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1. 发明授权

US09155830B2 Device for radiation-activated localized delivery of treatment agents 有权
标题翻译：用于辐射激活的局部递送治疗剂的装置
公开(公告)号：US09155830B2
公开(公告)日：2015-10-13
申请号：US13739318
申请日：2013-01-11
申请人： University of Miami
发明人： Mansoor M. Ahmed , Xiaodong Wu , Seema Gupta , Alan Pollack
IPC分类号： A61M5/142 , A61M5/00 , A61K47/48 , A61M31/00
CPC分类号： A61M5/00 , A61K47/6923 , A61M5/14276 , A61M31/00
摘要： The present invention provides for a biocompatible drug delivery device for the targeted treatment of cancer that is implantable within the tumorous mass of a patient. In one embodiment, the device comprises two polarizable elements mechanically coupled by a connecting element. The device also comprises one or more cancer treatment agents. When the polarizable elements are depolarized, such as by the application of ionizing radiation, the two polarizable elements are repelled from each other and release the cancer treatment agent. In another embodiment, one or more treatment agents are expelled from a miniaturized syringe when internal pressure of the device is increased by the production of gas bubbles in response to the application of ionizing radiation.
摘要翻译：本发明提供用于靶向治疗癌症的生物相容性药物递送装置，其可植入患者肿瘤块内。在一个实施例中，该装置包括由连接元件机械耦合的两个可极化元件。该装置还包含一种或多种癌症治疗剂。当可极化元件被去极化时，例如通过施加电离辐射，两个可极化元件彼此排斥并释放癌症治疗剂。在另一个实施方案中，响应于电离辐射的应用，通过产生气泡来增加装置的内部压力，将一种或多种处理剂从微型注射器排出。

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