专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

81. 发明申请

US20150313994A1 SURFACE-MODIFIED IRON OXIDE PARTICLES FOR CANCER ABLATION 审中-公开
标题翻译：表面改性铁氧化物颗粒用于癌症消融
公开(公告)号：US20150313994A1
公开(公告)日：2015-11-05
申请号：US14427142
申请日：2013-09-10
申请人： (UNIVERSITY OF TSUKUBA)
发明人： Tatsuya ODA , Yukio NAGASAKI , Kei ASAI , Eiji KITA , Hideto YANAGIHARA , Nobuhiro OHKOHCHI , Mikio KISHIMOTO
IPC分类号： A61K41/00 , A61K47/48 , A61K9/00
CPC分类号： A61K41/0052 , A61K9/0019 , A61K33/26 , A61K47/6923 , A61K47/6929 , B82Y30/00 , C01G49/06 , C01G49/08 , C01P2004/04 , C01P2004/20 , C01P2004/54 , C01P2004/62 , C01P2004/64 , C01P2006/12 , C01P2006/42 , Y10T428/2982
摘要： An object of the present invention is to provide surface-modified ferromagnetic iron oxide particles suitable for electromagnetic-induction cancer ablation, which have excellent heat generation properties and also have excellent dispersion stability in a medium for injection. The surface-modified iron oxide particles for cancer ablation of the present invention as a means for achieving the object are characterized in that a block copolymer of polyethylene glycol and polystyrene having a phosphorous acid group in the side chain is bound to the surface of ferromagnetic iron oxide particles having a plate-like shape with a length of 20 to 200 nm and a length-to-thickness ratio of 1.5 to 30 and having magnetic properties such that the coercivity is 30 to 300 Oe, the saturation magnetization is 20 to 80 emu/g, and the squareness ratio of the magnetic hysteresis loop is 0.20 to 0.50.
摘要翻译：本发明的目的是提供适用于电磁感应癌症消融的表面改性铁磁性氧化铁颗粒，其具有优异的发热性能，并且在注射介质中也具有优异的分散稳定性。本发明的用于癌症消融的表面改性氧化铁颗粒作为实现该目的的手段的特征在于，侧链中具有亚磷酸基的聚乙二醇和聚苯乙烯的嵌段共聚物与铁磁性铁的表面结合具有长度为20〜200nm，长度比为1.5〜30的板状的氧化物粒子，具有矫顽磁力为30〜300Oe的磁特性，饱和磁化强度为20〜80emu / g，磁滞回线的矩形比为0.20〜0.50。

82. 发明授权

US09163063B2 Peptides and nanoparticles for therapeutic and diagnostic applications 有权
标题翻译：用于治疗和诊断应用的肽和纳米颗粒
公开(公告)号：US09163063B2
公开(公告)日：2015-10-20
申请号：US14060932
申请日：2013-10-23
申请人： Trustees of Dartmouth College , Mayo Foundation for Medical Education and Research
发明人： Debabrata Mukhopadhyay , Priyabrata Mukherjee , Mark Spaller
IPC分类号： C07K7/06 , A61K47/48 , B82Y5/00 , C07K14/47
CPC分类号： C07K7/06 , A61K47/6923 , B82Y5/00 , C07K14/4706 , Y10S977/773 , Y10S977/906
摘要： Provided herein are peptides and nanoparticles conjugates thereof useful for the treatment of diseases and disorders mediated by GIPC/synectin, such as cancer.
摘要翻译：本文提供了可用于治疗由GIPC / synectin介导的疾病和病症如癌症的肽和其纳米颗粒缀合物。

83. 发明授权

US09155830B2 Device for radiation-activated localized delivery of treatment agents 有权
标题翻译：用于辐射激活的局部递送治疗剂的装置
公开(公告)号：US09155830B2
公开(公告)日：2015-10-13
申请号：US13739318
申请日：2013-01-11
申请人： University of Miami
发明人： Mansoor M. Ahmed , Xiaodong Wu , Seema Gupta , Alan Pollack
IPC分类号： A61M5/142 , A61M5/00 , A61K47/48 , A61M31/00
CPC分类号： A61M5/00 , A61K47/6923 , A61M5/14276 , A61M31/00
摘要： The present invention provides for a biocompatible drug delivery device for the targeted treatment of cancer that is implantable within the tumorous mass of a patient. In one embodiment, the device comprises two polarizable elements mechanically coupled by a connecting element. The device also comprises one or more cancer treatment agents. When the polarizable elements are depolarized, such as by the application of ionizing radiation, the two polarizable elements are repelled from each other and release the cancer treatment agent. In another embodiment, one or more treatment agents are expelled from a miniaturized syringe when internal pressure of the device is increased by the production of gas bubbles in response to the application of ionizing radiation.
摘要翻译：本发明提供用于靶向治疗癌症的生物相容性药物递送装置，其可植入患者肿瘤块内。在一个实施例中，该装置包括由连接元件机械耦合的两个可极化元件。该装置还包含一种或多种癌症治疗剂。当可极化元件被去极化时，例如通过施加电离辐射，两个可极化元件彼此排斥并释放癌症治疗剂。在另一个实施方案中，响应于电离辐射的应用，通过产生气泡来增加装置的内部压力，将一种或多种处理剂从微型注射器排出。

84. 发明授权

US09149544B2 Bioconjugation of calcium phosphosilicate nanoparticles for selective targeting of cells in vivo 有权
标题翻译：钙磷硅酸盐纳米颗粒的生物缀合用于体内细胞的选择性靶向
公开(公告)号：US09149544B2
公开(公告)日：2015-10-06
申请号：US12941719
申请日：2010-11-08
申请人： Thomas T. Morgan , Brian M. Barth , James H. Adair , Rahul Sharma , Mark Kester , Sriram S. Shanmugavelandy , Jill P. Smith , Erhan I. Altinoglu , Gail L. Matters , James M. Kaiser , Christopher McGovern
发明人： Thomas T. Morgan , Brian M. Barth , James H. Adair , Rahul Sharma , Mark Kester , Sriram S. Shanmugavelandy , Jill P. Smith , Erhan I. Altinoglu , Gail L. Matters , James M. Kaiser , Christopher McGovern
IPC分类号： A61K49/00 , A61K41/00 , A61K47/48
CPC分类号： A61K49/0093 , A61K41/0057 , A61K47/48861 , A61K47/6923 , A61K49/0034 , A61K49/0043
摘要： Non-aggregating resorbable calcium phosphosilicate nanoparticles (CPNPs) are bioconjugated to targeting molecules that are specific for particular cells. The CPNPs are stable particles at normal physiological pH. Chemotherapy and imaging agents may be integrally formed with the CPNPs so that they are compartmentalized within the CPNPs. In this manner, the agents are protected from interaction with the environment at normal physiological pH. However, once the CPNPs have been taken up, at intracellular pH, the CPNPs dissolve releasing the agent. Thus, chemotherapeutic or imaging agents are delivered to specific cells and permit the treatment and/or imaging of those cells. Use of the bioconjugated CPNPs both limits the amount of systemic exposure to the agent and delivers a higher concentration of the agent to the cell. The methods and principals of bioconjugating CPNPs are taught by examples of bioconjugation of targeting molecules for breast cancer, pancreatic cancer, and leukemia.
摘要翻译：非聚集的可再吸收的磷酸钙纳米粒子（CPNP）被生物缀合成靶向特定细胞特异性的分子。 CPNPs在正常生理pH下是稳定的颗粒。化疗和成像剂可以与CPNP整体形成，使得它们在CPNP内被分隔。以这种方式，保护试剂免于在正常生理pH下与环境的相互作用。然而，一旦CPNP被摄取，在细胞内的pH值下，CPNP溶解释放药剂。因此，化学治疗或显像剂被递送到特定的细胞并允许这些细胞的治疗和/或成像。使用生物共轭CPNP都限制了全身暴露于药剂的量，并将更高浓度的药剂递送至细胞。生物缀合CPNP的方法和原理通过乳腺癌，胰腺癌和白血病靶向分子的生物缀合的实例来教导。

85. 发明申请

US20150250871A1 METHODS AND COMPOSITIONS FOR TREATING MULTIPLE SCLEROSIS AND RELATED DISORDERS 审中-公开
标题翻译：治疗多发性硬化症和相关疾病的方法和组合
公开(公告)号：US20150250871A1
公开(公告)日：2015-09-10
申请号：US14723268
申请日：2015-05-27
申请人： UTI Limited Partnership
发明人： Pedro Santamaria
IPC分类号： A61K39/385 , A61K47/48 , A61K39/00
CPC分类号： A61K39/385 , A61K39/0008 , A61K47/6923 , A61K47/6929 , A61K2039/55555 , A61K2039/605 , G01N33/54313 , G01N33/564 , G01N33/56972 , G01N2333/70539 , G01N2800/042 , Y10T428/2982
摘要： This disclosure provides therapeutic compositions and methods for treating multiple sclerosis or a multiple sclerosis-related disorder in a subject in need thereof comprising administering an effective amount of an antigen-MHC-nanoparticle complex to the subject, wherein the antigen is a multiple sclerosis-related antigen.
摘要翻译：本公开提供了治疗组合物和方法，用于治疗有需要的受试者中的多发性硬化症或多发性硬化症相关疾病，包括向所述受试者施用有效量的抗原-MHC-纳米颗粒复合物，其中所述抗原是多发性硬化症相关抗原。

86. 发明授权

US09127168B2 Magnetic iron oxide fine particles, and magnetic particle-containing water dispersion and process for producing the same 有权
标题翻译：磁性氧化铁微粒和含磁性颗粒的水分散体及其制造方法
公开(公告)号：US09127168B2
公开(公告)日：2015-09-08
申请号：US14631353
申请日：2015-02-25
申请人： TODA KOGYO CORPORATION
发明人： Toshiyuki Hakata , Tomoko Okita
IPC分类号： C09C1/24 , A61K47/48 , B82Y30/00 , C01G49/08 , A61K41/00 , A61K49/00 , B82Y5/00 , A61K47/04 , A61K49/04 , A61K49/18
CPC分类号： C09C1/24 , A61K41/0052 , A61K47/6923 , A61K47/6929 , A61K49/0002 , A61K49/0428 , A61K49/1854 , B82Y5/00 , B82Y30/00 , C01G49/0036 , C01G49/08 , C01P2004/64 , C01P2004/80 , C01P2006/12 , C01P2006/42
摘要： The present invention relates to a magnetic particle-containing water dispersion wherein the magnetic particles have a primary particle diameter of 5 to 15 nm and an average secondary particle diameter of 10 to 60 nm, and the water dispersion has a zeta potential of not more than −20 mV when a pH value of the water dispersion lies within the range of 6 to 8, and further a surface of the respective magnetic particles is coated with a carboxyl group-containing polymer. The magnetic particle-containing water dispersion is produced by heating an aqueous solution in which the carboxyl group-containing polymer is dissolved, to a temperature of 90 to 100° C. in a nitrogen atmosphere; adding a solution of a ferrous (II) salt and a ferric (III) salt and an alkali solution to the aqueous solution to react with each other at the same temperature; adding ethanol to the solution to obtain a precipitate; and removing a supernatant liquid from the solution, and then dispersing the precipitate in water and subjecting the resulting dispersion to dialysis. The magnetic particle-containing water dispersion is useful as a magnetic particle-containing water dispersion capable of producing magnetic particle-containing drugs for diagnosis and therapies which can exhibit a uniform functionality, with a good reproducibility.
摘要翻译：本发明涉及一种含磁性颗粒的水分散体，其中磁性颗粒的初级粒径为5〜15nm，平均二次粒径为10〜60nm，水分散体的ζ电位不大于当水分散体的pH值在6至8的范围内时，-20mV，并且进一步用含羧基的聚合物涂覆各个磁性颗粒的表面。通过将含有羧基的聚合物溶解的水溶液在氮气气氛中加热至90〜100℃，制成含有磁性颗粒的水分散体; 在水溶液中加入亚铁（II）盐和三价铁（III）盐和碱溶液的溶液在相同温度下相互反应; 向溶液中加入乙醇以得到沉淀物; 从溶液中除去上清液，然后将沉淀物分散在水中，使得到的分散体透析。含有磁性颗粒的水分散体可用作能够产生含有磁性颗粒的药物用于诊断和治疗的含磁性颗粒的水分散体，其可以显示均匀的官能度，具有良好的再现性。

87. 发明授权

US09119875B2 Matrix incorporated fluorescent porous and non-porous silica particles for medical imaging 有权
标题翻译：基质掺入荧光多孔和无孔二氧化硅颗粒进行医学成像
公开(公告)号：US09119875B2
公开(公告)日：2015-09-01
申请号：US13803300
申请日：2013-03-14
申请人： International Business Machines Corporation
发明人： Dylan J. Boday , Jason T. Wertz
IPC分类号： A61K49/00 , A61K49/18
CPC分类号： A61K49/0021 , A61K47/6923 , A61K49/0054 , A61K49/0093 , A61K49/1848 , A61K2300/00
摘要： A silica particle for medical imaging includes a bridged silane fluorescent dye incorporated throughout the particle matrix. Copolymerization of a bridged silane fluorescent dye (e.g., (R′O)3Si—R—Si(OR′)3, where R is a fluorescent organic bridging group, and where R′ is a methyl or ethyl group) and a tetralkoxysilane (e.g., Si(OR′)4, where R′ is a methyl or ethyl group) generates particles of a predetermined size and shape. This leaves the surface of each particle available for further modification to facilitate dispersion of the particle into different media. Hence, a surface modifier may be subsequently bonded onto the particle surface. In some embodiments, poly(ethylene glycol) is selected as the surface modifier to increase dispersion of the silica particle in an aqueous media. In some embodiments, the particle is porous allowing for an additional functionality (e.g., a secondary imaging material, such as magnetic nanoparticles, and/or a pharmaceutical drug) to be loaded within the pores.
摘要翻译：用于医学成像的二氧化硅颗粒包括掺入整个颗粒基质中的桥接硅烷荧光染料。桥联硅烷荧光染料（例如（R'O）3Si-R-Si（OR'）3）的共聚合，其中R是荧光有机桥连基团，其中R'是甲基或乙基）和四氮烷氧基硅烷例如，Si（OR'）4，其中R'是甲基或乙基）产生预定尺寸和形状的颗粒。这使得每个颗粒的表面可用于进一步修饰以促进颗粒在不同介质中的分散。因此，表面改性剂可以随后结合到颗粒表面上。在一些实施方案中，选择聚（乙二醇）作为表面改性剂以增加二氧化硅颗粒在水性介质中的分散。在一些实施方案中，颗粒是多孔的，允许另外的功能（例如，次级成像材料，例如磁性纳米颗粒和/或药物药物）被加载到孔内。

88. 发明申请

US20150240411A1 NANOFIBER STRUCTURE WITH IMMOBILIZED ORGANIC SUBSTANCE AND THE METHOD OF ITS PREPARATION 审中-公开
标题翻译：具有固定有机物质的纳米结构及其制备方法
公开(公告)号：US20150240411A1
公开(公告)日：2015-08-27
申请号：US14421256
申请日：2012-12-10
申请人： TECHNICKA UNIVERZITA V LIBERCI
发明人： Irena Slamborova , Veronika Zajicova , Petr Exnar , Jarmila Studnickova
IPC分类号： D06M13/513 , D06M16/00 , D01F9/08 , D06M13/415 , D06M13/418
CPC分类号： D06M13/513 , A61K9/5115 , A61K9/5192 , A61K9/70 , A61K47/6923 , A61K47/6953 , A61L26/0004 , A61L26/0066 , A61L2400/12 , C04B35/6224 , C04B35/62844 , C04B2235/441 , C04B2235/5264 , D01D5/003 , D01F9/08 , D06M13/415 , D06M13/418 , D06M16/003 , D06M2400/01 , D10B2101/02
摘要： The invention concerns a nanofiber structure with immobilized organic agens that consists of silica nanofibers whose surface was modified with aminoaikyialkoxysilane and of subsequently immobilized organic agens. The invention also concerns a method of preparation of the nanofiber structure with immobilized organic agens, while silica nanofibers are prepared by electrostatic spinning from the initial sol synthesized by a sol-gel method from tetraalkoxysilane, heat-treated and their the surface modified by a solution of aminoaikyialkoxysilane and organic agens is then immobilized on the modified surface of the nanofibers.
摘要翻译：本发明涉及一种纳米纤维结构，其具有由二氧化硅纳米纤维组成的固定化有机物，其表面用氨基肟基氧基硅烷修饰，随后固定有机物。本发明还涉及一种制备具有固定化有机物的纳米纤维结构的方法，而二氧化硅纳米纤维通过溶胶 - 凝胶法由四烷氧基硅烷合成的初始溶胶静电纺丝制备，经热处理，其表面经溶液改性的氨基烷氧基硅烷和有机Agens固定在纳米纤维的改性表面上。

89. 发明申请

US20150231280A1 MATRIX-INCORPORATED FLUORESCENT POROUS AND NON-POROUS SILICA PARTICLES FOR MEDICAL IMAGING 有权
标题翻译： MATRIX-INCORPORATED荧光多孔和非多孔二氧化硅颗粒用于医学成像
公开(公告)号：US20150231280A1
公开(公告)日：2015-08-20
申请号：US14703955
申请日：2015-05-05
申请人： International Business Machines Corporation
发明人： Dylan J. Boday , Jason T. Wertz
IPC分类号： A61K49/00
CPC分类号： A61K49/0021 , A61K47/6923 , A61K49/0054 , A61K49/0093 , A61K49/1848 , A61K2300/00
摘要： A silica particle for medical imaging includes a bridged silane fluorescent dye incorporated throughout the particle matrix. Copolymerization of a bridged silane fluorescent dye (e.g., (R′O)3Si—R—Si(OR′)3, where R is a fluorescent organic bridging group, and where R′ is a methyl or ethyl group) and a tetralkoxysilane (e.g., Si(OR′)4, where R′ is a methyl or ethyl group) generates particles of a predetermined size and shape. This leaves the surface of each particle available for further modification to facilitate dispersion of the particle into different media. Hence, a surface modifier may be subsequently bonded onto the particle surface. In some embodiments, poly(ethylene glycol) is selected as the surface modifier to increase dispersion of the silica particle in an aqueous media. In some embodiments, the particle is porous allowing for an additional functionality (e.g., a secondary imaging material, such as magnetic nanoparticles, and/or a pharmaceutical drug) to be loaded within the pores.
摘要翻译：用于医学成像的二氧化硅颗粒包括掺入整个颗粒基质中的桥接硅烷荧光染料。桥联硅烷荧光染料（例如（R'O）3Si-R-Si（OR'）3）的共聚合，其中R是荧光有机桥连基团，其中R'是甲基或乙基）和四氮烷氧基硅烷例如，Si（OR'）4，其中R'是甲基或乙基）产生预定尺寸和形状的颗粒。这使得每个颗粒的表面可用于进一步修饰以促进颗粒在不同介质中的分散。因此，表面改性剂可以随后结合到颗粒表面上。在一些实施方案中，选择聚（乙二醇）作为表面改性剂以增加二氧化硅颗粒在水性介质中的分散。在一些实施方案中，颗粒是多孔的，允许另外的功能（例如，次级成像材料，例如磁性纳米颗粒和/或药物药物）被加载到孔内。

90. 发明申请

US20150231077A1 AMINE PASSIVATED NANOPARTICLES FOR CANCER TREATMENT AND IMAGING 审中-公开
标题翻译：用于癌症治疗和成像的胺被钝化的纳米颗粒
公开(公告)号：US20150231077A1
公开(公告)日：2015-08-20
申请号：US14623872
申请日：2015-02-17
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： Shunji Egusa , Yogen Saunthararajah
IPC分类号： A61K9/16 , A61K31/704 , A61K31/519
CPC分类号： A61K9/167 , A61K9/5115 , A61K31/519 , A61K31/704 , A61K47/6923 , B82Y5/00
摘要： Amine-passivated gold nanoparticles and methods of making and using such nanoparticles are described. The nanoparticles can be prepared in a manner in which amine-containing drugs or imaging agents associate with the surface of the nanoparticles to allow delivery of the drugs or agents in vivo, but the association is weak enough to allow the amine-containing drug or imaging agents to be released from the nanoparticle upon reaching its target. Amine passivated gold nanoparticles including targeting molecules which are attached through a thiol linkage can also be prepared and used.
摘要翻译：描述了胺钝化的金纳米颗粒以及制备和使用这种纳米颗粒的方法。纳米颗粒可以以含胺药物或成像剂与纳米颗粒表面相关联的方式制备，以允许体内递送药物或试剂，但是该结合足够弱以允许含胺药物或成像试剂在达到其目标时从纳米颗粒释放。包含通过硫醇键连接的靶向分子的胺钝化金纳米颗粒也可以制备和使用。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式