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81. 发明申请

US20110153007A1 Taxane Coatings for Implantable Medical Devices 有权
标题翻译：可植入医疗器械的紫杉烷涂层
公开(公告)号：US20110153007A1
公开(公告)日：2011-06-23
申请号：US12984733
申请日：2011-01-05
申请人： Priscilla Reyes , William F. Moore , Patrick H. Ruane , Darin G. Schaeffer , Melinda S. Morrell
发明人： Priscilla Reyes , William F. Moore , Patrick H. Ruane , Darin G. Schaeffer , Melinda S. Morrell
IPC分类号： A61F2/82 , A61F2/00 , A61K31/335 , A61M25/10
CPC分类号： A61L27/54 , A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91575 , A61F2230/0054 , A61F2250/0067 , A61F2310/0097 , A61K31/337 , A61L29/16 , A61L31/08 , A61L31/16 , A61L2300/416 , A61L2300/606
摘要： This disclosure relates to implantable medical devices coated with a taxane therapeutic agent, such as paclitaxel, in one or more solid form(s) having varying dissolution rates. Particularly preferred coatings comprise amorphous and/or solvated solid forms of taxane therapeutic agents that provide durable coatings that release the taxane over a desired period of time, which can be varied in the absence of a polymer by selecting the type and amount of solid forms of the taxane therapeutic agent in the coating. Other preferred embodiments relate to methods of coating medical devices and methods of treatment. The coatings can provide a sustained release of the taxane therapeutic agent within a body vessel without containing a polymer to achieve the desired rate of paclitaxel elution.
摘要翻译：本公开涉及涂覆有紫杉烷治疗剂（例如紫杉醇）的可植入医疗装置，其具有不同溶解速率的一种或多种固体形式。特别优选的涂层包括紫杉烷治疗剂的无定形和/或溶剂化固体形式，其提供耐久性涂层，其在期望的时间段内释放紫杉烷，其可以在不存在聚合物的情况下变化，通过选择固体形式的类型和量紫杉烷治疗剂在涂层中。其它优选实施方案涉及涂覆医疗装置的方法和治疗方法。涂层可以在体内容器内提供紫杉烷治疗剂的持续释放而不含聚合物以达到期望的紫杉醇洗脱速率。

82. 发明申请

US20110125249A1 Stent Graft and Introducer Assembly 有权
公开(公告)号：US20110125249A1
公开(公告)日：2011-05-26
申请号：US12946238
申请日：2010-11-15
申请人： Kim Moegelvang Jensen , Bent Oehlenschlaeger , Erik Rasmussen
发明人： Kim Moegelvang Jensen , Bent Oehlenschlaeger , Erik Rasmussen
IPC分类号： A61F2/82
CPC分类号： A61F2/95 , A61F2/07 , A61F2/86 , A61F2/89 , A61F2/915 , A61F2/966 , A61F2002/075 , A61F2002/9517 , A61F2230/0013 , A61F2230/0078
摘要： A stent graft (40) for treating Type-A dissections in the ascending aorta (22) is provided with a plurality of diameter reducing suture loops (56-60) operable to constrain the stent graft during deployment thereof in a patient's aorta. The diameter reducing loops (56-60) allow the stent graft (40) to be partially deployed, in such a manner that its location can be precisely adjusted in the patient's lumen. In this manner, the stent graft can be placed just by the coronary arteries (26, 28) with confidence that these will not be blocked. The stent graft (40) is also provided with proximal and distal bare stents (44,52) for anchoring purposes.

83. 发明申请

US20110118821A1 LOW PROFILE NON-SYMMETRICAL STENT 有权
标题翻译：低剖面非对称性STENT
公开(公告)号：US20110118821A1
公开(公告)日：2011-05-19
申请号：US12904452
申请日：2010-10-14
申请人： David Brocker , William K. Dierking , Alan R. Leewood , Timothy A.M. Chuter , Blayne A. Roeder , Steven J. Charlebois , Richard A. Swift , Sharath Gopalakrishnamurthy , Matthew S. Huser
发明人： David Brocker , William K. Dierking , Alan R. Leewood , Timothy A.M. Chuter , Blayne A. Roeder , Steven J. Charlebois , Richard A. Swift , Sharath Gopalakrishnamurthy , Matthew S. Huser
IPC分类号： A61F2/82
CPC分类号： A61F2/89 , A61F2/07 , A61F2/848 , A61F2/852 , A61F2/856 , A61F2/915 , A61F2002/061 , A61F2002/065 , A61F2002/075 , A61F2002/826 , A61F2002/8483 , A61F2002/8486 , A61F2002/91508 , A61F2002/91516 , A61F2002/91533 , A61F2002/91541 , A61F2210/0014 , A61F2220/0016 , A61F2220/0075 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2250/006
摘要： Various stents and stent-graft systems for treatment of medical conditions are disclosed. In one embodiment, an exemplary stent-graft system may be used for endovascular treatment of a thoracic aortic aneurysm. The stent-graft system may comprise proximal and distal components, each comprising a graft having proximal and distal ends, where upon deployment the proximal and distal components at least partially overlap with one another to provide a fluid passageway therebetween. The proximal component may comprise a proximal stent having a plurality of proximal and distal apices connected by a plurality of generally straight portions, where a radius of curvature of at least one of the proximal apices may be greater than the radius of curvature of at least one of the distal apices. The distal component may comprise a proximal z-stent coupled to the graft, where the proximal end of the graft comprises at least scallop formed therein that generally follows the shape of the proximal z-stent. Further, the distal component may comprise at least one z-stent stent coupled to the distal end of the graft and extending distally therefrom that reduces proximal migration of the distal component.
摘要翻译：公开了用于治疗医疗条件的各种支架和支架移植系统。在一个实施方案中，示例性支架移植物系统可用于胸主动脉瘤的血管内治疗。支架移植系统可以包括近端和远端部件，每个部件包括具有近端和远端的移植物，其中在展开时，近端和远端部件至少部分地彼此重叠以在其间提供流体通道。近端部件可以包括近端支架，其具有通过多个大致直线部分连接的多个近端和远侧顶点，其中近端顶点中的至少一个的曲率半径可以大于至少一个的近端顶点的曲率半径的远端顶点。远侧部件可以包括联接到移植物的近端Z支架，其中移植物的近端包括至少形成在其中的扇形，其大致遵循近端z支架的形状。此外，远侧部件可以包括联接到移植物的远端并从其远端延伸的至少一个z支架支架，其减少远侧部件的近端迁移。

84. 发明授权

US07875284B2 Methods of manufacturing and modifying taxane coatings for implantable medical devices 有权
标题翻译：制造和修饰可植入医疗器械的紫杉烷涂层的方法
公开(公告)号：US07875284B2
公开(公告)日：2011-01-25
申请号：US11823283
申请日：2007-06-27
申请人： Priscilla Reyes , William F. Moore , Randy Joe Myers , Patrick H. Ruane , Melinda S. Morrell
发明人： Priscilla Reyes , William F. Moore , Randy Joe Myers , Patrick H. Ruane , Melinda S. Morrell
IPC分类号： A61F2/00
CPC分类号： A61K31/335 , A61F2/0095 , A61F2/91 , A61F2250/0067 , A61F2250/0091
摘要： This disclosure relates to endolumenal medical devices coated with a taxane therapeutic agent in one or more solid form(s) having varying dissolution rates. Particularly preferred coatings comprise amorphous paclitaxel, dihydrate paclitaxel, or combinations thereof that provide durable coatings that release paclitaxel over a desired period of time, which can be on the order of hours, days or weeks. Preferred embodiments relate to medical device coatings of paclitaxel, or paclitaxel analogs or derivatives, having one or more polymorph solid forms that provide a prolonged release of paclitaxel within a body vessel without requiring a polymer carrier or barrier layer to achieve the desired rate of paclitaxel elution.
摘要翻译：本公开涉及用一种或多种具有不同溶解速率的固体形式涂覆紫杉烷治疗剂的腔内医疗器械。特别优选的涂层包括无定形紫杉醇，二水合紫杉醇或其组合，其提供耐久性涂层，其在期望的时间段内释放紫杉醇，其可以是数小时，数天或数周的数量级。优选实施方案涉及具有一种或多种多晶型固体形式的紫杉醇或紫杉醇类似物或衍生物的医疗器械涂层，其提供紫杉醇在体内容器内的延长释放，而不需要聚合物载体或阻挡层来实现所需的紫杉醇洗脱速率。

85. 发明授权

US07815687B2 Method of promoting cell proliferation and ingrowth by injury to the native tissue 有权
标题翻译：通过损伤天然组织促进细胞增殖和向内生长的方法
公开(公告)号：US07815687B2
公开(公告)日：2010-10-19
申请号：US12337163
申请日：2008-12-17
申请人： Clinton D. Bahler , Alan R. Leewood , Jichao Sun
发明人： Clinton D. Bahler , Alan R. Leewood , Jichao Sun
IPC分类号： A61F2/06 , A61F2/00
CPC分类号： A61F2/91 , A61F2002/0086 , A61F2220/0008 , A61F2220/0016 , Y10S623/901
摘要： The present invention relates to methods of treating tissue of the human body, specially, methods of promoting cell proliferation and ingrowth around implantable medical devices. The methods include inserting an apparatus comprising asperities adapted to injure native tissue at a desired anchoring location, injuring the native tissue at the desired anchoring location with the apparatus to initiate an injury response in the native tissue to thereby promote cell proliferation and ingrowth; and implanting the medical device at the treatment location.
摘要翻译：本发明涉及治疗人体组织的方法，特别是促进可植入医疗器械周围的细胞增殖和向内生长的方法。所述方法包括插入装置，其包括适于在期望的锚固位置处伤害天然组织的凹凸，用设备在期望的锚定位置损伤天然组织以在天然组织中引发损伤反应，从而促进细胞增殖和向内生长; 以及将医疗装置植入治疗位置。

86. 发明申请

US20100249899A1 PARARENAL STENT GRAFT 有权
标题翻译： PARNALNAL STENT GRAFT
公开(公告)号：US20100249899A1
公开(公告)日：2010-09-30
申请号：US12732542
申请日：2010-03-26
申请人： Timothy A. Chuter , David Ernest Hartley , Blayne A. Roeder
发明人： Timothy A. Chuter , David Ernest Hartley , Blayne A. Roeder
IPC分类号： A61F2/82
CPC分类号： A61F2/07 , A61F2/89 , A61F2/91 , A61F2002/061 , A61F2002/065 , A61F2002/075 , A61F2230/0013 , A61F2230/0067 , A61F2250/0039
摘要： A stent graft for endovascular introduction into the pararenal region of the descending aorta. The stent graft has an elongate tubular body (10) with a proximal portion (12), a distal portion (16) of a diameter less than the proximal portion and a tapered central portion (14). A notional transverse clock face on the tubular body has 12 o'clock at a notional anterior longitudinal datum line. The stent graft has a scalloped cut out (26) centered at about 12:30 o'clock and a fenestration (28) at about 12:00 o'clock in the proximal portion and first and second fenestration assemblies which can be low profile side arms at about 2:15 o'clock and about 10:00 o'clock in the tapered central portion. The tapered central portion can have an arcuate side wall (30) so that the tapered portion has an outer face which is concave.
摘要翻译：用于血管内引入下降主动脉的肾上腺区域的支架移植物。支架移植物具有细长的管状体（10），其具有近端部分（12），直径小于近端部分的远端部分（16）和锥形中心部分（14）。管状体上的名义横向钟表面在名义上的纵向基准线上有12点钟。支架移植物具有以约12:30为中心的扇形切口（26）和近端部分的约12:00点处的开窗（28），以及可以是低轮廓侧的第一和第二开窗组件在锥形中心部分约2:15时和大约10:00点的臂。锥形中心部分可以具有弓形侧壁（30），使得锥形部分具有凹面的外表面。

87. 发明授权

US07799261B2 Needle-to-needle electrospinning 有权
标题翻译：针针电纺
公开(公告)号：US07799261B2
公开(公告)日：2010-09-21
申请号：US12274530
申请日：2008-11-20
申请人： David E. Orr , William F. Moore
发明人： David E. Orr , William F. Moore
IPC分类号： B29C67/00
CPC分类号： B05D1/04 , B05B5/0255 , B05B5/08 , B05B5/087 , B05B5/12 , B05D2252/10 , B05D2254/02 , B05D2254/04 , D01D5/0061 , D01D5/0084
摘要： The disclosure relates to a method and apparatus for coating a medical device. The method includes providing an electrospinning apparatus and simultaneously electrospinning at least one solution onto a first surface and an opposing second surface. The apparatus comprises a first spinneret and a second spinneret. An energy source is electrically coupled to the first spinneret and the second spinneret. The first spinneret and second spinneret comprise a reservoir and an orifice fluidly coupled to the reservoir. The first spinneret orifice is located substantially opposite the second spinneret orifice.
摘要翻译：本公开涉及一种用于涂覆医疗装置的方法和装置。该方法包括提供静电纺丝装置，同时将至少一种溶液静电纺丝到第一表面和相对的第二表面上。该装置包括第一喷丝头和第二喷丝头。能量源电耦合到第一喷丝头和第二喷丝头。第一喷丝头和第二喷丝头包括流体耦合到储存器的储存器和孔口。第一喷丝孔与第二喷丝孔大致相对。

88. 发明申请

US20100161027A1 STENT AND STENT-GRAFT HAVING ONE OR MORE CONFORMANCE STRUTS 有权
标题翻译：具有一个或多个符合条件的STENT和STENT-GRAFT
公开(公告)号：US20100161027A1
公开(公告)日：2010-06-24
申请号：US12641125
申请日：2009-12-17
申请人： David E. Orr
发明人： David E. Orr
IPC分类号： A61F2/06 , A61F2/82
CPC分类号： A61F2/91 , A61F2/07 , A61F2/848 , A61F2/89 , A61F2/915 , A61F2002/075 , A61F2002/8483 , A61F2002/8486 , A61F2002/91508 , A61F2220/0016 , A61F2220/0058 , A61F2220/0075 , A61F2250/0048
摘要： A stent includes a main body having proximal and distal ends, and at least one conformance strut coupled to the proximal end of the main body. A portion of the at least one conformance strut extends proximal to a proximal end of a graft material in a compressed delivery configuration, and further is aligned inside the proximal end of the graft material in an expanded deployed configuration. In the deployed configuration, the proximal conformance strut may at least partially encircle the graft material just distal to the proximal end of the graft material, which may reduce the likelihood of infolding at the proximal edge of the graft material and potential endoleaks.
摘要翻译：支架包括具有近端和远端的主体，以及耦合到主体的近端的至少一个一致支柱。所述至少一个一致性支柱的一部分以压缩的输送构型延伸到移植物材料的近端附近，并且在扩展的展开构型中进一步在移植材料的近端内对准。在展开的构造中，近端一致性支柱可以至少部分地围绕移植物材料，其刚好在移植物材料的近端的远侧，这可以减少在移植物材料的近端处引起折叠的可能性和潜在的内漏。

89. 发明申请

US20100152835A1 Tapered Stent and Flexible Prosthesis 有权
标题翻译：锥形支架和柔性假体
公开(公告)号：US20100152835A1
公开(公告)日：2010-06-17
申请号：US12622739
申请日：2009-11-20
申请人： David E. Orr
发明人： David E. Orr
IPC分类号： A61F2/82
CPC分类号： A61F2/06 , A61F2/07 , A61F2/86 , A61F2/89 , A61F2/915 , A61F2002/826 , A61F2002/828 , A61F2250/0036 , A61F2250/0037
摘要： The disclosure relates to a tapered stent and flexible prosthesis. The stent has a first longitudinal region and a second longitudinal region. The second region is substantially parallel to and spaced axially apart from the first region. A plurality of struts is disposed intermediate the first region and the second region and circumferentially connects the first region and the second region. The first region has a longitudinal length that is greater than the second region longitudinal length. The struts have varying longitudinal lengths that gradually decrease from the first region to the second region. The flexible prosthesis comprises at least two alternating tapered stents.
摘要翻译：本公开涉及一种锥形支架和柔性假体。支架具有第一纵向区域和第二纵向区域。第二区域基本上与第一区域平行并与轴向间隔开。多个支柱设置在第一区域和第二区域之间，并且周向地连接第一区域和第二区域。第一区域具有大于第二区域纵向长度的纵向长度。支柱具有从第一区域逐渐减小到第二区域的纵向长度变化。柔性假体包括至少两个交替的锥形支架。

90. 发明申请

US20100104617A2 GRAFT PROSTHESIS, MATERIALS AND METHODS 有权
公开(公告)号：US20100104617A2
公开(公告)日：2010-04-29
申请号：US11931884
申请日：2007-10-31
申请人： William Cook , Michael Hiles , Thomas Kozma , Umesh Patel
发明人： William Cook , Michael Hiles , Thomas Kozma , Umesh Patel
IPC分类号： A61F2/02 , A61K47/42 , A61K35/12
CPC分类号： A61L27/386 , A61F2/06 , A61F2/07 , A61L2/0088 , A61L27/3604 , A61L27/3662 , A61L27/3683 , A61L27/3695 , A61L27/3839 , A61L27/3843 , A61L29/005 , A61L31/005
摘要： A graft prostheses (11), materials and method for implanting, transplanting, replacing, or repairing a part of a patient. The graft prosthesis includes a purified, collagen-based matrix structure removed from a submucosa tissue source. The submucosa tissue source is purified by disinfection and removal steps to deactivate and remove contaminants, thereby making the purified structure biocompatible and suitable for grafting on and/or in a patient.

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