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81. 发明申请

US20110005605A1 LIQUID DELIVERY CONTROL METHOD AND LIQUID DELIVERY CONTROL SYSTEM 审中-公开
标题翻译：液体输送控制方法和液体输送控制系统
公开(公告)号：US20110005605A1
公开(公告)日：2011-01-13
申请号：US12934021
申请日：2009-03-27
申请人： Masahiro Hanafusa
发明人： Masahiro Hanafusa
IPC分类号： F15D1/00
CPC分类号： G01N35/1095 , B01L3/50273 , B01L3/502746 , B01L2200/0642 , B01L2200/14 , B01L2300/0816 , B01L2300/087 , B01L2300/14 , B01L2300/16 , B01L2400/0415 , G01N2035/1034 , Y10T137/0379 , Y10T137/8593
摘要： The present invention provides a liquid delivery control method for delivering a liquid 8 by generating, in a microchannel 3 in which the liquid 8 is present, a differential pressure with respect to the liquid 8 by using a pump 6. The microchannel 3 is provided with a pressure loss varying portion 31 in which pressure loss changes in the direction of flow. The leading end 8a of the liquid 8 is judged to have reached the pressure loss varying portion 31 by detecting a change in pressure between the liquid 8 and the pump 6. With this arrangement, the location of the leading end of the liquid 8 can be properly detected without causing the structure that forms the microchannel 3 to become complex.
摘要翻译：本发明提供一种液体输送控制方法，用于通过使用泵6在存在液体8的微通道3中产生相对于液体8的压差来输送液体8.微通道3设置有压力损失变化部31，其中压力损失沿流动方向变化。通过检测液体8和泵6之间的压力变化来判断液体8的前端8a已经达到压力损失变化部分31.通过这种布置，液体8的前端的位置可以是适当地检测到不会导致形成微通道3的结构变得复杂。

82. 发明授权

US07867454B2 Thermal reaction device and method for using the same 有权
标题翻译：热反应装置及其使用方法
公开(公告)号：US07867454B2
公开(公告)日：2011-01-11
申请号：US11929370
申请日：2007-10-30
申请人： Federico Goodsaid , Marc Unger , Jiang Huang , Emerson Quan
发明人： Federico Goodsaid , Marc Unger , Jiang Huang , Emerson Quan
IPC分类号： B01L3/00
CPC分类号： B01L3/00 , B01L3/0248 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2200/0642 , B01L2200/142 , B01L2200/147 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/123 , B01L2300/1805 , B01L2400/0481 , B01L2400/0487 , B01L2400/0638 , B01L2400/0655 , C12Q1/686 , G01N27/453
摘要： An M.times.N matrix microfluidic device for performing a matrix of reactions, the device having a plurality of reaction cells in communication with one of either a sample inlet or a reagent inlet through a via formed within an elastomeric block of the device. Methods provided include a method for forming vias in parallel in an elastomeric layer of an elastomeric block of a microfluidic device, the method comprising using patterned photoresist masks and etching reagents to etch away regions or portions of an elastomeric layer of the elastomeric block.
摘要翻译：一种用于执行反应矩阵的M.times.N矩阵微流体装置，该装置具有多个反应池，其通过形成在装置的弹性体块内的通孔与样品入口或试剂入口之一连通。提供的方法包括在微流体装置的弹性体块的弹性体层中平行形成通孔的方法，该方法包括使用图案化的光致抗蚀剂掩模和蚀刻试剂来蚀刻掉弹性体块的弹性体层的区域或部分。

83. 发明授权

US07867453B2 Gravity-driven fraction separator and method thereof 有权
$Gravity-driven fraction separator and method thereof$
标题翻译：重力驱动级分分离器及其方法
公开(公告)号：US07867453B2
公开(公告)日：2011-01-11
申请号：US11524372
申请日：2006-09-21
申请人： Jhy-Wen Wu , Hung-Jen Yang , Nan-Kuang Yao
发明人： Jhy-Wen Wu , Hung-Jen Yang , Nan-Kuang Yao
IPC分类号： B01L3/00
CPC分类号： B01L3/502753 , B01L2200/0605 , B01L2200/0642 , B01L2300/069 , B01L2300/0816 , B01L2300/0864 , B01L2400/0457 , B01L2400/0487 , B01L2400/049
摘要： The present invention relates to a gravity-driven fraction separator and method thereof. The gravity-driven fraction separator is substantially a substrate having a microchannel structure arranged thereon, in which the microchannel structure is extending longitudinally on the substrate while sloping with respect to the level of the substrate by a specific angle. As a micro fluidics is being filled in a loading well situated upstream of the microchannel structure, the micro fluidics is driven by gravity to flow downstream in the microchannel structure while filling a plurality of manifolds formed in a area situated downstream of the microchannel structure, so that accurate quantification and separation of the micro fluidics using the plural manifolds, each having a specific length, can be achieved and provided for posterior inspection and analysis.
摘要翻译：本发明涉及一种重力驱动级分分离器及其方法。重力驱动级分分离器基本上是其上布置有微通道结构的基板，其中微通道结构在基板上纵向延伸，同时相对于基板的高度以特定角度倾斜。由于微流体被填充在位于微通道结构上游的装载井中，微流体通过重力驱动以在微通道结构的下游流动，同时填充形成在位于微通道结构下游的区域中的多个歧管，因此可以实现使用具有特定长度的多个歧管的微流体学的精确定量和分离，并提供用于后验检查和分析。

84. 发明申请

US20100294048A1 Sampling Device 有权
标题翻译：取样装置
公开(公告)号：US20100294048A1
公开(公告)日：2010-11-25
申请号：US12468367
申请日：2009-05-19
申请人： David McGuire , Kieran Curran , Julie Garvey , Damian Curtain
发明人： David McGuire , Kieran Curran , Julie Garvey , Damian Curtain
IPC分类号： G01N1/14
CPC分类号： C12Q1/6806 , B01L3/021 , B01L3/0293 , B01L7/52 , B01L2200/0642 , C12Q1/686
摘要： The present invention generally relates to devices, systems, and methods for acquiring and/or dispensing a sample without introducing a gas into a microfluidic system, such as a liquid bridge system. An exemplary embodiment provides a sampling device including: a sampling member for acquiring or dispensing a sample; and a supply of a fluid that is immiscible with the sample; in which the device is configured to provide a continuous flow of immiscible fluid enveloping the sampling member.
摘要翻译：本发明一般涉及用于获取和/或分配样品而不将气体引入诸如液体桥系统的微流体系统中的装置，系统和方法。示例性实施例提供一种采样装置，包括：用于获取或分配样本的采样部件; 和与样品不混溶的流体供应; 其中所述装置被配置为提供包围所述采样构件的不混溶流体的连续流。

85. 发明授权

US07825375B2 Microchip, method for using such microchip and mass spectrometry system 有权
标题翻译： Microchip，使用这种微芯片和质谱系统的方法
公开(公告)号：US07825375B2
公开(公告)日：2010-11-02
申请号：US12092357
申请日：2006-11-09
申请人： Toru Sano
发明人： Toru Sano
IPC分类号： H01J49/00
CPC分类号： H01J49/0418 , B01L3/502715 , B01L2200/027 , B01L2200/0642 , B01L2200/10 , B01L2300/0819 , G01N33/6851 , H01J49/0009
摘要： A microchip 100 is employed as target board of mass spectrometry. The microchip 100 includes a substrate 120, a plurality of sample-distributing sections, provided in the substrate 120 and contains samples that serve as a target of a mass spectrometry distributed therein, and a reference material-supplying channel provided in the substrate 120 and capable of being supplied with a reference material in the mass spectrometry. The plurality of sample-distributing sections are provided in the lateral side of the fine channel 102 for distributing the reference material along the fine channel 102 for distributing the reference material.
摘要翻译：使用微芯片100作为质谱的靶板。微芯片100包括基板120，多个样品分配部，设置在基板120中，并且包含用作分布在其中的质谱的靶的样品和设置在基板120中的参考材料供给通道，并且能够在质谱中提供参考物质。多个样品分配部分设置在细通道102的横向侧，用于沿着用于分配参考材料的细通道102分配参考材料。

86. 发明授权

US07815863B2 Cartridge for containing a specimen sample for optical analysis 有权
标题翻译：用于包含用于光学分析的样品样品的墨盒
公开(公告)号：US07815863B2
公开(公告)日：2010-10-19
申请号：US11294012
申请日：2005-12-05
申请人： Michael Kagan , Galla Chandra Rao , Jerry Prohaska , Tor Alden
发明人： Michael Kagan , Galla Chandra Rao , Jerry Prohaska , Tor Alden
IPC分类号： B01L3/00
CPC分类号： B01L3/508 , B01L2200/0642 , B01L2200/0689 , B01L2300/042 , B01L2300/046 , G01N21/11 , G01N35/0098 , Y10T436/2575
摘要： An improved cartridge for holding a fluid sample with a small volume is disclosed herein. The cartridge has a test chamber and a vestibule through which the test fluids are inserted into the test chamber. Improved grips are flared-out to aid manipulation. The handle portion is reinforced to prevent flexing, and a prefabricated trough along the edge of the land surface prevents introduction of the adhesive into the region for analysis. The cartridge has a stopper having a dual sealing mechanism, which seals the test chamber inlet between the vestibule and the test chamber, and the mouth of the vestibule so that when the stopper is in place, the test chamber is closed to the admission of air or other contaminants. The vestibule is similarly closed against escape of the overflow from the test chamber. The stopper is composed of a single elastomer. An improved locking mechanism has two flexible walls on either side of the handhold that locks into their respective keepers on the cartridge to provide a secure lock. Additionally, an improved method for loading the cartridge allows for an even distribution of magnetically responsive particles contained within a fluid sample to be viewed in an array through the optically clear land surface portion of the cartridge.
摘要翻译：本文公开了一种用于保持具有小体积的流体样品的改进的盒。盒具有测试室和前庭，测试流体通过该前庭插入测试室。改进的手柄被展开以帮助操纵。手柄部分被加强以防止弯曲，并且沿着陆面表面的边缘的预制槽防止粘合剂引入该区域用于分析。盒具有一个具有双重密封机构的塞子，该密封机构密封前庭和测试室之间的测试室入口以及前庭的口，使得当止动器就位时，测试室被关闭以允许空气或其他污染物。前庭也相似地封闭，防止溢出物从测试室逸出。止动器由单个弹性体组成。改进的锁定机构在手柄的任一侧具有两个柔性壁，其锁定在其相应的保持器上，以提供安全的锁定。此外，用于装载盒的改进方法允许包含在流体样品内的磁响应颗粒的均匀分布，以通过盒的光学透明的陆面表面部分在阵列中观察。

87. 发明申请

US20100251835A1 SAMPLE PROCESSING DEVICES, SYSTEMS, AND METHODS 审中-公开
标题翻译：样品处理装置，系统和方法
公开(公告)号：US20100251835A1
公开(公告)日：2010-10-07
申请号：US12754546
申请日：2010-04-05
申请人： Zbigniev Skrzypczynski
发明人： Zbigniev Skrzypczynski
IPC分类号： G01N1/10
CPC分类号： B01L3/502707 , B01L2200/0642 , B01L2300/0816 , B01L2300/1822 , B01L2300/1894 , B01L2400/0406 , B01L2400/0442 , B01L2400/049 , B01L2400/0677
摘要： The present invention provides microfluidic sample processing systems and devices comprising a plurality chambers and channels in fluidic communication with a sample loading port, and methods of making and employing such systems and devices. Preferably, the systems and devices of the present invention are configured such that temperature changes in the chambers allows liquid sample in the sample loading port to be drawn into the channels.
摘要翻译：本发明提供了微流体样品处理系统和装置，其包括与样品加载端口流体连通的多个室和通道，以及制造和采用这种系统和装置的方法。优选地，本发明的系统和装置被配置为使得室中的温度变化允许样品装载口中的液体样品被吸入通道。

88. 发明申请

US20100240142A1 ANALYZING DEVICE AND ANALYZING METHOD USING SAME 有权
标题翻译：分析装置和分析方法
公开(公告)号：US20100240142A1
公开(公告)日：2010-09-23
申请号：US12741929
申请日：2008-11-07
申请人： Hiroshi Saiki , Kouzou Tagashira , Tomohiro Kijima , Hirofumi Sugimoto , Kenji Watanabe , Hisashi Takahashi , Masaaki Kitoh
发明人： Hiroshi Saiki , Kouzou Tagashira , Tomohiro Kijima , Hirofumi Sugimoto , Kenji Watanabe , Hisashi Takahashi , Masaaki Kitoh
IPC分类号： G01N21/00 , G01N33/49 , G01N35/08
CPC分类号： G01N33/491 , B01L3/50273 , B01L3/502753 , B01L2200/027 , B01L2200/04 , B01L2200/0642 , B01L2200/10 , B01L2300/0654 , B01L2300/0806 , B01L2400/0406 , B01L2400/0409 , G01N21/07 , Y10T436/111666
摘要： A solution component 18a separated in a separating cavity 23 is connected to a measuring cavity through a connecting channel 37 and a measurement channel 38, and a first capillary cavity 33 is provided on one side of the separating cavity 23 so as to communicate with the connecting channel 37. The first capillary cavity 33 is formed to extend to the outside of a separation interface 18c of a sample liquid separated in the separating cavity 23.
摘要翻译：在分离空腔23中分离的溶液成分18a通过连接通道37和测量通道38连接到测量腔，并且第一毛细管腔33设置在分离空腔23的一侧，以便与连接第一毛细管腔33形成为延伸到在分离腔23中分离的样品液体的分离界面18c的外部。

89. 发明申请

US20100233798A1 CENTRIFUGAL FORCE-BASED MICROFLUIDIC DEVICE AND METHOD OF FABRICATING THE SAME 有权
标题翻译：基于离心力的微流体装置及其制造方法
公开(公告)号：US20100233798A1
公开(公告)日：2010-09-16
申请号：US12708021
申请日：2010-02-18
申请人： Chung-ung KIM , Ki-ju Lee , Jong-Jin Park , Dong-hwi Cho , Su-bong Bae , Jong-cheol Kim
发明人： Chung-ung KIM , Ki-ju Lee , Jong-Jin Park , Dong-hwi Cho , Su-bong Bae , Jong-cheol Kim
IPC分类号： C12M3/00 , B32B37/12 , B01D33/15 , B01J19/00
CPC分类号： B01L3/50273 , B01L3/502715 , B01L2200/0642 , B01L2200/141 , B01L2300/044 , B01L2300/0803 , B01L2300/0806 , B01L2300/0887 , B01L2400/0409
摘要： Provided are a centrifugal force-based microfluidic device, in which biochemical treatments of samples are executed, and a method of fabricating the centrifugal force-based microfluidic device. The centrifugal force-based microfluidic device is mountable on a rotatable device and includes: a disk-shaped portion; and an inlet hole defined within, configured to receive fluid from outside the centrifugal force-based microfluidic device having a first opening with a first inner diameter, and a second opening disposed on the first opening having a second inner diameter greater than the first inner diameter, and a depth of the second opening greater than a height of a fluid droplet formable in the second opening.
摘要翻译：提供了一种基于离心力的微流体装置，其中执行样品的生物化学处理，以及制造基于离心力的微流体装置的方法。基于离心力的微流体装置可安装在可旋转的装置上，包括：盘形部分; 以及限定在其内的入口孔，其构造成从具有第一内径的第一开口的基于离心力的微流体装置的外部接收流体，以及设置在第一开口上的第二开口，其具有大于第一内径的第二内径并且第二开口的深度大于在第二开口中可形成的流体液滴的高度。

90. 发明申请

US20100144054A1 REACTOR PLATE AND REACTION PROCESSING METHOD 有权
标题翻译：反应板和反应处理方法
公开(公告)号：US20100144054A1
公开(公告)日：2010-06-10
申请号：US12595515
申请日：2008-02-29
申请人： Nobuhiro Hanafusa
发明人： Nobuhiro Hanafusa
IPC分类号： G01N1/00 , G01N33/00 , C12M1/00 , G01N21/64 , G01N21/00
CPC分类号： B01L3/5025 , B01L3/5027 , B01L2200/0642 , B01L2200/141 , B01L2200/16 , B01L2300/046 , B01L2300/0829 , B01L2300/0864 , B01L2400/0478 , B01L2400/0622 , B01L2400/0644 , G01N2035/00158 , G01N2035/00277
摘要： Disclosed herein is a reactor plate which prevents the entry of foreign matter from outside and the pollution of an outside environment. The reactor plate includes a sealed reaction well (5), reaction well channels (13, 15, 17) connected to the reaction well (5), and a syringe (51) for sending a liquid to the reaction well channels (13, 15, 17) and the reaction well (5). The syringe (51) has a cylinder (51a), a plunger (51b), and a cover body (51d). The cover body (51d) has flexibility in the sliding direction of the plunger (51b), and is connected to the cylinder (51a) and the plunger (51b) to create a sealed space (51e) enclosed with the cylinder (51a), the plunger (51b), and the cover body (51d). The cover body (51d) is provided to hermetically cut off a part of an inner wall of the cylinder (51a) to be brought into contact with the plunger (51b) from an atmosphere outside the cylinder (51a).
摘要翻译：本文公开了一种反应器板，其防止外来物质进入外部并污染外部环境。反应器板包括密封的反应槽（5），连接到反应井（5）的反应井通道（13,15,17）和用于将液体送至反应井通道（13,15）的注射器，17）和反应槽（5）。注射器（51）具有圆筒（51a），柱塞（51b）和盖体（51d）。盖主体51d在柱塞51b的滑动方向上具有柔性，并与缸51a和柱塞51b连接，形成由气缸51a封闭的密封空间51e。柱塞（51b）和盖体（51d）。盖体（51d）设置成气缸（51a）的内壁的一部分与气缸（51a）外部的气氛与柱塞（51b）接触。

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