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81. 发明申请

US20140037579A1 Inhibition of Dendritic Cell-Driven Regulatory T Cell Activation and Potentiation of Tumor Antigen-Specific T Cell Responses by Interleukin-15 and MAP Kinase Inhibitor 审中-公开
标题翻译：抑制树突状细胞驱动的调节性T细胞激活和白细胞介素-15和MAP激酶抑制剂的肿瘤抗原特异性T细胞应答的增强
公开(公告)号：US20140037579A1
公开(公告)日：2014-02-06
申请号：US14040850
申请日：2013-09-30
申请人： The Board of Trustees of the University of Arkansas
发明人： Martin J. Cannon , Kellie Kozak Vaidya , Timothy J. O'Brien
IPC分类号： C12N5/0784 , C12N5/0783
CPC分类号： C12N5/0636 , A61K38/2086 , A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/57 , C12N5/0639 , C12N2501/02 , C12N2501/22 , C12N2501/23 , C12N2501/25 , A61K2300/00
摘要： The invention involves the discovery that if dendritic cells loaded with a tumor antigen are cultured in interleukin-15 (IL-15), or if T cells activated by the dendritic cells are cultured in IL-15, Treg activity that is specific for the tumor antigen is reduced. This reduction in Treg activity results in an increase in anti-tumor immune response. Another embodiment of the invention involves the discovery that incubating dendritic cells with a MAP kinase inhibitor in combination with IL-15 gives synergistic benefits when the dendritic cells are used to activate T cells. Dendritic cell and T cell compositions incubated with IL-15 or a MAP kinase inhibitor are provided.
摘要翻译：本发明涉及如下发现：如果在白细胞介素-15（IL-15）中培养载有肿瘤抗原的树突状细胞，或者如果在IL-15中培养由树突状细胞活化的T细胞，则对肿瘤特异性的Treg活性抗原减少。 Treg活性的这种降低导致抗肿瘤免疫反应的增加。本发明的另一个实施方案涉及发现当树突状细胞用于激活T细胞时，将具有MAP激酶抑制剂与IL-15组合的树突细胞产生协同效益。提供与IL-15或MAP激酶抑制剂一起孵育的树突状细胞和T细胞组合物。

82. 发明授权

US08608376B2 Method for modeling and parameter extraction of LDMOS devices 有权
标题翻译： LDMOS器件的建模和参数提取方法
公开(公告)号：US08608376B2
公开(公告)日：2013-12-17
申请号：US13134012
申请日：2011-05-26
申请人： Avinash S. Kashyap , H. Alan Mantooth
发明人： Avinash S. Kashyap , H. Alan Mantooth
IPC分类号： G01K7/01
CPC分类号： G01R31/2874 , G01R31/2862
摘要： A method for modeling the performance of a laterally diffused metal oxide semiconductor (LDMOS) device across a wide temperature range is disclosed. The method comprises the steps of positioning the device in an environment chamber operable to create a plurality of environment temperatures; connecting the pins of the device to a measurement system operable to measure at least one device characteristic; operating the environment chamber to set a series of four environment temperatures, acquiring a value of the device characteristic from the measurement system at each temperature, and extracting a temperature parameter set based on the value of the device characteristic at each temperature, then generating a temperature-scaling model for the device.
摘要翻译：公开了一种用于在宽的温度范围内对横向扩散的金属氧化物半导体（LDMOS）器件的性能进行建模的方法。该方法包括将设备定位在可操作以产生多个环境温度的环境室中的步骤; 将所述设备的引脚连接到可操作以测量至少一个设备特性的测量系统; 操作环境室以设定一系列四个环境温度，在每个温度下从测量系统获取设备特性的值，并且基于每个温度下的设备特性值提取设置的温度参数，然后产生温度该设备的缩放模型。

83. 发明申请

US20130323218A1 Methods of Selecting and Using Therapeutic and Prophylactic Probiotic Cultures to Reduce Bacterial Pathogen Loads 有权
标题翻译：选择和使用治疗和预防益生菌培养物减少细菌病原体负荷的方法
公开(公告)号：US20130323218A1
公开(公告)日：2013-12-05
申请号：US13876743
申请日：2011-09-30
申请人： Daniel James Donoghue , Ann Marian Donoghue
发明人： Daniel James Donoghue , Ann Marian Donoghue
IPC分类号： A61K35/74 , C12N1/20 , A23L1/30 , C12Q1/02
CPC分类号： A61K35/741 , A23L33/135 , A61K35/74 , A61K2035/11 , C12N1/20 , C12Q1/02
摘要： Methods are provided for selecting a bacterium capable of reducing pathogenic bacterial colonization of the intestinal tract in a subject comprising selecting the bacterium capable of migrating at least 0.75 cm from the point of inoculation on motility agar after incubation for 24 hours at 37° C. or capable of migrating from the point of inoculation to a diameter of at least 1.5 cm based on the farthest colonies from the point of inoculation on motility agar after incubation for 24 hours at 37° C. Bacteria selected using the method and compositions comprising these bacteria are also provided.
摘要翻译：提供了用于选择能够减少受试者肠道致病细菌定殖的细菌的方法，其包括在37℃孵育24小时之后，选择能够从运动性琼脂接种点至少0.75cm迁移的细菌，或能够从接种点迁移至至少1.5cm的直径，基于在37℃下培养24小时后，在运动性琼脂上接种点最远的菌落。使用包含这些细菌的方法和组合物选择的细菌是也提供。

84. 发明申请

US20130233802A1 RENEWABLE RESOURCE-BASED METAL OXIDE-CONTAINING MATERIALS AND APPLICATIONS OF THE SAME 有权
标题翻译：可再生资源的含金属氧化物的材料及其应用
公开(公告)号：US20130233802A1
公开(公告)日：2013-09-12
申请号：US13843106
申请日：2013-03-15
申请人： BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
发明人： Tito Viswanathan
IPC分类号： B01J20/02 , B01J20/24 , B01J20/30
CPC分类号： B01J20/02 , B01J20/06 , B01J20/20 , B01J20/24 , B01J20/3085 , C02F1/281 , C02F1/286 , C02F1/288 , C02F2101/103 , C02F2101/105 , C02F2101/106 , C02F2305/08
摘要： Metal nanocomposites and methods of producing the same are disclosed. The nanocomposites have metal nanoparticles dispersed in a matrix carrier and can be produced by: treating a matrix material having a functional group with a quaternary amine compound to form a function site; treating the matrix material with a metal salt such that a metal ion of the metal salt is chelated with the functional site; treating the matrix material with an alkali; and microwaving the matrix material to form the metal nanocomposites.
摘要翻译：公开了金属纳米复合材料及其制备方法。纳米复合材料具有分散在基质载体中的金属纳米颗粒，可以通过以下方法制备：用季胺化合物处理具有官能团的基质材料以形成功能部位; 用金属盐处理基质材料，使得金属盐的金属离子与官能位点螯合; 用碱处理基体材料; 和微波基体材料形成金属纳米复合材料。

85. 发明申请

US20130209446A1 Copy Number Variant-Dependent Genes As Diagnostic Tools, Predictive Biomarkers And Therapeutic Targets 审中-公开
标题翻译：作为诊断工具，预测生物标志物和治疗靶标的拷贝数变异依赖基因
公开(公告)号：US20130209446A1
公开(公告)日：2013-08-15
申请号：US13810705
申请日：2011-07-20
申请人： John D. Shaughnessy, JR. , Bart Barlogie , Erming Tian , Yiming Zhou
发明人： John D. Shaughnessy, JR. , Bart Barlogie , Erming Tian , Yiming Zhou
IPC分类号： C12Q1/68 , A61K45/00 , A61K45/06 , A61K31/727
CPC分类号： C12Q1/6886 , A61K31/727 , A61K45/00 , A61K45/06 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158
摘要： Provided herein are methods of diagnosing and/or treating malignant or pre-malignant conditions in a subject. Overexpression of copy number variant-dependent genes, e.g., genes encoding a cell surface receptor, resulting from copy number changes compared to control is diagnostic of the condition, such as multiple myeloma or monoclonal gammopathy of undetermined significance. Also provided are methods for treating malignant conditions, such as multiple myeloma or a hyperdiploid subtype, with therapeutic agents, with or without other anti-cancer drugs, to downrregulate the overexpressed CNV genes and/or up-regulate the underexpressed genes. Furthermore, methods for lowering drug resistance in multiple myeloma cells via inhibition of platelet activation or thrombin release and for increasing survivability of a multiple myeloma subject via lithibition of PSMD4 gene to increase b-catenin protein expression are provided.
摘要翻译：本文提供了诊断和/或治疗受试者中恶性或恶性前病症的方法。拷贝数变异依赖性基因的过度表达，例如编码细胞表面受体的基因，与对照相比拷贝数变化所得到的是病症的诊断，例如具有未确定意义的多发性骨髓瘤或单克隆丙种球蛋白病。还提供了用治疗剂（含或不含其他抗癌药物）治疗恶性病症如多发性骨髓瘤或高倍体二倍体亚型的方法来下调调节过表达的CNV基因和/或上调低表达基因。此外，提供了通过抑制血小板活化或凝血酶释放降低多发性骨髓瘤细胞耐药性的方法，以及通过PSMD4基因通过增加b-连环蛋白表达增加多发性骨髓瘤受试者的生存性。

86. 发明授权

US08492618B2 Cotton cultivar UA-48 有权
标题翻译：棉花品种UA-48
公开(公告)号：US08492618B2
公开(公告)日：2013-07-23
申请号：US12899959
申请日：2010-10-07
申请人： Fred Bourland
发明人： Fred Bourland
IPC分类号： A01H5/00 , A01H5/10 , A01H4/00 , A01H1/02 , C12N15/82
CPC分类号： A01H5/10
摘要： A cotton cultivar, designated UA-48, is disclosed. The invention relates to the seeds of cotton cultivar UA-48, to the plants of cotton UA-48 and to methods for producing a cotton plant produced by crossing the cultivar UA-48 with itself or another cotton variety. The invention further relates to hybrid cotton seeds and plants produced by crossing the cultivar UA-48 with another cotton cultivar.
摘要翻译：公布了一种称为UA-48的棉花品种。本发明涉及棉花品种UA-48的种子，棉花UA-48的植物以及通过将品种UA-48与其本身或其他棉花品种杂交而生产的棉花植物的方法。本发明还涉及通过将品种UA-48与另一棉花栽培品种杂交而产生的杂种棉花种子和植物。

87. 发明授权

US08492090B2 Gene expression profiling in primary ovarian serous papillary tumors and normal ovarian epithelium 有权
标题翻译：原发性卵巢浆液性乳头状瘤和正常卵巢上皮的基因表达谱
公开(公告)号：US08492090B2
公开(公告)日：2013-07-23
申请号：US13066004
申请日：2011-04-04
申请人： Alessandro D. Santin
发明人： Alessandro D. Santin
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： G01N33/689 , C12Q1/6886 , C12Q2600/106 , Y10S977/792
摘要： Provided herein are methods for treating ovarian serous papillary carcinoma by delivering Clostridium perfringens enterotoxins to ovarian tumor cells overexpressing claudin 3 or claudin 4 protein or by inhibiting the expression and function of tumor-associated calcium signal transducer 1 (TROP-1/Ep-CAM) gene or gene product. Also provided is a method of detecting ovarian serous papillary carcinoma by examining a tumor sample from the individual for gene or gene product expression levels within a group of genes and performing statistical analysis to determine those genes or gene products which are down-regulated compared to those in a normal individual.
摘要翻译：本文提供了通过将产气荚膜梭菌肠毒素递送至过表达克劳丁3或克拉丁蛋白4蛋白的卵巢肿瘤细胞或通过抑制肿瘤相关钙信号传导器1（TROP-1 / Ep-CAM）的表达和功能来治疗卵巢浆液性乳头状癌的方法。基因或基因产物。还提供了一种通过检查来自个体的肿瘤样品以检测一组基因内的基因或基因产物表达水平的卵巢浆液性乳头状癌的方法，并进行统计分析以确定与那些基因或基因产物相比下调的那些基因或基因产物在一个正常的个体。

88. 发明申请

US20130183274A1 MAINTENANCE AND PROPAGATION OF MESENCHYMAL STEM CELLS 有权
标题翻译：维持和传播细胞干细胞
公开(公告)号：US20130183274A1
公开(公告)日：2013-07-18
申请号：US13762887
申请日：2013-02-08
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS , THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIR
发明人： Xiao-Dong Chen , Robert L. Jilka
IPC分类号： C12N5/071
CPC分类号： C12N5/0662 , A61K35/28 , A61K2035/124 , C12M21/08 , C12M25/14 , C12N5/0663 , C12N5/0668 , C12N2513/00 , C12N2533/90
摘要： Various embodiments of the present invention include compositions, materials and methods for maintaining and propagating mammalian mesenchymal stem cells in an undifferentiated state in the absence of feeder cells and applications of the same.
摘要翻译：本发明的各种实施方案包括在不存在饲养细胞的情况下维持和增殖哺乳动物间充质干细胞处于未分化状态的组合物，材料和方法及其应用。

89. 发明申请

US20130091594A1 COTTON CULTIVAR UA03 有权
公开(公告)号：US20130091594A1
公开(公告)日：2013-04-11
申请号：US13268051
申请日：2011-10-07
申请人： FREDDIE M. BOURLAND
发明人： FREDDIE M. BOURLAND
IPC分类号： A01H5/00 , C12N15/82 , A01H1/02 , A01H5/10 , C12N5/04
CPC分类号： A01H5/10
摘要： A cotton cultivar, designated UA03, is disclosed. The invention relates to the seeds of cotton cultivar UA03, to the plants of cotton UA03 and to methods for producing a cotton plant produced by crossing the cultivar UA03 with itself or another cotton variety. The invention further relates to hybrid cotton seeds and plants produced by crossing the cultivar UA03 with another cotton cultivar.
摘要翻译：公布了一种称为UA03的棉花品种。本发明涉及棉花品种UA03的种子，棉花UA03的植物，以及通过将品种UA03与本身或另一种棉花品种杂交而生产的棉花植物的方法。本发明还涉及通过将品种UA03与另一棉花品种杂交而产生的杂种棉花种子和植物。

90. 发明授权

US08391565B2 System and method of determining nitrogen levels from a digital image 有权
标题翻译：从数字图像中确定氮水平的系统和方法
公开(公告)号：US08391565B2
公开(公告)日：2013-03-05
申请号：US12800849
申请日：2010-05-24
申请人： Larry C Purcell , Robert L. Rorie , Douglas E Karcher
发明人： Larry C Purcell , Robert L. Rorie , Douglas E Karcher
IPC分类号： G06K9/00
CPC分类号： G06K9/4652 , G01N21/25 , G01N21/84 , G01N2021/8466 , G06T7/0012
摘要： A system and method of determining nitrogen levels from a digital image. In particular, a method of determining leaf nitrogen concentration and yield from a digital photograph of a fully developed leaf (collared leaf) of a crop of nonlegumes, such as corn, rice, wheat, cotton, potatoes or sugarcane. The digital image is processed to determine a dark green color index (“DGCI”), which is closely related to leaf nitrogen concentration and yield. Standardized color disks having known DGCI values are included in the digital photograph and serve as an internal standard. The internal standard allows correction of DGCI of samples when using different cameras and/or when lighting conditions change.
摘要翻译：一种从数字图像中确定氮含量的系统和方法。特别地，一种从玉米，水稻，小麦，棉花，马铃薯或甘蔗等不规则作物的完全发育的叶（环状叶）的数字照片中确定叶氮浓度和产量的方法。处理数字图像以确定深绿色指数（DGCI），其与叶氮浓度和产量密切相关。具有已知DGCI值的标准色盘包括在数字照片中并用作内部标准。内部标准允许在使用不同的相机时和/或当照明条件改变时校正样品的DGCI。

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