： An apparatus and method for producing a coated analytic substrate using a compact and portable automated instrument located in the laboratory setting at the point of use which can consistently produce one or a plurality of coated analytic substrates “on demand” for using the analytic substrate immediately after coating, preferably without a step of rinsing the coated analytic substrate before use. The apparatus preferably uses applicator cartridges having a reservoir containing the coating compositions used to form the coatings. Preferably the cartridges are removable and interchangeable to facilitate the production of individual analytic substrates having different coatings or different coating patterns. These coated analytic substrates have superior specimen adhesion characteristics due to the improved quality of the coatings applied by the coating apparatus and due to the quickness with which the coated analytic substrates can be used in the lab after production.
摘要翻译：使用位于实验室设置中的紧凑且便携式的自动化仪器来生产涂覆的分析基底的装置和方法，其可以在“使用”上一致地产生一个或多个涂覆的分析基底，以便立即使用分析底物优选在使用前没有漂洗涂覆的分析底物的步骤。该设备优选地使用具有包含用于形成涂层的涂料组合物的储存器的涂布器盒。优选地，盒是可移除的和可互换的，以便于生产具有不同涂层或不同涂层图案的各个分析基底。这些涂布的分析基材由于涂覆设备施加的涂层质量的提高以及涂层分析基材在生产后可以在实验室中使用的快速性而具有优异的样品粘附特性。

88. 发明授权

US07767440B2 Cover for a hybridization chamber 失效
标题翻译：盖杂交室
公开(公告)号：US07767440B2
公开(公告)日：2010-08-03
申请号：US10931521
申请日：2004-09-01
申请人： Martin Seippel , Sandrine Hamels , Christopher VanHuffel
发明人： Martin Seippel , Sandrine Hamels , Christopher VanHuffel
IPC分类号： C12M1/34
CPC分类号： B01L3/50853 , B01L2300/043 , B01L2300/048 , B01L2300/0822 , B01L2300/123 , G01N33/54366
摘要： Cover of a hybridization chamber with a peripheral frame with filling and ventilation holes extending from the upper face to the lower face of the frame, a peripheral shoulder outside the filling and ventilation holes on the lower face of the frame, a cover wall arranged within the frame, flush with its lower face and downwardly offset relative to its upper face and which substantially consists of at least one resilient plastics material.
摘要翻译：具有周边框架的封套，其具有从框架的上表面延伸到下表面的填充和通风孔，框架下表面上的填充物和通风孔外部的周边肩部，布置在框架的下表面的盖壁框架，与其下表面齐平并相对于其上表面向下偏移，并且其基本上由至少一种弹性塑料材料组成。

89. 发明授权

US07753457B2 Apparatus for removably retaining a slide within a cassette 有权
标题翻译：用于可拆卸地将滑块保持在盒内的装置
公开(公告)号：US07753457B2
公开(公告)日：2010-07-13
申请号：US10459881
申请日：2003-06-12
申请人： Nathan P. Wood
发明人： Nathan P. Wood
IPC分类号： A47B81/06
CPC分类号： B01L9/52 , B01L2200/025 , B01L2300/0822 , G01N1/312 , G01N2035/00089 , G02B21/34
摘要： Apparatus and slide cassette for removably retaining or securing a slide. The cassette includes trays for holding a slide. Each tray has a retaining lip at an end thereof. A first edge of a slide contacts a support member within the cassette when the slide that is placed in a slot. The support member can be an elastomeric member, a spring, a foam member, or an insert with slide retention surfaces. The support member pushes or urges the slide in the opposite direction so that an opposite edge of the slide contacts the retaining lips of the trays. As a result, the slide is removably retained or secured on the trays and between the retaining lips and the support member(s).
摘要翻译：用于可拆卸地保持或固定滑块的装置和滑动盒。盒式磁带包括用于保持滑块的托盘。每个托盘在其一端具有保持唇。当放置在槽中的滑块时，滑块的第一边缘接触盒内的支撑构件。支撑构件可以是弹性构件，弹簧，泡沫构件或具有滑动保持表面的插入件。支撑构件沿相反方向推动或推动滑块，使得滑动件的相对边缘接触托盘的保持唇。结果，滑动件可移除地保持或固定在托盘上并且在保持唇缘和支撑构件之间。

90. 发明授权

US07738094B2 Method, system, and compositions for cell counting and analysis 有权
标题翻译：用于细胞计数和分析的方法，系统和组合物
公开(公告)号：US07738094B2
公开(公告)日：2010-06-15
申请号：US12009659
申请日：2008-01-22
申请人： Edward Michael Goldberg
发明人： Edward Michael Goldberg
IPC分类号： G01N1/10 , G01N33/48
CPC分类号： G01N21/0303 , B01L3/502715 , B01L3/502761 , B01L2200/0684 , B01L2300/0822 , G01N15/1434 , G01N15/1459 , G01N15/1463 , G01N21/6428 , G01N21/6456 , G01N33/49 , G01N33/5094 , G01N2015/1006 , G01N2021/0321 , G01N2021/0325 , G01N2021/0346 , G01N2021/6419 , G01N2021/6441
摘要： The present invention provides a low cost imaged-based system for detecting, measuring and/or counting labeled features of biological samples, particularly blood specimens. In one aspect, the invention includes a system for imaging multiple features of a specimen that includes one or more light sources capable of successively generating illumination beams each having a distinct wavelength band and a plurality of differentially excitable labels capable of labeling a specimen comprising multiple features, such that each different feature is labeled with a different differentially excitable label. System of the invention may further include a controller operationally associated with the one or more light sources for successively directing illumination beams onto the specimen so that each of the different differentially excitable labels is successively caused to emit an optical signal within the same wavelength band, an optical system capable of collecting such emitted optical signals and forming successive images corresponding to the labeled features of the specimen on a light-responsive surface to form successive sets of image data thereof, and a disposable cuvette for collection and optical analysis of non-red blood cells.
摘要翻译：本发明提供了用于检测，测量和/或计数生物样品，特别是血液标本的标记特征的低成本基于成像的系统。一方面，本发明包括用于对样本的多个特征进行成像的系统，该系统包括一个或多个能够连续产生具有不同波长带的照明光束的光源，以及能够标记包含多个特征的样本的多个可分辨的可标记标签，使得每个不同的特征被标记有不同的可分辨的标签。本发明的系统还可以包括与所述一个或多个光源操作地相关联的控制器，用于将照射光束连续地引导到所述样本上，使得每个所述不同的可分辨的可标记标签被连续地引起在相同波长带内发射光信号，光学系统，其能够收集这种发射的光信号，并且在光响应表面上形成对应于标本的标记特征的连续图像以形成其连续的图像数据集，以及用于非红血液的收集和光学分析的一次性比色皿细胞。

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