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81. 发明授权

US07300428B2 Tissue volume reduction 有权
标题翻译：组织体积减少
公开(公告)号：US07300428B2
公开(公告)日：2007-11-27
申请号：US11009379
申请日：2004-12-11
申请人： Edward P. Ingenito
发明人： Edward P. Ingenito
IPC分类号： A61M31/00
CPC分类号： A61K38/363 , A61B1/2676 , A61B17/00491 , A61B17/12022 , A61B17/12104 , A61B17/12136 , A61B17/12186 , A61B2017/00495 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/4833 , A61K45/06 , A61K2300/00
摘要： Devices, compositions, and methods for achieving non-surgical lung volume reduction (e.g., bronchoscopic lung volume reduction (BLVR)) are described. BLVR can be carried out by collapsing a region of the lung, adhering one portion of the collapsed region to another, and promoting fibrosis in or around the adherent tissue.
摘要翻译：描述了用于实现非手术肺容积减小的装置，组合物和方法（例如，支气管镜肺容积减小（BLVR））。 BLVR可以通过塌陷肺部区域，将塌陷区域的一部分粘附到另一部分，并且在粘附组织内或周围促进纤维化来进行。

82. 发明申请

US20070250105A1 DEVICE AND METHOD FOR TREATMENT OF SINUSITUS 有权
标题翻译：用于治疗麻醉药物的装置和方法
公开(公告)号：US20070250105A1
公开(公告)日：2007-10-25
申请号：US11379691
申请日：2006-04-21
申请人： Thomas Ressemann , Peter Keith , Theodore Truitt
发明人： Thomas Ressemann , Peter Keith , Theodore Truitt
IPC分类号： A61M29/00
CPC分类号： A61M29/02 , A61B17/12022 , A61B17/12104 , A61B17/12136 , A61B17/24 , A61B17/3421 , A61B17/3468 , A61B90/30 , A61B90/50 , A61B2017/1205 , A61B2090/3945 , A61F2/82 , A61M2029/025 , A61M2210/0618 , A61M2210/0681
摘要： A method of treating a constricted sinus passageway of a patient includes traversing the canine fossa region of the patient so as to form a passageway in the sinus cavity. An elongate member is inserted through the passageway, the elongate member having an inflation member such as a balloon disposed thereon. The inflation member is positioned within the constricted passageway. The inflation member is expanded so as to expand at least a portion of the constricted sinus passageway.
摘要翻译：治疗患者的收缩性窦通道的方法包括横穿病人的犬窝区域，以在窦腔中形成通道。细长构件插入穿过通道，细长构件具有膨胀构件，例如设置在其上的球囊。充气构件位于狭窄通道内。膨胀构件膨胀以扩张收缩的窦通道的至少一部分。

83. 发明申请

US20070135789A1 Use of mechanical dilator devices to enlarge ostia of paranasal sinuses and other passages in the ear, nose, throat and paranasal sinuses 有权
标题翻译：使用机械扩张装置扩大耳鼻窦和鼻，鼻，鼻旁窦中的其他通道
公开(公告)号：US20070135789A1
公开(公告)日：2007-06-14
申请号：US11655794
申请日：2007-01-18
申请人： John Chang , Joshua Makower , Julia Vrany , John Morriss , Ketan Muni , Isaac Kim , Hung Ha , William Facteau , Amrish Walke
发明人： John Chang , Joshua Makower , Julia Vrany , John Morriss , Ketan Muni , Isaac Kim , Hung Ha , William Facteau , Amrish Walke
IPC分类号： A61K9/02 , A61M31/00
CPC分类号： A61M29/00 , A61B1/233 , A61B17/12104 , A61B17/12136 , A61B17/1657 , A61B17/1688 , A61B17/24 , A61B17/320016 , A61B17/320725 , A61B34/20 , A61B2017/00292 , A61B2017/246 , A61B2034/2051 , A61B2090/3764 , A61B2503/40 , A61M25/0041 , A61M25/0054 , A61M25/0662 , A61M25/09 , A61M25/1002 , A61M29/02 , A61M2025/0008 , A61M2025/1079 , A61M2029/025 , A61M2210/0618 , A61M2210/1028
摘要： Sinusitis and other disorders of the ear, nose and throat are diagnosed and/or treated using minimally invasive approaches with flexible or rigid instruments. Various methods and devices are used for remodeling or changing the shape, size or configuration of a sinus ostium or duct or other anatomical structure in the ear, nose or throat; implanting a device, cells or tissues; removing matter from the ear, nose or throat; delivering diagnostic or therapeutic substances or performing other diagnostic or therapeutic procedures. Introducing devices (e.g., guide catheters, tubes, guidewires, elongate probes, other elongate members) may be used to facilitate insertion of working devices (e.g. catheters e.g. balloon catheters, guidewires, tissue cutting or remodeling devices, devices for implanting elements like stents, electrosurgical devices, energy emitting devices, devices for delivering diagnostic or therapeutic agents, substance delivery implants, scopes etc.) into the paranasal sinuses or other structures in the ear, nose or throat. Specific devices (e.g., tubular guides, guidewires, balloon catheters, tubular sheaths) are provided as are methods for manufacturing and using such devices to treat disorders of the ear, nose or throat.
摘要翻译：使用具有柔性或刚性器械的微创方法诊断和/或治疗鼻窦炎和其他耳朵，鼻子和喉咙疾病。各种方法和装置用于重建或改变耳朵，鼻子或喉咙中的窦口或导管或其他解剖结构的形状，尺寸或构型; 植入装置，细胞或组织; 从耳朵，鼻子或喉咙去除物质; 提供诊断或治疗物质或执行其他诊断或治疗程序。可以使用引入装置（例如，引导导管，管，导线，细长探针，其它细长构件）来促进工作装置（例如，导管例如球囊导管，导线，组织切割或重塑装置，用于植入元件如支架的装置，电外科装置，能量发射装置，用于递送诊断或治疗剂，物质输送植入物，范围等的装置）到耳鼻窦或耳朵，鼻子或喉咙中的其他结构中。提供特定装置（例如，管状引导件，导丝，气囊导管，管状护套），制造和使用这种装置来治疗耳朵，鼻子或喉咙的障碍的方法。

84. 发明授权

US07128747B2 Apparatus and methods for reducing lung volume 失效
公开(公告)号：US07128747B2
公开(公告)日：2006-10-31
申请号：US10682458
申请日：2003-10-08
申请人： Richard S. Ginn
发明人： Richard S. Ginn
IPC分类号： A61B17/24
CPC分类号： A61B17/12104 , A61B17/04 , A61B17/0644 , A61B17/068 , A61B17/12022 , A61B17/12172 , A61B17/1227 , A61B17/1285 , A61B18/1492 , A61B2017/0641 , A61B2017/1205 , A61B2018/00541
摘要： Apparatus and methods are provided for reducing the volume of a lung using a clip including a plurality of tines. The clip is advanced along an interior of a bronchial passage to a predetermined location with the tines in a contracted condition. The tines are expanded outwardly to engage surrounding tissue, and then collapsed towards the contracted condition, thereby drawing the surrounding tissue inwardly to substantially close the bronchial passage from air flow therethrough. Optionally, electrical energy may be applied to the surrounding tissue after collapsing the tines to the contracted condition, thereby fusing the surrounding tissue together. The clip is then released within or removed from the passage.

85. 发明申请

US20060235432A1 Intra-bronchial obstructing device that controls biological interaction with the patient 审中-公开
公开(公告)号：US20060235432A1
公开(公告)日：2006-10-19
申请号：US11417553
申请日：2006-05-03
申请人： Lauri DeVore , Richard Shea , John Wang
发明人： Lauri DeVore , Richard Shea , John Wang
IPC分类号： A61F11/00
CPC分类号： A61M31/00 , A61B17/12022 , A61B17/1204 , A61B17/12104 , A61B17/12159 , A61B17/12172 , A61B2017/1205 , A61B2017/22051 , A61B2017/22067 , A61B2017/242 , A61B2217/005 , A61F2002/043 , A61M1/0023 , A61M25/04 , A61M2025/0076 , A61M2210/1035 , A61N2005/1021
摘要： The present invention provides an intra-bronchial device and method that controls biological interaction of the device with the patient. The intra-bronchial device is adapted to be placed in an air passageway of a patient to collapse a lung portion associated with the air passageway. The device includes an obstructing member that prevents air from being inhaled into the lung portion to collapse the lung portion, and a medicant carried by the obstructing member. The medicant may overlie at least a portion of the obstructing member, or the medicant may be absorbed in at least a portion of the obstructing member. The obstructing member may further include an absorptive member, and the medicant is absorbed by the absorptive member.

86. 发明申请

US20060210605A1 Devices, systems and methods useable for treating sinusitis 有权
公开(公告)号：US20060210605A1
公开(公告)日：2006-09-21
申请号：US11150847
申请日：2005-06-10
申请人： John Chang , Joshua Makower , Julia Vrany , John Morriss , Ketan Muni , Isaac Kim , Hung Ha , William Facteau , Amrish Walke
发明人： John Chang , Joshua Makower , Julia Vrany , John Morriss , Ketan Muni , Isaac Kim , Hung Ha , William Facteau , Amrish Walke
IPC分类号： A61M31/00
CPC分类号： A61M29/00 , A61B1/233 , A61B17/12104 , A61B17/12136 , A61B17/1657 , A61B17/1688 , A61B17/24 , A61B17/320016 , A61B17/320725 , A61B34/20 , A61B2017/00292 , A61B2017/246 , A61B2034/2051 , A61B2090/3764 , A61B2503/40 , A61M25/0041 , A61M25/0054 , A61M25/0662 , A61M25/09 , A61M25/1002 , A61M29/02 , A61M2025/0008 , A61M2025/1079 , A61M2029/025 , A61M2210/0618 , A61M2210/1028
摘要： Sinusitis and other disorders of the ear, nose and throat are diagnosed and/or treated using minimally invasive approaches with flexible or rigid instruments. Various methods and devices are used for remodeling or changing the shape, size or configuration of a sinus ostium or duct or other anatomical structure in the ear, nose or throat; implanting a device, cells or tissues; removing matter from the ear, nose or throat; delivering diagnostic or therapeutic substances or performing other diagnostic or therapeutic procedures. Introducing devices (e.g., guide catheters, tubes, guidewires, elongate probes, other elongate members) may be used to facilitate insertion of working devices (e.g. catheters e.g. balloon catheters, guidewires, tissue cutting or remodeling devices, devices for implanting elements like stents, electrosurgical devices, energy emitting devices, devices for delivering diagnostic or therapeutic agents, substance delivery implants, scopes etc.) into the paranasal sinuses or other structures in the ear, nose or throat. Specific devices (e.g., tubular guides, guidewires, balloon catheters, tubular sheaths) are provided as are methods for manufacturing and using such devices to treat disorders of the ear, nose or throat.

87. 发明申请

US20060174870A1 Methods and devices for use in performing pulmonary procedures 有权
公开(公告)号：US20060174870A1
公开(公告)日：2006-08-10
申请号：US11395396
申请日：2006-03-30
申请人： Mark Deem , Hanson Gifford , Ronald French , Douglas Sutton
发明人： Mark Deem , Hanson Gifford , Ronald French , Douglas Sutton
IPC分类号： A61M16/00 , A62B9/06
CPC分类号： F16K15/147 , A61B17/12022 , A61B17/12104 , A61B17/12131 , A61B17/12172 , A61B17/221 , A61B2017/1205 , A61B2017/2215 , A61B2090/061 , A61F2/04 , A61F2/24 , A61F2/2403 , A61F2/2412 , A61F2/2418 , A61F2/91 , A61F2002/043 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , Y10S128/912
摘要： Systems, methods and devices for performing pulmonary procedures, and in particular treating lung disease. A flow control element includes a valve that prevents airflow in the inhalation direction but permits airflow in the exhalation direction. The flow control element is guided to and positioned at the site by a bronchoscope that is introduced into the patient's trachea and used to view the lungs during delivery of the flow control element. The valve may include one, two or more valve elements, and it may be collapsible for easier delivery. A source of vacuum or suction may be used to increase the amount of fluid withdrawn from the lung tissue. A device for measuring hollow structures, such as bronchioles, and a device for removing a previously-placed flow control element are disclosed as well.

88. 发明申请

US20060162731A1 Pulmonary occlusal stent delivery catheter, loading system and methods of use 审中-公开
公开(公告)号：US20060162731A1
公开(公告)日：2006-07-27
申请号：US11280530
申请日：2005-11-15
申请人： Anthony Wondka , Peter Soltesz , Robert Kotmel , Nadia Matov , Thomas Crowder
发明人： Anthony Wondka , Peter Soltesz , Robert Kotmel , Nadia Matov , Thomas Crowder
IPC分类号： A62B9/06 , A61M16/00
CPC分类号： A61B17/12104 , A61B1/012 , A61B1/2676 , A61B17/12022 , A61B17/12172 , A61B2017/00867 , A61B2017/12054 , A61B2017/12086 , A61B2017/22069
摘要： Methods, systems and devices are provided for performing lung volume reduction in patients suffering from chronic obstructive pulmonary disease or other conditions where isolation of a lung segment or reduction of lung volume is desired. The methods are minimally invasive with instruments being introduced through the mouth (endotracheally) and rely on isolating the target lung tissue segment from other regions of the lung and occluding various lung passageways with the use of occlusal stents. The occlusal stents are delivered with the use of an occlusal stent delivery system which is loaded with the occlusal stent with the use of an occlusal stent loading system.

89. 发明申请

US20060135947A1 Occlusal stent and methods for its use 审中-公开
标题翻译：咬合支架及其使用方法
公开(公告)号：US20060135947A1
公开(公告)日：2006-06-22
申请号：US11280592
申请日：2005-11-15
申请人： Peter Soltesz , Anthony Wondka , Jeffrey Lee , Robert Kotmel
发明人： Peter Soltesz , Anthony Wondka , Jeffrey Lee , Robert Kotmel
IPC分类号： A61M31/00
CPC分类号： A61B17/12104 , A61B17/12136 , A61B17/12159 , A61B17/12172 , A61B17/1219 , A61B2017/00862 , A61B2017/00867
摘要： Improved methods, systems and devices for occluding body passageways, particularly lung passageways. Such occlusion is achieved with occlusal stents which are particularly suited for use in performing Endobronchial Volume Reduction (EVR) in patients suffering from chronic obstructive pulmonary disease or other conditions where isolation of a lung segment or reduction of lung volume is desired. The present invention is likewise suitable for the treatment of bronchopleural fistula and potentially for other pulmonary diseases, such as hemoptysis and pneumothorax. The occlusal stents are delivered with the use of any suitable delivery system, particularly minimally invasive with instruments introduced through the mouth (endotracheally). A target lung tissue segment is isolated from other regions of the lung by deploying an occlusal stent into a target area of a lung passageway. A variety of different occlusal stent designs are provided to improve the performance and reliability of the delivered occlusal stent.
摘要翻译：改进的阻塞体通道的方法，系统和装置，特别是肺通道。使用特别适用于在患有慢性阻塞性肺疾病或其它需要肺部分离或肺容积减少的其他病症的患者中进行支气管扩张减少（EVR）的咬合支架实现这种阻塞。本发明同样适用于治疗支气管胸膜瘘并且可能用于其它肺部疾病，例如咯血和气胸。咬合支架使用任何合适的输送系统递送，特别是通过口腔（气管内）引入的器械具有最小的侵入性。通过将咬合支架部署到肺通道的目标区域中，从肺的其他区域分离出目标肺组织段。提供了各种不同的咬合支架设计，以改善输送的咬合支架的性能和可靠性。

90. 发明申请

US20060090761A1 Endobronchial blocking device having a replaceable snare 有权
公开(公告)号：US20060090761A1
公开(公告)日：2006-05-04
申请号：US11250693
申请日：2005-10-11
申请人： Michael Kurrus
发明人： Michael Kurrus
IPC分类号： A61M16/00
CPC分类号： A61M16/0488 , A61B1/2676 , A61B17/12104 , A61B17/12136 , A61M16/04 , A61M16/0404 , A61M16/0445 , A61M16/0459 , A61M16/0475 , A61M16/0486 , A61M2025/1052
摘要： An endobronchial blocker catheter for use in blocking a selected mainstem bronchus under guidance of a bronchoscope. The endobronchial blocker catheter comprises a tubular assembly and an elongated body that receives the tubular assembly. The tubular assembly comprises a tubular member and a loop disposed at a distal end of the tubular member. The loop is sized such that the bronchoscope is passable through the loop. The elongated body has a plurality of lumens therein, and an inflatable blocker balloon disposed about a distal portion of the elongated body. One of the lumens extends to an interior of the balloon to accomplish inflation of the balloon for retaining the blocker catheter in the mainstem bronchus, and another lumen is sized for receiving the tubular assembly in a manner such that the loop extends from a distal end of the elongated body. The blocker catheter is guided by the bronchoscope to the desired inflation site via the loop.

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