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81. 发明授权

US08401626B2 System and method for assessing sleep quality 有权
标题翻译：睡眠质量评估系统和方法
公开(公告)号：US08401626B2
公开(公告)日：2013-03-19
申请号：US12570163
申请日：2009-09-30
申请人： Joseph E. Mietus , Chung-Kang Peng , Robert Joseph Thomas , Ary L. Goldberger
发明人： Joseph E. Mietus , Chung-Kang Peng , Robert Joseph Thomas , Ary L. Goldberger
IPC分类号： A61B5/08 , A61B5/04
CPC分类号： A61B5/0472 , A61B5/0205 , A61B5/021 , A61B5/0456 , A61B5/0476 , A61B5/0496 , A61B5/0816 , A61B5/087 , A61B5/0878 , A61B5/4812 , A61B5/4815 , A61B5/4818 , A61B5/7257 , A61B5/7278 , A61B8/06 , G16H50/20 , Y02A90/26
摘要： An assessment of sleep quality and sleep disordered breathing is determined from cardiopulmonary coupling between two physiological data series. An R-R interval series is derived from an electrocardiogram (ECG) signal. The normal beats from the R-R interval series are extracted to produce a normal-to-normal interval series. The amplitude variations in the QRS complex are used to extract a surrogate respiration signal (i.e., ECG-derived respiration) associated with the NN interval series. The two series are corrected to remove outliers, and resampled. The cross-spectral power and coherence of the two resampled signals are calculated over a plurality of coherence windows. For each coherence window, the product of the coherence and cross-spectral power is used to calculate coherent cross-power. Using the appropriate thresholds for the coherent cross-power, the proportion of sleep spent in CAP, non-CAP, and wake and/or REM are determined. Coherent cross-power can be applied to differentiate obstructive from non-obstructive disease, and admixtures of the same.
摘要翻译：通过两个生理数据序列之间的心肺耦合来确定睡眠质量和睡眠呼吸紊乱的评估。从心电图（ECG）信号导出R-R间期序列。提取R-R间隔序列的正常搏动以产生正常到正常的间隔序列。 QRS复合体的振幅变化用于提取与NN间隔序列相关联的替代呼吸信号（即ECG导出的呼吸）。纠正这两个系列以消除异常值，并重新采样。在多个相干窗口上计算两个重采样信号的交叉光谱功率和相干性。对于每个相干窗口，使用相干和交叉光谱功率的乘积来计算相干交叉功率。使用相干交叉功率的适当阈值，确定在CAP，非CAP和唤醒和/或REM中花费的睡眠比例。相干交叉功能可以应用于区分阻塞性和非阻塞性疾病，以及它们的混合物。

82. 发明授权

US08386015B2 Integration of micro and macro information for biomedical imaging 有权
标题翻译：微信息与微信息的集成用于生物医学成像
公开(公告)号：US08386015B2
公开(公告)日：2013-02-26
申请号：US12604504
申请日：2009-10-23
申请人： Ali Kamen , Fred S. Azar , John V. Frangioni
发明人： Ali Kamen , Fred S. Azar , John V. Frangioni
IPC分类号： A61B5/00
CPC分类号： G06T5/50 , A61B6/03 , A61B6/037 , A61B6/5247 , A61B8/00 , A61B8/5238 , A61B90/39 , G06T7/32 , G06T7/33 , G06T7/337 , G06T2207/10056 , G06T2207/10072 , G06T2207/30004
摘要： Macroscopic imaging data, such as from a CT, MR, PET, or SPECT scanner, is obtained. Microscopic imaging data of at least a portion of the same tissue is obtained. To align the microscopic imaging data with the macroscopic imaging data, intermediate data is also obtained. For example, photographic data is acquired at an intermediary stage of a process of preparing tissue for microscopic scan. The macroscopic and microscopic data are registered to the intermediary photographic data. Once registered to the intermediary data, the spatial relationship between the macroscopic and microscopic data is known and may be used for imaging or quantification.
摘要翻译：获得宏观成像数据，例如来自CT，MR，PET或SPECT扫描仪。得到至少一部分相同组织的显微成像数据。为了将显微成像数据与宏观成像数据对准，还获得中间数据。例如，在制备用于显微镜扫描的组织的过程的中间阶段获取摄影数据。宏观和微观数据被登记到中间摄影数据。一旦注册到中间数据，宏观和微观数据之间的空间关系是已知的，并且可以用于成像或定量。

83. 发明申请

US20120323136A1 ELECTRICAL IMPEDANCE MYOGRAPHY 有权
标题翻译：电阻机构
公开(公告)号：US20120323136A1
公开(公告)日：2012-12-20
申请号：US13598109
申请日：2012-08-29
申请人： Carl A. Shiffman , Ronald Aaron , Seward B. Rutkove
发明人： Carl A. Shiffman , Ronald Aaron , Seward B. Rutkove
IPC分类号： A61B5/053
CPC分类号： A61B5/0492 , A61B5/0488 , A61B5/053 , A61B5/0531 , A61B5/0536 , A61B2562/0209 , A61B2562/046 , A61B2562/164
摘要： Electrical impedance myography (EIM) can be used for the assessment and diagnosis of muscular disorders. EIM includes applying an electrical signal to a region of tissue and measuring a resulting signal. A characteristic of the region of tissue is determined based on the measurement. Performing EIM at different frequencies and/or different angular orientations with respect to a muscle can aid in the assessment and diagnosis. Devices are described that facilitate assessment and diagnosis using EIM.
摘要翻译：电阻抗成像（EIM）可用于肌肉疾病的评估和诊断。 EIM包括将电信号施加到组织的区域并测量结果信号。基于测量确定组织区域的特征。以相对于肌肉的不同频率和/或不同角度取向执行EIM可以帮助评估和诊断。描述了使用EIM进行评估和诊断的设备。

84. 发明申请

US20120295950A1 RBP4 IN INSULIN SENSITIVITY/RESISTANCE, DIABETES, AND OBESITY 有权
标题翻译： RBP4在胰岛素敏感性/耐药性，糖尿病和肥胖中的作用
公开(公告)号：US20120295950A1
公开(公告)日：2012-11-22
申请号：US13477790
申请日：2012-05-22
申请人： Barbara B. Kahn , Qin Yang , Tim Graham , Odile Peroni
发明人： Barbara B. Kahn , Qin Yang , Tim Graham , Odile Peroni
IPC分类号： A61K31/167 , A61P3/08 , G01N33/566 , A61K31/426 , A61K31/7088 , C12Q1/68
CPC分类号： A61K31/167 , A61K48/00 , A61K49/0008 , C07K14/705 , C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/5088 , G01N33/6893 , G01N2500/00 , G01N2800/042
摘要： Methods for screening molecules that modulate the activity of Retinol Binding Protein 4 (RBP4) and their use in treatment of insulin resistance are described. Also described are methods of diagnosing insulin resistance and related conditions by detecting modulation of RBP4 activity.
摘要翻译：描述了筛选调节视黄醇结合蛋白4（RBP4）活性的分子及其在治疗胰岛素抵抗中的应用的方法。还描述了通过检测RBP4活性的调节来诊断胰岛素抵抗和相关条件的方法。

85. 发明申请

US20120245436A1 HAND-HELD DEVICE FOR ELECTRICAL IMPEDANCE MYOGRAPHY 有权
标题翻译：手持式电磁感应装置
公开(公告)号：US20120245436A1
公开(公告)日：2012-09-27
申请号：US13391484
申请日：2010-08-20
申请人： Seward B. Rutkove , Joel L. Dawson
发明人： Seward B. Rutkove , Joel L. Dawson
IPC分类号： A61B5/04 , A61B5/01 , A61B5/05 , A61B5/103 , A61B5/0492 , A61B8/00 , A61B5/053 , A61B5/00
CPC分类号： A61B5/053 , A61B5/0536 , A61B5/0537 , A61B5/4519 , A61B5/6843 , A61B2560/0252 , A61B2560/0276 , A61B2562/0209 , A61B2562/046
摘要： A device for determining muscle condition of a region of tissue. The device comprises an electrical impedance myography (EIM) portable probe bearing an electrode array. The electrode array comprises excitation electrodes used to apply multi-frequency electrical signals to the region of tissue and pickup electrodes that are used to collect electrical signals resulting from the application of the multi-frequency electrical signals to the region of tissue. To improve accuracy and reproducibility of EIM measurements, the electrode array is reconfigurable to select different subsets of excitation and pickup electrodes so that the electrodes are oriented differently with respect to muscle fibers. Additional devices may be associated with the EIM probe to measure such parameters as temperature, moisture content of the region, quality of contact of electrodes of the electrode array with a surface of the region and pressure with which the EEM probe is applied to the region. The EIM measurements may be adjusted based on these parameters. Also, ultrasound and electrical impedance tomography measurements may supplement the ELM measurements for more complete analysis of the muscle condition.
摘要翻译：用于确定组织区域的肌肉状况的装置。该装置包括具有电极阵列的电阻抗成像（EIM）便携式探针。电极阵列包括用于将多频电信号施加到组织和拾取电极的区域的激励电极，所述区域用于收集由多频电信号施加到组织区域而产生的电信号。为了提高EIM测量的精度和再现性，电极阵列是可重构的，以选择激励和拾取电极的不同子集，使得电极相对于肌肉纤维取向不同。附加装置可以与EIM探针相关联，以测量诸如区域的温度，水分含量，电极阵列的电极与区域表面的接触质量以及将EEM探针施加到该区域的压力等参数。可以基于这些参数调整EIM测量。此外，超声和电阻抗层析成像测量可补充ELM测量以更完整地分析肌肉状况。

86. 发明申请

US20120231028A1 POLYVALENT VACCINE 有权
公开(公告)号：US20120231028A1
公开(公告)日：2012-09-13
申请号：US13399963
申请日：2012-02-17
申请人： Bette T. KORBER , Simon PERKINS , Tanmoy BHATTACHARYA , William M. FISCHER , James THEILER , Norman LETVIN , Barton F. HAYNES , Beatrice H. HAHN , Karina YUSIM , Carla KUIKEN
发明人： Bette T. KORBER , Simon PERKINS , Tanmoy BHATTACHARYA , William M. FISCHER , James THEILER , Norman LETVIN , Barton F. HAYNES , Beatrice H. HAHN , Karina YUSIM , Carla KUIKEN
IPC分类号： A61K39/21 , A61P37/04 , C12N15/867 , C07K14/155 , C07H21/04
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , C12N2740/16034
摘要： The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.

87. 发明授权

US08252894B2 Poly-N-acetyl glucosamine (PNAG/dPNAG)-binding peptides and methods of use thereof 有权
标题翻译：聚-N-乙酰氨基葡萄糖（PNAG / dPNAG）结合肽及其使用方法
公开(公告)号：US08252894B2
公开(公告)日：2012-08-28
申请号：US13103532
申请日：2011-05-09
申请人： Gerald B. Pier , Casie Anne Kelly-Quintos , Lisa Cavacini , Marshall R. Posner
发明人： Gerald B. Pier , Casie Anne Kelly-Quintos , Lisa Cavacini , Marshall R. Posner
IPC分类号： C07K14/00 , C07K17/00 , C12P21/06
CPC分类号： C07K16/1271 , A61K2039/505 , C07K16/12 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , Y02A50/407
摘要： The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as Staphylococcal PNAG, in acetylated, partially acetylated and/or fully deacetylated form. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of infections by bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Some antibodies of the invention enhance opsonophagocytic killing and in vivo protection against bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
摘要翻译：本发明涉及在乙酰化，部分乙酰化和/或完全脱乙酰化形式中特异性结合聚-N-乙酰葡糖胺（PNAG）如葡萄球菌PNAG的肽，特别是人单克隆抗体。本发明还提供了在诊断，预防和治疗表达PNAG（例如但不限于葡萄球菌和大肠杆菌）的细菌的感染中使用这些肽的方法。本发明的一些抗体增强对表达PNAG（例如但不限于葡萄球菌和大肠杆菌）的细菌的调理吞噬杀伤和体内保护。还提供了这些肽的组合物，包括药物组合物，以及这些肽的功能上等同的变体。

88. 发明申请

US20120201834A1 POLY-N-ACETYL GLUCOSAMINE (PNAG/dPNAG)-BINDING PEPTIDES AND METHODS OF USE THEREOF 有权
公开(公告)号：US20120201834A1
公开(公告)日：2012-08-09
申请号：US13334869
申请日：2011-12-22
申请人： Gerald B. Pier , Casie Anne Kelly-Quintos , Lisa Cavacini , Marshall R. Posner
发明人： Gerald B. Pier , Casie Anne Kelly-Quintos , Lisa Cavacini , Marshall R. Posner
IPC分类号： A61K39/40 , A61P31/04 , C07K16/12
CPC分类号： C07K16/1271 , A61K2039/505 , C07K16/12 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , Y02A50/407
摘要： The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as Staphylococcal PNAG, in acetylated, partially acetylated and/or fully deacetylated form. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of infections by bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Some antibodies of the invention enhance opsonophagocytic killing and in vivo protection against bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.

89. 发明申请

US20110243956A1 METHODS OF DIAGNOSING AND TREATING COMPLICATIONS OF PREGNANCY 审中-公开
标题翻译：诊断和治疗妊娠合并方法
公开(公告)号：US20110243956A1
公开(公告)日：2011-10-06
申请号：US13095500
申请日：2011-04-27
申请人： S. Ananth Karumanchi , Vikas Sukhatme
发明人： S. Ananth Karumanchi , Vikas Sukhatme
IPC分类号： A61K39/395 , A61K38/22 , A61K31/465 , A61K31/522 , A61K31/7076 , A61K31/4422 , A61K31/506 , A61K33/06 , A61K38/18 , C12Q1/02 , G01N33/68 , G01N33/50 , A61P9/12
摘要： Disclosed herein are methods for diagnosing a pregnancy related hypertensive disorder or a predisposition to a pregnancy related hypertensive disorder by measuring the level or biological activity of soluble endoglin. Also disclosed herein are methods for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using compounds that alter soluble endoglin levels or biological activity.
摘要翻译：本文公开了通过测量可溶内皮糖蛋白的水平或生物学活性来诊断与怀孕有关的高血压病症的妊娠相关的高血压病症或倾向性的方法。本文还公开了使用改变可溶内皮糖蛋白水平或生物活性的化合物治疗妊娠相关的高血压病症如先兆子痫和子痫的方法。

90. 发明授权

US07993927B2 Histology methods 失效
标题翻译：组织学方法
公开(公告)号：US07993927B2
公开(公告)日：2011-08-09
申请号：US11824915
申请日：2007-07-03
申请人： John V. Frangioni
发明人： John V. Frangioni
IPC分类号： G01N33/48
CPC分类号： G01N33/52 , B82Y15/00 , G01N33/582 , G01N33/588 , Y10S436/808 , Y10T436/2525
摘要： Described are methods of visualizing biological samples using histological staining and invisible light (e.g., infrared or near-infrared) fluorescence.
摘要翻译：描述了使用组织学染色和不可见光（例如，红外或近红外）荧光来可视化生物样品的方法。

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