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81. 发明申请

US20090082544A1 PROCESS FOR PRODUCING POLYTHIOL COMPOUND FOR OPTICAL MATERIALS, AND POLYMERIZABLE COMPOSITION CONTAINING POLYTHIOL COMPOUND 审中-公开
标题翻译：用于制造光学材料用聚合物的方法以及含有聚合物化合物的聚合性组合物
公开(公告)号：US20090082544A1
公开(公告)日：2009-03-26
申请号：US12297269
申请日：2007-04-12
申请人： Shigetoshi Kuma , Masaru Kawaguchi , Seiichi Kobayashi
发明人： Shigetoshi Kuma , Masaru Kawaguchi , Seiichi Kobayashi
IPC分类号： C07C319/08 , C08G75/02
CPC分类号： C07C319/14 , C08G18/3876 , C08G18/7642 , C07C321/14
摘要： Provided is a process for producing a polythiol compound for an optical material, the method includes reacting 2-mercaptoethanol with an epihalohydrin compound to give polyalcohol, and preparing a polythiol compound through the polyalcohol, wherein a content of bis(2-hydroxyethyl) disulfide in the 2-mercaptoethanol is 0.5 wt % or less.
摘要翻译：本发明提供了一种用于制备光学材料用多硫醇化合物的方法，该方法包括使2-巯基乙醇与表卤代醇化合物反应得到多元醇，并通过多元醇制备多硫醇化合物，其中二（2-羟乙基）二硫化物的含量 2-巯基乙醇为0.5重量％以下。

82. 发明授权

US07314936B2 Deazapurines and uses thereof 失效
标题翻译：脱氮嘌呤及其用途
公开(公告)号：US07314936B2
公开(公告)日：2008-01-01
申请号：US10500840
申请日：2003-01-07
申请人： Jane Daun , Heather A. Davis , Bruce DeCosta , Fabian Gusovsky , Ieharu Hishinuma , Yimin Jiang , Toshihiko Kaneko , Kouichi Kikuchi , Seiichi Kobayashi , André Lescarbeau , Xiang-Yi Li , Kenzo Muramoto , Norihito Ohi , Marc Pesant , Boris M. Seletsky , Motohiro Soejima , Mark Spyvee , Lynda Tremblay , Ye Yao , Hiromitsu Yokohama , Yan (Janet) Zhao , Wanjun Zheng
发明人： Jane Daun , Heather A. Davis , Bruce DeCosta , Fabian Gusovsky , Ieharu Hishinuma , Yimin Jiang , Toshihiko Kaneko , Kouichi Kikuchi , Seiichi Kobayashi , André Lescarbeau , Xiang-Yi Li , Kenzo Muramoto , Norihito Ohi , Marc Pesant , Boris M. Seletsky , Motohiro Soejima , Mark Spyvee , Lynda Tremblay , Ye Yao , Hiromitsu Yokohama , Yan (Janet) Zhao , Wanjun Zheng
IPC分类号： C07D498/02 , C07D513/02 , C07D515/02 , C07D471/02
CPC分类号： A61K31/437 , C07D471/04
摘要： The present invention provides compounds having formula (I), wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally
摘要翻译：本发明提供具有式（I）的化合物，其中R 1，R 2，R 3和n如通常和类别所述并且另外提供其药物组合物，及其用于治疗炎性或自身免疫性和增殖性疾病的方法，以及作为细胞粘附分子表达和炎性细胞因子信号转导的抑制剂

83. 发明申请

US20070203318A1 Polyurethanes Polymerizable Composition And Method For Producing Optical Resin Of The Same 有权
标题翻译：聚氨酯可聚合组合物及其制备方法
公开(公告)号：US20070203318A1
公开(公告)日：2007-08-30
申请号：US10592375
申请日：2005-02-22
申请人： Shigetoshi Kuma , Koichi Tokunaga , Hiroyuki Morijiri , Seiichi Kobayashi
发明人： Shigetoshi Kuma , Koichi Tokunaga , Hiroyuki Morijiri , Seiichi Kobayashi
IPC分类号： C08G18/00
CPC分类号： C08G18/758 , C08G18/3876 , C08G18/757 , G02B1/04 , C08L75/04 , C08L81/00
摘要： A resin composition for an optical material that has excellent balance of refractive index of resin, Abbe number, heat resistance, specific gravity, and resin strength, a resin obtained by curing the resin composition, and an optical material are provided. A polymerizable composition comprising the following is used: An alicyclic isocyanate compound represented by the formula (1) and/or the formula (2): (In the formula (1), n represents integer of 0 to 3) and (a) at least one compound of the polythiol compound having at least two thiol groups in one molecule and/or the polythiol compound having at least two thiol groups and at least one (poly)sulfide bond other than the thiol group in one molecule, and (b) at least one compound of the polyhydroxy compound having at least two hydroxy groups in one molecule and/or the (poly)hydroxy(poly)mercapto compound having at least one hydroxy group and at least one thiol group.
摘要翻译：提供了树脂折射率，阿贝数，耐热性，比重和树脂强度优异的光学材料用树脂组合物，通过树脂组合物固化得到的树脂和光学材料。使用包含以下的可聚合组合物：由式（1）和/或式（2）表示的脂环族异氰酸酯化合物：（式（1）中，n表示0〜3的整数），（a）至少一种在一个分子中具有至少两个硫醇基的多硫醇化合物和/或在一个分子中具有至少两个硫醇基和除硫醇基以外的至少一个（多）硫键的多硫醇化合物，和（b）至少一种在一个分子中具有至少两个羟基的多羟基化合物的化合物和/或具有至少一个羟基和至少一个硫醇基的（多）羟基（多）巯基化合物。

84. 发明申请

US20070154605A1 System for softening and dispensing frozen confectionary, and process therefor 审中-公开
标题翻译：用于软化和分配冷冻糖果的系统及其处理方法
公开(公告)号：US20070154605A1
公开(公告)日：2007-07-05
申请号：US10584450
申请日：2004-12-27
申请人： Seiichi Kobayashi , Ryoji Kobayashi
发明人： Seiichi Kobayashi , Ryoji Kobayashi
IPC分类号： A23G3/02
CPC分类号： A23G9/28
摘要： Object To obtain a system and a method for softening a frozen confectionary without applying heat thereto, and then dispensing the same, which make it possible to dispense the frozen confectionary in an appropriately soft state, regardless of the kind of frozen confectionary. Means for achieving the object The system of the present invention includes therein a bag-shaped container 100 having an outlet port, the bag-shaped container including therein the frozen solid confectionary; a frozen confectionary softening unit 14 for softening the frozen confectionary in the bag-shaped container by application of pressure in the absence of heat application thereto; a dispensing unit 16 for dispensing the frozen confectionary from the outlet port after the frozen confectionary being softened by the pressure application operation to the bag-shaped container 100; a bag-shaped container transporting means 18 for transporting the bag-shaped container 100 to a softening operation and a dispensing operation; a species recognition means 12 for recognizing the species of the frozen confectionary provided in the bag-shaped container 100; and a control unit 20 for controlling the frozen confectionary softening unit so as to function based on appropriate pre-stored conditions for the softening operation, depending on the recognized species of the frozen confectionary, in the absence of heat application.
摘要翻译：对象为了获得用于软化冷冻糖食而不向其施加热量的系统和方法，然后分配该系统和方法，这使得可以以适当的软状态分配冷冻糖食，而不管冷冻糖食的种类如何。用于实现目的的手段本发明的系统包括具有出口的袋状容器100，其中包含冷冻固体糖果的袋形容器; 冷冻糖果软化单元14，用于通过在不施加热量的情况下施加压力来软化袋形容器中的冷冻糖果; 一个分配单元16，用于在通过压力施加操作将冰冻的糖食软化到袋形容器100之后，从出口端口分配冷冻甜食; 用于将袋形容器100运送到软化操作和分配操作的袋状容器输送装置18; 用于识别设置在袋状容器100中的冷冻糖果的种类的物种识别装置12; 以及控制单元20，用于控制冷冻甜食软化单元，以便在没有热施加的情况下，根据冷冻糖果的公认种类，基于用于软化操作的适当的预先存储条件起作用。

85. 发明申请

US20070054876A1 Pharmaceutical composition promoting defecation 审中-公开
标题翻译：药物组成促进排便
公开(公告)号：US20070054876A1
公开(公告)日：2007-03-08
申请号：US11594132
申请日：2006-11-08
申请人： Masahiro Yasuda , Hitoshi Harada , Shuhei Miyazawa , Seiichi Kobayashi , Kokichi Harada , Takayuki Hida , Hisashi Shibata , Nobuyuki Yasuda , Osamu Asano , Yoshihiko Kotake
发明人： Masahiro Yasuda , Hitoshi Harada , Shuhei Miyazawa , Seiichi Kobayashi , Kokichi Harada , Takayuki Hida , Hisashi Shibata , Nobuyuki Yasuda , Osamu Asano , Yoshihiko Kotake
IPC分类号： A61K31/7076 , A61K31/522
CPC分类号： A61K31/506 , A61K31/519 , A61K31/522 , A61K31/5377 , A61K31/7076 , H04B10/112
摘要： The present invention provides a medicament having a gentle but strong defecation-promoting action without causing diarrhea. That is, it provides a defecation-promoting agent comprising a compound having an adenosine A2 receptor antagonism, preferably an adenosine A2b receptor antagonism, or a salt thereof.
摘要翻译：本发明提供一种具有温和但强烈的排便促进作用而不引起腹泻的药物。也就是说，它提供了包含具有腺苷A 2受体拮抗作用的化合物，优选腺苷A 2b受体拮抗剂或其盐的排便促进剂。

86. 发明授权

US07128491B2 Composite writing instrument 失效
标题翻译：复合书写工具
公开(公告)号：US07128491B2
公开(公告)日：2006-10-31
申请号：US10944826
申请日：2004-09-21
申请人： Seiichi Kobayashi
发明人： Seiichi Kobayashi
IPC分类号： A46B11/02 , B43K27/00 , B43K5/16
CPC分类号： B43K7/03 , B43K24/146 , B43K24/163 , B43K25/028 , B43K27/12
摘要： In a composite writing instrument having mounted therein a plurality of writing devices including at least one ball-point pen refill equipped with a tip of the ball-point pen at a top end and an ink reservoir section at a rear end so that writing tip portions may be alternately allowed to project and retreat from an front body top, a pumping type pressurization mechanism is provided behind the ball-point pen refill, and a rear end of ink is pressurized by way of knock operation in a situation where a tip end portion has projected from a body end, so as to help the ink flow towards the tip side.
摘要翻译：在一种其中安装有多个书写装置的复合书写工具中，所述书写装置包括至少一个圆珠笔笔芯，该圆珠笔笔芯在顶端装有圆珠笔的尖端，在后端具有墨水储存部分，可以交替地从前体顶部突出和退避，在圆珠笔笔芯后面设置抽吸式加压机构，并且在前端部分的情况下通过敲击操作来加压墨水后端从身体端突出，以帮助墨流向尖端侧。

87. 再颁专利

USRE39112E1 Purine derivatives and adenosine A2 receptor antagonists serving as preventives/remedies for diabetes 失效
标题翻译：嘌呤衍生物和腺苷A2受体拮抗剂作为糖尿病的预防药物/治疗药物
公开(公告)号：USRE39112E1
公开(公告)日：2006-05-30
申请号：US11057854
申请日：1998-12-24
申请人： Osamu Asano , Hitoshi Harada , Yorihisa Hoshino , Seiji Yoshikawa , Takashi Inoue , Tatsuo Horizoe , Nobuyuki Yasuda , Kaya Ohashi , Junsaku Nagaoka , Manabu Murakami , Seiichi Kobayashi
发明人： Osamu Asano , Hitoshi Harada , Yorihisa Hoshino , Seiji Yoshikawa , Takashi Inoue , Tatsuo Horizoe , Nobuyuki Yasuda , Kaya Ohashi , Junsaku Nagaoka , Manabu Murakami , Seiichi Kobayashi
IPC分类号： C07D473/34 , C07D473/30 , C07D473/00 , A61K31/52 , A61K31/522
CPC分类号： C07D473/30 , A61K31/52 , C07D473/00 , C07D473/34
摘要： The present invention provides a preventive or therapeutic agent of a new type for diabetes mellitus and diabetic complications on the basis of an adenosine A2 receptor antagonist action.A purine compound represented by the formula (I), its pharmacologically acceptable salt or hydrates thereof has an adenosine A2 receptor antagonistic action and is useful for prevention or therapy of diabetes mellitus and diabetic complications. In addition, adenosine A2 receptor antagonists having different structures from those of the compounds described above, for example KW6002, are also effective for prevention or therapy of diabetes mellitus and diabetic complications. In the formula, W is —CH2CH2—, or —CH═CH— or —C≡C—; R1 is: (in the formula, X is hydrogen atom, hydroxyl group, a lower alkyl group, a lower alkoxy group, etc.; and R5 and R6 are the same as or different from each other and each represents hydrogen atom, a lower alkyl group, a cycloalkyl group, etc.) and the like; R2 is an amino group, etc. which maybe substituted with a lower alkyl group, etc.; R3 is a cycloalkyl group, an optionally substituted aryl group, etc.; and R4 is a lower alkyl group etc.
摘要翻译：本发明提供了基于腺苷A2受体拮抗剂作用的糖尿病新型糖尿病并发症的预防或治疗剂。由式（I）表示的嘌呤化合物，其药理学上可接受的盐或其水合物具有腺苷A2受体拮抗作用，可用于预防或治疗糖尿病和糖尿病并发症。此外，与上述化合物（例如KW6002）具有不同结构的腺苷A2受体拮抗剂对于糖尿病和糖尿病并发症的预防或治疗也是有效的。在该式中，W是-CH 2 CH 2 - ，或-CH-CH-或-C≡C-; R 1是：（在该式中，X是氢原子，羟基，低级烷基，低级烷氧基等; R 5和R 5， SUP> 6 <！ - SIPO - >相同或不同，各自表示氢原子，低级烷基，环烷基等）等; R 2是可以被低级烷基等取代的氨基等; R 3是环烷基，任选取代的芳基等; R 4是低级烷基等。

88. 发明申请

US20050124649A1 Deazapurines and uses thereof 失效
标题翻译：脱氮嘌呤及其用途
公开(公告)号：US20050124649A1
公开(公告)日：2005-06-09
申请号：US10500840
申请日：2003-01-07
申请人： Jane Daun , Heather Davis , Bruce DeAcosta , Fabian Gusovsky , Ieharu Hishinuma , Yimin Jiang , Toshihiko Kaneko , Kouichi Kikuchi , Seiichi Kobayashi , Andre Lescarbeau , Xiang-Yi Li , Kenzo Muramoto , Norihito Ohi , Marc Pesant , Boris Seletsky , Mark Spyvee , Lynda Tremblay , Ye Yao , Hiromitsu Yokohama , Yan (Janet) Zhao , Wanjun Zheng
发明人： Jane Daun , Heather Davis , Bruce DeAcosta , Fabian Gusovsky , Ieharu Hishinuma , Yimin Jiang , Toshihiko Kaneko , Kouichi Kikuchi , Seiichi Kobayashi , Andre Lescarbeau , Xiang-Yi Li , Kenzo Muramoto , Norihito Ohi , Marc Pesant , Boris Seletsky , Mark Spyvee , Lynda Tremblay , Ye Yao , Hiromitsu Yokohama , Yan (Janet) Zhao , Wanjun Zheng
IPC分类号： A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , A61P1/04 , A61P3/10 , A61P7/04 , A61P9/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/04 , A61P17/06 , A61P19/02 , A61P21/04 , A61P25/00 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07D471/04 , C07D519/00 , C07D471/02 , A61K31/4745
CPC分类号： A61K31/437 , C07D471/04
摘要： The present invention provides compounds having formula (I), wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally.
摘要翻译：本发明提供具有式（I）的化合物，其中R 1，R 2，R 3和n如通常和类别所述并且另外提供其药物组合物，以及其用于治疗炎症或自身免疫和增殖性疾病的方法，以及作为细胞粘附分子表达和炎性细胞因子信号转导的抑制剂。

89. 发明授权

US06579868B1 Purine derivatives and adenosine A2 receptor antagonists serving as preventives/remedies for diabetes 有权
标题翻译：嘌呤衍生物和腺苷A2受体拮抗剂作为糖尿病的预防药物/治疗药物
公开(公告)号：US06579868B1
公开(公告)日：2003-06-17
申请号：US09582840
申请日：2000-07-05
申请人： Osamu Asano , Hitoshi Harada , Yorihisa Hoshino , Seiji Yoshikawa , Takashi Inoue , Tatsuo Horizoe , Nobuyuki Yasuda , Kaya Nagata , Junsaku Nagaoka , Manabu Murakami , Seiichi Kobayashi
发明人： Osamu Asano , Hitoshi Harada , Yorihisa Hoshino , Seiji Yoshikawa , Takashi Inoue , Tatsuo Horizoe , Nobuyuki Yasuda , Kaya Nagata , Junsaku Nagaoka , Manabu Murakami , Seiichi Kobayashi
IPC分类号： C07D47334
CPC分类号： C07D473/30 , A61K31/52 , C07D473/00 , C07D473/34
摘要： The present invention provides a preventive or therapeutic agent of a new type for diabetes mellitus and diabetic complications on the basis of an adenosine A2 receptor antagonistic action. A purine compound represented by the formula (I), its pharmacologically acceptable salt or hydrates thereof has an adenosine A2 receptor antagonistic action and is useful for prevention or therapy of diabetes mellitus and diabetic complications. In addition, adenosine A2 receptor antagonists having different structures from those of the compounds described above, for example KW6002, are also effective for prevention or therapy of diabetes mellitus and diabetic complications. In the formula, W is —CH2CH2—, —CH═CH— or —C≡C—; R1 is: (in the formula, X is hydrogen atom, hydroxyl group, a lower alkyl group, a lower alkoxy group, etc.; and R5 and R6 are the same as or different from each other and each represents hydrogen atom, a lower alkyl group, a cycloalkyl group, etc.) and the like; R2 is an amino group, etc. which maybe substituted with a lower alkyl group, etc.; R3 is a cycloalkyl group, an optionally substituted aryl group, etc.; and R4 is a lower alkyl group etc.
摘要翻译：本发明提供了基于腺苷A2受体拮抗作用的新型糖尿病和糖尿病并发症的预防或治疗剂。由式（I）表示的嘌呤化合物，其药理学上可接受的盐或其水合物具有腺苷A2受体拮抗作用，可用于预防或治疗糖尿病和糖尿病并发症。此外，与上述化合物例如KW6002具有不同结构的腺苷A2受体拮抗剂对于预防或治疗糖尿病和糖尿病并发症也是有效的。在该式中，W是-CH 2 CH 2 - ， - CH = CH - 或-C = C-; R1为（式中，X为氢原子，羟基，低级烷基，低级烷氧基等），R5和R6彼此相同或不同，分别表示氢原子，低级烷基，环烷基等）等; R2是可被低级烷基取代的氨基等; R3是环烷基，任选取代的芳基等; R4为低级烷基等。

90. 发明授权

US06435751B1 Click type writing implement 失效
标题翻译：点击类型书写工具
公开(公告)号：US06435751B1
公开(公告)日：2002-08-20
申请号：US09980790
申请日：2001-12-06
申请人： Makoto Ono , Hitoshi Nakamura , Tadashi Koriki , Tamotsu Eguchi , Seiichi Kobayashi
发明人： Makoto Ono , Hitoshi Nakamura , Tadashi Koriki , Tamotsu Eguchi , Seiichi Kobayashi
IPC分类号： A46B1102
CPC分类号： B43K24/082
摘要： A click type writing implement includes: a ball-pen refill composed of a point assembly at the front end thereof, an ink storage at the rear thereof and a pressurizing mechanism of a pumping type at the rear of the ink storage; an arrangement for holding the refill and engaging it so as to allow the tip of the point assembly to be projected from and retracted into the front end; and a clicking mechanism for keeping the tip of the point assembly projected, the clicking mechanism comprising: a first clicking mechanism for advancing and contracting ink by a short stroke and a second clicking mechanism for advancing and contracting ink by a large stroke, so that the rear end of ink can be pressurized at two levels so as to promote flow of ink toward the point assembly.
摘要翻译：点击型书写工具包括：在其前端由点组件，其后部的墨水储存器和在墨水存储器后部的泵送型加压机构组成的圆珠笔填充物; 用于保持再充填并将其接合以使点组件的尖端从前端伸出并缩回到前端的装置; 以及用于保持点组件的尖端投影的咔嗒机构，所述咔嗒机构包括：用于通过短行程使油墨前进和收缩的第一咔嗒机构，以及用于大笔画进给和收缩油墨的第二咔嗒机构，油墨的后端可以被加压到两个水平，以促进油墨朝向点组件的流动。

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