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81. 发明申请

US20140221522A1 COATING FOR SUBSTRATE 有权
标题翻译：涂层涂料
公开(公告)号：US20140221522A1
公开(公告)日：2014-08-07
申请号：US14172342
申请日：2014-02-04
申请人： Per Antoni , Daniel Nystrom , Lars Vincent , Krzysztof Pietrzak
发明人： Per Antoni , Daniel Nystrom , Lars Vincent , Krzysztof Pietrzak
IPC分类号： A61L31/10 , A61L33/08 , A61L33/00 , A61L31/16
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/404 , A61L2300/416 , A61L2300/42 , A61L2300/452 , A61L2400/10 , A61L2420/06
摘要： There is provided inter alia a substrate with a surface having a hydrophilic coating comprising a cross-linked copolymer of components A and B, and optional components C and D; wherein component A comprises one or more C2-C16 hydrophilic monomers each bearing one or more alkene and/or alkyne groups; component B comprises one or more hydrophilic polymers each bearing two or more alkene and/or alkyne groups; component C, if present, comprises one or more beneficial agents each bearing one or more alkene or alkyne groups; and component D, if present, comprises one or more low molecular weight cross-linking agents each bearing two or more functional groups independently selected from thiol, alkene and alkyne groups; wherein the cross-linked copolymer is formed by radical polymerisation involving the alkene and/or alkyne groups of components A, B and C (if present) and involving the functional groups of component D (if present); wherein the hydrophilic coating optionally comprises component E which comprises one or more beneficial agents, wherein component E does not form a copolymer with components A, B, C (if present) and D (if present); and wherein the hydrophilic coating is covalently attached to the surface of the substrate.
摘要翻译：尤其提供一种具有表面的基底，该表面具有包含组分A和B的交联共聚物和任选的组分C和D的亲水涂层; 其中组分A包含一个或多个各自带有一个或多个烯烃和/或炔烃基团的C 2 -C 16亲水性单体; 组分B包含一种或多种各自带有两个或多个烯烃和/或炔基的亲水性聚合物; 组分C（如果存在）包含一种或多种各自带有一个或多个烯烃或炔基的有益试剂; 和组分D（如果存在）包含一种或多种低分子量交联剂，其各自具有独立地选自硫醇，烯烃和炔基的两个或多个官能团; 其中所述交联共聚物通过包含组分A，B和C的烯烃和/或炔基（如果存在）并涉及组分D（如果存在）的官能团的自由基聚合形成; 其中亲水涂层任选地包含组分E，其包含一种或多种有益试剂，其中组分E不与组分A，B，C（如果存在）和D（如果存在）形成共聚物; 并且其中所述亲水涂层共价连接到所述基材的表面。

82. 发明授权

US08741378B1 Methods of coating an implantable device 有权
标题翻译：涂敷可植入装置的方法
公开(公告)号：US08741378B1
公开(公告)日：2014-06-03
申请号：US11022228
申请日：2004-12-23
申请人： Wouter E. Roorda , Ni Ding
发明人： Wouter E. Roorda , Ni Ding
IPC分类号： B05D3/02 , B05D1/02 , A61L33/00
CPC分类号： A61L31/08 , A61F2/82 , A61F2002/30062 , A61F2002/30064 , A61K31/436 , A61K31/439 , A61L31/10 , A61L31/16 , A61L2300/216 , A61L2300/606 , A61L2420/02 , A61L2420/06 , B05D1/02
摘要： Methods of coating an implantable device, such as a stent, are provided.
摘要翻译：提供了诸如支架之类的可植入装置的涂覆方法。

83. 发明授权

US08739379B2 Crimping apparatus 有权
标题翻译：压接装置
公开(公告)号：US08739379B2
公开(公告)日：2014-06-03
申请号：US13197611
申请日：2011-08-03
申请人： Stephen Dirk Pacetti
发明人： Stephen Dirk Pacetti
IPC分类号： B23P19/04 , A61F2/82
CPC分类号： A61F2/958 , A61F2/06 , A61F2/07 , A61F2/82 , A61F2002/9522 , A61F2240/001 , A61L31/022 , A61L31/048 , A61L31/16 , A61L2300/416 , A61L2420/06 , B05C11/00 , B21D39/048 , Y10T29/49863 , Y10T29/49865 , Y10T29/49925 , Y10T29/49927 , Y10T29/53996
摘要： An apparatus is disclosed including a workspace for receiving a stent and a delivery device for the stent; a source for exposing the stent in the workspace to a plasticizing agent, vapor, or moisture, wherein the stent can be reduced in diameter in the workspace while under exposure of the plasticizing agent, vapor or moisture; and a device for reducing the diameter of the stent in the workspace to position the stent on or within the deliver device.
摘要翻译：公开了一种包括用于接收支架的工作空间和用于支架的输送装置的装置; 用于将工作空间中的支架暴露于塑化剂，蒸汽或水分的源，其中在塑化剂，蒸气或水分暴露的同时，支架可以在工作空间中直径减小; 以及用于在工作空间中减小支架的直径以将支架定位在输送装置上或内部的装置。

84. 发明授权

US08734825B2 Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens 有权
标题翻译：将水溶性或水不溶性治疗剂局部输送到体腔表面
公开(公告)号：US08734825B2
公开(公告)日：2014-05-27
申请号：US13919443
申请日：2013-06-17
申请人： Covidien LP
发明人： Eugene T. Michal , Matthew J. Pollman
IPC分类号： A61F13/00 , A61L29/08 , A61L29/16 , A61M25/10
CPC分类号： A61L29/085 , A61L29/148 , A61L29/16 , A61L33/0005 , A61L2300/204 , A61L2300/416 , A61L2400/00 , A61L2420/06 , A61M25/10 , A61M25/1027 , A61M2025/105 , A61M2025/1075 , A61M2025/1081 , A61M2025/109 , C08L33/02
摘要： A method and device for local delivery of a water-insoluble therapeutic agent to the tissue of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with a non-durable coating which comprises poly(HEMA) complexed with iodine and has a substantially water-insoluble therapeutic agent dispersed therein. The medical disposable device is inserted into a body lumen, and expanded to contact the non-durable coating against the body lumen and deliver the substantially water-insoluble therapeutic agent to the body lumen tissue.
摘要翻译：公开了一种用于将水不溶性治疗剂局部递送到正常或患病体腔的组织的方法和装置。医疗一次性装置（例如球囊导管的球囊）的可膨胀结构涂覆有非耐久涂层，其包含与碘络合的聚（HEMA），并且其中分散有基本上不溶于水的治疗剂。将医疗一次性装置插入体腔中，并且膨胀以将非耐久涂层接触体腔，并将基本上不溶于水的治疗剂输送到体腔组织。

85. 发明申请

US20140100644A1 DRUG-ELUTING MEDICAL IMPLANTS 有权
标题翻译：药物植入药剂
公开(公告)号：US20140100644A1
公开(公告)日：2014-04-10
申请号：US14102945
申请日：2013-12-11
申请人： Maria Palasis , Changcheng You , Danny Concagh , Lee Core , Kicherl Ho , Upma Sharma , Gregory T. Zugates
发明人： Maria Palasis , Changcheng You , Danny Concagh , Lee Core , Kicherl Ho , Upma Sharma , Gregory T. Zugates
IPC分类号： A61F2/86
CPC分类号： A61L31/16 , A61F2/04 , A61F2/86 , A61F2/90 , A61F2210/0004 , A61F2210/0057 , A61F2230/0054 , A61F2250/0067 , A61K9/0024 , A61K31/337 , A61L31/06 , A61L31/10 , A61L31/148 , A61L2300/216 , A61L2300/416 , A61L2420/06 , A61L2420/08 , C08L67/04 , D04C1/06 , D10B2403/0112 , D10B2509/06
摘要： Disclosed are self-expanding medical implants for placement within a lumen of a patient. The implants comprise a woven or non-woven structure having a substantially tubular configuration, and are designed to be low-profile such that they are deliverable with a small diameter catheter. The implants have a high recoverability and desired mechanical properties.
摘要翻译：公开了用于放置在患者的内腔内的自扩张医用植入物。植入物包括具有基本上管状构造的织造或非织造结构，并且被设计为低轮廓，使得它们可以用小直径导管递送。植入物具有高回收性和所需的机械性能。

86. 发明授权

US08664202B2 Cross-linked bioactive hydrogel matrices 有权
标题翻译：交联生物活性水凝胶基质
公开(公告)号：US08664202B2
公开(公告)日：2014-03-04
申请号：US13252500
申请日：2011-10-04
申请人： Francis V. Lamberti , Richard Chris Klann , Ronald Stewart Hill
发明人： Francis V. Lamberti , Richard Chris Klann , Ronald Stewart Hill
IPC分类号： A01N57/00
CPC分类号： A61L27/222 , A61F2/0063 , A61K47/42 , A61L27/025 , A61L27/12 , A61L27/20 , A61L27/22 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/3608 , A61L27/446 , A61L27/46 , A61L27/52 , A61L27/54 , A61L31/10 , A61L2300/112 , A61L2300/412 , A61L2420/04 , A61L2420/06 , A61L2430/02 , B29C39/003 , B29L2031/7532 , Y10T428/29 , Y10T428/2947 , Y10T428/31551 , Y10T428/31786 , C08L5/02 , C08L89/00
摘要： The present invention is directed to a stabilized cross-linked hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component that are covalently linked, and at least one stabilizing or enhancing agent, wherein the first high molecular weight component and the second high molecular weight component are each selected from the group consisting of polyglycans and polypeptides. This stabilized hydrogel matrix may be prepared as bioactive gels, pastes, slurries, cell attachment scaffolds for implantable medical devices, and casting or binding materials suitable for the construction of medical devices. The intrinsic bioactivity of the hydrogel matrix makes it useful as a gel or paste in multiple applications, including as a cell attachment scaffold that promotes wound healing around an implanted device, as gels and pastes for induction of localized vasculogenesis, wound healing, tissue repair, and regeneration, as a wound adhesive, and for tissue bulking.
摘要翻译：本发明涉及包含共价连接的第一高分子量组分和第二高分子量组分以及至少一种稳定或增强剂的稳定的交联水凝胶基质，其中第一高分子量组分和第二高分子量组分各自选自聚糖和多肽。这种稳定化的水凝胶基质可以制备成用于可植入医疗装置的生物活性凝胶，糊剂，浆液，细胞附着支架，以及适于构建医疗装置的浇铸或粘结材料。水凝胶基质的固有生物活性使其可用作多种应用中的凝胶或糊状物，包括作为促进植入装置周围的伤口愈合的细胞附着支架，作为用于诱导局部血管发生，伤口愈合，组织修复的凝胶和糊剂，并再生，作为伤口粘合剂，并用于组织膨胀。

87. 发明授权

US08652645B2 Osteosynthesis with nano-silver 有权
标题翻译：纳米银骨质合成
公开(公告)号：US08652645B2
公开(公告)日：2014-02-18
申请号：US12792234
申请日：2010-06-02
申请人： Elvira Dingeldein , Cyrille Gasqueres , Frank Witte , Amir Eliezer
发明人： Elvira Dingeldein , Cyrille Gasqueres , Frank Witte , Amir Eliezer
IPC分类号： B32B15/04 , A61F2/02 , C25D11/00
CPC分类号： C25D11/024 , A61L27/306 , A61L27/54 , A61L31/088 , A61L31/16 , A61L2300/102 , A61L2300/104 , A61L2300/606 , A61L2300/802 , A61L2400/12 , A61L2400/18 , A61L2420/06 , C25D11/005 , C25D11/022
摘要： The present invention relates generally to an antibacterial coating which is composed of silver, to medical tools and to implants comprising such a coating and to a method as well to an apparatus for the production of such a coating. The medical tools or the dental or orthopaedic implant comprises a metal or metal alloy having a treated surface wherein the treated surface is at least partially converted to an oxide film by plasma electrolytic oxidation using a colloid-dispersed system and wherein the converted surface is partially covered by islands formed by colloid-dispersed silver-particles of the colloid-dispersed system. An Ag—TiO2 coating shows excellent properties in terms of antibacterial efficacy (even against multi-resistant strains), adhesion and biocompatibility. The life-time of an implant in a human body is increased. The antibacterial coating can be used in the field of traumatology, orthopaedic, osteosynthesis and/or endoprothesis, especially where high infection risk exists.
摘要翻译：本发明一般涉及一种由银组成的抗菌涂层，医用工具以及包含这种涂层的植入物以及制备这种涂层的方法。医疗工具或牙科或矫形植入物包括具有处理表面的金属或金属合金，其中经处理的表面至少部分地通过使用胶体分散系统的等离子体电解氧化转化为氧化膜，并且其中转换的表面被部分覆盖由胶体分散体系的胶体分散的银颗粒形成的岛。 Ag-TiO2涂层在抗菌功效（甚至抗多抗菌株），粘附和生物相容性方面表现出优异的性能。植入物在人体内的寿命增加。抗菌涂层可用于创伤学，骨科，骨接合术和/或内切除术领域，特别是在存在高感染风险的地方。

88. 发明申请

US20130344130A1 Smart, Self-Decontaminating Polymer and Method for Inhibiting The Growth Of A Bacteria and Fungus 有权
公开(公告)号：US20130344130A1
公开(公告)日：2013-12-26
申请号：US13915839
申请日：2013-06-12
申请人： Agentase, LLC, a subsidiary of FLIR Systems, Inc.
发明人： Anna M. Leech , Jeremy P. Walker , Scott Donahue , Jermaine D. Johnson , Jessica J. Sinclair
IPC分类号： A61K38/44 , A61K9/70
CPC分类号： A61L15/38 , A61F13/00059 , A61F13/00063 , A61K9/06 , A61K9/7007 , A61K38/443 , A61L15/26 , A61L15/425 , A61L15/44 , A61L15/46 , A61L2300/404 , A61L2300/434 , A61L2420/06 , C08L75/04
摘要： A smart antimicrobial material and dressing to inhibit microbial growth is provided. Endogenous chemicals, such as metabolites produced from bacteria are utilized as chemical substrates and converted by enzymes to produce a disinfecting compound that will in turn inhibit the targeted microorganism. The material shall remain passive until such time as it encounters a microbe which expresses and/or secretes specific metabolites or markers. The enzyme or enzymes embedded in the smart material converts the metabolite into a disinfecting compound, which in turn either kills the microorganism or prevents it from multiplying on the surface of the material.

89. 发明申请

US20130280410A1 LOCAL DELIVERY OF WATER-SOLUBLE OR WATER-INSOLUBLE THERAPEUTIC AGENTS TO THE SURFACE OF BODY LUMENS 有权
标题翻译：将水溶性或水不溶性治疗剂局部输送到身体的表面
公开(公告)号：US20130280410A1
公开(公告)日：2013-10-24
申请号：US13919443
申请日：2013-06-17
申请人： Covidien LP
发明人： Eugene T. Michal , Matthew J. Pollman
IPC分类号： A61M25/10
CPC分类号： A61L29/085 , A61L29/148 , A61L29/16 , A61L33/0005 , A61L2300/204 , A61L2300/416 , A61L2400/00 , A61L2420/06 , A61M25/10 , A61M25/1027 , A61M2025/105 , A61M2025/1075 , A61M2025/1081 , A61M2025/109 , C08L33/02
摘要： A method and device for local delivery of a water-insoluble therapeutic agent to the tissue of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with a non-durable coating which comprises poly(HEMA) complexed with iodine and has a substantially water-insoluble therapeutic agent dispersed therein. The medical disposable device is inserted into a body lumen, and expanded to contact the non-durable coating against the body lumen and deliver the substantially water-insoluble therapeutic agent to the body lumen tissue.
摘要翻译：公开了一种用于将水不溶性治疗剂局部递送到正常或患病体腔的组织的方法和装置。医疗一次性装置（例如球囊导管的球囊）的可膨胀结构涂覆有非耐久涂层，其包含与碘络合的聚（HEMA），并且其中分散有基本上不溶于水的治疗剂。将医疗一次性装置插入体腔中，并且膨胀以将非耐久涂层接触体腔，并将基本上不溶于水的治疗剂输送到体腔组织。

90. 发明申请

US20130195891A1 Micro-RNA family that Modulates Fibrosis and Uses Thereof 有权
标题翻译：调节纤维化及其用途的微RNA家族
公开(公告)号：US20130195891A1
公开(公告)日：2013-08-01
申请号：US13840823
申请日：2013-03-15
申请人： The Board of Regents, The University of Texas System
发明人： Eric N. Olson , Eva van Rooij
IPC分类号： A61K31/7105 , A61K31/713 , A61K31/7125 , A61K31/712 , A61K39/395 , A61K45/06
CPC分类号： C12N15/113 , A01K67/0276 , A01K2207/30 , A01K2217/052 , A01K2217/075 , A01K2217/15 , A01K2217/206 , A01K2227/105 , A01K2267/0375 , A61K31/07 , A61K31/355 , A61K31/375 , A61K31/7105 , A61K31/712 , A61K31/7125 , A61K31/713 , A61K38/2242 , A61K39/3955 , A61K45/06 , A61L31/08 , A61L31/16 , A61L2300/258 , A61L2300/45 , A61L2420/06 , C12N9/16 , C12N15/8509 , C12N2310/113 , C12N2310/141 , C12N2310/315 , C12N2310/321 , C12N2310/346 , C12N2310/3515 , C12N2310/3521 , C12N2320/30 , C12N2320/31 , C12N2320/32 , C12N2330/10 , G06F19/00 , Y02A90/26 , A61K2300/00
摘要： The present invention relates to the identification of a microRNA family, designated miR-29a-c, that is a key regulator of fibrosis in cardiac tissue. The inventors show that members of the miR-29 family are down-regulated in the heart tissue in response to stress, and are up-regulated in heart tissue of mice that are resistant to both stress and fibrosis. Also provided are methods of modulating expression and activity of the miR-29 family of miRNAs as a treatment for fibrotic disease, including cardiac hypertrophy, skeletal muscle fibrosis other fibrosis related diseases and collagen loss-related disease.
摘要翻译：本发明涉及一种称为miR-29a-c的微小RNA家族的鉴定，其是心脏组织中纤维化的关键调节剂。发明人显示miR-29家族的成员在心脏组织中响应于应激被下调，并且在对应激和纤维化两者都有抗性的小鼠的心脏组织中上调。还提供了调节miRNA的miR-29家族的表达和活性的方法，作为纤维化疾病的治疗，包括心脏肥大，骨骼肌纤维化等纤维化相关疾病和胶原损失相关疾病。

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