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81. 发明申请

US20090214706A1 Polypeptide 有权
标题翻译：多肽
公开(公告)号：US20090214706A1
公开(公告)日：2009-08-27
申请号：US11887977
申请日：2005-07-07
申请人： Casper Tune Berg , Patrick M.F. Derkx , Carol Fioresi , Gijsbert Gerritse , Anja Hemmingen Kellet-Smith , Karsten Matthias Kragh , Wei Liu , Andrew Shaw , Bo Spange Sørensen , Charlotte Refdahl Thoudahl
发明人： Casper Tune Berg , Patrick M.F. Derkx , Carol Fioresi , Gijsbert Gerritse , Anja Hemmingen Kellet-Smith , Karsten Matthias Kragh , Wei Liu , Andrew Shaw , Bo Spange Sørensen , Charlotte Refdahl Thoudahl
IPC分类号： A21D2/26 , C12N9/28 , A21D13/06 , C12N15/56 , C12N15/74 , C12N1/21 , A23K1/165
CPC分类号： C12Y302/0106 , A21D8/042 , A23K20/189 , A23L7/107 , A23L29/35 , A23V2002/00 , C12N9/2417 , A23V2300/21
摘要： We describe a PS4 variant polypeptide derivable from a parent polypeptide having non-maltogenic exoamylase activity, in which the PS4 variant polypeptide comprises an amino acid mutation at one or more positions selected from the group consisting of: 121, 161, 223, 146, 157, 158, 198, 229, 303, 306, 309, 316, 353, 26, 70, 145, 188, 272, 339, with reference to the position numbering of a Pseudomonas saccharophilia exoamylase sequence shown as SEQ ID NO: 1.
摘要翻译：我们描述了可从具有非麦芽糖苷外切酶活性的亲本多肽衍生的PS4变体多肽，其中PS4变体多肽在选自以下的一个或多个位置包含氨基酸突变：121,161,223,146,157 ，158,198,229,303,306,309,316,353,26,70,205,188,272,339，参考SEQ ID NO：1所示的假单胞菌属的嗜酸芽胞弧菌外切酶序列的位置编号。

82. 发明授权

US07096460B1 Switching to original modifiable instruction copy comparison check to validate prior translation when translated sub-area protection exception slows down operation 有权
标题翻译：切换到原始可修改指令复制比较检查，以确认转换后的区域保护异常减慢操作时的先前转换
公开(公告)号：US07096460B1
公开(公告)日：2006-08-22
申请号：US10463846
申请日：2003-06-16
申请人： John Banning , H. Peter Anvin , Robert Bedichek , Guillermo J. Rozas , Andrew Shaw , Linus Torvalds , Jason Wilson
发明人： John Banning , H. Peter Anvin , Robert Bedichek , Guillermo J. Rozas , Andrew Shaw , Linus Torvalds , Jason Wilson
IPC分类号： G06F9/455 , G06F9/318
CPC分类号： G06F9/3808 , G06F9/3812
摘要： In a computer system that translates target instructions from a target instruction set into host instructions from a host instruction set, a method for checking a sequence of target instructions for changes. The method includes testing whether the target instructions at a memory location have changed subsequent to the translating by examining a bit indicator associated with the memory location and determining whether the testing is slowing the operation of the computer system. If the testing is slowing the operation of the computer system, a checking process initiated, which includes storing a copy of the sequence of target instructions and comparing the copy with the sequence of target instructions.
摘要翻译：在将来自目标指令集的目标指令从主机指令集转换为主机指令的计算机系统中，用于检查目标指令序列以用于改变的方法。该方法包括通过检查与存储器位置相关联的位指示器来确定测试是否减慢了计算机系统的操作，来测试在转换之后存储器位置处的目标指令是否已经改变。如果测试正在减慢计算机系统的操作，则发起检查过程，其包括存储目标指令序列的副本并将该副本与目标指令的顺序进行比较。

83. 发明申请

US20050137111A1 Thermostable amylase polypeptides, nucleic acids encoding those polypeptides and uses thereof 有权
标题翻译：热稳定淀粉酶多肽，编码那些多肽的核酸及其用途
公开(公告)号：US20050137111A1
公开(公告)日：2005-06-23
申请号：US10886905
申请日：2004-07-07
申请人： Karsten Kragh , Casper Berg , Patrick Derkx , Anja Kellett-Smith , Charlotte Thoudahl , Oene Veltman , Carol Fioresi , Wei Liu , Andrew Shaw , Gijsbert Gerritse
发明人： Karsten Kragh , Casper Berg , Patrick Derkx , Anja Kellett-Smith , Charlotte Thoudahl , Oene Veltman , Carol Fioresi , Wei Liu , Andrew Shaw , Gijsbert Gerritse
IPC分类号： A21D8/02 , A21D8/04 , A23L1/03 , A23L1/09 , A23L1/305 , C07H21/04 , C11D3/386 , C12N1/21 , C12N9/28 , C12N9/32 , C12N15/74
CPC分类号： C12N9/2417 , A21D8/042 , A23L29/06 , A23L29/35 , A23L33/17 , A23V2002/00 , A23V2300/21
摘要： This invention relates to amylase polypeptides, and nucleic acids encoding the polpypeptides and uses thereof. The amylases of the present invention have been engineered to have more beneficial qualities. Specifically, the amylases of the current invention show an altered thermostability.
摘要翻译：本发明涉及淀粉酶多肽和编码多肽的核酸及其用途。本发明的淀粉酶已被设计成具有更多的有益品质。具体地说，本发明的淀粉酶显示出改变的热稳定性。

84. 发明授权

US5521179A Heterocyclic amides 失效
标题翻译：杂环酰胺
公开(公告)号：US5521179A
公开(公告)日：1996-05-28
申请号：US045009
申请日：1993-04-08
申请人： Peter R. Bernstein , Andrew Shaw , Royston M. Thomas , Peter Warner , Donald J. Wolanin
发明人： Peter R. Bernstein , Andrew Shaw , Royston M. Thomas , Peter Warner , Donald J. Wolanin
IPC分类号： A61K38/00 , C07K5/06 , C07D237/00 , C07D211/72 , C07D215/14 , C07D401/00
CPC分类号： C07K5/06191 , A61K38/00
摘要： The present invention relates to certain novel heterocyclic amides which are 1-pyridylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic amides, processes for preparing the heterocyclic amides, pharmaceutical compositions containing such heterocyclic amides and methods for their use.
摘要翻译：本发明涉及某些新颖的杂环酰胺，它们是本文列出的式I的1-吡啶基乙酰胺化合物，其是人类白细胞弹性蛋白酶（HLE）的抑制剂，也被称为人嗜中性粒细胞弹性蛋白酶（HNE）），使得它们在这种抑制是期望的，例如在药理学，诊断和相关研究中的研究工具以及涉及HLE的哺乳动物的疾病的治疗。本发明还包括可用于合成这些杂环酰胺的中间体，制备杂环酰胺的方法，含有这种杂环酰胺的药物组合物及其使用方法。

85. 发明授权

US4126685A 6-Aryl-pyrrolo[1,2,9]imidazole derivatives which possess anti-hypertensive activity 失效
标题翻译： 6-ARYL-PYRROLO（1,2,9）具有抗高血压活性的咪唑衍生物
公开(公告)号：US4126685A
公开(公告)日：1978-11-21
申请号：US797349
申请日：1977-05-16
申请人： Andrew Shaw
发明人： Andrew Shaw
IPC分类号： C07C205/04 , C07C205/26 , C07C205/53 , C07C205/56 , C07D207/22 , C07D207/26 , C07D207/277 , C07D209/96 , C07D233/20 , C07D233/26 , C07D303/08 , C07D307/33 , C07D333/12 , C07D333/22 , C07D333/24 , A61K31/44 , A61K31/415 , C07D487/04
CPC分类号： C07D207/26 , C07C205/09 , C07C205/26 , C07C205/53 , C07D207/22 , C07D207/277 , C07D209/96 , C07D233/20 , C07D233/26 , C07D303/08 , C07D307/33 , C07D333/12 , C07D333/22 , C07D333/24
摘要： 6-Arylpyrrolo[1,2-a]imidazole derivatives, processes for their manufacture, pharmaceutical compositions containing them and a method of using them to lower blood pressure in warm-blooded animals. Representative of the compounds disclosed is 6-(2,6-dichlorophenyl)-2,3,6,7-tetrahydro-5H-pyrrolo[1,2-a]imidazole.

86. 发明授权

US08722381B2 Variants of a Bacillus strearothermophilus alpha-amylase and uses thereof 失效
标题翻译：芽孢杆菌嗜热芽孢杆菌α-淀粉酶的变体及其用途
公开(公告)号：US08722381B2
公开(公告)日：2014-05-13
申请号：US12365411
申请日：2009-02-04
申请人： Sandra W. Ramer , Michael J. Pepsin , Andrew Shaw
发明人： Sandra W. Ramer , Michael J. Pepsin , Andrew Shaw
IPC分类号： C12N9/28 , C12P19/14 , C12P19/04 , C12P7/06 , C12P7/08 , C12P7/14 , C07H21/04 , A61K9/68
CPC分类号： C12N9/2417 , Y02E50/17
摘要： Described are variants of alpha (α)-amylases having altered starch hydrolysis profiles. The variants have improved thermostability and increased specific activity, resulting in reduced peak viscosity and altered final viscosity during starch liquefaction. The amylase variants are useful, e.g., in liquefaction and other starch degradation processes.
摘要翻译：描述了具有改变的淀粉水解曲线的α（α） - 酰胺酶的变体。这些变体具有改善的热稳定性和增加的比活性，导致在淀粉液化期间降低的峰值粘度和改变的最终粘度。淀粉酶变体是有用的，例如在液化和其它淀粉降解过程中。

87. 发明授权

US08535927B1 Micrococcineae serine protease polypeptides and compositions thereof 失效
标题翻译：微球菌丝氨酸蛋白酶多肽及其组合物
公开(公告)号：US08535927B1
公开(公告)日：2013-09-17
申请号：US10576331
申请日：2004-11-19
申请人： Brian E. Jones , Marc Kolkman , Chris Leeflang , Hiroshi Oh , Ayrookaran J. Poulose , Eugene S. Sadlowski , Andrew Shaw , Leo van Marrewijk , Wilhelmus A. H. Van Der Kleij
发明人： Brian E. Jones , Marc Kolkman , Chris Leeflang , Hiroshi Oh , Ayrookaran J. Poulose , Eugene S. Sadlowski , Andrew Shaw , Leo van Marrewijk , Wilhelmus A. H. Van Der Kleij
IPC分类号： C12N9/48 , C11D3/386
CPC分类号： C12N9/52 , C07K2299/00 , C11D3/386
摘要： The present invention provides novel serine proteases, novel genetic material encoding these enzymes, and proteolytic proteins obtained from Micrococcineae spp., including but not limited to Cellulomonas spp. and variant proteins developed therefrom. In particular, the present invention provides protease compositions obtained from a Cellulomonas spp, DNA encoding the protease, vectors comprising the DNA encoding the protease, host cells transformed with the vector DNA, and an enzyme produced by the host cells. The present invention also provides cleaning compositions (e.g., detergent compositions), animal feed compositions, and textile and leather processing compositions comprising protease(s) obtained from a Micrococcineae spp., including but not limited to Cellulomonas spp. In alternative embodiments, the present invention provides mutant (i.e., variant) proteases derived from the wild-type proteases described herein. These mutant proteases also find use in numerous applications.
摘要翻译：本发明提供了新的丝氨酸蛋白酶，编码这些酶的新型遗传物质，以及从微球菌属（Micrococcineae spp。）获得的蛋白水解蛋白，包括但不限于纤维单胞菌属（Cellulomonas spp）和从其开发的变体蛋白质。特别地，本发明提供了从纤维单胞菌属（Splulomonas spp）获得的蛋白酶组合物，编码蛋白酶的DNA，包含编码蛋白酶的载体的载体，用载体DNA转化的宿主细胞和由宿主细胞产生的酶。本发明还提供了清洁组合物（例如洗涤剂组合物），动物饲料组合物，以及包含从微球菌（Micrococcineae spp。）获得的蛋白酶的纺织和皮革加工组合物，其包括但不限于纤维单胞菌属（Cellulomonas spp）在替代实施方案中，本发明提供衍生自本文所述的野生型蛋白酶的突变体（即，变体）蛋白酶。这些突变型蛋白酶也可用于许多应用。

88. 发明申请

US20120178132A1 ENDOGLUCANASES 有权
标题翻译：内生菌
公开(公告)号：US20120178132A1
公开(公告)日：2012-07-12
申请号：US13323724
申请日：2011-12-12
申请人： Jie Yang , Andrew Shaw , Ish Kumar Dhawan , Onorato Campopiano , Kripa Rao
发明人： Jie Yang , Andrew Shaw , Ish Kumar Dhawan , Onorato Campopiano , Kripa Rao
IPC分类号： C12P19/14 , C07K19/00 , C12N15/75 , C12N1/21 , C12N9/42 , C12N15/56
CPC分类号： C12N9/2437 , C07K2319/02 , C12N9/2445 , C12N15/75 , C12P7/10 , C12P19/14 , C12Y302/01004 , C12Y302/01021 , C12Y302/01091 , Y02E50/16
摘要： The present invention relates to variant endoglucanases and particularly endoglucanases having improved properties over wild-type endoglucanase.
摘要翻译：本发明涉及与野生型内切葡聚糖酶相比具有改进性质的变体内切葡聚糖酶，特别是内切葡聚糖酶。

89. 发明授权

US08206966B2 Alpha-amylase variants with altered properties 有权
标题翻译：具有改变性质的α-淀粉酶变体
公开(公告)号：US08206966B2
公开(公告)日：2012-06-26
申请号：US12263886
申请日：2008-11-03
申请人： Luis G. Cascāo-Pereira , James T. Kellis, Jr. , Bradley A. Paulson , Scott D. Power , Sandra W. Ramer , Vivek Sharma , Andrew Shaw , Jayarama K. Shetty , Donald E. Ward
发明人： Luis G. Cascāo-Pereira , James T. Kellis, Jr. , Bradley A. Paulson , Scott D. Power , Sandra W. Ramer , Vivek Sharma , Andrew Shaw , Jayarama K. Shetty , Donald E. Ward
IPC分类号： C12N9/26 , C12N9/28 , C12N9/14 , C12N9/16 , C12N1/20 , C12N15/00 , C12P19/14 , C12P21/06 , C12P19/34 , C07H21/04 , C12C11/00 , A21D2/16 , C07K1/00
CPC分类号： C11D3/38681 , C11D3/386 , C12N9/2417 , D06M16/003
摘要： Disclosed are compositions comprising variants of alpha-amylase that have alpha-amylase activity and which exhibit altered properties relative to a parent AmyS-like alpha-amylase from which they are derived. The compositions comprise an additional enzyme such as a phytase. Also disclosed are methods of using the compositions, and kits related thereto.
摘要翻译：公开了包含α-淀粉酶变体的组合物，其具有α-淀粉酶活性，并且相对于其来源的亲本AmyS样α-淀粉酶表现出改变的性质。组合物包含另外的酶如植酸酶。还公开了使用组合物的方法和与其相关的试剂盒。

90. 发明申请

US20120150000A1 Non-Invasive Monitoring Device 审中-公开
标题翻译：无创监测装置
公开(公告)号：US20120150000A1
公开(公告)日：2012-06-14
申请号：US13320002
申请日：2010-05-11
申请人： Ahmed Al-Shamma'a , Alex Mason , Andrew Shaw
发明人： Ahmed Al-Shamma'a , Alex Mason , Andrew Shaw
IPC分类号： A61B5/145
CPC分类号： H01P3/003 , A61B5/0507 , A61B5/14532 , H01Q7/00
摘要： The invention concerns a device for non invasive monitoring of the concentration of a constituent of a human or animal bloodstream. In the preferred example the device comprises drive circuitry (50) for provision of an alternating current at a microwave frequency. This frequency is adjustable. The drive circuitry may for example comprise a voltage controlled oscillator. The device has a sensor (19) adapted to be placed in proximity to the body of the human or animal, the sensor being electrically connected to said drive circuitry to receive said alternating current and being adapted to project microwave energy into the said body. Detector circuitry is provided for detecting a signal transmitted and/or reflected by the sensor, the detected signal properties being dependent on the concentration of the said blood constituent.
摘要翻译：本发明涉及用于非侵入性监测人或动物血流成分浓度的装置。在优选示例中，该装置包括用于提供微波频率的交流电的驱动电路（50）。该频率可调。驱动电路可以例如包括压控振荡器。该装置具有适于放置在靠近人或动物身体的传感器（19），所述传感器电连接到所述驱动电路以接收所述交流电并适于将微波能量投射到所述体内。检测器电路用于检测由传感器传输和/或反射的信号，所检测的信号特性取决于所述血液成分的浓度。

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