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81. 发明授权

US08790703B2 Method for producing preparations of substances poorly soluble in water 有权
标题翻译：生产水溶性差的物质的制备方法
公开(公告)号：US08790703B2
公开(公告)日：2014-07-29
申请号：US13262380
申请日：2010-03-30
申请人： Kathrin Meyer-Böhm , Rainer Dobrawa , Stefan Fischer , Karl Kolter
发明人： Kathrin Meyer-Böhm , Rainer Dobrawa , Stefan Fischer , Karl Kolter
IPC分类号： A61K9/14 , C08F283/06 , C08F18/08 , C08F226/06 , C08F226/10 , A61K8/91 , A61K9/20 , A23L1/29 , A23L1/27 , A23L1/30 , A61K47/34 , A61K8/86 , A61K9/16
CPC分类号： A61K9/2095 , A23L5/40 , A23L33/00 , A23L33/10 , A23P10/30 , A61K8/86 , A61K8/91 , A61K9/146 , A61K9/1641 , A61K9/1682 , A61K9/1694 , A61K47/34 , A61Q19/00 , C08F18/08 , C08F226/06 , C08F226/10 , C08F283/06
摘要： The invention relates to a process for producing formulations of sparingly water-soluble substances, said sparingly soluble substances being present in amorphous embedded form in a copolymer, and said copolymer being obtained by free-radically initiated polymerization of a mixture of i) 30 to 80% by weight of N-vinyllactam, ii) 10 to 50% by weight of vinyl acetate, and iii) 10 to 50% by weight of a polyether, with the proviso that the sum of components i), ii) and iii) equals 100% by weight, which comprises embedding the sparingly soluble substance into the copolymer at temperatures above the melting point of the sparingly soluble substances.
摘要翻译：本发明涉及一种制备少量水溶性物质的制剂的方法，所述微溶物质以无定形嵌入的形式存在于共聚物中，所述共聚物通过i）30至80的混合物的自由基引发聚合而获得重量％的N-乙烯基内酰胺，ii）10-50％重量的乙酸乙烯酯，和iii）10-50％重量的聚醚，条件是组分i），ii）和iii）之和等于 100重量％，其包括在高于易溶性物质的熔点的温度下将微溶物质包埋在共聚物中。

82. 发明申请

US20140186503A1 FOOD ARTICLES WITH DELIVERY DEVICES AND METHODS FOR THE PREPARATION THEREOF 审中-公开
标题翻译：具有递送装置的食品及其制备方法
公开(公告)号：US20140186503A1
公开(公告)日：2014-07-03
申请号：US14198079
申请日：2014-03-05
申请人： DSM Nutritional Products
发明人： Peter H. Mattson , Richard A. Gorski , Brenda Y. Fong , Laura M. Tringale , Deepa Mathew , Peter C. Dea , Sharon Ann Spurvey , Suzelle Rejeanne Robert , Michelle M. Boyden
IPC分类号： A23L1/29
CPC分类号： A23L33/40 , A23C9/1315 , A23C9/1528 , A23C2260/152 , A23P10/30 , A23V2002/00 , A23V2300/41
摘要： Disclosed are food articles comprising microcapsules as delivery devices. Methods of preparing such food articles are also disclosed.
摘要翻译：公开了包含微胶囊作为递送装置的食品。还公开了制备这种食品的方法。

83. 发明申请

US20140166026A1 Capsule Formation 审中-公开
标题翻译：胶囊形成
公开(公告)号：US20140166026A1
公开(公告)日：2014-06-19
申请号：US14237812
申请日：2012-07-27
申请人： Robert Whiffen
发明人： Robert Whiffen
IPC分类号： A24B15/28
CPC分类号： A24B15/283 , A23P10/30 , B01J13/04 , B01J13/206
摘要： A capsule forming apparatus comprising a first support in which a plurality of first outputs configured to output a first capsule material are located; a second support in which a plurality of second outputs configured to output a second capsule material are located; and a second capsule material feed region between the first and second supports from which the second capsule material can enter the second outputs. A method of forming capsules is also described.
摘要翻译：一种胶囊形成装置，包括：第一支撑件，其中配置成输出第一胶囊材料的多个第一输出部位于其中; 配置成输出第二胶囊材料的多个第二输出件的第二支撑件; 以及在所述第一和第二支撑件之间的第二胶囊材料进给区域，所述第二胶囊材料可从所述第二胶囊材料进给区域进入还描述了形成胶囊的方法。

84. 发明授权

US08741337B2 Encapsulation of oxidatively unstable compounds 有权
标题翻译：氧化不稳定化合物的包封
公开(公告)号：US08741337B2
公开(公告)日：2014-06-03
申请号：US12811479
申请日：2009-01-02
申请人： William A. Hendrickson , John M. Finney , Olaf C. Moberg , Christopher J. Rueb , Robert G. Bowman , Chetan S. Rao , Nita M. Bentley
发明人： William A. Hendrickson , John M. Finney , Olaf C. Moberg , Christopher J. Rueb , Robert G. Bowman , Chetan S. Rao , Nita M. Bentley
IPC分类号： A61K9/127 , A61J3/07 , A23L2/00 , A23L1/221
CPC分类号： A23L2/39 , A23L2/52 , A23L27/72 , A23L33/105 , A23L33/12 , A23L33/16 , A23P10/30 , A61K9/5015 , A61K9/5036 , A61K9/5063 , A61K9/5073
摘要： An encapsulated material containing an oxidation-sensitive core is covered by at least a dried phospholipid layer, and contains at least one phytosterol in the core, the phospholipid layer or in a further layer or layers. By using microencapsulation, oxidatively unstable materials may be provided with a synthetic protective barrier and rendered less susceptible to oxidative degradation.
摘要翻译：含有氧化敏感核心的包封材料至少被干燥的磷脂层覆盖，并且在芯部，磷脂层中或在另外的层中含有至少一种植物甾醇。通过使用微胶囊化，氧化不稳定的材料可以具有合成的保护屏障，并且对氧化降解的影响较小。

85. 发明申请

US20140147501A1 METHOD FOR THE EMBEDDING AND ENCAPSULATION OF COMPONENTS 审中-公开
标题翻译：组件嵌入和封装的方法
公开(公告)号：US20140147501A1
公开(公告)日：2014-05-29
申请号：US14167097
申请日：2014-01-29
申请人： GENERAL MILLS, INC.
发明人： Bernhard H. VAN LENGERICH
IPC分类号： A61K9/20 , A23L1/00
CPC分类号： A61K9/2086 , A23L27/72 , A23P10/30 , B01J13/02 , B29B7/421 , B29B7/46 , B29B7/482 , B29B7/823 , B29B7/845 , B29B7/86 , B29C48/40 , B29C48/832
摘要： Controlled release, discrete, solid particles which contain an encapsulated and/or embedded component such as a heat sensitive or readily oxidizable pharmaceutically, biologically, or nutritionally active component are continuously produced without substantial destruction of the matrix material or encapsulant. A release-rate controlling component is incorporated into the matrix to control the rate of release of the encapsulant from the particles. The additional component may be a hydrophobic component or a high water binding capacity component for extending the release time. The plasticizable matrix material, such as starch, is admixed with at least one plasticizer, such as water, and at least one release-rate controlling component under low shear mixing conditions to plasticize the plasticizable material without substantially destroying the at least one plasticizable material and to obtain a substantially homogeneous plasticized mass. The plasticizer content is substantially reduced and the temperature of the plasticized mass are substantially reduced prior to admixing the plasticized mass with the encapsulant to avoid substantial destruction of the encapsulant and to obtain a formable, extrudable mixture. The mixture is extruded through a die without substantial or essentially no expansion and cut into discrete, relatively dense particles. Release properties may also be controlled by precoating the encapsulant and/or coating the extrudate particles with a film-forming component.
摘要翻译：含有包封和/或嵌入的组分如热敏或易氧化的药学，生物学或营养活性组分的受控释放的离散固体颗粒被连续地生产而基本上不破坏基质材料或密封剂。将释放速率控制组分并入基质中以控制密封剂从颗粒中释放的速率。附加组分可以是用于延长释放时间的疏水组分或高水结合能力组分。可塑性基质材料如淀粉在低剪切混合条件下与至少一种增塑剂（例如水）和至少一种释放速率控制组分混合，以塑化可塑化材料，而基本上不破坏至少一种可塑化材料，以获得基本均匀的增塑物质。在将塑化物料与密封剂混合之前，增塑剂含量显着降低，并且塑化物料的温度显着降低，以避免密封剂的实质破坏并获得可成形的可挤压混合物。将混合物通过模具挤出而没有实质或基本上没有膨胀，并切成离散的相对致密的颗粒。释放性质也可以通过预先涂覆密封剂和/或用成膜组分涂覆挤出物颗粒来控制。

86. 发明申请

US20140037830A1 SUSTAINED RELEASE OF NUTRIENTS IN VIVO 审中-公开
公开(公告)号：US20140037830A1
公开(公告)日：2014-02-06
申请号：US14046731
申请日：2013-10-04
申请人： NEW WORLD PHARMACEUTICALS, LLC
发明人： Frederick A. SEXTON , Sitaraman Krishnan , Venkat Kalyan Vendra
IPC分类号： A23L1/29
CPC分类号： A23L33/15 , A23G4/06 , A23L2/52 , A23L5/00 , A23L29/206 , A23L29/272 , A23L29/30 , A23L33/125 , A23L33/16 , A23L33/175 , A23L33/24 , A23L33/25 , A23L33/26 , A23L33/30 , A23L33/40 , A23P10/25 , A23P10/30 , A23V2002/00 , A23V2200/33 , A23V2250/51086 , A23V2250/51 , A23V2250/5026 , A23V2250/606 , A23V2250/608 , A23V2250/616 , A23V2250/612 , A23V2250/5114 , A23V2250/06 , A23V2250/50
摘要： Nutritional compositions delivered in vivo in a time controlled manner sustainable over long periods of time, provide enhancing athletic performance, increased hand/eye coordination and concentration on the task at hand.

87. 发明申请

US20140037722A1 METHODS AND COMPOSITIONS OF CAMEL DERIVED PRODUCTS 审中-公开
标题翻译： CAMEL衍生产品的方法和组成
公开(公告)号：US20140037722A1
公开(公告)日：2014-02-06
申请号：US13953888
申请日：2013-07-30
申请人： Shaker A. Mousa , Abdulqader Al Haider , Abdelgalil Abdelgader , Abdullah M. Aldahmash , Abdulkareem Almomen
发明人： Shaker A. Mousa , Abdulqader Al Haider , Abdelgalil Abdelgader , Abdullah M. Aldahmash , Abdulkareem Almomen
IPC分类号： A61K9/48 , A61K47/42 , A61K31/727 , A61K31/704 , A61K31/12 , A23C9/152 , A61K31/337
CPC分类号： A61K9/4866 , A23C9/152 , A23C2260/152 , A23G9/00 , A23L33/19 , A23P10/30 , A23V2002/00 , A61K8/0283 , A61K8/63 , A61K8/64 , A61K8/73 , A61K8/736 , A61K9/5153 , A61K9/5169 , A61K31/12 , A61K31/337 , A61K31/704 , A61K31/726 , A61K31/727 , A61K31/728 , A61K31/738 , A61K38/00 , A61K47/42 , A61K47/644 , A61K47/68 , A61K47/6929 , A61K47/6937 , A61K2800/413 , A61Q11/00 , A23V2200/25 , A23V2250/54246 , A23V2250/54248
摘要： The present invention provides a composition, a dairy product, and a method for treating a disorder in a subject. The composition includes (i) polymeric nanoparticles and (ii) camel derived glycosaminoglycans (GAG)s ionic complex encapsulated into the nanoparticles, at least one active ingredient encapsulated into the nanoparticles, or combinations thereof. The nanoparticles are lactoferrin nanoparticles including camel derived lactoferrin, casein nanoparticles including camel derived casein, or combinations thereof. The dairy product includes ice cream or frozen yogurt, wherein the ice cream or frozen yogurt includes the composition and is derived from camel milk or other species of milk. The method for treating a disorder in a subject includes administering a therapeutic dose of the composition to the subject.
摘要翻译：本发明提供组合物，乳制品和治疗受试者中的病症的方法。组合物包括（i）聚合物纳米颗粒和（ii）包封在纳米颗粒中的骆驼衍生的糖胺聚糖（GAG）离子络合物，包封到纳米颗粒中的至少一种活性成分或其组合。纳米颗粒是乳铁蛋白纳米颗粒，包括骆驼衍生的乳铁蛋白，酪蛋白纳米颗粒，包括骆驼衍生的酪蛋白，或其组合。乳制品包括冰淇淋或冷冻酸奶，其中冰淇淋或冷冻酸奶包括该组合物并且来自骆驼乳或其它种类的牛奶。用于治疗受试者中的病症的方法包括向受试者施用治疗剂量的组合物。

88. 发明申请

US20140023693A1 PROTECTION OF MICROBIAL CELLS FROM ACIDIC DEGRADATION 审中-公开
标题翻译：保护微生物从酸性降解
公开(公告)号：US20140023693A1
公开(公告)日：2014-01-23
申请号：US13981789
申请日：2012-01-25
申请人： Walter H. Guenzburg , Eva Maria Brandtner , Brian Salmons Salmons , John A. Dangerfield
发明人： Walter H. Guenzburg , Eva Maria Brandtner , Brian Salmons Salmons , John A. Dangerfield
IPC分类号： A61K9/48 , A23L1/30 , A61K35/74
CPC分类号： A61K9/48 , A23L29/06 , A23L29/262 , A23L33/135 , A23P10/30 , A23V2002/00 , A23Y2220/03 , A61K9/5026 , A61K9/5031 , A61K9/5047 , A61K35/741 , A61K35/742 , A61K35/747 , A61K36/064 , A23V2200/224 , A23V2200/32 , A23V2250/51088
摘要： A simple cellulose sulphate based microencapsulation technology has been applied to encapsulate bacterial or other microbial cells, which produce and release digestive enzymes and thereby provides an acid resistant shelter for these microbial cells. Surprisingly, the resulting spheres were found to provide sufficient protection for encapsulated cells from treatment with aqueous acidic solutions. Thereby the cellulose sulphate microencapsulated cells, such as probiotics are now enabled to survive passage, for example, through the stomach after consumption by a human or animal with a higher survival rate than those not within a microcapsule. After passing the stomach these cells are delivering products produced by them, e.g. enzymes or other nutrition factors. This technology therefore proves to be very useful in providing digestive or otherwise beneficial enzymes and/or of living microbial cells, into the lower gastrointestinal tract, where they could confer their health benefit to the host.
摘要翻译：已经应用简单的基于硫酸纤维素的微囊化技术来包封细菌或其他微生物细胞，其产生和释放消化酶，从而为这些微生物细胞提供耐酸性的避孕所。令人惊奇的是，发现所得的球体为包封的细胞提供了足够的保护，不能用酸性水溶液处理。因此，现在使纤维素硫酸盐微胶囊化细胞例如益生菌能够通过人类或动物消耗后通过胃中存活，比具有不在微胶囊内的人或动物具有更高的存活率。通过胃后，这些细胞递送由它们产生的产物，例如酶或其他营养因素。因此，该技术证明在将消化或其它有益的酶和/或活的微生物细胞提供到下胃肠道中是非常有用的，在那里它们可以给宿主带来健康益处。

89. 发明申请

US20140004179A1 COMPOSITION COMPRISING DIAMINE OXIDASE FOR USE IN THE TREATMENT OR PREVENTION OF FIBROMYALGIA OR CHRONIC FATIGUE SYNDROME 审中-公开
标题翻译：包含DIAMINE氧化酶的组合物用于治疗或预防纤维瘤或慢性疲劳综合征
公开(公告)号：US20140004179A1
公开(公告)日：2014-01-02
申请号：US14005020
申请日：2012-03-16
申请人： Carlos Duelo Riu , Juan José Duelo Riu
发明人： Carlos Duelo Riu , Juan José Duelo Riu
IPC分类号： A61K38/44 , A61K31/522
CPC分类号： A61K31/522 , A23L33/10 , A23L33/105 , A23L33/17 , A23P10/28 , A23P10/30 , A23P10/40 , A61K9/2018 , A61K9/48 , A61K9/5026 , A61K9/5047 , A61K38/44 , C12N9/0022 , C12Y104/03022
摘要： The present invention refers to a composition comprising diamine oxidase for use in the prevention or treatment of the symptoms and disorders caused by fibromyalgia or chronic fatigue syndrome.
摘要翻译：本发明涉及包含用于预防或治疗由纤维肌痛或慢性疲劳综合征引起的症状和障碍的二胺氧化酶的组合物。

90. 发明申请

US20130317098A1 PROTECTIVE HYDROCOLLOID FOR ACTIVE INGREDIENTS 审中-公开
标题翻译：活性成分的保护性水解剂
公开(公告)号：US20130317098A1
公开(公告)日：2013-11-28
申请号：US13989601
申请日：2011-11-10
申请人： Christian Schaefer
发明人： Christian Schaefer
IPC分类号： A23J1/12 , A61K8/64 , A23J3/18 , A61K47/42
CPC分类号： A61K47/42 , A23J1/12 , A23J1/125 , A23J3/14 , A23J3/18 , A23K20/147 , A23K20/158 , A23K20/174 , A23K20/179 , A23L2/52 , A23L2/58 , A23L2/66 , A23L5/41 , A23L5/43 , A23L5/44 , A23L33/10 , A23L33/115 , A23L33/15 , A23L33/185 , A23P10/30 , A23V2002/00 , A61K8/31 , A61K8/645 , A61K9/0095 , A61K9/10 , A61K31/015 , A61K31/07 , A61K31/355 , A61K2800/10 , A61K2800/42 , A61Q17/04 , A61Q19/00 , A23V2250/211 , A23V2250/548 , A23V2250/702 , A23V2250/712
摘要： (Modified) sorghum protein is used as novel protective hydrocolloid for active ingredients, especially fat-soluble active ingredients and/or colorants. Included are compositions comprising (modified) sorghum protein and at least one active ingredient and to their manufacture, as well as to the (modified) sorghum protein itself and its manufacture. These compositions are used for the enrichment, fortification and/or coloration of food, beverages, animal feed, personal care or pharmaceutical compositions, and to food, beverages, animal feed, personal care and pharmaceutical compositions containing such a (modified) sorghum protein and such a composition, respectively.
摘要翻译：（改性）高粱蛋白用作活性成分的新型保护性水胶体，特别是脂溶性活性成分和/或着色剂。包括的是包含（修饰的）高粱蛋白质和至少一种活性成分及其制备以及（修饰的）高粱蛋白质本身及其制造的组合物。这些组合物用于食品，饮料，动物饲料，个人护理或药物组合物的富集，强化和/或着色，以及含有这种（修饰的）高粱蛋白质的食品，饮料，动物饲料，个人护理和药物组合物，以及这样的组合物。

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