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1. 发明授权

US07217508B1 Cloned DNA sequence related to genomic RNA of human immunodeficiency virus (HIV-1) 失效
标题翻译：与人类免疫缺陷病毒（HIV-1）的基因组RNA相关的克隆DNA序列
公开(公告)号：US07217508B1
公开(公告)日：2007-05-15
申请号：US07158652
申请日：1988-02-22
申请人： Simon Wain-Hobson , Solange Chamaret , Claudine Axler-Blin , Francoise Rey , Marie-Therese Nugeyre , Jacques Gruest, legal representative , Charles Dauguet , Willy Rozenbaum , Christine Rouzioux , Francois Brun-Vezinet , Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Pierre Tiollais , Marc Alizon , Pierre Sonigo , Stewart Cole , Oliver Danos , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
发明人： Jacqueline Gruest, deceased
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02
CPC分类号： C07K14/005 , C12N2740/16021 , C12Q1/703
摘要： This invention is in the field of lymphadenopathy virus, which has been designated Human Immunodeficiency Virus Type 1 (HIV-1). This invention relates to a diagnostic means and method to detect the presence of DNA, RNA or antibodies of the lymphadenopathy retrovirus associated with the acquired immune deficiency syndrome or of the lymphadenopathy syndrome by the use of DNA fragments or the peptides encoded by said DNA fragments. The invention further relates to the DNA fragments, vectors comprising them and the proteins expressed.
摘要翻译：本发明在淋巴结病毒病毒领域已被指定为1型HIV-1型人类免疫缺陷病毒。本发明涉及通过使用DNA片段或由所述DNA片段编码的肽来检测与所获得的免疫缺陷综合征或淋巴结病综合征相关的淋巴结病变逆转录病毒的DNA，RNA或抗体的存在的诊断方法和方法。本发明还涉及DNA片段，包含它们的载体和表达的蛋白质。

2. 发明授权

US06894152B1 Cloned DNA sequences related to the genomic RNA of lymphadenopathy-associated-virus (LAV) and proteins encoded by said LAV genomic RNA 失效
标题翻译：与淋巴结病毒相关病毒（LAV）的基因组RNA相关的克隆DNA序列和由所述LAV基因组RNA编码的蛋白质
公开(公告)号：US06894152B1
公开(公告)日：2005-05-17
申请号：US08202239
申请日：1994-02-25
申请人： Marc Alizon , Pierre Sonigo , Cole Stewart , Oliver Danos , Simon Wain-Hobson
发明人： Marc Alizon , Pierre Sonigo , Cole Stewart , Oliver Danos , Simon Wain-Hobson
IPC分类号： C07H21/02 , C12Q1/68
CPC分类号： C12Q1/703
摘要： This invention is in the field of lymphadenopathy virus which has been designated Human Immunodeficiency Virus Type 1 (HIV-1). This invention relates to a diagnostic means and method to detect the presence of DNA, RNA or antibodies of the lymphadenopathy retrovirus associated with the acquired immune deficiency syndrome or of the lymphadenopathy syndrome by the use of DNA fragments of the peptides encoded by said DNA fragments. The invention further relates to the DNA fragments, vectors comprising them and the proteins expressed.
摘要翻译：本发明属于已被指定为1型HIV（1型）免疫缺陷病毒的淋巴结病毒病毒。本发明涉及通过使用由所述DNA片段编码的肽的DNA片段来检测与获得性免疫缺陷综合征或淋巴结病综合征相关的淋巴结病变逆转录病毒的DNA，RNA或抗体的存在的诊断方法和方法。本发明还涉及DNA片段，包含它们的载体和表达的蛋白质。

3. 发明授权

US07045130B1 Antibodies against antigens of human immunodeficiency virus (HIV-1) 失效
标题翻译：针对人类免疫缺陷病毒（HIV-1）抗原的抗体
公开(公告)号：US07045130B1
公开(公告)日：2006-05-16
申请号：US08026736
申请日：1993-03-05
申请人： Marc Alizon , Pierre Sonigo , Cole Stewart , Oliver Danos , Simon Wain-Hobson
发明人： Marc Alizon , Pierre Sonigo , Cole Stewart , Oliver Danos , Simon Wain-Hobson
IPC分类号： A61K39/42
CPC分类号： C07K16/1063
摘要： This invention is in the field of lymphadenopathy virus, which has been designated Human Immunodeficiency Virus Type 1 (HIV-1). This invention relates to a diagnostic means and method to detect the presence of DNA, RNA or antibodies of the lymphadenopathy retrovirus associated with the acquired immune deficiency syndrome or of the lymphadenopathy syndrome by the use of DNA fragments or the peptides encoded by said DNA fragments. The invention further relates to the DNA fragments, vectors comprising them and the proteins expressed.
摘要翻译：本发明在淋巴结病毒病毒领域已被指定为1型HIV-1型人类免疫缺陷病毒。本发明涉及通过使用DNA片段或由所述DNA片段编码的肽来检测与所获得的免疫缺陷综合征或淋巴结病综合征相关的淋巴结病变逆转录病毒的DNA，RNA或抗体的存在的诊断方法和方法。本发明还涉及DNA片段，包含它们的载体和表达的蛋白质。

4. 发明授权

US06706268B1 Human deficiency virus type-1 (HIV-1) peptide encoded by the VIF gene 失效
标题翻译：由VIF基因编码的人类免疫缺陷病毒1型（HIV-1）肽
公开(公告)号：US06706268B1
公开(公告)日：2004-03-16
申请号：US09709316
申请日：2000-11-13
申请人： Marc Alizon , Pierre Sonigo , Cole Stewart , Oliver Danos , Simon Wain-Hobson
发明人： Marc Alizon , Pierre Sonigo , Cole Stewart , Oliver Danos , Simon Wain-Hobson
IPC分类号： A61K3921
CPC分类号： C07K14/005 , C12N2740/16322
摘要： This invention is in the field of lymphadenopathy virus. This invention relates to a diagnostic means and method to detect the presence of DNA, RNA or antibodies of the lymphadenopathy retrovirus associated with the acquired immune deficiency syndrome or of the lymphadenopathy syndrome by the use of DNA fragments or the peptides encoded by said DNA fragments. The invention further relates to the DNA fragments, vectors comprising them and the proteins expressed.
摘要翻译：本发明在淋巴结病毒病毒领域。本发明涉及通过使用DNA片段或由所述DNA片段编码的肽来检测与所获得的免疫缺陷综合征或淋巴结病综合征相关的淋巴结病变逆转录病毒的DNA，RNA或抗体的存在的诊断方法和方法。本发明还涉及DNA片段，包含它们的载体和表达的蛋白质。

5. 发明授权

US06555112B1 Peptides derived from the lymphadenopathy-associated virus (LAV) envelope coding region 失效
标题翻译：衍生自淋巴结病相关病毒（LAV）包膜编码区的肽
公开(公告)号：US06555112B1
公开(公告)日：2003-04-29
申请号：US08391271
申请日：1995-02-21
申请人： Marc Alizon , Pierre Sonigo , Cole Stewart , Oliver Danos , Simon Wain-Hobson
发明人： Marc Alizon , Pierre Sonigo , Cole Stewart , Oliver Danos , Simon Wain-Hobson
IPC分类号： A61K3921
CPC分类号： A61K38/162 , A61K39/00
摘要： The molecular cloning and characterization of a novel human retrovirus, designated lymphadenopathy-associated virus, or LAV, is disclosed. LAV was originally isolated from a patient with acquired immune deficiency syndrome (AIDS). A cloned LAV complementary DNA (cDNA) was used to screen a library of recombinant phages constructed from the genomic DNA of LAV-infected T lymphocytes. The nucleotide sequence of an insert obtained from the recombinant phage clone &lgr;J19 was ascertained through M13 shotgun cloning and the dideoxy chain termination sequencing method. The env coding region was identified and peptides obtained therefrom. These peptides correspond to amino acids 239-294, 273-317, 300-327, 334-381, 397-424, and 466-500 of the LAV env. These peptides provide suitable diagnostic reagents for the detection LAV-specific antibodies and for the generation of LAV-specific immunological reagents.
摘要翻译：公开了一种新型人类逆转录病毒（称为淋巴结病相关病毒）或LAV的分子克隆和表征。 LAV最初与获得性免疫缺陷综合征（AIDS）的患者分离。使用克隆的LAV互补DNA（cDNA）筛选由LAV感染的T淋巴细胞的基因组DNA构建的重组噬菌体文库。通过M13霰弹枪克隆和双脱氧链终止测序方法确定从重组噬菌体克隆lambdJ19获得的插入物的核苷酸序列。鉴定了env编码区和从其获得的肽。这些肽对应于LAV环境的氨基酸239-294,273-317,300-327,334-381,397-424和466-500。这些肽为检测LAV特异性抗体和产生LAV特异性免疫试剂提供合适的诊断试剂。

6. 发明授权

US5980900A Amino acid DNA sequences related to genomic RNA of human immunodeficiency virus (HIV-1) 失效
标题翻译：与人类免疫缺陷病毒（HIV-1）的基因组RNA相关的氨基酸DNA序列
公开(公告)号：US5980900A
公开(公告)日：1999-11-09
申请号：US751059
申请日：1991-08-28
申请人： Marc Alizon , Pierre Sonigo , Cole Stewart , Oliver Danos , Simon Wain-Hobson
发明人： Marc Alizon , Pierre Sonigo , Cole Stewart , Oliver Danos , Simon Wain-Hobson
IPC分类号： A61K39/00 , A61K39/12 , A61K39/21 , A61K39/38 , A61P31/18
CPC分类号： A61K39/00 , A61K39/12 , A61K39/21 , A61K39/38
摘要： This invention is in the field of lymphadenopathy virus which has been desogmated Human Immunodeficiency Virus Type 1 (HIV-1) This invention relates to a diagnostic means and method to detect the presence of DNA, RNA or antibodies of the lymphadenopathy retrovirus associated with the acquired immune deficiency syndrome or of the lymphadenopathy syndrome by the use of DNA fragments or the peptides encoded by said DNA fragments. The invention further relates to the DNA fragments, vectors comprising them and the proteins expressed.
摘要翻译：本发明涉及已经脱盐的人类免疫缺陷病毒1型（HIV-1）的淋巴结病毒病毒领域本发明涉及检测与所获得的淋巴结转移病毒逆转录病毒的DNA，RNA或抗体的存在的诊断方法和方法免疫缺陷综合征或淋巴腺病综合征，通过使用DNA片段或由所述DNA片段编码的肽。本发明还涉及DNA片段，包含它们的载体和表达的蛋白质。

7. 发明授权

US07119181B1 DNA sequences and peptides of human immunodeficiency virus (HIV-1) 失效
标题翻译：人类免疫缺陷病毒（HIV-1）的DNA序列和肽
公开(公告)号：US07119181B1
公开(公告)日：2006-10-10
申请号：US08308218
申请日：1994-09-19
申请人： Marc Alizon , Pierre Sonigo , Cole Stewart , Oliver Danos , Simon Wain-Hobson
发明人： Marc Alizon , Pierre Sonigo , Cole Stewart , Oliver Danos , Simon Wain-Hobson
IPC分类号： C07H21/02 , C12N15/00
CPC分类号： C07K14/005 , C12N2740/16322
摘要： This invention is in the field of lymphadenopathy virus, which has been designated Human Immunodeficiency Virus Type 1 (HIV-1). This invention relates to a diagnostic means and method to detect the presence of DNA, RNA or antibodies of the lymphadenopathy retrovirus associated with the acquired immune deficiency syndrome or of the lymphadenopathy syndrome by the use of DNA fragments or the peptides encoded by said DNA fragments. The invention further relates to the DNA fragments, vectors comprising them and the proteins expressed.
摘要翻译：本发明在淋巴结病毒病毒领域已被指定为1型HIV-1型人类免疫缺陷病毒。本发明涉及通过使用DNA片段或由所述DNA片段编码的肽来检测与所获得的免疫缺陷综合征或淋巴结病综合征相关的淋巴结病变逆转录病毒的DNA，RNA或抗体的存在的诊断方法和方法。本发明还涉及DNA片段，包含它们的载体和表达的蛋白质。

8. 发明授权

US07351412B1 Cloned DNA sequences related to the genomic RNA of lymphadenopathy-associated-virus (LAV) and proteins encoded by said LAV genomic RNA 失效
标题翻译：与淋巴结病毒相关病毒（LAV）的基因组RNA相关的克隆DNA序列和由所述LAV基因组RNA编码的蛋白质
公开(公告)号：US07351412B1
公开(公告)日：2008-04-01
申请号：US08156930
申请日：1993-11-24
申请人： Marc Alizon , Pierre Sonigo , Cole Stewart , Oliver Danos , Simon Wain-Hobson
发明人： Marc Alizon , Pierre Sonigo , Cole Stewart , Oliver Danos , Simon Wain-Hobson
IPC分类号： A61K39/21
CPC分类号： A61K39/21 , A61K39/12 , C12N2740/16134
摘要： This invention is in the field of lymphadenopathy virus, which has been designated Human Immunodeficiency Virus (HIV). This invention relates to a diagnostic means and method to detect the presence of DNA, RNA or antibodies of the lymphadenopathy retrovirus associated with the acquired immune deficiency syndrome or of the lymphadenopathy syndrome by the use of DNA fragments or the peptides encoded by said DNA fragments. The invention further relates to the DNA fragments, vectors comprising them and the proteins expressed.
摘要翻译：本发明属于已被指定为人类免疫缺陷病毒（HIV）的淋巴结病毒病毒。本发明涉及通过使用DNA片段或由所述DNA片段编码的肽来检测与所获得的免疫缺陷综合征或淋巴结病综合征相关的淋巴结病变逆转录病毒的DNA，RNA或抗体的存在的诊断方法和方法。本发明还涉及DNA片段，包含它们的载体和表达的蛋白质。

9. 发明授权

US07232654B1 DNA sequence of the LTR region of human immunodeficiency virus type 1 (HIV-1) 失效
标题翻译：人类免疫缺陷病毒1型（HIV-1）的LTR区的DNA序列
公开(公告)号：US07232654B1
公开(公告)日：2007-06-19
申请号：US08308219
申请日：1994-09-19
申请人： Jean-Claude Chermann , Solange Chamaret , Claudine Axler-Blin , Francoise Rey , Marie-Therese Nugeyre , Jacques Gruest, legal representative , Charles Dauguet , Willy Rozenbaum , Christine Rouzioux , Francois Brun-Vezinet , Luc Montagnier , Francoise Barre-Sinoussi , Pierre Tiollais , Marc Alizon , Pierre Sonigo , Simon Wain-Hobson , Stewart Cole , Oliver Danos , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
发明人： Jacqueline Gruest, deceased
IPC分类号： C12Q1/68 , C07H21/02
CPC分类号： C12Q1/703
摘要： This invention is in the field of lymphadenopathy virus, which has been designated Human Immunodeficiency Virus Type 1 (HIV-1) to detect the presence of DNA, RNA or antibodies of the lymphadenopathy retrovirus associated with the acquired immune deficiency syndrome or of the lymphadenopathy syndrome by the use of DNA fragments or the peptides encoded by said DNA fragments. The invention further relates tot he DNA fragments, vectors comprising them and the proteins expressed.
摘要翻译：本发明属于淋巴结病毒病毒领域，已被指定为1型HIV（1型）免疫缺陷病毒（HIV-1），用于检测与获得性免疫缺陷综合征或淋巴结病综合征相关的淋巴结病变逆转录病毒的DNA，RNA或抗体的存在通过使用DNA片段或由所述DNA片段编码的肽。本发明还涉及DNA片段，包含它们的载体和表达的蛋白质。

10. 发明授权

US06261564B1 Peptides of human immunodeficiency virus type 1 (HIV-1) 失效
标题翻译：人类免疫缺陷病毒1型（HIV-1）
公开(公告)号：US06261564B1
公开(公告)日：2001-07-17
申请号：US09344449
申请日：1997-12-31
申请人： Marc Alizon , Pierre Sonigo , Cole Stewart , Oliver Danos , Simon Wain-Hobson
发明人： Marc Alizon , Pierre Sonigo , Cole Stewart , Oliver Danos , Simon Wain-Hobson
IPC分类号： A61K3921
CPC分类号： C07K14/005 , C12N2740/16322
摘要： This invention is in the field of lymphadenopathy virus, which has been designated Human Immunodeficiency Virus Type 1 (HIV-1). This invention relates to a diagnostic means and method to detect the presence of DNA, RNA or antibodies of the lymphadenopathy retrovirus associated with the acquired immune deficiency syndrome or of the lymphadenopathy syndrome by the use of DNA fragments or the peptides encoded by said DNA fragments. The invention further relates to the DNA fragments, vectors comprising them and the proteins expressed.
摘要翻译：本发明在淋巴结病毒病毒领域已被指定为1型HIV-1型人类免疫缺陷病毒。本发明涉及通过使用DNA片段或由所述DNA片段编码的肽来检测与所获得的免疫缺陷综合征或淋巴结病综合征相关的淋巴结病变逆转录病毒的DNA，RNA或抗体的存在的诊断方法和方法。本发明还涉及DNA片段，包含它们的载体和表达的蛋白质。

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