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1. 发明授权

US08652645B2 Osteosynthesis with nano-silver 有权
标题翻译：纳米银骨质合成
公开(公告)号：US08652645B2
公开(公告)日：2014-02-18
申请号：US12792234
申请日：2010-06-02
申请人： Elvira Dingeldein , Cyrille Gasqueres , Frank Witte , Amir Eliezer
发明人： Elvira Dingeldein , Cyrille Gasqueres , Frank Witte , Amir Eliezer
IPC分类号： B32B15/04 , A61F2/02 , C25D11/00
CPC分类号： C25D11/024 , A61L27/306 , A61L27/54 , A61L31/088 , A61L31/16 , A61L2300/102 , A61L2300/104 , A61L2300/606 , A61L2300/802 , A61L2400/12 , A61L2400/18 , A61L2420/06 , C25D11/005 , C25D11/022
摘要： The present invention relates generally to an antibacterial coating which is composed of silver, to medical tools and to implants comprising such a coating and to a method as well to an apparatus for the production of such a coating. The medical tools or the dental or orthopaedic implant comprises a metal or metal alloy having a treated surface wherein the treated surface is at least partially converted to an oxide film by plasma electrolytic oxidation using a colloid-dispersed system and wherein the converted surface is partially covered by islands formed by colloid-dispersed silver-particles of the colloid-dispersed system. An Ag—TiO2 coating shows excellent properties in terms of antibacterial efficacy (even against multi-resistant strains), adhesion and biocompatibility. The life-time of an implant in a human body is increased. The antibacterial coating can be used in the field of traumatology, orthopaedic, osteosynthesis and/or endoprothesis, especially where high infection risk exists.
摘要翻译：本发明一般涉及一种由银组成的抗菌涂层，医用工具以及包含这种涂层的植入物以及制备这种涂层的方法。医疗工具或牙科或矫形植入物包括具有处理表面的金属或金属合金，其中经处理的表面至少部分地通过使用胶体分散系统的等离子体电解氧化转化为氧化膜，并且其中转换的表面被部分覆盖由胶体分散体系的胶体分散的银颗粒形成的岛。 Ag-TiO2涂层在抗菌功效（甚至抗多抗菌株），粘附和生物相容性方面表现出优异的性能。植入物在人体内的寿命增加。抗菌涂层可用于创伤学，骨科，骨接合术和/或内切除术领域，特别是在存在高感染风险的地方。

2. 发明申请

US20100316686A1 Osteosynthesis with nano-silver 有权
标题翻译：纳米银骨质合成
公开(公告)号：US20100316686A1
公开(公告)日：2010-12-16
申请号：US12792234
申请日：2010-06-02
申请人： Elvira Dingeldein , Cyrille Gasqueres , Frank Witte , Amir Eliezer
发明人： Elvira Dingeldein , Cyrille Gasqueres , Frank Witte , Amir Eliezer
IPC分类号： A61F2/00 , A61K9/00 , A01P1/00 , C25D17/00 , C25D5/16
CPC分类号： C25D11/024 , A61L27/306 , A61L27/54 , A61L31/088 , A61L31/16 , A61L2300/102 , A61L2300/104 , A61L2300/606 , A61L2300/802 , A61L2400/12 , A61L2400/18 , A61L2420/06 , C25D11/005 , C25D11/022
摘要： The present invention relates generally to an antibacterial coating which is composed of silver, to medical tools and to implants comprising such a coating and to a method as well to an apparatus for the production of such a coating. The medical tools or the dental or orthopaedic implant comprises a metal or metal alloy having a treated surface wherein the treated surface is at least partially converted to an oxide film by plasma electrolytic oxidation using a colloid-dispersed system and wherein the converted surface is partially covered by islands formed by colloid-dispersed silver-particles of the colloid-dispersed system. An Ag—TiO2 coating shows excellent properties in terms of antibacterial efficacy (even against multi-resistant strains), adhesion and biocompatibility. The life-time of an implant in a human body is increased. The antibacterial coating can be used in the field of traumatology, orthopaedic, osteosynthesis and/or endoprothesis, especially where high infection risk exists.
摘要翻译：本发明一般涉及一种由银组成的抗菌涂层，医用工具以及包含这种涂层的植入物以及制备这种涂层的方法。医疗工具或牙科或矫形植入物包括具有处理表面的金属或金属合金，其中经处理的表面至少部分地通过使用胶体分散系统的等离子体电解氧化转化为氧化膜，并且其中转换的表面被部分覆盖由胶体分散体系的胶体分散的银颗粒形成的岛。 Ag-TiO2涂层在抗菌功效（甚至抗多抗菌株），粘附和生物相容性方面表现出优异的性能。植入物在人体内的寿命增加。抗菌涂层可用于创伤学，骨科，骨接合术和/或内切除术领域，特别是在存在高感染风险的地方。

3. 发明授权

US08266940B2 Apparatus and method for customized shaping of orthodontic archwires and other medical devices 有权
标题翻译：矫正弓形线和其他医疗器械定制成形的装置和方法
公开(公告)号：US08266940B2
公开(公告)日：2012-09-18
申请号：US12387542
申请日：2009-05-04
申请人： Friedrich Riemeier , Werner Butscher , Frank Witte , Christoph Radinger , Andrew Cordell , Rohit Sachdeva
发明人： Friedrich Riemeier , Werner Butscher , Frank Witte , Christoph Radinger , Andrew Cordell , Rohit Sachdeva
IPC分类号： B21D39/02
CPC分类号： B21D7/02 , A61C7/002 , A61C7/20 , B21D7/022 , B21F1/00 , B21F3/00 , B21F45/008 , B25J9/1682 , G05B2219/37426 , G05B2219/45097 , G05B2219/45167
摘要： An apparatus and method for bending or shaping orthodontic archwires or other medical devices into a complex, patient individual shape is described. The apparatus comprises of two moveable, compact, manipulators with, in total, at least three revolute joints defining three rotation axes and at least three prismatic joints defining at least three translation axes. Gripping tools are provided on the manipulators. The two manipulators are arranged to allow a relative movement in six degrees of freedom. A reduced complexity embodiment is also described having only one or two revolute joints.
摘要翻译：描述了一种用于将正畸弓线或其他医疗装置弯曲或成形为复杂的患者个体形状的装置和方法。该装置包括两个可移动的，紧凑的操纵器，总共具有限定三个旋转轴线的至少三个旋转接头和限定至少三个平移轴线的至少三个棱柱形接头。操纵器上提供夹具。两个操纵器被布置成允许六个自由度的相对运动。还描述了仅具有一个或两个旋转接头的简化复杂性实施例。

4. 发明申请

US20070249052A1 Cartilage Regeneration By Generation Of Chondrons Under High Concentrations Of Magnesium 审中-公开
标题翻译：软骨再生通过在高浓度镁下产生软骨细胞
公开(公告)号：US20070249052A1
公开(公告)日：2007-10-25
申请号：US10575232
申请日：2004-10-08
申请人： Frank Witte , Henning Windhagen , Volker Kaese , Frank Feyerabend
发明人： Frank Witte , Henning Windhagen , Volker Kaese , Frank Feyerabend
IPC分类号： C12N5/02
CPC分类号： A61L27/02 , A61L27/04 , A61L2430/06 , A61L2430/40 , C12N5/0655 , C12N2500/16 , C12N2500/32 , C12N2500/34 , C12N2500/42 , C12N2501/105 , C12N2501/115 , C12N2501/15 , C12N2501/23 , C12N2533/74 , C12N2533/76
摘要： The present invention relates to a method for the generation of chondrons and of cartilaginous tissue. In particular, the present invention relates to the ability of Mg ions to stimulate the growth and regeneration of chondrons, particularly of pseudo-chondrons as an intermediate in the regeneration and growth of cartilaginous tissue. Especially, Unphysiologically high extracellular concentrations of Mg are able to regenerate hyaline cartilage, elastic cartilage and/or fibrocartilage via the intermediate form of chondrons.
摘要翻译：本发明涉及产生软骨细胞和软骨组织的方法。特别地，本发明涉及Mg离子在软骨组织的再生和生长中刺激软骨细胞，特别是假软骨细胞的生长和再生的能力，作为中间体。特别地，非生物学上高的细胞外浓度的Mg能够通过中间形式的软骨再生透明软骨，弹性软骨和/或纤维软骨。

5. 发明授权

US10709816B2 Implant 有权
公开(公告)号：US10709816B2
公开(公告)日：2020-07-14
申请号：US14234681
申请日：2011-07-27
申请人： Olaf Andersen , Ingrid Morgenthal , Thomas Studnitzky , Frank Witte
发明人： Olaf Andersen , Ingrid Morgenthal , Thomas Studnitzky , Frank Witte
IPC分类号： A61L27/58 , A61F2/30 , A61L27/04 , C22C49/14 , B22F1/00 , A61L31/14 , B22F9/06 , A61B17/80 , A61F2/28 , A61F2/02 , A61B17/00
摘要： The invention relates to implants that are implanted into living beings as temporary implants and that disintegrate in the body through biological adsorption over a period of time, in addition to a process for producing aforesaid implants. The implant according to the invention consists of magnesium or a magnesium master alloy. It is formed from fibers of magnesium or a magnesium master alloy that are connected to one another through sintering bridges that are locally spaced vis-à-vis each other and form an open-pored body. The fibers may be produced with the help of the melt extraction process and may subsequently be sintered with one another.

6. 发明申请

US20160095670A1 TOOTH ATTACHMENT PLACEMENT DEVICE 审中-公开
标题翻译：牙齿贴装设备
公开(公告)号：US20160095670A1
公开(公告)日：2016-04-07
申请号：US14795764
申请日：2015-07-09
申请人： Frank Witte , Friedrich Riemeier , Rohit Sachdeva , Phillip Getto
发明人： Frank Witte , Friedrich Riemeier , Rohit Sachdeva , Phillip Getto
IPC分类号： A61C7/14 , A61C7/00
CPC分类号： A61C7/146 , A61C7/002 , B33Y80/00
摘要： In a preferred embodiment of the invention, tooth attachment placement (TAP) device or for assisting a user in placing one or more appliances or attachments on one or more teeth is disclosed. The TAP device comprises single tooth jigs connected through splines. The geometry of the device is automatically designed in the treatment planning unified workstation, thereby generating a digital STL file. Then the device is created from a non-flexible biocompatible material by a 3D printer in accordance with the digital STL file. Appliance, for example, may be a bracket or a bracket shim; and the attachment may be an aligner attachment or a pad. Different embodiments of the TAP device are disclosed. Methods for verifying the accuracy of the placements of the brackets on the teeth using the TAP device are disclosed.
摘要翻译：在本发明的优选实施例中，公开了牙齿附着放置（TAP）装置或用于辅助使用者将一个或多个器具或附件放置在一个或多个牙齿上。 TAP装置包括通过花键连接的单牙夹具。在治疗计划统一工作站中自动设计设备的几何形状，从而生成数字STL文件。然后根据数字STL文件，通过3D打印机从非柔性生物相容性材料创建设备。例如，电器可以是支架或支架垫片; 并且附件可以是对准器附件或垫。公开了TAP设备的不同实施例。公开了使用TAP装置验证牙齿上托架的放置准确度的方法。

7. 发明申请

US20140076015A1 APPARATUS AND METHOD FOR CUSTOMIZED SHAPING OF ORTHODONTIC ARCHWIRES AND OTHER MEDICAL DEVICES 有权
标题翻译：用于定制正交构造和其他医疗设备的装置和方法
公开(公告)号：US20140076015A1
公开(公告)日：2014-03-20
申请号：US13621848
申请日：2012-09-18
申请人： Friedrich Riemeier , Werner Butscher , Frank Witte , Christoph Radinger , Andrew Cordell , Rohit Sachdeva
发明人： Friedrich Riemeier , Werner Butscher , Frank Witte , Christoph Radinger , Andrew Cordell , Rohit Sachdeva
IPC分类号： B21C51/00
CPC分类号： B21F45/008 , A61C7/002 , A61C7/20 , B21C51/00 , B21F1/008 , B25J9/1682 , G01B11/24 , G05B2219/37426 , G05B2219/45097 , G05B2219/45167
摘要： An apparatus and method for bending or shaping orthodontic archwires or other medical devices into a complex, patient individual shape is described. The apparatus comprises of two moveable, compact, manipulators with, in total, at least three revolute joints defining three rotation axes and at least three prismatic joints defining at least three translation axes. Gripping tools are provided on the manipulators. The two manipulators are arranged to allow a relative movement in six degrees of freedom. A reduced complexity embodiment is also described having only one or two revolute joints.
摘要翻译：描述了一种用于将正畸弓线或其他医疗装置弯曲或成形为复杂的患者个体形状的装置和方法。该装置包括两个可移动的，紧凑的操纵器，总共具有限定三个旋转轴线的至少三个旋转接头和限定至少三个平移轴线的至少三个棱柱形接头。操纵器上提供夹具。两个操纵器被布置成允许六个自由度的相对运动。还描述了仅具有一个或两个旋转接头的简化复杂性实施例。

8. 发明申请

US20110313527A1 IMPLANT MADE OF A MAGNESIUM ALLOY AND METHOD FOR THE PRODUCTION THEREOF 审中-公开
标题翻译：镁合金的植入物及其生产方法
公开(公告)号：US20110313527A1
公开(公告)日：2011-12-22
申请号：US13058573
申请日：2009-08-11
申请人： Frank Witte , Norbert Hort , Marco Wolfstadter , Bernd Frohlich , Wolfgang Voith , Hans-Joachim Fischer
发明人： Frank Witte , Norbert Hort , Marco Wolfstadter , Bernd Frohlich , Wolfgang Voith , Hans-Joachim Fischer
IPC分类号： A61F2/28 , B22D25/00 , B22D17/00
CPC分类号： B22D25/02 , A61B17/0401 , A61B17/8052 , A61B17/864 , A61B17/866 , A61B2017/00004 , A61B2017/00212 , A61B2017/00411 , A61B2017/0412 , A61B2017/0414 , A61B2017/0437 , A61B2017/044 , A61B2017/0445 , A61B2017/0459 , A61F2002/30062 , A61F2210/0004 , A61F2250/0023 , A61F2250/0024 , A61F2310/00041 , A61L27/047 , A61L27/56 , A61L31/022 , A61L31/146 , A61L31/148 , B22D17/00 , B22D21/007 , B22D25/06
摘要： The invention relates to an implant from a magnesium alloy, in which porosity increases towards the core.
摘要翻译：本发明涉及一种镁合金的植入物，其中孔隙度朝向核心增加。

9. 发明申请

US20050079088A1 Medical implants, prostheses, prosthesis parts, medical instruments, devices and auxiliary contrivances made of a halogenide-modified magnesium substance 审中-公开
标题翻译：医疗植入物，假体，假肢部件，医疗器械，器具和由卤化物改性的镁物质制成的辅助设备
公开(公告)号：US20050079088A1
公开(公告)日：2005-04-14
申请号：US10499992
申请日：2002-12-13
申请人： Carl-Joachim Wirth , Henning Windhagen , Frank Witte , Friedrich-Wilhelm Bach , Volker Kaese
发明人： Carl-Joachim Wirth , Henning Windhagen , Frank Witte , Friedrich-Wilhelm Bach , Volker Kaese
IPC分类号： A61L27/00 , A61F2/28 , A61L27/04 , A61L31/02 , C22C23/02 , C22C23/06
CPC分类号： A61L31/148 , A61L27/047 , A61L31/022
摘要： The use of a magnesium substance, whose corrosiveness is altered as a result of modification with halogenides, enables medical implants, prostheses or prosthesis parts and medical instruments, devices and auxiliary contrivances, especially surgical instruments or tools, for use in and on the human or animal body to be produced, whereby the degree of corrosion-resistance thereof can be adjusted to full corrosion-resistance.
摘要翻译：由于用卤化物改性而使腐蚀性改变的镁物质的使用使得医用植入物，假体或假体部件以及医疗器械，装置和辅助设备尤其是手术器械或工具可用于人体或人体内要生产的动物体，由此可以将其耐腐蚀性的程度调节到完全的耐腐蚀性。

10. 发明授权

US09610628B2 Apparatus and method for customized shaping of orthodontic archwires and other medical devices 有权
公开(公告)号：US09610628B2
公开(公告)日：2017-04-04
申请号：US13621848
申请日：2012-09-18
申请人： Friedrich Riemeier , Werner Butscher , Frank Witte , Christoph Radinger , Andrew Cordell , Rohit Sachdeva
发明人： Friedrich Riemeier , Werner Butscher , Frank Witte , Christoph Radinger , Andrew Cordell , Rohit Sachdeva
IPC分类号： B21F45/00 , A61C7/00 , B25J9/16 , B21F1/00 , B21C51/00
CPC分类号： B21F45/008 , A61C7/002 , A61C7/20 , B21C51/00 , B21F1/008 , B25J9/1682 , G01B11/24 , G05B2219/37426 , G05B2219/45097 , G05B2219/45167
摘要： An apparatus and method for bending or shaping orthodontic archwires or other medical devices into a complex, patient individual shape is described. The apparatus comprises of two moveable, compact, manipulators with, in total, at least three revolute joints defining three rotation axes and at least three prismatic joints defining at least three translation axes. Gripping tools are provided on the manipulators. The two manipulators are arranged to allow a relative movement in six degrees of freedom. A reduced complexity embodiment is also described having only one or two revolute joints.

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