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81. 发明申请

US20090123456A1 Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists 有权
标题翻译：使用α7受体结合胆碱能激动剂治疗胰腺炎
公开(公告)号：US20090123456A1
公开(公告)日：2009-05-14
申请号：US11724605
申请日：2007-03-15
申请人： Kevin J. Tracey , Hong Wang
发明人： Kevin J. Tracey , Hong Wang
IPC分类号： A61K39/395 , C07K16/28 , G01N33/53 , C12Q1/68 , A61K31/715
CPC分类号： A61K31/46 , A61K31/00 , A61K31/439 , A61K31/444 , G01N33/6863 , G01N33/9406 , G01N2333/525 , G01N2333/54 , Y02A50/385 , Y02A50/411
摘要： A method of treating a patient suffering from pancreatitis comprising treating said patient with a therapeutically effective amount of a cholinergic agonist selective for an α7 nicotinic receptor in an amount sufficient to decrease the amount of the proinflammatory cytokine that is released from a macrophage wherein said condition is acute pancreatitis. The compounds of the present invention include a quaternary analog of cocaine; (1-aza-bicyclo[2.2.2]oct-3-yl)-carbamic acid 1-(2-fluorophenyl)-ethyl ester; a compound of formula (I), a compound of formula (II), a compound of formula (III), a compound of formula (IV), and an oligonucleotide or mimetic capable of attenuating the symptoms of acute pancreatitis wherein the oligonucleotide or mimetic consists essentially of a sequence greater than 5 nucleotides long that is complementary to an mRNA of an α7 cholinergic receptor. The variables of formulae (I), (II), (III) and (IV) are described herein.
摘要翻译：一种治疗患有胰腺炎的患者的方法，其包括以足以减少从巨噬细胞释放的促炎细胞因子的量的治疗有效量的对α7烟碱受体选择性的胆碱能激动剂治疗所述患者，其中所述病症是急性胰腺炎。本发明的化合物包括可卡因的四元类似物; （1-氮杂 - 双环[2.2.2]辛-3-基） - 氨基甲酸1-（2-氟苯基） - 乙酯; 式（I）化合物，式（II）化合物，式（III）化合物，式（IV）化合物和能够减弱急性胰腺炎症状的寡核苷酸或模拟物，其中寡核苷酸或模拟物基本上由大于5个核苷酸长的序列组成，其与α7胆碱能受体的mRNA互补。本文描述了式（I），（II），（III）和（IV）的变量。

82. 发明申请

US20090099099A1 Isoflavone Glycosides as Peroxisome Proliferator-Activated Receptor-alpha Modulator 审中-公开
标题翻译：异黄酮糖苷作为过氧化物酶体增殖物激活受体-α调节剂
公开(公告)号：US20090099099A1
公开(公告)日：2009-04-16
申请号：US11872771
申请日：2007-10-16
申请人： Hong Wang , David Y-W Lee
发明人： Hong Wang , David Y-W Lee
IPC分类号： A61K31/7048 , C07H3/02 , A61P3/04
CPC分类号： C07H3/02
摘要： A method of treating or preventing diseases related to modulation of PPAR-α in comprising administering to a human or other mammals in need of such treatment an effective amount of plant material derived from plants of the genera Puerila Lobata.
摘要翻译：一种治疗或预防与PPAR-α调节有关的疾病的方法，其包括对需要这种治疗的人或其他哺乳动物施用有效量的源自普拉里巴拉杜鹃属植物的植物材料。

83. 发明申请

US20090074694A1 DYED-HAIR-BINDING PEPTIDES AND PEPTIDE-BASED HAIR REAGENTS FOR PERSONAL CARE 失效
标题翻译：用于个人护理的染发头发胶原和基于肽的头发试剂
公开(公告)号：US20090074694A1
公开(公告)日：2009-03-19
申请号：US12198382
申请日：2008-08-26
申请人： R. EDWARD BENSON , Stephen R. Fahnestock , Paul Hamilton , John P. O'Brien , Hong Wang
发明人： R. EDWARD BENSON , Stephen R. Fahnestock , Paul Hamilton , John P. O'Brien , Hong Wang
IPC分类号： A61K8/64 , C07K14/00 , A61Q5/12 , A61Q5/00
CPC分类号： C07K14/001 , A61K8/64 , A61K2800/57 , A61Q5/065 , A61Q5/10 , A61Q5/12
摘要： Peptides have been identified that bind with high affinity to dyed hair. Peptide-based hair reagents formed by coupling a dyed-hair-binding peptide to a benefit agent are described. The peptide-based hair reagents include peptide-based hair conditioners and hair colorants. The peptide-based hair conditioners and hair colorants are comprised of a dyed-hair-binding peptide coupled to a hair conditioning agent or a coloring agent, respectively. The peptide-based hair reagents or the dyed-hair-binding peptides may also be used as a protective sealant to improve color retention of dyed hair.
摘要翻译：已经鉴定出以高亲和力结合染色的头发的肽。描述了通过将染色结合肽偶联到有益剂形成的基于肽的毛发试剂。基于肽的毛发试剂包括基于肽的护发素和头发着色剂。基于肽的护发素和毛发着色剂分别由与头发调理剂或着色剂偶联的染色结合肽组成。基于肽的毛发试剂或染色结合肽也可以用作保护性密封剂，以改善染色头发的保色性。

84. 发明授权

US07498141B2 Assay system for GLP-2 receptor ligands 失效
标题翻译： GLP-2受体配体的测定系统
公开(公告)号：US07498141B2
公开(公告)日：2009-03-03
申请号：US11607030
申请日：2006-12-01
申请人： Lidia Demchyshyn , Hong Wang
发明人： Lidia Demchyshyn , Hong Wang
IPC分类号： G01N33/567 , G01N33/53 , C12Q1/00
CPC分类号： G01N33/5082 , G01N33/5088 , G01N33/74 , G01N2333/605 , G01N2333/726 , G01N2500/04 , G01N2500/10
摘要： Disclosed herein is a method for measuring the contractility of intestinal tissue upon treatment with GLP-2 or a GLP-2 ligand. Also disclosed is an assay which directly measures the activity of GLP-2 or GLP-2 ligands ex vivo and permits the screening of putative GLP-2 ligands in native tissue.
摘要翻译：本文公开了一种用于在用GLP-2或GLP-2配体处理时测量肠组织的收缩性的方法。还公开了一种直接测量GLP-2或GLP-2配体活性的测定法，并允许在天然组织中筛选推定的GLP-2配体。

85. 发明授权

US07437581B2 Method and apparatus for varying energy per instruction according to the amount of available parallelism 有权
标题翻译：根据可用的并行度量来改变每个指令的能量的方法和装置
公开(公告)号：US07437581B2
公开(公告)日：2008-10-14
申请号：US10952627
申请日：2004-09-28
申请人： Edward Grochowski , John Shen , Hong Wang , Doron Orenstein , Gad S Sheaffer , Ronny Ronen , Murali M. Annavaram
发明人： Edward Grochowski , John Shen , Hong Wang , Doron Orenstein , Gad S Sheaffer , Ronny Ronen , Murali M. Annavaram
IPC分类号： G06F1/32 , G06F9/46
CPC分类号： G06F9/3851 , G06F1/206 , G06F1/3203 , G06F1/329 , G06F9/3885 , G06F9/3891 , G06F9/3897 , Y02D10/16 , Y02D10/24 , Y02D50/20
摘要： A method and apparatus for changing the configuration of a multi-core processor is disclosed. In one embodiment, a throttle module (or throttle logic) may determine the amount of parallelism present in the currently-executing program, and change the execution of the threads of that program on the various cores. If the amount of parallelism is high, then the processor may be configured to run a larger amount of threads on cores configured to consume less power. If the amount of parallelism is low, then the processor may be configured to run a smaller amount of threads on cores configured for greater scalar performance.
摘要翻译：公开了一种用于改变多核处理器的配置的方法和装置。在一个实施例中，节气门模块（或节气门逻辑）可以确定当前执行的程序中存在的并行度量，并且改变该程序在各种核心上的线程的执行。如果并行量高，则处理器可以被配置为在被配置为消耗较少功率的核上运行更大量的线程。如果并行量较低，则处理器可能被配置为在配置为更高标量性能的核心上运行较少量的线程。

86. 发明申请

US20080163183A1 METHODS AND APPARATUS TO PROVIDE PARAMETERIZED OFFLOADING ON MULTIPROCESSOR ARCHITECTURES 审中-公开
标题翻译：在多处理器架构上提供参数化卸载的方法和装置
公开(公告)号：US20080163183A1
公开(公告)日：2008-07-03
申请号：US11618143
申请日：2006-12-29
申请人： Zhiyuan Li , Xinmin Tian , Wei Li , Hong Wang
发明人： Zhiyuan Li , Xinmin Tian , Wei Li , Hong Wang
IPC分类号： G06F9/45
CPC分类号： G06F8/456 , G06F2209/509
摘要： Methods and apparatus to provide parameterized offloading in multiprocessor systems are disclosed. An example method includes partitioning source code into a first task and a second task, and compiling object code from the source code, such that the first task is compiled to execute on a first processor core and the second task is compiled to execute on a second processor core, the assignment of the first task to the first core being dependent on an input parameter.
摘要翻译：公开了在多处理器系统中提供参数化卸载的方法和装置。示例性方法包括将源代码分割成第一任务和第二任务，以及从源代码编译目标代码，使得第一任务被编译为在第一处理器核上执行，并且第二任务被编译为在第二任务上执行处理器核心，将第一个任务分配给第一个内核取决于输入参数。

87. 发明申请

US20080152600A1 PEPTIDE-BASED ORAL CARE SURFACE REAGENTS FOR PERSONAL CARE 有权
标题翻译：基于肽的口腔护理面部个人护理试剂
公开(公告)号：US20080152600A1
公开(公告)日：2008-06-26
申请号：US11971975
申请日：2008-01-10
申请人： Xueying Huang , John P. O'Brien , Hong Wang
发明人： Xueying Huang , John P. O'Brien , Hong Wang
IPC分类号： A61K8/66 , A61K8/64 , A61K8/97 , A61K8/21 , A61Q11/00
CPC分类号： A61K8/29 , A61K8/64 , A61K2800/413 , A61K2800/42 , A61K2800/57 , A61K2800/94 , A61Q1/02 , A61Q1/10 , A61Q3/00 , A61Q5/065 , A61Q5/12 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/04 , B82Y5/00 , C07K7/06 , C07K7/08
摘要： Peptides have been identified that bind to oral surfaces such as teeth and gums. Peptide based oral care reagents have been created by couple such peptides to oral care benefit agents such as whiteners.
摘要翻译：已经鉴定了结合口腔表面如牙齿和牙龈的肽。基于肽的口腔护理试剂已经通过将这些肽与口腔护理有益剂如增白剂相结合而形成。

88. 发明授权

US07390901B2 Fluorinated dyes or colorants and their uses 失效
标题翻译：氟化染料或着色剂及其用途
公开(公告)号：US07390901B2
公开(公告)日：2008-06-24
申请号：US10903923
申请日：2004-07-29
申请人： Jin Yang , Kai-Chia Feng , Ying-Syi Li , HongMei Zang , Hong Wang , Chien-Hung Chou , Rong-Chang Liang
发明人： Jin Yang , Kai-Chia Feng , Ying-Syi Li , HongMei Zang , Hong Wang , Chien-Hung Chou , Rong-Chang Liang
IPC分类号： C07D221/22
CPC分类号： C09B5/62 , C09B1/262 , C09B47/00 , C09B47/14 , C09B47/20 , C09B47/22 , C09B47/26 , C09B48/00 , C09B57/004
摘要： This invention relates to novel fluorinated dyes or colorants having high solubility and low viscosity in halogenated, especially fluorinated, solvents. The dyes or colorants of the present invention have shown to improve the performance of electrophoretic displays.
摘要翻译：本发明涉及在卤化的，特别是氟化的溶剂中具有高溶解性和低粘度的新型氟化染料或着色剂。本发明的染料或着色剂已经显示出改进了电泳显示器的性能。

89. 发明申请

US20080138987A1 EDGE REMOVAL OF SILICON-ON-INSULATOR TRANSFER WAFER 有权
标题翻译：绝缘体绝缘子转移膜的边缘去除
公开(公告)号：US20080138987A1
公开(公告)日：2008-06-12
申请号：US12033727
申请日：2008-02-19
申请人： Raymond John Donohoe , Krishna Vepa , Paul V. Miller , Ronald Rayandayan , Hong Wang
发明人： Raymond John Donohoe , Krishna Vepa , Paul V. Miller , Ronald Rayandayan , Hong Wang
IPC分类号： H01L21/302
CPC分类号： H01L21/76254 , H01L21/02032 , H01L21/304 , H01L21/30625 , H01L21/76251 , Y10S438/974
摘要： A silicon-on-insulator transfer wafer having a front surface with a circumferential lip around a circular recess is polished. In one version, the circular recess on the front surface of the wafer is masked by filling the recess with spin-on-glass. The front surface of the wafer is exposed to an etchant to preferentially etch away the circumferential lip, while the circular recess is masked by the spin-on-glass. The spin-on glass is removed, and the front surface of the transfer wafer is polished. Other methods of removing the circumferential lip include applying a higher pressure to the circumferential lip in a polishing process, and directing a pressurized fluid jet at the base of the circumferential lip.
摘要翻译：抛光具有围绕圆形凹槽的具有周向唇缘的前表面的绝缘体上硅转移晶片。在一个版本中，通过用旋转玻璃填充凹槽来掩蔽晶片前表面上的圆形凹槽。将晶片的前表面暴露于蚀刻剂以优先蚀刻掉周缘，同时圆形凹槽被旋涂玻璃掩蔽。去除旋涂玻璃，并且转印晶片的前表面被抛光。去除圆周唇缘的其它方法包括在抛光过程中向周缘施加更高的压力，并且在周向唇缘的底部引导加压流体射流。

90. 发明申请

US20080107614A1 PEPTIDE-BASED CONDITIONERS 审中-公开
标题翻译：基于肽的调节剂
公开(公告)号：US20080107614A1
公开(公告)日：2008-05-08
申请号：US11923829
申请日：2007-10-25
申请人： Stephen Fahnestock , John O'Brien , Hong Wang
发明人： Stephen Fahnestock , John O'Brien , Hong Wang
IPC分类号： A61K8/64 , A61Q19/00 , A61Q3/00 , A61Q5/00 , C07K14/00 , C07K14/78 , C07K7/00
CPC分类号： C07K7/08 , A61K8/64 , A61K2800/94 , A61Q3/00 , A61Q5/12 , A61Q19/00 , C07K7/06 , C07K14/001 , C07K2319/01
摘要： Peptides have been identified that bind with high affinity to hair, skin, and nails. The peptide-based conditioners consist of a body surface-binding peptide coupled to a conditioning peptide. Conditioning peptides are typically derived from proteins and peptide having repeating amino acid sequences. Personal care compositions containing these peptide-based conditioners are also described.
摘要翻译：已经鉴定出以高亲和力结合头发，皮肤和指甲的肽。基于肽的调理剂由与调理肽偶联的体表面结合肽组成。调理肽通常衍生自具有重复氨基酸序列的蛋白质和肽。还描述了含有这些基于肽的调理剂的个人护理组合物。

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