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81. 发明申请

US20160310642A1 Water Disintegrable Flushable Catheter with a Hydrophilic Coating 审中-公开
标题翻译：具有亲水性涂层的水分散性可冲洗导管
公开(公告)号：US20160310642A1
公开(公告)日：2016-10-27
申请号：US15103774
申请日：2014-12-10
申请人： HOLLISTER INCORPORATED
发明人： John T. CLARKE , Horacio MONTES DE OCA BALDERAS , Shamsedin ROSTAMI
IPC分类号： A61L29/08 , A61L29/14 , A61M25/00
CPC分类号： A61L29/085 , A61L29/043 , A61L29/14 , A61L29/148 , A61L2400/10 , A61L2420/08 , A61M25/002 , A61M25/0043 , A61M25/0045 , A61M25/0082 , A61M25/0097 , C08L67/04 , C08L39/06
摘要： This is a water disintegrable, flushable catheter that will dissolve or biodegrade in water. It is coated with a hydrophilic coating and will achieve lubricity values typical of a hydrophilic catheter. The catheter may be formed of a bi-layer tube that has a biodegradable outer layer such as polylactic acid and a purely water disintegrable inner layer, e.g., polyvinyl alcohol (PVOH). The outer layer will support the hydrophilic coating even when it's wetted and thus acts as a stable primer layer for hydrophilic style coatings. The outer layer bonds well to the water disintegrable inner layer but also allows a hydrophilic coating to be applied on top. The outer layer acts as a temporary water barrier. This water barrier allows the hydrophilic coating to be hydrated prior to use but prevents water molecules from attacking the PVOH inner layer. Alternatively, a hydrophilic coating that bonds to either the tubing directly or a via a primer layer but unlike typical hydrophilic coatings the coating is pre-activated by organic activation agents other than water and thus the catheter does not break down in the packaging or sterilization
摘要翻译：这是一种水分解，可冲洗的导管，将在水中溶解或生物降解。它涂覆有亲水涂层，并且将实现亲水导管的典型的润滑性值。导管可以由双层管形成，该双层管具有可生物降解的外层，例如聚乳酸和纯水崩解内层，例如聚乙烯醇（PVOH）。外层即使在润湿时也能支撑亲水性涂层，因此作为亲水性涂层的稳定底漆层。外层与水可分解内层良好结合，但也可以在顶部施加亲水涂层。外层作为临时防水屏障。该水屏障允许亲水涂层在使用前水合，但防止水分子攻击PVOH内层。或者，亲水涂层直接或通过底漆层连接到管道上，但与典型的亲水涂层不同，涂层由水以外的有机活化剂预活化，因此导管不会在包装或灭菌中分解

82. 发明申请

US20140193476A1 CHITOSAN HYDROGEL DERIVATIVES AS A COATING AGENT WITH BROAD SPECTRUM OF ANTIMICROBIAL ACTIVITIES 有权
标题翻译： CHOSOSAN氢化衍生物作为具有广谱抗体活性的涂层剂
公开(公告)号：US20140193476A1
公开(公告)日：2014-07-10
申请号：US14209602
申请日：2014-03-13
申请人： Chan Bee Eng Mary , Poon Yin Fun , Mouad Lamrani , Shinichi Hamaguchi
发明人： Chan Bee Eng Mary , Poon Yin Fun , Mouad Lamrani , Shinichi Hamaguchi
IPC分类号： A61L27/34 , A61L27/20 , A61K8/73 , A61L27/54
CPC分类号： A61L27/34 , A61K8/042 , A61K8/736 , A61L27/20 , A61L27/52 , A61L27/54 , A61L29/043 , A61L29/085 , A61L29/145 , A61L31/042 , A61L31/10 , A61L31/145 , A61L31/16 , A61L2300/232 , A61L2300/404 , A61Q19/00 , C08B37/003 , C08F290/10 , C08G81/00 , C08J3/075 , C08J3/24 , C08J3/28 , C08J2305/08 , G02B1/043 , C08L1/00 , C08F220/28 , C08L5/08
摘要： The present invention relates to water soluble quaternized chitosan derivatives which form hydrogel matrix with broad antimicrobial properties for the protection and coating of medical device. Hydrogel is attractive as an antimicrobial coating since its hydrophilicity intrinsically prevents the reversible nonspecific attachment of microbes.In order to achieve hydrogel formation, quaternized chitosan can be grafted with polymerizable groups, especially photocrosslinkable groups, such as methacrylates, PEG derivatives and be converted into hydrogels through a thermal or UV polymerization process. Hydrogels are hydrated cross-linked polymeric systems that contain water in an equilibrium state forming cushion water shield. The present invention is widely used in many medical devices. This invention describes the formation of novel hydrogels based on quaternized ammonium chitosan derivatives which has been grafted with photocrosslinkable groups, hence providing hydrogels as antimicrobial water shield coating agent.
摘要翻译：本发明涉及水溶性季铵化壳聚糖衍生物，其形成具有广泛抗微生物性质的水凝胶基质用于保护和涂覆医疗装置。水凝胶作为抗微生物涂层是有吸引力的，因为它的亲水性本质上防止微生物的可逆非特异性附着。为了实现水凝胶形成，季铵化壳聚糖可以用可聚合基团，特别是可光致交联的基团如甲基丙烯酸酯，PEG衍生物接枝，并通过热或UV聚合方法转化成水凝胶。水凝胶是水合交联聚合物体系，其在平衡状态下形成缓冲水屏蔽层。本发明广泛应用于许多医疗装置。本发明描述了基于已经用光可交联基团接枝的季铵化壳聚糖衍生物的新型水凝胶的形成，因此提供水凝胶作为抗微生物水屏蔽涂层剂。

83. 发明授权

US08753664B2 Medical device intended to come into contact with a patient's tissue and related manufacturing method 有权
标题翻译：旨在与患者组织接触的医疗装置及相关制造方法
公开(公告)号：US08753664B2
公开(公告)日：2014-06-17
申请号：US13316022
申请日：2011-12-09
申请人： Vithuy Dao , Robert Michelot , Eric Perouse
发明人： Vithuy Dao , Robert Michelot , Eric Perouse
IPC分类号： A61F2/00 , A61K8/73 , A61K9/70
CPC分类号： A61K8/731 , A61K9/7007 , A61L27/20 , A61L27/58 , A61L29/043 , A61L29/148 , A61L31/042 , A61L31/148 , C08L1/04
摘要： A device including a body (12) including fibers without oxidized cellulose. The body (12) also includes fibers containing oxidized cellulose.
摘要翻译：一种包括主体（12）的装置，包括没有氧化纤维素的纤维。主体（12）还包括含有氧化纤维素的纤维。

84. 发明授权

US08709470B2 Chitosan hydrogel derivatives as a coating agent with broad spectrum of antimicrobial activities 有权
标题翻译：壳聚糖水凝胶衍生物作为具有广谱抗菌活性的涂层剂
公开(公告)号：US08709470B2
公开(公告)日：2014-04-29
申请号：US13383684
申请日：2009-07-13
申请人： Chan Bee Eng Mary , Poon Yin Fun , Mouad Lamrani , Shinichi Hamaguchi
发明人： Chan Bee Eng Mary , Poon Yin Fun , Mouad Lamrani , Shinichi Hamaguchi
IPC分类号： A61K9/00 , A61K31/722 , A61K8/60 , C08B37/08
CPC分类号： A61L27/34 , A61K8/042 , A61K8/736 , A61L27/20 , A61L27/52 , A61L27/54 , A61L29/043 , A61L29/085 , A61L29/145 , A61L31/042 , A61L31/10 , A61L31/145 , A61L31/16 , A61L2300/232 , A61L2300/404 , A61Q19/00 , C08B37/003 , C08F290/10 , C08G81/00 , C08J3/075 , C08J3/24 , C08J3/28 , C08J2305/08 , G02B1/043 , C08L1/00 , C08F220/28 , C08L5/08
摘要： The present invention relates to water soluble quaternized chitosan derivatives which form hydrogel matrix with broad antimicrobial properties for the protection and coating of medical device. Hydrogel is attractive as an antimicrobial coating since its hydrophilicity intrinsically prevents the reversible nonspecific attachment of microbes.In order to achieve hydrogel formation, quaternized chitosan can be grafted with polymerizable groups, especially photocrosslinkable groups, such as methacrylates, PEG derivatives and be converted into hydrogels through a thermal or UV polymerization process. Hydrogels are hydrated cross-linked polymeric systems that contain water in an equilibrium state forming cushion water shield. The present invention is widely used in many medical devices. This invention describes the formation of novel hydrogels based on quaternized ammonium chitosan derivatives which has been grafted with photocrosslinkable groups, hence providing hydrogels as antimicrobial water shield coating agent.
摘要翻译：本发明涉及水溶性季铵化壳聚糖衍生物，其形成具有广泛抗微生物性质的水凝胶基质用于保护和涂覆医疗装置。水凝胶作为抗微生物涂层是有吸引力的，因为它的亲水性本质上防止微生物的可逆非特异性附着。为了实现水凝胶形成，季铵化壳聚糖可以用可聚合基团，特别是可光致交联的基团如甲基丙烯酸酯，PEG衍生物接枝，并通过热或UV聚合方法转化成水凝胶。水凝胶是水合交联聚合物体系，其在平衡状态下形成缓冲水屏蔽层。本发明广泛应用于许多医疗装置。本发明描述了基于已经用光可交联基团接枝的季铵化壳聚糖衍生物的新型水凝胶的形成，因此提供水凝胶作为抗微生物水屏蔽涂层剂。

85. 发明授权

US08541393B2 Antimicrobial locking solutions comprising taurinamide derivatives and biologically acceptable salts and acids, with the addition of small concentrations of heparin 有权
标题翻译：包含牛磺酰胺衍生物和生物可接受的盐和酸的抗微生物锁定溶液，加入少量肝素
公开(公告)号：US08541393B2
公开(公告)日：2013-09-24
申请号：US13199605
申请日：2011-09-02
申请人： Frank R. Prosl
发明人： Frank R. Prosl
IPC分类号： A61K31/727 , A61K31/185 , A61K31/18
CPC分类号： A61L29/16 , A01N25/02 , A01N43/88 , A61K31/18 , A61K31/185 , A61K31/727 , A61L29/00 , A61L29/043 , A61L2300/204 , A61L2300/406 , A61K2300/00
摘要： The present invention relates to inhibiting or preventing infection and protecting against patency complications after a blood catheter has been inserted in a patient comprising administering to the device a pharmaceutically effective amount of a composition comprising (A) at least one taurinamide derivative, (B) at least one compound selected from the group consisting of biologically acceptable acids and biologically acceptable salts thereof; and (C) heparin at a low concentration.
摘要翻译：本发明涉及在血管插入患者之后抑制或预防感染并防止通畅并发症，包括向该装置施用药学有效量的组合物，其包含（A）至少一种牛磺酰胺衍生物，（B）在选自生物可接受的酸和其生物可接受的盐的至少一种化合物; 和（C）低浓度的肝素。

86. 发明授权

US08414925B2 Processing of acylchitosan hydrogels 有权
公开(公告)号：US08414925B2
公开(公告)日：2013-04-09
申请号：US12067727
申请日：2006-10-11
申请人： Thomas Freier
发明人： Thomas Freier
IPC分类号： A61K9/14
CPC分类号： A61L31/042 , A61K9/0024 , A61K9/0092 , A61K9/1652 , A61K47/36 , A61L27/20 , A61L27/34 , A61L27/50 , A61L27/52 , A61L29/043 , A61L29/085 , A61L29/14 , A61L29/145 , A61L31/10 , A61L31/14 , A61L31/145 , C08B37/003 , C08J3/075 , C08J2305/08 , C08L5/08 , D01D5/06 , D01F9/00
摘要： An article containing N-acylchitosan is manufactured by a process comprising the steps of providing a mixture containing chitosan and/or N-acylchitosan, and extruding the mixture to form an N-acylchitosan hydrogel. Alternatively, the process comprising the steps of providing a chitosan and/or N-acylchitosan hydrogel, and extruding the hydrogel. An article with a memorized shape is formed by fixing the N-acylchitosan hydrogel in a desired shape, and at least partially drying the fixed hydrogel. A patient is treated by injecting the N-acylchitosan hydrogel.

87. 发明申请

US20120213838A1 MEDICAL DEVICE FOR PLACEMENT INTO A LUMEN AND MANUFACTURING METHOD THEREOF 审中-公开
标题翻译：用于放置在其中的医疗装置及其制造方法
公开(公告)号：US20120213838A1
公开(公告)日：2012-08-23
申请号：US13392028
申请日：2010-08-26
申请人： Kensuke Egashira , Hiroyuki Tsujimoto , Kaori Hara , Yusuke Tsukada , Yohei Bando , Matsuya Manabe
发明人： Kensuke Egashira , Hiroyuki Tsujimoto , Kaori Hara , Yusuke Tsukada , Yohei Bando , Matsuya Manabe
IPC分类号： A61K9/00 , A61K31/4709 , A61K31/10 , A61P7/02 , A61F2/82 , A61K9/10 , C25D13/12 , B05D5/00 , A61K31/722 , A61P9/08 , B82Y5/00
CPC分类号： A61L31/16 , A61F2/82 , A61F2250/0067 , A61L29/043 , A61L29/06 , A61L29/08 , A61L29/085 , A61L29/16 , A61L31/022 , A61L31/042 , A61L31/06 , A61L31/08 , A61L31/10 , A61L2300/416 , A61L2300/42 , A61L2300/606 , A61L2300/624 , A61L2400/12 , A61L2400/18 , C08L5/08 , C08L67/04 , C08L5/04
摘要： The present invention provides a medical device for placement into a lumen such as a stent and a catheter whose surface is uniformly and sufficiently coated with a drug, and a process thereof with easy way and with low cost. The medical device is coated with mixed particles of drug particles whose surface is modified with positive-charge and biocompatible nanoparticles. In the invention, a drug can be taken into a cell through the dissolution of the drug particle together with the biocompatible nanoparticle after a DES is placed in a biological body.
摘要翻译：本发明提供了一种医疗装置，其用于放置在诸如支架和内窥镜的管腔中，其表面均匀且充分地涂覆药物，并且其方法以简单的方式并且以低成本。该医疗装置涂覆有表面用正电荷和生物相容性纳米粒子改性的药物颗粒的混合颗粒。在本发明中，通过在将DES置于生物体中之后通过药物颗粒与生物相容纳米颗粒的溶解将药物吸入细胞。

88. 发明申请

US20120177719A1 MEDICAL DEVICE INTENDED TO COME INTO CONTACT WITH A PATIENT'S TISSUE AND RELATED MANUFACTURING METHOD 有权
标题翻译：旨在与患者组织接触的医疗器械及相关制造方法
公开(公告)号：US20120177719A1
公开(公告)日：2012-07-12
申请号：US13316022
申请日：2011-12-09
申请人： Vithuy Dao , Robert Michelot , Eric Perouse
发明人： Vithuy Dao , Robert Michelot , Eric Perouse
IPC分类号： A61K9/70 , A61K31/717 , A61K38/14 , A61P31/00 , A61P7/02 , A61P33/00 , A61P29/00 , A61P31/10 , A61K47/38 , D06M101/06
CPC分类号： A61K8/731 , A61K9/7007 , A61L27/20 , A61L27/58 , A61L29/043 , A61L29/148 , A61L31/042 , A61L31/148 , C08L1/04
摘要： A device including a body (12) including fibers without oxidized cellulose. The body (12) also includes fibers containing oxidized cellulose.
摘要翻译：一种包括主体（12）的装置，包括没有氧化纤维素的纤维。主体（12）还包括含有氧化纤维素的纤维。

89. 发明授权

US08178663B2 Ester derivatives of hyaluronic acid for the preparation of hydrogel materials by photocuring 有权
公开(公告)号：US08178663B2
公开(公告)日：2012-05-15
申请号：US12246970
申请日：2008-10-07
申请人： Davide Bellini , Anna Maria Zanellato
发明人： Davide Bellini , Anna Maria Zanellato
IPC分类号： C08B37/08
CPC分类号： A61K9/0014 , A61K9/0019 , A61K47/36 , A61L27/20 , A61L29/043 , A61L31/042 , C08B37/0072 , C08L5/08
摘要： The present invention relates to hyaluronic acid ester derivatives, whose carboxylic groups are partially esterified with hydroxy groups of propiophenone derivatives, to the hydrogel materials consisting of the said hyaluronic acid ester derivatives, to their preparation process by photocuring of the hyaluronic acid ester derivatives, and their use in the biomedical, sanitary and surgical fields, and in the medical field as controlled release systems for drugs.

90. 发明申请

US20110076314A1 HYDROPHOBIC POLYSACCHARIDES WITH SILYL ETHER LINKAGES HAVING ENHANCED DEGRADATION AND MEDICAL ARTICLES MADE THEREFROM 有权
标题翻译：具有增强降解的SILYL以及其他链接的疏水性多糖与其制成的医学文章
公开(公告)号：US20110076314A1
公开(公告)日：2011-03-31
申请号：US12894929
申请日：2010-09-30
申请人： Aleksey V. Kurdyumov
发明人： Aleksey V. Kurdyumov
IPC分类号： A61K9/14 , C08B30/18 , A61K31/715 , A61P9/12 , A61P35/00 , A61P25/08 , A61P25/16 , A61P7/02 , A61P31/10 , A61P27/06 , A61P25/24 , A61P25/04 , A61F2/00
CPC分类号： A61L29/043 , A61L15/28 , A61L27/20 , A61L31/042 , C08L5/00
摘要： Hydrophobic α(1→4)glucopyranose polymers with enhanced degradation properties are described. Between the α(1→4)glucopyranose polymeric portion and the hydrophobic portion exists a linker portion having a silyl ether chemistry that facilitates degradation of the polymer. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo at an increased rate. Matrices including and capable of releasing a bioactive agent in vivo are also described.
摘要翻译：描述了具有增强的降解性质的疏水性α（1→4）吡喃葡萄糖聚合物。在α（1→4）吡喃葡萄糖聚合物部分和疏水部分之间存在具有促进聚合物降解的甲硅烷基醚化学性质的接头部分。可以由这些聚合物形成可生物降解的基质，并且该基质可用于制备可植入和可注射的医疗装置，其中基质能够以增加的速率在体内降解。还描述了包括和能够在体内释放生物活性剂的基质。

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