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1. 发明授权

US09149544B2 Bioconjugation of calcium phosphosilicate nanoparticles for selective targeting of cells in vivo 有权
标题翻译：钙磷硅酸盐纳米颗粒的生物缀合用于体内细胞的选择性靶向
公开(公告)号：US09149544B2
公开(公告)日：2015-10-06
申请号：US12941719
申请日：2010-11-08
申请人： Thomas T. Morgan , Brian M. Barth , James H. Adair , Rahul Sharma , Mark Kester , Sriram S. Shanmugavelandy , Jill P. Smith , Erhan I. Altinoglu , Gail L. Matters , James M. Kaiser , Christopher McGovern
发明人： Thomas T. Morgan , Brian M. Barth , James H. Adair , Rahul Sharma , Mark Kester , Sriram S. Shanmugavelandy , Jill P. Smith , Erhan I. Altinoglu , Gail L. Matters , James M. Kaiser , Christopher McGovern
IPC分类号： A61K49/00 , A61K41/00 , A61K47/48
CPC分类号： A61K49/0093 , A61K41/0057 , A61K47/48861 , A61K47/6923 , A61K49/0034 , A61K49/0043
摘要： Non-aggregating resorbable calcium phosphosilicate nanoparticles (CPNPs) are bioconjugated to targeting molecules that are specific for particular cells. The CPNPs are stable particles at normal physiological pH. Chemotherapy and imaging agents may be integrally formed with the CPNPs so that they are compartmentalized within the CPNPs. In this manner, the agents are protected from interaction with the environment at normal physiological pH. However, once the CPNPs have been taken up, at intracellular pH, the CPNPs dissolve releasing the agent. Thus, chemotherapeutic or imaging agents are delivered to specific cells and permit the treatment and/or imaging of those cells. Use of the bioconjugated CPNPs both limits the amount of systemic exposure to the agent and delivers a higher concentration of the agent to the cell. The methods and principals of bioconjugating CPNPs are taught by examples of bioconjugation of targeting molecules for breast cancer, pancreatic cancer, and leukemia.
摘要翻译：非聚集的可再吸收的磷酸钙纳米粒子（CPNP）被生物缀合成靶向特定细胞特异性的分子。 CPNPs在正常生理pH下是稳定的颗粒。化疗和成像剂可以与CPNP整体形成，使得它们在CPNP内被分隔。以这种方式，保护试剂免于在正常生理pH下与环境的相互作用。然而，一旦CPNP被摄取，在细胞内的pH值下，CPNP溶解释放药剂。因此，化学治疗或显像剂被递送到特定的细胞并允许这些细胞的治疗和/或成像。使用生物共轭CPNP都限制了全身暴露于药剂的量，并将更高浓度的药剂递送至细胞。生物缀合CPNP的方法和原理通过乳腺癌，胰腺癌和白血病靶向分子的生物缀合的实例来教导。

2. 发明申请

US20110129413A1 Bioconjugation of Calcium Phosphosilicate Nanoparticles For Selective Targeting of Cells In Vivo 有权
标题翻译：磷酸钙纳米粒子用于体内细胞选择性靶向的生物缀合
公开(公告)号：US20110129413A1
公开(公告)日：2011-06-02
申请号：US12941719
申请日：2010-11-08
申请人： Thomas T. Morgan , Brian M. Barth , James H. Adair , Rahul Sharma , Mark Kester , Sriram S. Shanmugavelandy , Jill P. Smith , Erhan I. Altinoglu , Gail L. Matters , James M. Kaiser , Christopher McGovern
发明人： Thomas T. Morgan , Brian M. Barth , James H. Adair , Rahul Sharma , Mark Kester , Sriram S. Shanmugavelandy , Jill P. Smith , Erhan I. Altinoglu , Gail L. Matters , James M. Kaiser , Christopher McGovern
IPC分类号： A61K51/12 , C07K14/77 , C07K16/00 , C07K2/00 , C07K7/06 , A61K49/00 , A61K47/42 , A61K47/22 , A61K49/18 , A61K9/14 , B82Y5/00 , B82Y40/00
CPC分类号： A61K49/0093 , A61K41/0057 , A61K47/48861 , A61K47/6923 , A61K49/0034 , A61K49/0043
摘要： Non-aggregating resorbable calcium phosphosilicate nanoparticles (CPNPs) are bioconjugated to targeting molecules that are specific for particular cells. The CPNPs are stable particles at normal physiological pH. Chemotherapy and imaging agents may be integrally formed with the CPNPs so that they are compartmentalized within the CPNPs. In this manner, the agents are protected from interaction with the environment at normal physiological pH. However, once the CPNPs have been taken up, at intracellular pH, the CPNPs dissolve releasing the agent. Thus, chemotherapeutic or imaging agents are delivered to specific cells and permit the treatment and/or imaging of those cells. Use of the bioconjugated CPNPs both limits the amount of systemic exposure to the agent and delivers a higher concentration of the agent to the cell. The methods and principals of bioconjugating CPNPs are taught by examples of bioconjugation of targeting molecules for breast cancer, pancreatic cancer, and leukemia.
摘要翻译：非聚集的可再吸收的磷酸钙纳米粒子（CPNP）被生物缀合成靶向特定细胞特异性的分子。 CPNPs在正常生理pH下是稳定的颗粒。化疗和成像剂可以与CPNP整体形成，使得它们在CPNP内被分隔。以这种方式，保护试剂免于在正常生理pH下与环境的相互作用。然而，一旦CPNP被摄取，在细胞内的pH值下，CPNP溶解释放药剂。因此，化学治疗或显像剂被递送到特定的细胞并允许这些细胞的治疗和/或成像。使用生物共轭CPNP都限制了全身暴露于药剂的量，并将更高浓度的药剂递送至细胞。生物缀合CPNP的方法和原理通过乳腺癌，胰腺癌和白血病靶向分子的生物缀合的实例来教导。

3. 发明授权

US5475988A Refrigerated display case with an improved air flow control and a contaminant control apparatus 失效
标题翻译：具有改进的气流控制和污染物控制装置的冷藏展示柜
公开(公告)号：US5475988A
公开(公告)日：1995-12-19
申请号：US341722
申请日：1994-11-17
申请人： Christopher McGovern
发明人： Christopher McGovern
IPC分类号： A47F3/04 , F25D21/14
CPC分类号： F25D21/14 , A47F3/0447
摘要： A refrigerated display case with an improved air flow control system located in the lower portion thereof along with an improved means for controlling spillages and other contaminants which commonly fall downwardly into the tank or lower area thereof. The spillage controls including a waste control outlet along with an inclined coil cover and fan housing as well as a deck plate extending thereover. The deck plate also defining the plenum chamber within which the inclined fan housing and inclined coil and coil cover are located. A front bracket is included which allows attachment of a return grill thereto along with a support shelf for holding the refrigeration line means away from the waste receiving outlet.
摘要翻译：一种具有改进的空气流量控制系统的冷藏展示柜，其位于其下部，以及用于控制通常向下落入其罐或其下部区域中的溢出物和其它污染物的改进装置。泄漏控制包括废物控制出口以及倾斜的线圈盖和风扇壳体以及在其上延伸的甲板板。甲板板还限定了倾斜风扇壳体和倾斜线圈和线圈盖所在的增压室。包括前支架，其允许将返回格栅附接到其上，以及用于将制冷管路装置保持远离废物接收出口的支撑架。

4. 发明授权

US5475987A Refrigerated display case apparatus with enhanced airflow and improved insulation construction 失效
标题翻译：具有增强气流和改善绝缘结构的冷藏陈列柜设备
公开(公告)号：US5475987A
公开(公告)日：1995-12-19
申请号：US340929
申请日：1994-11-17
申请人： Christopher McGovern
发明人： Christopher McGovern
IPC分类号： A47F3/04
CPC分类号： A47F3/0447
摘要： An improved design for a refrigerated display case which significantly enhances airflow characteristics by including a gradual radius within the transition sections in areas where the refrigerated airflow path must change directions to greatly facilitate smooth flow of refrigerated air therethrough. Also disclosed is an improved construction for providing insulation for a refrigerated display case including an inner and outer panel spaced apart to define an insulation holding chamber therebetween and including thermal breakers at the ends thereof for maintaining the panels in spaced relation to each other and for closing off the end section thereof to retain insulation therein. The inner insulation panel defines the outer boundary of the airflow path. Also an improved design for a shelf support standard is positioned within the insulated housing to provide structural strength to the display case apparatus and to support shelving thereon and also to include a case liner secured thereto for defining the inner boundary of the improved airflow path. Thermally non-conductive bolt assemblies are included to attach the insulated foam assemblies to shelf support standards. The design further includes a novel castor configuration to facilitate relocation of the refrigerated display case.
摘要翻译：一种用于冷藏展示柜的改进的设计，其通过在冷冻气流路径必须改变方向的区域中的过渡部分内包括逐渐的半径来显着地增强气流特性，从而极大地促进冷藏空气的顺畅流动。还公开了一种用于为冷藏陈列柜提供绝缘的改进结构，其包括间隔开的内部和外部板，以在其间限定绝缘保持室，并且在其端部包括热断路器，用于将板彼此间隔开并关闭离开其端部以保持其中的绝缘。内绝缘板限定气流路径的外边界。而且，用于搁板支撑标准的改进的设计被定位在绝缘壳体内，以向展示柜设备提供结构强度并且支撑在其上的搁架，并且还包括固定到其上的壳体衬套以限定改进的气流路径的内边界。包括热非导电螺栓组件以将绝缘泡沫组件附接到货架支撑标准。该设计还包括一种新颖的脚轮结构，以便于冷藏陈列柜的重新定位。

5. 外观设计

USD368534S Interlocking thermal breaker extrusion 失效
公开(公告)号：USD368534S
公开(公告)日：1996-04-02
申请号：US31069
申请日：1994-11-17
申请人： Christopher McGovern
设计人： Christopher McGovern

6. 发明授权

US5508898A Interior lighting apparatus for a refrigerated display case 失效
标题翻译：用于冷藏展示柜的室内照明装置
公开(公告)号：US5508898A
公开(公告)日：1996-04-16
申请号：US340932
申请日：1994-11-17
申请人： Christopher McGovern
发明人： Christopher McGovern
IPC分类号： A47F11/10 , F21V7/00 , F21V19/00 , F25D27/00 , H01R33/08
CPC分类号： F21V19/008 , A47F11/10 , F21V7/005 , F25D27/00 , H01R33/08 , F21W2131/305 , F21W2131/405 , F21Y2103/00 , F21Y2113/00
摘要： An improved lighting apparatus is disclosed for illuminating the interior of a refrigerated display case which uses in combination a unique configuration of a main lighting unit behind the cornice as well as an illumination device under the front edge of each shelf wherein each shelf includes a lightrace extending longitudinally adjacent the front edge thereof for retaining the power supply wires therein and wherein the electrical power is supplied to the lighting means through a one-piece end plug electrical coupling designed to seal the end of the lightrace while simultaneously providing electrical connection to a mounting fixture for a fluorescent lamp. The mounting fixture preferably includes a means for mounting of the lamp therein as well as a coupling adapted to engage the electrical coupling of the one-piece end plug electrical coupling in the end of the lightrace for facilitating powering of the shelf illumination lights. The present design includes a novel ballast retaining chamber behind the cornice as well as several specially designed reflector members to facilitate downward illumination from the main lighting within the upper portion of the housing to fully capture and efficiently direct the lumen output of the fluorescent lamps.
摘要翻译：公开了一种改进的照明装置，用于照亮冷藏展示柜的内部，其结合了檐口后面的主照明单元的独特配置以及在每个搁板的前边缘下方的照明装置，其中每个搁架包括延伸的光线纵向邻近其前边缘，用于将电源线保持在其中，并且其中电功率通过一体式端塞电耦合供应到照明装置，所述一体端塞电耦合被设计成密封光线的端部，同时提供与安装夹具的电连接用于荧光灯。安装固定件优选地包括用于将灯安装在其中的装置以及适于接合光束的端部中的一体式端塞电耦合的电耦合的联接器，以便于搁架照明灯的供电。本设计包括在檐口后面的新颖的镇流器保持室以及几个专门设计的反射器构件，以便于在外壳的上部内的主照明的向下照明，以完全捕获并有效地引导荧光灯的管腔输出。

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