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81. 发明授权

US07217508B1 Cloned DNA sequence related to genomic RNA of human immunodeficiency virus (HIV-1) 失效
标题翻译：与人类免疫缺陷病毒（HIV-1）的基因组RNA相关的克隆DNA序列
公开(公告)号：US07217508B1
公开(公告)日：2007-05-15
申请号：US07158652
申请日：1988-02-22
申请人： Simon Wain-Hobson , Solange Chamaret , Claudine Axler-Blin , Francoise Rey , Marie-Therese Nugeyre , Jacques Gruest, legal representative , Charles Dauguet , Willy Rozenbaum , Christine Rouzioux , Francois Brun-Vezinet , Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Pierre Tiollais , Marc Alizon , Pierre Sonigo , Stewart Cole , Oliver Danos , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
发明人： Jacqueline Gruest, deceased
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02
CPC分类号： C07K14/005 , C12N2740/16021 , C12Q1/703
摘要： This invention is in the field of lymphadenopathy virus, which has been designated Human Immunodeficiency Virus Type 1 (HIV-1). This invention relates to a diagnostic means and method to detect the presence of DNA, RNA or antibodies of the lymphadenopathy retrovirus associated with the acquired immune deficiency syndrome or of the lymphadenopathy syndrome by the use of DNA fragments or the peptides encoded by said DNA fragments. The invention further relates to the DNA fragments, vectors comprising them and the proteins expressed.
摘要翻译：本发明在淋巴结病毒病毒领域已被指定为1型HIV-1型人类免疫缺陷病毒。本发明涉及通过使用DNA片段或由所述DNA片段编码的肽来检测与所获得的免疫缺陷综合征或淋巴结病综合征相关的淋巴结病变逆转录病毒的DNA，RNA或抗体的存在的诊断方法和方法。本发明还涉及DNA片段，包含它们的载体和表达的蛋白质。

82. 发明授权

US07189812B2 Human gene critical to fertility 有权
标题翻译：人类对生育关键的基因
公开(公告)号：US07189812B2
公开(公告)日：2007-03-13
申请号：US10677943
申请日：2003-10-01
申请人： Lawrence M. Nelson , Zhi-Bin Tong
发明人： Lawrence M. Nelson , Zhi-Bin Tong
IPC分类号： C07K14/00
CPC分类号： C07H21/04 , A01K2217/05 , C07K14/47 , C07K16/18 , C07K2319/00 , G01N33/689 , G01N2800/361 , G01N2800/367 , Y10S424/811 , Y10S530/806 , Y10S530/853
摘要： Disclosed herein are novel nucleic acid and protein sequences that are essential to fertility. In particular, human Mater genomic, cDNA and protein sequences are provided, as are fragments and variants thereof. Functional MATER is required for female fertility; zygotes that arise from Mater null oocytes do not progress beyond the two-cell stage. Methods are described for using Mater molecules in diagnoses, prognosis, and treatment of infertility and reduced fertility, and kits related to such methods. Also provided are methods for using MATER as a contraceptive agent. The disclosure also describes compounds involved in such methods, and the identification of such compounds.
摘要翻译：本文公开了对生育力至关重要的新的核酸和蛋白质序列。特别地，提供人母细胞基因组，cDNA和蛋白质序列，以及其片段和变体。女性生育需要功能性MATER; 来自Mater的卵母细胞不能超过两细胞阶段。描述了使用Mater分子诊断，预后和治疗不孕症和降低生育力的方法，以及与这些方法相关的试剂盒。还提供了使用MATER作为避孕药的方法。本公开还描述了涉及这些方法的化合物以及这些化合物的鉴定。

83. 发明授权

US07189393B2 Recombinant anti-tumor RNAse 失效
标题翻译：重组抗肿瘤RNA酶
公开(公告)号：US07189393B2
公开(公告)日：2007-03-13
申请号：US09948391
申请日：2001-09-06
申请人： Susanna M. Rybak , Dianne L. Newton
发明人： Susanna M. Rybak , Dianne L. Newton
IPC分类号： A61K38/43
CPC分类号： C12N9/22 , A61K38/00 , A61K47/6815
摘要： This invention provides for new recombinant ribonuclease proteins which are active when expressed by bacteria. This allows the recombinant ribonucleases of this invention to be fused in-frame with ligand binding moieties to form cytotoxic fusion proteins. Furthermore, these proteins are more active than ribonucleases currently available even though the proteins of this invention lack an N-terminal pyroglutamic acid, which has been found to be necessary for ribonucleolytic activity. Because these proteins are recombinant proteins, mutations which increase cytotoxicity can be engineered.
摘要翻译：本发明提供了当由细菌表达时具有活性的新的重组核糖核酸酶蛋白。这允许本发明的重组核糖核酸酶与配体结合部分框架融合以形成细胞毒性融合蛋白。此外，这些蛋白质比现有的核糖核酸酶更有活性，即使本发明的蛋白质缺乏已经被认为是核糖核酸分解活性所必需的N-末端焦谷氨酸。因为这些蛋白质是重组蛋白，所以可以设计增加细胞毒性的突变。

84. 发明授权

US07179899B2 Composite antibodies of humanized human subgroup IV light chain capable of binding to TAG-72 有权
标题翻译：能够结合TAG-72的人源化人亚组IV轻链的复合抗体
公开(公告)号：US07179899B2
公开(公告)日：2007-02-20
申请号：US10255478
申请日：2002-09-25
申请人： Peter S. Mezes , Ruth A. Richard , Kimberly S. Johnson , Jeffrey Schlom , Syed V. S. Kashmiri , Liming Shu , Eduardo A. Padlan
发明人： Peter S. Mezes , Ruth A. Richard , Kimberly S. Johnson , Jeffrey Schlom , Syed V. S. Kashmiri , Liming Shu , Eduardo A. Padlan
IPC分类号： C07H21/04
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/622 , Y10S530/866 , Y10S530/867
摘要： Novel composite and humanized anti-TAG-72 monoclonal antibodies, antibody fragments, and derivatives thereof using human subgroup IV kappa light chain framework regions.
摘要翻译：使用人亚组IVκ轻链框架区的新型复合和人源化抗TAG-72单克隆抗体，抗体片段及其衍生物。

85. 发明授权

US07179621B1 Pigment epithelium-derived factor: sequence of the PEDF gene 失效
标题翻译：颜料上皮衍生因子：PEDF基因序列
公开(公告)号：US07179621B1
公开(公告)日：2007-02-20
申请号：US09630629
申请日：2000-08-01
申请人： Gerald J. Chader , Ignacio R. Rodriguez , Joyce Tombran-Tink , Sofia Patricia Becerra , Fintan R. Steele , Lincoln V. Johnson
发明人： Gerald J. Chader , Ignacio R. Rodriguez , Joyce Tombran-Tink , Sofia Patricia Becerra , Fintan R. Steele , Lincoln V. Johnson
IPC分类号： C12N15/18 , C12N15/79 , C12N15/63 , C12N1/21
CPC分类号： C07K14/811 , A61K38/00 , C07K14/475 , C07K16/38
摘要： Nucleic acids encoding the neurotrophic protein known as pigment epithelium derived factor (PEDF), a truncated version of PEDF referred to as rPEDF, and equivalent proteins, vectors comprising such nucleic acids, host cells into which such vectors have been introduced, recombinant methods for producing PEDF, rPEDF, and equivalent proteins, the rPEDF protein and equivalent proteins of rPEDF and PEDF-BP, -BX and BA, and the PEDF protein produced by recombinant methods. Effects and uses of these variants on 1) neuronal differentiation (neurotrophic effect) 2) neuron survival (neuronotrophic effect) and 3) glial inhibition (gliastatic effect) are described.
摘要翻译：编码称为色素上皮衍生因子（PEDF）的神经营养蛋白的核酸，被称为rPEDF的PEDF的截短形式，以及等效蛋白质，包含这种核酸的载体，其中引入了这些载体的宿主细胞，重组方法产生PEDF，rPEDF和等效蛋白质，rPEDF蛋白和rPEDF和PEDF-BP，-BX和BA的相应蛋白质和通过重组方法产生的PEDF蛋白。这些变体的作用和用途1）神经元分化（神经营养作用）2）神经元存活（神经营养作用）和3）胶质细胞抑制（神经营养作用）。

86. 发明授权

US07152919B2 Wearable kneel-sit support device 有权
标题翻译：可穿戴式跪坐支撑装置
公开(公告)号：US07152919B2
公开(公告)日：2006-12-26
申请号：US10481532
申请日：2002-05-28
申请人： Steven J. Wurzelbacher , Ova E. Johnston , Stephen D. Hudock
发明人： Steven J. Wurzelbacher , Ova E. Johnston , Stephen D. Hudock
IPC分类号： A47C1/00 , A47C7/50
CPC分类号： A47C9/027 , A47C16/04
摘要： A wearable kneel-sit support device includes a U-shaped body that is pivotally connected to both a seat member and a base member. A linking member connects the seat member and the base member, such that moving one of the seat member and the base member causes both the seat member and the base member to rotate from a folded position adjacent the leg of the user to an unfolded position. In the unfolded position, the base member can rest on a horizontal surface and the seat member is substantially parallel to the base member, so that the wearer can sit on the seat while kneeling. The device may be worn on the lower leg of a user in a folded position to allow unhindered ambulation.
摘要翻译：可佩戴的跪坐支撑装置包括U形主体，该U形主体枢转地连接到座椅构件和基座构件。连接构件连接座椅构件和基座构件，使得移动座椅构件和基座构件中的一个使得座椅构件和基座构件两者从邻近使用者的腿部的折叠位置旋转到展开位置。在展开位置，基部构件可以搁置在水平表面上，并且座椅构件基本上平行于基部构件，使得穿着者可以在跪下的同时坐在座椅上。该装置可以在折叠位置佩戴在使用者的小腿上，以允许不受阻碍的行走。

87. 发明授权

US07150984B2 Attenuated human rotavirus vaccine 失效
标题翻译：减毒人轮状病毒疫苗
公开(公告)号：US07150984B2
公开(公告)日：2006-12-19
申请号：US08500564
申请日：1995-07-11
申请人： Yasutaka Hoshino , Albert Z. Kapikian , Robert M. Chanock
发明人： Yasutaka Hoshino , Albert Z. Kapikian , Robert M. Chanock
IPC分类号： C12N7/04 , C12N7/08 , A61K39/15
CPC分类号： C12N7/00 , A61K39/12 , A61K39/15 , A61K2039/5254 , A61K2039/542 , C12N2720/12334 , C12N2720/12364
摘要： The present invention provides vaccine compositions of attenuated human rotavirus. More particularly, the attenuated human rotavirus is produced by cold passage and thus contains attenuating mutations which produce virus having a cold-adapted (ca) and temperature sensitive (ts) phenotype. The attenuated strains are used in methods for stimulating the immune system of an individual to induce protection against human rotavirus by administration of the ca attenuated rotavirus.
摘要翻译：本发明提供了减毒人轮状病毒的疫苗组合物。更具体地，减毒的人轮状病毒通过冷传播产生，因此含有产生具有冷适应（ca）和温度敏感（ts）表型的病毒的减毒突变。减毒菌株用于刺激个体的免疫系统以通过施用ca减毒轮状病毒诱导针对人轮状病毒的保护的方法。

88. 发明授权

US07148323B2 Major neutralization site of hepatitis E virus and use of this neutralization site in methods of vaccination and in methods of screening for neutralizing antibodies to hepatitis E virus 有权
标题翻译：丙型肝炎病毒的主要中和位点，以及在接种方法中使用该中和部位和筛选中和乙型肝炎病毒抗体的方法
公开(公告)号：US07148323B2
公开(公告)日：2006-12-12
申请号：US11054041
申请日：2005-02-09
申请人： Darren Schofield , Suzanne U. Emerson , Robert H. Purcell
发明人： Darren Schofield , Suzanne U. Emerson , Robert H. Purcell
IPC分类号： C12P21/08 , C07K16/08 , A61K39/42 , A61K39/29 , G01N33/53 , A61K39/395
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K16/10 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C12N2770/28122
摘要： The invention describes the identification of a major neutralization site of hepatitis E virus (HEV) and the use of this neutralization site in methods of vaccination and in methods of screening for neutralizing antibodies to HEV. The invention also describes the isolation and characterization of neutralizing chimpanzee monoclonal antibodies reactive to the neutralization site and the use of these antibodies in the diagnosis, treatment and prevention of HEV.
摘要翻译：本发明描述了乙型肝炎病毒（HEV）的主要中和位点的鉴定以及该中和位点在接种方法中的用途以及筛选HEV中和抗体的方法。本发明还描述了对中和黑素族中和位点反应的中和黑猩猩单克隆抗体的分离和表征以及这些抗体在HEV的诊断，治疗和预防中的用途。

89. 发明授权

US07141589B2 Methods of inhibiting formation of vascular channels and methods of inhibiting proliferation 有权
标题翻译：抑制血管通道形成的方法和抑制增殖的方法
公开(公告)号：US07141589B2
公开(公告)日：2006-11-28
申请号：US10486671
申请日：2002-08-23
申请人： Myung Hee Park , Paul M Clement , Hartmut M Hanauske-Abel , Edith C. Wolff , Hynda K Kleinman , Bernadette M Cracchiolo
发明人： Myung Hee Park , Paul M Clement , Hartmut M Hanauske-Abel , Edith C. Wolff , Hynda K Kleinman , Bernadette M Cracchiolo
IPC分类号： A61K31/44 , A61K38/00
CPC分类号： A61K31/16 , A61K31/44 , A61K31/4412
摘要： A method of inhibiting formation of vascular channels in tissues and a method of inhibiting proliferation of a cell of a non-vascularized intraepithelial neoplasia, both of which methods comprise administering to the tissues or the cell a compound.
摘要翻译：抑制组织中血管通道形成的方法和抑制非血管化上皮内瘤变细胞增殖的方法，所述方法包括向组织或细胞施用化合物。

90. 发明授权

US07138493B1 ATP-binding cassette protein responsible for cytotoxin resistance 有权
标题翻译：负责细胞毒素抗性的ATP结合盒蛋白
公开(公告)号：US07138493B1
公开(公告)日：2006-11-21
申请号：US09856927
申请日：1999-11-24
申请人： Michael Dean , Rando L. Allikmets , Susan E. Bates , Antonio T. Fojo
发明人： Michael Dean , Rando L. Allikmets , Susan E. Bates , Antonio T. Fojo
IPC分类号： C07K5/00
CPC分类号： C07K14/705
摘要： This invention provides for a novel ATP-binding cassette protein which is responsible for cytotoxin resistance. The invention also provides for methods of expressing the protein and assays for identification of inhibitors of the protein.
摘要翻译：本发明提供了一种负责细胞毒素抗性的新型ATP结合盒蛋白。本发明还提供表达蛋白质的方法和用于鉴定蛋白质抑制剂的测定法。

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