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81. 发明申请

US20110230738A1 Optical examination of biological tissue using non-contact irradiation and detection 审中-公开
公开(公告)号：US20110230738A1
公开(公告)日：2011-09-22
申请号：US12932625
申请日：2011-03-07
申请人： Britton Chance
发明人： Britton Chance
IPC分类号： A61B5/145
CPC分类号： A61B5/0059 , A61B5/0037 , A61B5/0068 , A61B5/0091 , A61B5/415 , A61B5/418 , A61B5/4312 , A61B5/6834 , A61B5/7285
摘要： An optical system for examination of biological tissue includes a light source, a light detector, optics and electronics. The light source generates a light beam, transmitted to the biological tissue, spaced apart from the source. The light detector is located away (i.e., in a non-contact position) from the examined biological tissue and is constructed to detect light that has migrated in the examined tissue. The electronics controls the light source and the light detector, and a system separates the reflected photons (e.g., directly reflected or scattered from the surface or superficial photons) from the photons that have migrated in the examined tissue. The system prevents detection of the “noise” photons by the light detector or, after detection, eliminates the “noise” photons in the detected optical data used for tissue examination.

82. 发明申请

US20110224512A1 INTRACELLULAR pH IMAGING METHOD AND APPARATUS USING FLURESCENCE LIFETIME 审中-公开
标题翻译：细胞内pH值成像方法和装置使用灵活的生命
公开(公告)号：US20110224512A1
公开(公告)日：2011-09-15
申请号：US13044452
申请日：2011-03-09
申请人： Shinya OGIKUBO , Takashi ADACHI , Nobuhiro OHTA , Takakazu NAKABAYASHI
发明人： Shinya OGIKUBO , Takashi ADACHI , Nobuhiro OHTA , Takakazu NAKABAYASHI
IPC分类号： A61B5/1455 , C12Q1/26 , C12M1/34
CPC分类号： G01N33/84 , A61B1/043 , A61B5/0068 , A61B5/0071 , A61B5/6852 , G01N21/6408
摘要： In a pH measurement method, pulsed excitation light including a wavelength that can excite a predetermined fluorescent material contained in living matter is generated. The fluorescent material acts as coenzyme in oxidation/reduction reaction in vivo. Further, the intensity of the pulsed excitation light does not damage a tissue nor a cell in the living matter, and does not substantially change the pH of the living matter. Further, a predetermined position in the living matter is illuminated with the pulsed excitation light, and light including fluorescence emitted from the fluorescent material excited by illumination with the pulsed excitation light is received. The lifetime of the fluorescence is calculated by time-resolving the intensity of the received fluorescence, and the pH of the living matter is measured based on the lifetime.
摘要翻译：在pH测定方法中，产生包含可以激发生物中所含有的预定荧光物质的波长的脉冲激发光。荧光材料在体内作为氧化/还原反应中的辅酶。此外，脉冲激发光的强度不会损伤生物体中的组织和细胞，并且基本上不改变生物体的pH。此外，利用脉冲激发光照射生物体中的预定位置，并且接收包括通过用脉冲激发光照射而激发的荧光材料发出的荧光的光。通过时间分辨接收到的荧光的强度来计算荧光的寿命，并且基于寿命测量生物体的pH。

83. 发明申请

US20110206291A1 COMBINED SPECTRAL AND POLARIMETRY IMAGING AND DIAGNOSTICS 有权
标题翻译：组合光谱和极化成像和诊断
公开(公告)号：US20110206291A1
公开(公告)日：2011-08-25
申请号：US13021524
申请日：2011-02-04
申请人： Amir H. Kashani , Mark S. Humayun
发明人： Amir H. Kashani , Mark S. Humayun
IPC分类号： G06K9/40 , G01N21/00 , A61B3/14 , A61B3/12 , H04N7/18
CPC分类号： G01J4/04 , A61B3/12 , A61B5/0059 , A61B5/0068 , A61B5/0075 , A61B5/14555 , A61B5/14558 , A61B5/4842 , G01J3/2823 , G01N2201/0221
摘要： Combined spectral and polarimetry imaging and diagnostic techniques are disclosed, including an imaging system that simultaneously records spatially co-registered spectral and polarization information from an image of a target scene such as an ocular structure or material or device in an around the eye. Image acquisition and image calibration by such an imaging system or an imaging spectrometer or polarimeter are also disclosed. Methods of data storage and image display relevant to medical practice in general and ophthalmology practice specifically are further disclosed.
摘要翻译：公开了组合的光谱和偏振成像和诊断技术，包括同时从眼睛周围的目标场景的图像（例如眼睛结构或材料或装置）记录空间共同注册的光谱和偏振信息的成像系统。还公开了通过这种成像系统或成像光谱仪或偏振计的图像采集和图像校准。进一步公开了与一般医学实践和眼科实践相关的数据存储和图像显示的方法。

84. 发明申请

US20110201914A1 Reflection-Mode Photoacoustic Tomography Using A Flexibly-Supported Cantilever Beam 有权
标题翻译：使用灵活支持的悬臂梁的反射模式光声层析成像
公开(公告)号：US20110201914A1
公开(公告)日：2011-08-18
申请号：US13125522
申请日：2009-10-21
申请人： Lihong Wang , Konstantin Maslov
发明人： Lihong Wang , Konstantin Maslov
IPC分类号： A61B5/05
CPC分类号： G01N29/2418 , A61B5/0059 , A61B5/0068 , A61B5/0095 , A61B5/14552 , A61B5/415 , A61B5/418 , A61B5/4866 , A61B8/00 , A61B8/06 , A61B8/4444 , G01N29/0672 , G01N2291/02475 , G01N2291/0427
摘要： Noninvasively imaging biological tissue using a handheld device. A light pulse is focused into a predetermined area inside an object using a flexibly mounted cantilever beam, acoustic waves emitted by the object in response to the at least one light pulse are detected by a transducer, and an image of the predetermined area inside the object is generated based on a signal generated by the transducer representative of the acoustic waves.
摘要翻译：使用手持设备非侵入性地成像生物组织。使用灵活安装的悬臂梁将光脉冲聚焦到物体内部的预定区域中，响应于至少一个光脉冲由物体发射的声波由换能器检测，并且物体内的预定区域的图像是基于代表声波的换能器产生的信号而产生的。

85. 发明授权

US07986415B2 Apparatus and method for optical 3D measurement 有权
标题翻译：用于光学3D测量的装置和方法
公开(公告)号：US07986415B2
公开(公告)日：2011-07-26
申请号：US12506531
申请日：2009-07-21
申请人： Frank Thiel , Joachim Pfeiffer , Peter Fornoff
发明人： Frank Thiel , Joachim Pfeiffer , Peter Fornoff
IPC分类号： G01B11/24
CPC分类号： G01B11/24 , A61B5/0068 , A61B5/0088 , A61B5/1077 , A61C9/0053
摘要： The invention relates to an apparatus and a method for optical 3D measurement, comprising a first beam deflector for deflecting an illuminating beam onto a measurement object and for deflecting the observation beam which is radiated back by the measurement object, wherein the first beam deflector can move along a path distance S.
摘要翻译：本发明涉及一种用于光学3D测量的装置和方法，包括用于将照明光束偏转到测量对象上的第一光束偏转器和用于偏转被测量对象辐射回的观察光束，其中第一光束偏转器可以移动沿路径距离S.

86. 发明申请

US20110144504A1 METHOD AND APPARATUS FOR OPTICAL IMAGING VIA SPECTRAL ENCODING 有权
标题翻译：通过光谱编码进行光学成像的方法和装置
公开(公告)号：US20110144504A1
公开(公告)日：2011-06-16
申请号：US12946635
申请日：2010-11-15
申请人： Guillermo J. Tearney , Dvir Yelin , Brett Eugene Bouma
发明人： Guillermo J. Tearney , Dvir Yelin , Brett Eugene Bouma
IPC分类号： A61B6/00
CPC分类号： G01N33/4833 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6852 , G01B9/02 , G01B9/02027 , G01B9/02049 , G01B9/02064 , G01B9/02087 , G01B9/02091 , G01B9/04 , G01N21/25 , G01N21/27 , G01N21/4795 , G01N21/6458 , G01N21/6486 , G01N23/046 , G01N2021/1765 , G01N2223/419 , G02B21/0028 , G02B23/2423 , G02B23/243 , G02B23/2461 , G02B23/2476
摘要： Method, apparatus and arrangement according an exemplary embodiment of the present invention can be provided for generating an image of at least one portion of an anatomical structure. For example, the portion can have an area greater than about 1 mm2, and the image can have a resolution a transverse resolution that is below about 10 μm. For example, light can be scanned over such portion so as to generate first information which is related to the portion, where the light may be provided through a diffraction arrangement to generate a spectrally dispersed line. Method, apparatus and arrangement according to a further exemplary embodiment of the present invention can be provided for positioning a radiation or optical beam within an anatomical structure based on signals generated by scanning a portion of the structure using the same or a different beam.
摘要翻译：可以提供根据本发明的示例性实施例的方法，装置和装置，用于生成解剖结构的至少一部分的图像。例如，该部分可以具有大于约1mm 2的面积，并且图像可以具有低于约10μm的横向分辨率的分辨率。例如，可以在这样的部分上扫描光，以便产生与该部分相关的第一信息，其中可以通过衍射装置提供光以产生光谱分散的线。可以提供根据本发明的另一示例性实施例的方法，装置和装置，用于基于通过使用相同或不同的束扫描结构的一部分而产生的信号来将辐射或光束定位在解剖结构内。

87. 发明申请

US20110058178A1 ARRANGEMENTS AND METHODS FOR PROVIDING MULTIMODALITY MICROSCOPIC IMAGING OF ONE OR MORE BIOLOGICAL STRUCTURES 有权
标题翻译：提供一种或多种生物结构的多重微观显微成像的安排和方法
公开(公告)号：US20110058178A1
公开(公告)日：2011-03-10
申请号：US12943762
申请日：2010-11-10
申请人： Guillermo J. Tearney , Dvir Yelin , Benjamin J. Vakoc , Wang-Yuhl Oh , Brett Eugene Bouma
发明人： Guillermo J. Tearney , Dvir Yelin , Benjamin J. Vakoc , Wang-Yuhl Oh , Brett Eugene Bouma
IPC分类号： G01B9/02
CPC分类号： G01N33/4833 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6852 , G01B9/02 , G01B9/02027 , G01B9/02049 , G01B9/02064 , G01B9/02087 , G01B9/02091 , G01B9/04 , G01N21/25 , G01N21/27 , G01N21/4795 , G01N21/6458 , G01N21/6486 , G01N23/046 , G01N2021/1765 , G01N2223/419 , G02B21/0028 , G02B23/2423 , G02B23/243 , G02B23/2461 , G02B23/2476
摘要： Method and apparatus according to an exemplary embodiment of the present invention can be provided. For example, first data associated with a first signal received from at least one region of at least one sample can be provided based on a first modality, and second data associated with a second signal received from the at least one sample can be provided based on a second modality which is different from the first modality. Third data associated with a reference can be received. Further data can be generated based on the first, second and third data. In addition, third data associated with a second signal received from the at least one sample can be obtained. Each of the third data can be based on a further modality which is different from the first modality and the second modality, and the further data can be further determined based on the third data. Further, the first modality can be a spectral-encoded modality, and the second modality can be a non-spectral-encoding modality.
摘要翻译：可以提供根据本发明的示例性实施例的方法和装置。例如，可以基于第一模态来提供与从至少一个样本的至少一个区域接收的第一信号相关联的第一数据，并且可以基于从至少一个样本接收的与第二信号相关联的第二数据基于第二种模式与第一种模式不同。可以接收与参考相关联的第三数据。可以基于第一，第二和第三数据生成进一步的数据。此外，可以获得与从至少一个样本接收的第二信号相关联的第三数据。第三数据中的每一个可以基于与第一模态和第二模态不同的另一模态，并且可以基于第三数据进一步确定另外的数据。此外，第一模式可以是频谱编码模式，并且第二模态可以是非频谱编码模式。

88. 发明申请

US20110054348A1 OPTICAL BIOPSY DEVICE 有权
标题翻译：光学生物设备
公开(公告)号：US20110054348A1
公开(公告)日：2011-03-03
申请号：US12593298
申请日：2008-03-31
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper
IPC分类号： A61B10/02 , G02B3/10
CPC分类号： G02B23/243 , A61B5/0068 , A61B5/0084 , A61B10/00 , A61B90/20 , A61B90/361 , A61B2017/00061 , A61B2090/3616 , G02B3/0081 , G02B3/02 , G02B3/10 , G02B26/10 , G02B26/103
摘要： An objective lens system for an optical biopsy device has a lens that comprises a first part configured for viewing at a first magnification, and a second part configured for viewing at a second magnification. The second magnification is substantially different from the first magnification. The first magnification enables viewing a larger area of a target and the second magnification enables viewing the target at a cellular level with high sensitivity and specificity. Combining viewing at two different magnifications in a single objective lens results in a compact optical biopsy device.
摘要翻译：用于光学活检装置的物镜系统具有透镜，该透镜包括被配置为以第一放大率观看的第一部分和被配置为以第二放大率观看的第二部分。第二放大率与第一放大率基本不同。第一放大使得能够观察到目标的较大区域，并且第二放大能够以高灵敏度和特异性在细胞水平上观察目标。将单个物镜中的两种不同放大倍数的观察结合在一起形成了紧凑的光学活检装置。

89. 发明授权

US07869679B2 Modular imaging system, modules for this system and method implemented using this system 有权
标题翻译：模块化成像系统，该系统的模块和使用该系统实现的方法
公开(公告)号：US07869679B2
公开(公告)日：2011-01-11
申请号：US12249665
申请日：2008-10-10
申请人： Bertrand Viellerobe , Francois Lacombe , Nicolas Boularot , Francois Doussoux , Nicolas Lavillonniere
发明人： Bertrand Viellerobe , Francois Lacombe , Nicolas Boularot , Francois Doussoux , Nicolas Lavillonniere
IPC分类号： G02B6/06
CPC分类号： G01N21/6458 , A61B1/00165 , A61B1/00186 , A61B1/043 , A61B1/0638 , A61B1/07 , A61B5/0068 , A61B5/0071 , A61B5/0084 , G01N2021/6419 , G01N2021/6421 , G01N2201/024 , G01N2201/0846 , G01N2201/086
摘要： An imaging device includes an illumination module comprising at least one emitter for emitting at least one excitation beam; a scanning and injection module comprising an image guide, a proximal end and a distal end of which are linked by a plurality of optical fibers; a scanning and injection optical system configured to alternately inject the at least one excitation beam into an optical fiber of the image guide from the proximal end of the image guide; a detection module comprising a detector for detecting a luminous flux collected at the distal end of the image guide, wherein at least one of the illumination module and the detection module is optically conjugated with the scanning and injection module using a conjugating optical fiber.
摘要翻译：一种成像装置包括：照明模块，包括至少一个用于发射至少一个激发光束的发射器; 扫描和注射模块，包括图像引导件，其近端和远端由多根光纤连接; 扫描和注射光学系统，被配置为从所述图像引导件的近端交替地将所述至少一个激发光束注入到所述图像引导件的光纤中; 检测模块，包括用于检测在图像引导件的远端处收集的光通量的检测器，其中照明模块和检测模块中的至少一个使用共轭光纤与扫描和注射模块光学共轭。

90. 发明授权

US07859749B2 Confocal microscope for imaging of selected locations of the body of a patient 有权
标题翻译：共焦显微镜，用于对患者身体的选定位置进行成像
公开(公告)号：US07859749B2
公开(公告)日：2010-12-28
申请号：US12154981
申请日：2008-05-29
申请人： William J. Fox , Christopher C. DiStasio , Scott R. Grodevant
发明人： William J. Fox , Christopher C. DiStasio , Scott R. Grodevant
IPC分类号： G02B21/00
CPC分类号： G02B21/0048 , A61B5/0064 , A61B5/0068 , A61B5/6835 , G02B21/0012 , G02B21/0028 , G02B21/008 , G02B21/362
摘要： A confocal imaging microscope, especially for the cellular imaging of the skin at selected locations, is ergonomic in use, compact, and positionable at the locations thereby providing for patient comfort during imaging. The head (28) contains an integrated assembly of the optical and mechanical components of the microscope. The assembly includes a main chassis plate (82). The optical components are mounted principally on one side of the plate while a PC board (130) is mounted on the opposite side of the plate. The board (130) mounts the electronic components, including interfaces, a microprocessor (222), and drivers (206, 208, 210) for motors (105, 106, 108) which control scanning and may also control fine positioning of the locations being imaged. The head (28) is detachable from the arm for manual disposition which is useful when imaging, not only the skin but other tissues, especially for research in investigating living processes at the cellular level.
摘要翻译：共焦成像显微镜，特别是用于在选定位置处的皮肤的细胞成像，其在使用中是人体工程学的，紧凑的和可定位的，从而在成像期间提供患者的舒适度。头部（28）包含显微镜的光学和机械部件的集成组件。组件包括主底盘（82）。光学部件主要安装在板的一侧，而PC板（130）安装在板的相对侧上。板（130）安装包括接口的电子部件，微处理器（222）和用于控制扫描的电动机（105,106,108）的驱动器（206,208,210），并且还可以控制位置的精细定位成像。头部（28）可从手臂上拆卸，用于手动配置，这对于成像不仅皮肤而且其它组织尤其是用于调查细胞水平的生物过程的研究是有用的。

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