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1. 发明授权

US07982057B2 Compound of stemphones and production thereof 有权
标题翻译：手机和其生产的组合
公开(公告)号：US07982057B2
公开(公告)日：2011-07-19
申请号：US11911868
申请日：2006-03-15
申请人： Satoshi Omura , Hiroshi Tomoda , Rokuro Masuda
发明人： Satoshi Omura , Hiroshi Tomoda , Rokuro Masuda
IPC分类号： C07D311/78
CPC分类号： C12P17/06 , C07D493/04
摘要： The present invention relates to novel compound of stemphones obtained by culturing microorganism belonging to genus Aspergillus and having ability to produce compound of stemphones selected from the group consisting of stemphone D substance, stemphone E substance, stemphone E1 substance, stemphone E2 substance, stemphone E3 substance and stemphone F substance, accumulating the compound of stemphones in the cultured mass, and isolating the compound of stemphones from the cultured mass. Since the obtained compound has enhancing activity for imipenem and activity for reducing cytotoxicity, it can be expected to be useful as lead compounds for combination remedy for methicillin resistant Staphylococcus aureus (MRSA) infection.
摘要翻译：本发明涉及通过培养属于曲霉属微生物的微生物获得的具有能够产生选自以下的干细胞的化合物的新型化合物：选自以下的组合：选自以下的组合：干扰素D物质，主体E物质，和干扰素F物质，将培养物质中的电话的化合物积聚，并从培养的物质中分离出手机的化合物。由于所得化合物对亚胺培南具有增强的活性和降低细胞毒性的活性，因此可预期作为用于耐甲氧西林金黄色葡萄球菌（MRSA）感染的组合治疗的铅化合物是有用的。

2. 发明申请

US20090093646A1 NOVEL COMPOUND OF STEMPHONES AND PRODUCTION THEREOF 有权
标题翻译：新型混合物及其生产方法
公开(公告)号：US20090093646A1
公开(公告)日：2009-04-09
申请号：US11911868
申请日：2006-03-15
申请人： Satoshi Omura , Hiroshi Tomoda , Rokuro Masuda
发明人： Satoshi Omura , Hiroshi Tomoda , Rokuro Masuda
IPC分类号： C07D493/22 , C12P17/18
CPC分类号： C12P17/06 , C07D493/04
摘要： The present invention relates to novel compound of stemphones obtained by culturing microorganism belonging to genus Aspergillus and having ability to produce compound of stemphones selected from the group consisting of stemphone D substance, stemphone E substance, stemphone E1 substance, stemphone E2 substance, stemphone E3 substance and stemphone F substance, accumulating the compound of stemphones in the cultured mass, and isolating the compound of stemphones from the cultured mass. Since the obtained compound has enhancing activity for imipenem and activity for reducing cytotoxicity, it can be expected to be useful as lead compounds for combination remedy for methicillin resistant Staphylococcus aureus (MRSA) infection.
摘要翻译：本发明涉及通过培养属于曲霉属微生物的微生物获得的具有能够产生选自以下的干细胞的化合物的新型化合物：选自以下的组合：选自以下的组合：干扰素D物质，主体E物质，和干扰素F物质，将培养物质中的电话的化合物积聚，并从培养的物质中分离出手机的化合物。由于所得化合物对亚胺培南具有增强的活性和降低细胞毒性的活性，因此可预期作为用于耐甲氧西林金黄色葡萄球菌（MRSA）感染的组合治疗的铅化合物是有用的。

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