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81. 发明申请

US20070124837A1 DESATURASE GENES, ENZYMES ENCODED THEREBY, AND USES THEREOF 有权
标题翻译：去饱和基因，编码的酶，及其用途
公开(公告)号：US20070124837A1
公开(公告)日：2007-05-31
申请号：US11621446
申请日：2007-01-09
申请人： Pradip Mukerji , Suzette Pereira , Yung-Sheng Huang
发明人： Pradip Mukerji , Suzette Pereira , Yung-Sheng Huang
IPC分类号： A01H1/00 , C07H21/04
CPC分类号： C12N9/0083 , C12P7/6427 , C12P7/6472
摘要： Disclosed are isolated polynucleotides encoding an omega-3 desaturase and a delta-12 desaturase, the enzymes encoded by the isolated polynucleotides, vectors containing the isolated polynucleotides, transgenic hosts that contain the isolated polynucleotides that express the enzymes encoded thereby, methods for producing the desaturase enzymes, and method of using the enzymes to make polyunsaturated fatty acids. The isolated polynucleotides are derived from a fungus, Saprolegnia diclina (ATCC 56851). In particular, omega-3-desaturase may be utilized, for example, in the conversion of arachidonic acid (AA) to eicosapentaenoic acid (EPA). Delta-12 desaturase may be used, for example, in the conversion of oleic acid (OA) to linoleic (LA). EPA or polyunsaturated fatty acids produced therefrom may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.
摘要翻译：公开了编码ω-3去饱和酶和δ-12去饱和酶的分离的多核苷酸，由分离的多核苷酸编码的酶，含有分离的多核苷酸的载体，含有表达由其编码的酶的分离的多核苷酸的转基因宿主，用于产生去饱和酶的方法酶和使用酶制备多不饱和脂肪酸的方法。分离的多核苷酸衍生自真菌Saprolegnia diclina（ATCC 56851）。特别地，ω-3-去饱和酶可用于例如花生四烯酸（AA）转化为二十碳五烯酸（EPA）。 Δ-12去饱和酶可以用于例如将油酸（OA）转化为亚油酸（LA）。由此产生的EPA或多不饱和脂肪酸可以加入到药物组合物，营养组合物，动物饲料中，以及其它产品如化妆品中。

82. 发明授权

US07211656B2 Desaturase genes, enzymes encoded thereby, and uses thereof 有权
标题翻译：去饱和酶基因，由此编码的酶及其用途
公开(公告)号：US07211656B2
公开(公告)日：2007-05-01
申请号：US10060793
申请日：2002-01-30
申请人： Pradip Mukerji , Suzette L. Pereira , Yung-Sheng Huang
发明人： Pradip Mukerji , Suzette L. Pereira , Yung-Sheng Huang
IPC分类号： C07H21/04
CPC分类号： C12N9/0083 , C12P7/6427 , C12P7/6472
摘要： Disclosed are isolated polynucleotides encoding an omega-3 desaturase and a delta-12 desaturase, the enzymes encoded by the isolated polynucleotides, vectors containing the isolated polynucleotides, transgenic hosts that contain the isolated polynucleotides that express the enzymes encoded thereby, methods for producing the desaturase enzymes, and method of using the enzymes to make polyunsaturated fatty acids. The isolated polynucleotides are derived from a fungus, Saprolegnia diclina (ATCC 56851). In particular, omega-3-desaturase may be utilized, for example, in the conversion of arachidonic acid (AA) to eicosapentaenoic acid (EPA). Delta-12 desaturase may be used, for example, in the conversion of oleic acid (OA) to linoleic (LA). EPA or polyunsaturated fatty acids produced therefrom may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.
摘要翻译：公开了编码ω-3去饱和酶和δ-12去饱和酶的分离的多核苷酸，由分离的多核苷酸编码的酶，含有分离的多核苷酸的载体，含有表达由其编码的酶的分离的多核苷酸的转基因宿主，用于产生去饱和酶的方法酶和使用酶制备多不饱和脂肪酸的方法。分离的多核苷酸衍生自真菌Saprolegnia diclina（ATCC 56851）。特别地，ω-3-去饱和酶可用于例如花生四烯酸（AA）转化为二十碳五烯酸（EPA）。 Δ-12去饱和酶可以用于例如将油酸（OA）转化为亚油酸（LA）。由此产生的EPA或多不饱和脂肪酸可以加入到药物组合物，营养组合物，动物饲料中，以及其它产品如化妆品中。

83. 发明授权

US07070970B2 Elongase genes and uses thereof 失效
公开(公告)号：US07070970B2
公开(公告)日：2006-07-04
申请号：US10408736
申请日：2003-04-04
申请人： Pradip Mukerji , Tapas Das , Yung-Sheng Huang , Jennifer Parker-Barnes , Amanda E. Leonard , Jennifer M. Thurmond
发明人： Pradip Mukerji , Tapas Das , Yung-Sheng Huang , Jennifer Parker-Barnes , Amanda E. Leonard , Jennifer M. Thurmond
IPC分类号： C12N9/10 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： A01K67/0275 , A23K20/158 , A23L33/12 , C12N9/1029 , C12N15/8247 , C12P7/6427
摘要： The subject invention relates to the identification of four genes involved in the elongation of polyunsaturated acids (i.e., “elongases”) and to uses thereof. Two of these genes are also involved in the elongation of monounsaturated fatty acids. In particular, elongase is utilized in the conversion of gamma linolenic acid (GLA) to dihomogamma linolenic acid (DGLA) and in the conversion of DGLA or 20:4n-3 to eicosapentaenoic acid (EPA). DGLA may be utilized in the production of polyunsaturated fatty acids, such as arachidonic acid (AA), docosahexaenoic acid (DHA), EPA, adrenic acid, ω6-docosapentaenoic acid or ω3-docosapentaenoic acid which may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.

84. 发明申请

US20060001429A1 Method of monitoring motor vehicle's electric power by comparing internal resistance of battery with a predeterminated warning resistance thereof and apparatus therefor 有权
标题翻译：通过比较电池的内部电阻和预先确定的警告电阻来监测机动车辆电力的方法及其装置
公开(公告)号：US20060001429A1
公开(公告)日：2006-01-05
申请号：US10882196
申请日：2004-07-02
申请人： Yung-Sheng Huang
发明人： Yung-Sheng Huang
IPC分类号： G01N27/416
CPC分类号： G01R31/3662 , B60L11/1861 , B60L2240/547 , B60L2240/549 , Y02T10/7005 , Y02T10/7044 , Y02T10/705
摘要： The method comprises coupling an external load having a predetermined resistance directly in series with the battery, conducting a power transistor to supply a transient large current to the battery for sampling voltage of the battery in a set very short period of time, and determining the internal resistance of the battery. The internal resistance of the battery can then be compared with a predetermined warning value of internal resistance of the battery so as to determine whether the former is equal to or larger than the warning value, and displaying a warning on a display if the determination is affirmative. The invention enables a driver to correctly know the condition of the battery in substantially real time while consuming a minimum amount of current.
摘要翻译：该方法包括将具有预定电阻的外部负载直接与电池串联耦合，导通功率晶体管以在非常短的时间段内为电池提供瞬时大电流以对电池进行采样电压，以及确定内部电池的电阻。然后可以将电池的内部电阻与电池的内部电阻的预定警告值进行比较，以便确定前者是否等于或大于警告值，并且如果确定是肯定的，则在显示器上显示警告。本发明使驾驶员能够在消耗最小量的电流的情况下基本上实时地正确地知道电池的状况。

85. 发明申请

US20050009140A1 Elongase genes and uses thereof 有权
标题翻译：延长酶基因及其用途
公开(公告)号：US20050009140A1
公开(公告)日：2005-01-13
申请号：US10912446
申请日：2004-08-05
申请人： Pradip Mukerji , Amanda Leonard , Yung-Sheng Huang , Suzette Pereira
发明人： Pradip Mukerji , Amanda Leonard , Yung-Sheng Huang , Suzette Pereira
IPC分类号： A01H5/00 , A23D9/00 , A23K1/16 , A61K8/30 , A61K8/36 , A61K8/60 , A61K8/64 , A61K31/202 , A61K38/00 , A61P3/02 , A61P3/04 , A61P3/10 , A61P7/00 , A61P7/02 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/04 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/16 , A61P19/02 , A61P19/10 , A61P25/00 , A61P29/00 , A61P31/18 , A61Q19/00 , C07H21/04 , C12N1/12 , C12N1/15 , C12N1/19 , C12N1/20 , C12N1/21 , C12N5/00 , C12N5/10 , C12N9/00 , C12N9/10 , C12N15/00 , C12N15/09 , C12N15/82 , C12P7/64 , C12P21/06
CPC分类号： A23D9/00 , A01K2217/05 , A23K20/158 , A61K8/361 , A61K8/606 , A61K8/64 , A61K31/202 , A61K38/00 , A61K2800/86 , A61Q19/00 , C12N9/1029 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： The subject invention relates to the identification of several genes involved in the elongation of polyunsaturated acids (i.e., “elongases”) and to uses thereof. At least two of these genes are also involved in the elongation of monounsaturated fatty acids. In particular, elongase is utilized in the conversion of gamma linolenic acid (GLA) to dihomogamma linolenic acid (DGLA) and in the conversion of AA to adrenic acid (ADA), or eicosapentaenoic acid (EPA) to ω3-docosapentaenoic acid (DPA). DGLA may be utilized in the production of polyunsaturated fatty acids, such as arachidonic acid (AA), docosahexaenoic acid (DHA), EPA, adrenic acid, ω6-docosapentaenoic acid or ω3-docosapentaenoic acid which may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.
摘要翻译：本发明涉及鉴定涉及多不饱和酸延伸的几种基因（即“延伸酶”）及其应用。这些基因中至少有两个也参与单不饱和脂肪酸的延伸。特别地，延长酶用于将γ-亚麻酸（GLA）转化为二亚麻酸（DGLA）和将AA转化为肾上腺素（ADA）或二十碳五烯酸（EPA）转化为ω-二十二碳五烯酸（DPA）。 DGLA可用于生产多不饱和脂肪酸，例如花生四烯酸（AA），二十二碳六烯酸（DHA），EPA，肾上腺素，ω6-二十二碳五烯酸或ω3-二十二碳五烯酸，其可加入到药物组合物中，营养组合物，动物饲料，以及化妆品等其他产品。

86. 发明申请

US20050005328A1 Delta4-desaturase genes and uses thereof 有权
公开(公告)号：US20050005328A1
公开(公告)日：2005-01-06
申请号：US10913226
申请日：2004-08-06
申请人： Pradip Mukerji , Jennifer Thurmond , Yung-Sheng Huang , Tapas Das , Amanda Leonard , Suzette Pereira
发明人： Pradip Mukerji , Jennifer Thurmond , Yung-Sheng Huang , Tapas Das , Amanda Leonard , Suzette Pereira
IPC分类号： A01H5/00 , A23D9/00 , A23K1/16 , A23L1/164 , A23L1/187 , A61K31/202 , A61K38/00 , A61P3/02 , C12N1/19 , C12N5/02 , C12N5/10 , C12N9/02 , C12N15/09 , C12P7/64 , A01H1/00 , C07H21/04 , C12N5/04 , C12N9/04 , C12N15/82 , C12Q1/68
CPC分类号： C12N9/0083 , A23D9/00 , A23K20/158 , A23L7/126 , A23L9/12 , A61K38/00 , C12P7/6427 , C12P7/6472
摘要： The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 4 (i.e., “Δ4-desaturase”). In particular, Δ4-desaturase may be utilized, for example, in the conversion of adrenic acid to ω6-docosapentaenoic acid and in the conversion of ω3-docosapentaenoic acid to docosahexaenoic acid. The polyunsaturated fatty acids produced by use of the enzyme may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.

87. 发明授权

US06704629B2 Device for monitoring motor vehicle's electric power and method therefor 有权
标题翻译：监测机动车电力的装置及其方法
公开(公告)号：US06704629B2
公开(公告)日：2004-03-09
申请号：US09996813
申请日：2001-11-30
申请人： Yung-Sheng Huang
发明人： Yung-Sheng Huang
IPC分类号： G06F700
CPC分类号： G01R31/3648 , G01R31/007 , G01R31/3606
摘要： A method and a device for monitoring a motor vehicle's electric power, in which the method comprises the steps of sampling, calculating, comparing, displaying results, and counting intervals, and the device comprises a stabilizing circuit, a CPU, a voltage sampling circuit, a current control circuit, and a color lamp display circuit. The step of sampling is performed when the load and power transistor are enabled (i.e., there is a great amount of current) and with a very short sampling time so that the invention can inform a driver about a status of a battery by consuming very little power.
摘要翻译：一种用于监测机动车辆电力的方法和装置，其中该方法包括采样，计算，比较，显示结果和计数间隔的步骤，并且该装置包括稳定电路，CPU，电压采样电路，电流控制电路和彩色显示电路。当负载和功率晶体管被使能（即，存在大量电流）并且具有非常短的采样时间时，执行采样步骤，使得本发明可以通过消耗很少的信息通知驾驶员电池的状态功率。

88. 发明授权

US06428990B1 Human desaturase gene and uses thereof 有权
公开(公告)号：US06428990B1
公开(公告)日：2002-08-06
申请号：US09439261
申请日：1999-11-12
申请人： Pradip Mukerji , Amanda Eun-Yeong Leonard , Yung-Sheng Huang , Jennifer M. Parker-Barnes
发明人： Pradip Mukerji , Amanda Eun-Yeong Leonard , Yung-Sheng Huang , Jennifer M. Parker-Barnes
IPC分类号： C12P764
CPC分类号： A23D9/00 , A01K2217/05 , A23K20/158 , A23L7/126 , A23L9/10 , A23L33/10 , A23L33/12 , A23L33/13 , A23L33/17 , A23L33/40 , A23V2002/00 , A61K8/361 , A61K8/67 , A61K31/202 , A61K38/00 , A61Q19/00 , C12N9/0083 , C12N15/81 , C12N15/8247 , C12P7/6427 , C12P7/6472 , A23V2250/19 , A23V2250/1882 , A23V2250/1862
摘要： The subject invention relates to the identification of a gene involved in the desaturation of polyunsaturated fatty acids at carbon 5 (i.e., “human &Dgr;5-desaturase”) and to uses thereof. In particular, human &Dgr;5-desaturase may be utilized, for example, in the conversion of dihomo-&ggr;-linolenic acid (DGLA) to arachidonic acid (AA) and in the conversion of 20:4n-3 to eicosapentaenoic acid (EPA). AA or polyunsaturated fatty acids produced therefrom may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.

89. 发明授权

US06410288B1 Methods and compositions for synthesis of long chain poly-unsaturated fatty acids 有权
标题翻译：用于合成长链多不饱和脂肪酸的方法和组合物
公开(公告)号：US06410288B1
公开(公告)日：2002-06-25
申请号：US09363526
申请日：1999-07-29
申请人： Deborah Knutzon , Pradip Mukerji , Yung-Sheng Huang , Jennifer Thurmond , Sunita Chaudhary
发明人： Deborah Knutzon , Pradip Mukerji , Yung-Sheng Huang , Jennifer Thurmond , Sunita Chaudhary
IPC分类号： C12N902
CPC分类号： C12N9/0083 , A01K2217/05 , A23D9/00 , A23K20/158 , A23L33/12 , A23L33/40 , A61K38/00 , C12N15/81 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： The present invention relates to fatty acid desaturases able to catalyze the conversion of oleic acid to linoleic acid, linoleic acid to gamma-linolenic acid, or of alpha-linolenic acid to stearidonic acid. Nucleic acid sequences encoding desaturases, nucleic acid sequences which hybridize thereto, DNA constructs comprising a desaturase gene, and recombinant host microorganism or animal expressing increased levels of a desaturase are described. Methods for desaturating a fatty acid and for producing a desaturated fatty acid by expressing increased levels of a desaturase are disclosed. Fatty acids, and oils containing them, which have been desaturated by a desaturase produced by recombinant host microorganisms or animals are provided. Pharmaceutical compositions, infant formulas or dietary supplements containing fatty acids which have been desaturated by a desaturase produced by a recombinant host microorganism or animal also are described.
摘要翻译：本发明涉及能够催化油酸向亚油酸，亚麻油酸，γ-亚麻酸或α-亚麻酸转化成十八碳四烯酸的脂肪酸去饱和酶。描述了编码去饱和酶的核酸序列，与其杂交的核酸序列，包含去饱和酶基因的DNA构建体和表达增加的去饱和酶水平的重组宿主微生物或动物。公开了通过表达增加的去饱和酶水平使脂肪酸去饱和并产生去饱和脂肪酸的方法。提供了通过由重组宿主微生物或动物产生的去饱和酶已经去饱和的含有它们的脂肪酸和油。还描述了通过由重组宿主微生物或动物产生的去饱和酶已经去饱和的含有脂肪酸的药物组合物，婴儿配方食品或膳食补充剂。

90. 发明授权

US06258375B1 Antibacterial phosphoinositides 失效
标题翻译：抗菌磷酸肌醇
公开(公告)号：US06258375B1
公开(公告)日：2001-07-10
申请号：US09035602
申请日：1998-03-05
申请人： Shie-Ming Hwang , Yung-Sheng Huang , Jim-Wen Liu , Pradip Mukerji , Steven Neal Anderson , Jonathan A. Meulbroek
发明人： Shie-Ming Hwang , Yung-Sheng Huang , Jim-Wen Liu , Pradip Mukerji , Steven Neal Anderson , Jonathan A. Meulbroek
IPC分类号： A61K900
CPC分类号： A23L33/10 , Y10S514/888
摘要： It has been discovered that certain phosphoinositides demonstrate antibacterial activity. Particularly, these phosphoinositides have been discovered to prevent the adhesion of H. influenzae onto the nasopharyngeal cells of mammals, and, in particular, humans. Phosphoinositides useful with the present invention have the following formula: wherein R1 and R2 are selected from the group consisting of hydrogen and monounsaturated and saturated fatty acids having a carbon chain length of C6 to C20 and R1 and R2 can be the same or different; and R3 to R7 are selected from the group consisting of hydrogen or a phosphate moiety with at least two of R3 to R7 being a phosphate moiety; and hydrates and pharmaceutically acceptable salts thereof.
摘要翻译：已经发现某些磷酸肌醇表现出抗菌活性。特别地，这些磷酸肌醇已被发现以防止流感嗜血杆菌粘附到哺乳动物，特别是人的鼻咽细胞上。适用于本发明的磷酸肌醇具有下式：其中R 1和R 2选自氢和单链不饱和和碳原子数为C6〜C20的饱和脂肪酸，R1和R2可以相同或不同; 并且R 3至R 7选自氢或磷酸酯部分，其中至少两个R 3至R 7为磷酸酯部分; 及其水合物及其药学上可接受的盐。

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