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81. 发明申请

US20140114182A1 Opto-Acoustic Imaging Devices and Methods 审中-公开
标题翻译：光声成像设备和方法
公开(公告)号：US20140114182A1
公开(公告)日：2014-04-24
申请号：US13841399
申请日：2013-03-15
申请人： LightLab Imaging, Inc.
发明人： Christopher L. Petersen , Joseph M. Schmitt
IPC分类号： A61B5/00 , A61B8/12
CPC分类号： A61B5/0066 , A61B5/0095 , A61B5/6852 , A61B8/12 , A61B8/445 , A61B8/4461
摘要： In one aspect, the invention relates to a probe. The probe includes a sheath, a flexible, bi-directionally rotatable, optical subsystem positioned within the sheath, the optical subsystem comprising a transmission fiber, the optical subsystem capable of transmitting and collecting light of a predetermined range of wavelengths along a first beam having a predetermined beam size. The probe also includes an ultrasound subsystem, the ultrasound subsystem positioned within the sheath and adapted to propagate energy of a predetermined range of frequencies along a second beam having a second predetermined beam size, wherein a portion of the first and second beams overlap a region during a scan.
摘要翻译：一方面，本发明涉及一种探针。探针包括位于护套内的护套，柔性双向可旋转的光学子系统，光学子系统包括传输光纤，该光学子系统能够沿着具有第一光束的第一光束发射和收集预定波长范围的光预定的光束尺寸。所述探针还包括超声子系统，所述超声子系统位于护套内并且适于沿具有第二预定光束尺寸的第二光束传播预定频率范围的能量，其中第一和第二光束的一部分在扫描。

82. 发明申请

US20130310698A1 Apparatus, Systems, and Methods of In-Vivo Blood Clearing in a Lumen 有权
标题翻译：仪器，系统和流明体内血液清除方法
公开(公告)号：US20130310698A1
公开(公告)日：2013-11-21
申请号：US13780611
申请日：2013-02-28
申请人： Neil Judell , Robert Steinbrecher , Joel Friedman , Christopher Petersen
发明人： Neil Judell , Robert Steinbrecher , Joel Friedman , Christopher Petersen
IPC分类号： A61B5/00
CPC分类号： A61B5/0073 , A61B5/0066 , A61B5/02007 , A61B5/6852 , A61B5/7285
摘要： In one aspect, the invention relates to a computer-implemented method of triggering optical coherence tomography data collection. The method includes collecting optical coherence tomography data with respect to a vessel using an optical coherence tomography probe disposed in the vessel; determining a clearing radius and a quality value for each frame of optical coherence tomography data collected for the vessel using a computer; determining if a blood clearing state has occurred using at least one clearing radius and at least one quality value; and generating a trigger signal in response to the blood clearing state.
摘要翻译：一方面，本发明涉及触发光学相干层析成像数据采集的计算机实现的方法。该方法包括使用设置在容器中的光学相干断层摄影探针来收集关于血管的光学相干断层摄影数据; 使用计算机为所述船舶收集的光学相干断层摄影数据的每帧确定清除半径和质量值; 使用至少一个清除半径和至少一个质量值来确定是否已经发生血液清除状态; 以及响应于血液清除状态产生触发信号。

83. 发明授权

US08581643B1 Phase-lock loop-based clocking system, methods and apparatus 有权
标题翻译：基于锁相环的计时系统，方法和装置
公开(公告)号：US08581643B1
公开(公告)日：2013-11-12
申请号：US13284122
申请日：2011-10-28
申请人： Joseph M. Schmitt
发明人： Joseph M. Schmitt
IPC分类号： H03L7/06
CPC分类号： H03L7/104 , H03L7/07 , H03L7/0805 , H03L7/093
摘要： In part, the invention relates to an optical coherence tomography system that includes one or more phased-locked loop circuits. In one embodiment, the phased-locked loop circuit includes a phase detector, a loop filter, and a voltage controlled oscillator wherein the phased-locked loop circuit is configured to generate a sample clock. The optical coherence tomography system can include an analog to digital converter having a sample clock input, an interferometric signal input, and a sample data output, the analog to digital converter configured to receive the sample clock and sample OCT data in response thereto. In one embodiment, the phased-locked loop circuit is configured to lock on a first signal in less than or equal to about 1 microseconds.
摘要翻译：部分地，本发明涉及一种包括一个或多个锁相环电路的光学相干断层摄影系统。在一个实施例中，锁相环电路包括相位检测器，环路滤波器和压控振荡器，其中锁相环电路被配置为产生采样时钟。光学相干断层摄影系统可以包括具有采样时钟输入，干涉信号输入和采样数据输出的模数转换器，模数转换器被配置为接收采样时钟并响应于此采样OCT数据。在一个实施例中，锁相环电路被配置为在小于或等于约1微秒内锁定第一信号。

84. 发明申请

US20120250028A1 Optical Buffering Methods, Apparatus, and Systems for Increasing the Repetition Rate of Tunable Light Sources 有权
标题翻译：用于提高可调光源重复率的光缓冲方法，装置和系统
公开(公告)号：US20120250028A1
公开(公告)日：2012-10-04
申请号：US13077075
申请日：2011-03-31
申请人： Joseph M. Schmitt , Desmond Adler
发明人： Joseph M. Schmitt , Desmond Adler
IPC分类号： G02B6/27 , F21V11/00 , G01B9/02 , G02B6/26 , G02B6/35
CPC分类号： G02B6/2861 , G01B9/02004 , G01B9/02091 , G02B6/2808 , G02B6/3502
摘要： In one embodiment, the invention relates to an apparatus for increasing the repetition rate in a light source. The apparatus includes a first optical coupler comprising a first arm, a second arm and a third arm; a first mirror in optical communication with the second arm of the first optical coupler; and a first optical delay line having a first end in optical communication with the third arm of the first optical coupler and a second end in optical communication with a second mirror, wherein light entering the first arm of the first optical coupler leaves the first arm of the first optical coupler either delayed by an amount (τ) or substantially undelayed.
摘要翻译：在一个实施例中，本发明涉及一种用于增加光源中的重复率的装置。该装置包括：第一光耦合器，包括第一臂，第二臂和第三臂; 与第一光耦合器的第二臂光学通信的第一反射镜; 以及第一光学延迟线，其具有与第一光耦合器的第三臂光学通信的第一端和与第二反射镜光学连通的第二端，其中进入第一光耦合器的第一臂的光离开第一臂的第一臂第一光耦合器延迟量（τ）或基本上不延迟。

85. 发明申请

US20120236883A1 Methods, Systems, and Devices for Timing Control in Electromagnetic Radiation Sources 有权
标题翻译：电磁辐射源定时控制的方法，系统和设备
公开(公告)号：US20120236883A1
公开(公告)日：2012-09-20
申请号：US13048441
申请日：2011-03-15
申请人： Desmond Adler
发明人： Desmond Adler
IPC分类号： H01S3/10
CPC分类号： H01S3/1062 , G01B9/02004 , G01B9/02069 , G01B9/02091 , H01S3/06791 , H01S3/08013 , H01S3/08059 , H01S3/083 , H01S3/1109 , H01S5/1071 , H01S5/146
摘要： In one embodiment, the invention relates to systems, methods and devices for improving the operation of an electromagnetic radiation source or component thereof. In one embodiment, the source is a laser source. A Fourier domain mode locked laser can be used in various embodiments. The sources described herein can be used in an optical coherence tomography (OCT) system such as a frequency domain OCT system. In one embodiment, laser coherence length is increased by compensating for dispersion. A frequency shifter can also be used in one embodiment to compensate for a tunable filter induced Doppler shift.
摘要翻译：在一个实施例中，本发明涉及用于改善电磁辐射源或其部件的操作的系统，方法和装置。在一个实施例中，源是激光源。在各种实施例中可以使用傅里叶域模式锁定激光器。本文描述的来源可用于光学相干层析成像（OCT）系统，例如频域OCT系统。在一个实施例中，通过补偿色散来增加激光相干长度。在一个实施例中也可以使用移频器来补偿可调滤波器引起的多普勒频移。

86. 发明申请

US20120075691A1 Wavelength-Tunable Light Source 有权
标题翻译：波长可调光源
公开(公告)号：US20120075691A1
公开(公告)日：2012-03-29
申请号：US13308120
申请日：2011-11-30
申请人： Robert Alexander Huber , Christoph Eigenwillig , Benjamin Biedermann
发明人： Robert Alexander Huber , Christoph Eigenwillig , Benjamin Biedermann
IPC分类号： H01S3/13
CPC分类号： A61B5/0059 , A61B5/0066 , G02B5/20 , G02B5/284 , G02B26/002 , H01S3/08009 , H01S3/08059 , H01S3/105
摘要： In at least one embodiment of the wavelength-tunable light source, it comprises an output source, which is capable in operation of generating electromagnetic radiation. Furthermore, the light source has a wavelength-selective first filter element, which is situated downstream from the output source. Moreover, the light source contains a first amplifier medium, which is situated downstream from the first filter element and is capable of at least partial amplification of the radiation emitted by the output source. The light source further comprises at least one wavelength-selective second filter element, which is situated downstream from the first amplifier medium, the second filter element having an optical spacing to the first filter element. The first filter element and the at least one second filter element are tunable via a control unit, which the light source has.
摘要翻译：在波长可调光源的至少一个实施例中，它包括能够产生电磁辐射的输出源。此外，光源具有位于输出源下游的波长选择性第一滤光元件。此外，光源包含第一放大器介质，其位于第一滤光元件的下游，并且能够至少部分地放大由输出源发射的辐射。光源还包括位于第一放大器介质下游的至少一个波长选择性第二滤光器元件，第二滤光元件具有与第一滤光元件的光学间隔。第一过滤器元件和至少一个第二过滤器元件可通过光源具有的控制单元来调节。

87. 发明授权

US07916387B2 Methods and apparatus for swept-source optical coherence tomography 有权
标题翻译：扫频源光学相干断层扫描的方法和装置
公开(公告)号：US07916387B2
公开(公告)日：2011-03-29
申请号：US12008403
申请日：2008-01-10
申请人： Joseph M. Schmitt
发明人： Joseph M. Schmitt
IPC分类号： H01S5/00 , H01S3/098
CPC分类号： G01B9/02091 , A61B5/0066 , A61B5/0073 , G01B9/02004 , G01B9/02043 , G01B9/02069 , G01B2290/25 , G01B2290/60 , H01S3/1062 , H01S5/141 , H01S5/146 , H01S5/5036
摘要： In one embodiment of the invention, a semiconductor optical amplifier (SOA) in a laser ring is chosen to provide low polarization-dependent gain (PDG) and a booster semiconductor optical amplifier, outside of the ring, is chosen to provide high polarization-dependent gain. The use of a semiconductor optical amplifier with low polarization-dependent gain nearly eliminates variations in the polarization state of the light at the output of the laser, but does not eliminate the intra-sweep variations in the polarization state at the output of the laser, which can degrade the performance of the SS-OCT system.
摘要翻译：在本发明的一个实施例中，选择激光环中的半导体光放大器（SOA）以提供低偏振相关增益（PDG），并且选择在环外部的升压半导体光放大器以提供高偏振相关获得。使用具有低偏振相关增益的半导体光放大器几乎消除了在激光器的输出处的光的偏振状态的变化，但是不消除激光器的输出处的偏振状态的扫描内变化，这可能会降低SS-OCT系统的性能。

88. 发明授权

US07848791B2 Optical coherence tomography apparatus and methods 有权
标题翻译：光学相干断层扫描仪和方法
公开(公告)号：US07848791B2
公开(公告)日：2010-12-07
申请号：US11351896
申请日：2006-02-10
申请人： Joseph M. Schmitt , Amanda Koski , Michael Atlas , Christopher Petersen
发明人： Joseph M. Schmitt , Amanda Koski , Michael Atlas , Christopher Petersen
IPC分类号： A61B6/00
CPC分类号： G01B9/02091 , A61B5/0066 , A61B5/6852 , G01B9/0205 , G01B2290/65 , G01B2290/70 , G01N21/474 , G01N21/4795 , G01N21/8507 , G01N2021/1787 , G01N2021/8514 , G01N2021/8528 , G02B6/262
摘要： In one aspect, the invention relates to an imaging probe. The imaging probe includes an elongate body having a proximal end and distal end, the elongate body adapted to enclose a portion of a slidable optical fiber, the optical fiber having a longitudinal axis; and a first optical assembly attached to a distal end of the fiber. The first optical assembly includes a beam director adapted to direct light emitted from the fiber to a plane at a predetermined angle to the longitudinal axis, a linear actuator disposed at the proximal portion of the elongated body, the actuator adapted to affect relative linear motion between the elongate body and the optical fiber; and a second optical assembly located at the distal portion of the elongate body and attached thereto, the second optical assembly comprising a reflector in optical communication with the first optical assembly, the reflector adapted to direct the light to a position distal to the elongate body.
摘要翻译：一方面，本发明涉及一种成像探针。成像探头包括具有近端和远端的细长主体，细长主体适于包围可滑动光纤的一部分，光纤具有纵向轴线; 以及附接到纤维的远端的第一光学组件。第一光学组件包括光束引导器，其适于将从光纤发射的光引导到与纵向轴线成预定角度的平面;线性致动器，设置在细长主体的近端部分处，致动器适于影响细长体和光纤; 以及第二光学组件，其位于细长主体的远端部分并附接到其上，第二光学组件包括与第一光学组件光学连通的反射器，反射器适于将光引导到远离细长主体的位置。

89. 发明申请

US20100094127A1 METHODS FOR STENT STRUT DETECTION AND RELATED MEASUREMENT AND DISPLAY USING OPTICAL COHERENCE TOMOGRAPHY 有权
标题翻译：使用光学相干测量方法进行STESTR STRUT检测和相关测量和显示
公开(公告)号：US20100094127A1
公开(公告)日：2010-04-15
申请号：US12579333
申请日：2009-10-14
申请人： Chenyang Xu
发明人： Chenyang Xu
IPC分类号： A61B5/05 , G06K9/00
CPC分类号： A61B5/0066 , A61B5/0084 , A61B5/6852 , A61B5/7425 , A61B2576/00 , G06K9/46 , G06K9/6267 , G06K2009/4666 , G06T5/00 , G06T7/0012 , G06T7/11 , G06T7/246 , G06T7/73 , G06T7/90 , G06T2207/10101 , G06T2207/20061 , G06T2207/20182 , G06T2207/30101
摘要： In one embodiment, the invention relates to a processor based method for generating positional and other information relating to a stent in the lumen of a vessel using a computer. The method includes the steps of generating an optical coherence image data set in response to an OCT scan of a sample containing at least one stent; and identifying at least one one-dimensional local cue in the image data set relating to the position of the stent.
摘要翻译：在一个实施例中，本发明涉及一种基于处理器的方法，用于使用计算机产生与容器内腔中的支架相关的位置信息和其它信息。该方法包括以下步骤：响应于包含至少一个支架的样本的OCT扫描产生光学相干图像数据集; 以及识别与所述支架的位置有关的图像数据集中的至少一个一维局部提示。

90. 发明申请

US20090306520A1 Quantitative methods for obtaining tissue characteristics from optical coherence tomography images 审中-公开
标题翻译：从光学相干断层扫描图像获得组织特征的定量方法
公开(公告)号：US20090306520A1
公开(公告)日：2009-12-10
申请号：US12455523
申请日：2009-06-02
申请人： Joseph M. Schmitt , Chenyang Xu
发明人： Joseph M. Schmitt , Chenyang Xu
IPC分类号： A61B6/00
CPC分类号： A61B5/6852 , A61B5/0066 , A61B5/7264
摘要： A method and apparatus for determining properties of a tissue or tissues imaged by optical coherence tomography (OCT). In one embodiment the backscatter and attenuation of the OCT optical beam is measured and based on these measurements and indicium such as color is assigned for each portion of the image corresponding to the specific value of the backscatter and attenuation for that portion. The image is then displayed with the indicia and a user can then determine the tissue characteristics. In an alternative embodiment the tissue characteristics is classified automatically by a program given the combination of backscatter and attenuation values.
摘要翻译：用于确定通过光学相干断层摄影（OCT）成像的组织或组织的性质的方法和装置。在一个实施例中，测量OCT光束的后向散射和衰减，并且基于这些测量，并且针对对应于该部分的后向散射和衰减的特定值的图像的每个部分分配诸如颜色的标记。然后用标记显示图像，然后用户可以确定组织特征。在替代实施例中，通过给出反向散射和衰减值的组合的程序，组织特征被自动分类。

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