专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

81. 发明授权

US4304859A Process for producing A73A, a new Efrotomycin-like antibiotic in fermentation broth 失效
标题翻译：生产A73A的方法，一种新型的发酵液中的类似霉菌素的抗生素
公开(公告)号：US4304859A
公开(公告)日：1981-12-08
申请号：US201097
申请日：1980-10-27
申请人： Ray S. Dewey , James E. Flor , Sheldon B. Zimmerman , Patrick J. Cassidy , Satoshi Omura , Ruiko Oiwa
发明人： Ray S. Dewey , James E. Flor , Sheldon B. Zimmerman , Patrick J. Cassidy , Satoshi Omura , Ruiko Oiwa
IPC分类号： C07H7/02 , C12P17/16
CPC分类号： C12R1/465 , C07H7/02 , C12P17/16 , Y10S435/886
摘要： There is disclosed a new antibiotic agent, A73A, produced by Streptomyces viridifaciens MA-4864 (ATCC 31495) under suitable conditions. Said antibiotic shows antibacterial and growth-permittant activity.
摘要翻译：公开了在合适的条件下由链霉菌（Streptomyces viridifaciens）MA-4864（ATCC 31495）生产的新型抗生素A73A。所述抗生素显示抗菌和生长 - 吸收剂活性。

82. 发明授权

US4242504A 3"-Acylated macrolide antibiotics 失效
标题翻译： 3“ - 酰化大环内酯抗生素
公开(公告)号：US4242504A
公开(公告)日：1980-12-30
申请号：US37859
申请日：1979-05-10
申请人： Hideo Sakakibara , Osamu Okegawa , Toshiyuki Watanabe , Tatsuro Fujiwara , Susumu Watanabe , Satoshi Omura , Tetsuo Matsuda
发明人： Hideo Sakakibara , Osamu Okegawa , Toshiyuki Watanabe , Tatsuro Fujiwara , Susumu Watanabe , Satoshi Omura , Tetsuo Matsuda
IPC分类号： C07H17/08
CPC分类号： C07H17/08
摘要： 3"-acylated macrolide antibiotics of the formula ##STR1## wherein R.sub.1 is hydrogen or C.sub.2-3 alkanoyl, R.sub.2 is hydrogen or C.sub.2-4 alkanoyl, at least one of R.sub.1 and R.sub.2 being hydrogen, and one of R' and R" being R.sub.3 and the other R.sub.4, R.sub.3 being C.sub.2-6 alkanoyl and R.sub.4 being C.sub.2-5 alkanoyl, or a pharmaceutically acceptable salt thereof.
摘要翻译： 3“ - 酰化大环内酯类抗生素，其中R1是氢或C2-3烷酰基，R2是氢或C2-4烷酰基，R1和R2中的至少一个是氢，R' 和R“为R3且另一个R4，R3为C2-6烷酰基，R4为C2-5烷酰基，或其药学上可接受的盐。

83. 发明授权

US4196266A Production of nanaomycin A and derivatives thereof 失效
标题翻译：生产纳诺霉素A及其衍生物
公开(公告)号：US4196266A
公开(公告)日：1980-04-01
申请号：US858215
申请日：1977-12-07
申请人： Satoshi Omura , Haruo Tanaka , Juichi Awaya , Toju Hata
发明人： Satoshi Omura , Haruo Tanaka , Juichi Awaya , Toju Hata
IPC分类号： C12P17/06 , C12D9/14
CPC分类号： C12R1/465 , C12P17/06 , Y10S435/886
摘要： The present invention relates to new compound nanaomycin A and derivatives thereof represented by general formula: ##STR1## in which (a) R is H and R' is OH (nanaomycin A),(b) R is H and R' is NH.sub.2 (nanaomycin C),(c) R is COCH.sub.3 and R' is CH (acetylnanaomycin A), and(d) R is H and R' is OCH.sub.3 (nanaomycin A methyl ester).Nanaomycin A is a new compound of quinone type and its acute toxicity (LD.sub.50, intra-penetrial injection) in mice is 28.2 mg/Kg. Nanaomycin A and derivatives thereof are active on Gram-positive bacteria, trichophyton and mycoplasma and are useful as a medicament for humans and animals. Nanaomycins A and C are produced by culturing a nanaomycin-producing strain belonging to the genus Streptomyces aerobically in a medium to accumulate nanaomycins A and C in the cultured broths. The derivatives acetylnanaomycin A and nanaomycin A methyl ester have similar properties to those of nanaomycin A.
摘要翻译：本发明涉及由以下通式表示的新化合物纳那霉素A及其衍生物：其中（a）R是H，R'是OH（纳那霉素A），（b）R是H和R' 是NH2（纳那霉素C），（c）R是COCH 3，R'是CH（乙酰氨基霉素A），和（d）R是H，R'是OCH 3（纳诺霉素A甲酯）。 Nanaomycin A是醌类的新化合物，其在小鼠中的急性毒性（LD50，内渗注射）为28.2mg / Kg。纳诺霉素A及其衍生物对革兰氏阳性菌，毛毛虫和支原体具有活性，可用作人和动物的药物。 Nanaomycins A和C通过在培养基中培养产生链霉菌属的链霉菌属的纳米霉素生产菌株在培养基中培养以在培养的肉汤中积累纳米菌素A和C而产生。乙酰纳他霉素A和纳那霉素A甲酯的衍生物具有与纳那霉素A相似的性质。

84. 发明授权

US4194064A Production of nanaomycin B 失效
标题翻译：生产纳诺霉素B
公开(公告)号：US4194064A
公开(公告)日：1980-03-18
申请号：US858216
申请日：1977-12-07
申请人： Satoshi Omura , Haruo Tanaka , Juichi Awaya , Toju Hata
发明人： Satoshi Omura , Haruo Tanaka , Juichi Awaya , Toju Hata
IPC分类号： C12P17/06 , C12D9/14
CPC分类号： C12R1/465 , C12P17/06 , Y10S435/886
摘要： The present invention relates to new compound designated as nanaomycin B represented by general formula: ##STR1## Nanaomycin B is a quinone type and is active on mycoplasma, Gram-positive bacteria and trycophyton. This compound is useful as a medicament for infectious diseases of humans and animals caused by a parasite of trichophyton or mycoplasma etc. The acute toxicity (LD.sub.50, intra-penetrial injection) in mice of this compound is 169 mg/kg. Nanaomycin B is produced by fermentation in which a nanaomycin-producing strain belonging to the genus Streptomyces is cultured in a medium under aerobic conditions and the accumulated nanaomycin B in the cultured broths is recovered therefrom.
摘要翻译：本发明涉及以通式表示的纳那霉素B的新化合物：＆lt; IMAGE＆gt; Nanaomycin B是醌类，对支原体，革兰氏阳性菌和真菌是有活性的。该化合物可用作由毛癣菌或支原体寄生虫等引起的人类和动物感染性疾病的药物。该化合物小鼠的急性毒性（LD50，内渗注射）为169mg / kg。纳豆霉素B通过发酵生产，其中在需氧条件下培养在属于链霉菌属的纳米霉素生产菌株，并从其中回收培养肉汤中积累的纳诺霉素B.

85. 发明授权

US3956276A Novel antifugal antibiotic substance, process for production of the same, and agricultural and horticultural fungicidal composition containing said substance 失效
标题翻译：新型防冻抗生素，其生产方法，以及含有该物质的农业和园艺杀真菌组合物
公开(公告)号：US3956276A
公开(公告)日：1976-05-11
申请号：US272217
申请日：1972-07-17
申请人： Toju Hata , Satoshi Omura , Michiko Katagiri , Juichi Awaya , Shimpei Kuyama , Shizuo Higashikawa , Kazuomi Yasui , Haruko Terada
发明人： Toju Hata , Satoshi Omura , Michiko Katagiri , Juichi Awaya , Shimpei Kuyama , Shizuo Higashikawa , Kazuomi Yasui , Haruko Terada
IPC分类号： C07H13/04 , C07H5/00
CPC分类号： C07H13/04
摘要： The antifungal antibiotic substance "F-1028" having the following formula, ##EQU1## or an acid salt thereof, a process for the production of the same by fermentation, and a fungicidal composition useful for agricultural and horticultural use.
摘要翻译：具有下式的抗真菌抗生素物质“F-1028”，或其酸式盐，方法用于通过发酵生产它们，以及用于农业和园艺用途的杀真菌组合物。

86. 发明授权

US08202890B2 Pest control agent 有权
标题翻译：害虫控制剂
公开(公告)号：US08202890B2
公开(公告)日：2012-06-19
申请号：US12312866
申请日：2007-11-30
申请人： Kimihiko Goto , Ryo Horikoshi , Kazuhiko Oyama , Satoshi Omura , Toshiaki Sunazuka
发明人： Kimihiko Goto , Ryo Horikoshi , Kazuhiko Oyama , Satoshi Omura , Toshiaki Sunazuka
IPC分类号： A01N43/40 , A61K31/44 , C07D405/00
CPC分类号： A01N43/90 , C07D493/04
摘要： Disclosed is a compound usable as a pest control agent and has excellent pest control activity. A compound represented by formula (I) has excellent pest control activity. The compound or an agriculturally or horticulturally acceptable salt thereof is thus useful as a pest control agent.
摘要翻译：公开了可用作害虫防治剂并具有优异的害虫防治活性的化合物。由式（I）表示的化合物具有优异的害虫防治活性。因此，化合物或其农业上或园艺上可接受的盐可用作害虫防治剂。

87. 发明申请

US20110195998A1 PEST CONTROL AGENT 有权
标题翻译：虫控制剂
公开(公告)号：US20110195998A1
公开(公告)日：2011-08-11
申请号：US12312866
申请日：2007-11-30
申请人： Kimihiko Goto , Ryo Horikoshi , Kazuhiko Oyama , Satoshi Omura , Toshiaki Sunazuka
发明人： Kimihiko Goto , Ryo Horikoshi , Kazuhiko Oyama , Satoshi Omura , Toshiaki Sunazuka
IPC分类号： A01N43/40 , C07D405/14 , A01P7/00
CPC分类号： A01N43/90 , C07D493/04
摘要： Disclosed is a compound usable as a pest control agent and has excellent pest control activity. A compound represented by formula (I) has excellent pest control activity. The compound or an agriculturally or horticulturally acceptable salt thereof is thus useful as a pest control agent.
摘要翻译：公开了可用作害虫防治剂并具有优异的害虫防治活性的化合物。由式（I）表示的化合物具有优异的害虫防治活性。因此，化合物或其农业上或园艺上可接受的盐可用作害虫防治剂。

88. 发明授权

US07982057B2 Compound of stemphones and production thereof 有权
标题翻译：手机和其生产的组合
公开(公告)号：US07982057B2
公开(公告)日：2011-07-19
申请号：US11911868
申请日：2006-03-15
申请人： Satoshi Omura , Hiroshi Tomoda , Rokuro Masuda
发明人： Satoshi Omura , Hiroshi Tomoda , Rokuro Masuda
IPC分类号： C07D311/78
CPC分类号： C12P17/06 , C07D493/04
摘要： The present invention relates to novel compound of stemphones obtained by culturing microorganism belonging to genus Aspergillus and having ability to produce compound of stemphones selected from the group consisting of stemphone D substance, stemphone E substance, stemphone E1 substance, stemphone E2 substance, stemphone E3 substance and stemphone F substance, accumulating the compound of stemphones in the cultured mass, and isolating the compound of stemphones from the cultured mass. Since the obtained compound has enhancing activity for imipenem and activity for reducing cytotoxicity, it can be expected to be useful as lead compounds for combination remedy for methicillin resistant Staphylococcus aureus (MRSA) infection.
摘要翻译：本发明涉及通过培养属于曲霉属微生物的微生物获得的具有能够产生选自以下的干细胞的化合物的新型化合物：选自以下的组合：选自以下的组合：干扰素D物质，主体E物质，和干扰素F物质，将培养物质中的电话的化合物积聚，并从培养的物质中分离出手机的化合物。由于所得化合物对亚胺培南具有增强的活性和降低细胞毒性的活性，因此可预期作为用于耐甲氧西林金黄色葡萄球菌（MRSA）感染的组合治疗的铅化合物是有用的。

89. 发明授权

US07670827B2 Strain belonging to the genus Streptomyces and being capable of producing nemadictin and process for producing nemadictin using the strain 失效
标题翻译：属于链霉菌属的菌株，并且能够使用该菌株产生新霉素和制备nemadictin的方法
公开(公告)号：US07670827B2
公开(公告)日：2010-03-02
申请号：US10535263
申请日：2003-06-11
申请人： Satoshi Omura , Haruo Ikeda , Yumiko Ogasawara
发明人： Satoshi Omura , Haruo Ikeda , Yumiko Ogasawara
IPC分类号： C12N1/21
CPC分类号： C12N1/20 , C12N15/52 , C12P17/181
摘要： In the present invention, a recombination of gene groups of nemadectin aglycon biosynthesis is performed for obtaining C-13 hydroxylnemadectin, to which sugar groups can be attached, and a production strain which produces C-13 hydroxylnemadectin is produced. Further, C-13 glycosylnemadectin producing strain is prepared by introducing aveBI-BVIII genes involving glycosidation of avermectin and biosynthesis of oleandrose. As described, C-13 hydroxylnemadectin and C-13 glycosidated nemadectin can be obtained effectively by using the producing strain prepared by means of the molecular genetic technology, and improvement in the biological activity thereof can be expected.
摘要翻译：在本发明中，进行奈马替丁糖苷配基生物合成的基因组的重组，得到可以附着糖基的C-13羟基去神道菌素，生成产生C-13羟基神马丁的生产菌株。此外，通过引入涉及除虫菌素糖基化和含有甘油糖的生物合成的aveBI-BVIII基因来制备C-13糖基胚乳肽生成菌株。如上所述，可以通过使用通过分子遗传技术制备的生产菌株有效地获得C-13羟基去神道肽和C-13糖苷化的奈马克丁，并且可以预期其生物活性的改善。

90. 发明授权

US07630836B2 Polynucleotides 失效
标题翻译：多核苷酸
公开(公告)号：US07630836B2
公开(公告)日：2009-12-08
申请号：US10156761
申请日：2002-05-29
申请人： Satoshi Omura , Haruo Ikeda , Jun Ishikawa , Hiroshi Horikawa , Tadayoshi Shiba , Yoshiyuki Sakaki , Masahira Hattori
发明人： Satoshi Omura , Haruo Ikeda , Jun Ishikawa , Hiroshi Horikawa , Tadayoshi Shiba , Yoshiyuki Sakaki , Masahira Hattori
IPC分类号： G01N33/48
CPC分类号： C07K14/36 , C12Q1/689
摘要： Novel polynucleotides derived from microorganisms belonging to actinomycetes and fragments thereof, polypeptides encoded by the polynucleotides and fragments thereof, polynucleotide arrays comprising the polynucleotides and fragments thereof, recording media in which the nucleotide sequences of the polynucleotide and fragments thereof have been recorded which are readable in a computer, and use of them.
摘要翻译：衍生自属于放线菌及其片段的微生物的新型多核苷酸，由多核苷酸及其片段编码的多肽，包含多核苷酸及其片段的多核苷酸阵列，其中记录了多核苷酸及其片段的核苷酸序列已被记录的可记录的多核苷酸一台电脑，并使用它们。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式