专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20120150000A1 Non-Invasive Monitoring Device 审中-公开
标题翻译：无创监测装置
公开(公告)号：US20120150000A1
公开(公告)日：2012-06-14
申请号：US13320002
申请日：2010-05-11
申请人： Ahmed Al-Shamma'a , Alex Mason , Andrew Shaw
发明人： Ahmed Al-Shamma'a , Alex Mason , Andrew Shaw
IPC分类号： A61B5/145
CPC分类号： H01P3/003 , A61B5/0507 , A61B5/14532 , H01Q7/00
摘要： The invention concerns a device for non invasive monitoring of the concentration of a constituent of a human or animal bloodstream. In the preferred example the device comprises drive circuitry (50) for provision of an alternating current at a microwave frequency. This frequency is adjustable. The drive circuitry may for example comprise a voltage controlled oscillator. The device has a sensor (19) adapted to be placed in proximity to the body of the human or animal, the sensor being electrically connected to said drive circuitry to receive said alternating current and being adapted to project microwave energy into the said body. Detector circuitry is provided for detecting a signal transmitted and/or reflected by the sensor, the detected signal properties being dependent on the concentration of the said blood constituent.
摘要翻译：本发明涉及用于非侵入性监测人或动物血流成分浓度的装置。在优选示例中，该装置包括用于提供微波频率的交流电的驱动电路（50）。该频率可调。驱动电路可以例如包括压控振荡器。该装置具有适于放置在靠近人或动物身体的传感器（19），所述传感器电连接到所述驱动电路以接收所述交流电并适于将微波能量投射到所述体内。检测器电路用于检测由传感器传输和/或反射的信号，所检测的信号特性取决于所述血液成分的浓度。

2. 发明申请

US20130076557A1 ELECTROMAGNETIC SENSOR 审中-公开
标题翻译：电磁传感器
公开(公告)号：US20130076557A1
公开(公告)日：2013-03-28
申请号：US13642271
申请日：2011-04-21
申请人： Andrew Shaw , Ahmed Al-Shamma'a
发明人： Andrew Shaw , Ahmed Al-Shamma'a
IPC分类号： F17D5/06 , G01S13/89
CPC分类号： F17D5/06 , G01S13/89
摘要： Disclosed is a probe for use in a fluid pipeline, comprising: a transmitter for transmitting an RF signal via an antenna (50); a receiver for receiving an RF signal via an antenna; a processor operable to compare the received signal with an expected signal. Also disclosed is a method of assessing the condition of a pipeline by means of a probe located inside the pipeline, comprising the steps of: transmitting an RF signal from the probe; receiving an RF signal at the probe; comparing the received and an expected signal and, based on the result of the comparison, indicating that the pipeline is acceptable or not.
摘要翻译：公开了一种用于流体管道的探针，包括：用于经由天线（50）发送RF信号的发射器; 用于经由天线接收RF信号的接收机; 处理器，其可操作以将所接收的信号与预期信号进行比较。还公开了一种通过位于管线内的探头来评估管道状况的方法，包括以下步骤：从探头发送RF信号; 在探头处接收RF信号; 比较接收的和预期的信号，并且基于比较的结果，指示管道是否可接受。

3. 发明申请

US20160285685A1 BUILDING A HYPER-SCALE MONITORING FABRIC 审中-公开
标题翻译：建立一个超大型监控织物
公开(公告)号：US20160285685A1
公开(公告)日：2016-09-29
申请号：US15081166
申请日：2016-03-25
申请人： Shudong Zhou , Sandip Shah , Andrew Shaw
发明人： Shudong Zhou , Sandip Shah , Andrew Shaw
IPC分类号： H04L12/24 , H04L29/12 , H04L12/707
CPC分类号： H04L41/0816 , H04L41/0604 , H04L41/0668 , H04L41/14 , H04L45/22 , H04L61/103 , H04L61/2015
摘要： Systems and methods for building a hyper-scale monitoring fabric are described. The system receives a duplicate of a first portion of traffic information from a production network as first traffic information and communicates the first traffic information in the hyper-scale monitoring fabric. The first traffic information is communicated to a controller computer that configures the hyper-scale monitoring fabric. The system receives a duplicate of a second portion of the traffic information from the production network as second traffic information. The system forwards the second traffic information to a tool farm.
摘要翻译：描述了用于构建超级监视结构的系统和方法。系统从生产网络接收作为第一业务信息的交通信息的第一部分的副本，并将第一业务信息传送到超级监视结构中。第一个交通信息被传送到配置超级监视结构的控制器计算机。系统从生产网络接收交通信息的第二部分的副本作为第二交通信息。系统将第二个交通信息转发到工具栏。

4. 发明授权

US09090887B2 Variant alpha-amylases from Bacillus subtilis and methods of use, thereof 有权
标题翻译：来自枯草芽孢杆菌的变体α-淀粉酶及其使用方法
公开(公告)号：US09090887B2
公开(公告)日：2015-07-28
申请号：US12479416
申请日：2009-06-05
申请人： William A Cuevas , Sang-Kyu Lee , Sandra W Ramer , Andrew Shaw , Amr R Toppozada , David E Estell , Louise Wallace , Regina Chin , Carol A Requadt , Scott D Power , Michael J Pepsin
发明人： William A Cuevas , Sang-Kyu Lee , Sandra W Ramer , Andrew Shaw , Amr R Toppozada , David E Estell , Louise Wallace , Regina Chin , Carol A Requadt , Scott D Power , Michael J Pepsin
IPC分类号： C12N9/26 , C12N9/28 , G01N11/00
CPC分类号： C12N9/2417 , A21D8/042 , C12N9/2408 , C12P7/14 , C12P19/02 , C12P19/14 , G01N11/00 , Y02E50/17
摘要： Alpha-amylases from Bacillus subtilis (AmyE), variants thereof, nucleic acids encoding the same, and host cells comprising the nucleic acids are provided. Methods of using AmyE or variants thereof are disclosed, including liquefaction and/or saccharification of starch. Such methods may yield sugars useful for ethanol production or high fructose corn syrup production. In some cases, the amylases can be used at low pH, in the absence of calcium, and/or in the absence of a glucoamylase.
摘要翻译：提供了来自枯草芽孢杆菌（AmyE）的α-淀粉酶，其变体，编码它们的核酸和包含核酸的宿主细胞。公开了使用AmyE或其变体的方法，包括淀粉的液化和/或糖化。这样的方法可能产生可用于乙醇生产或高果糖玉米糖浆生产的糖。在一些情况下，淀粉酶可以在低pH，不存在钙的情况下和/或不存在葡糖淀粉酶的情况下使用。

5. 发明授权

US08841107B2 Hybrid alpha-amylases 有权
标题翻译：混合型α-淀粉酶
公开(公告)号：US08841107B2
公开(公告)日：2014-09-23
申请号：US13132881
申请日：2009-12-11
申请人： Scott D. Power , Andrew Shaw
发明人： Scott D. Power , Andrew Shaw
IPC分类号： C12N9/96 , C12N9/00 , C12N9/28
CPC分类号： C12N9/2417 , C07K2319/00 , G06F19/12 , G06F19/16
摘要： Hybrid alpha-amylases are provided that share a conserved 3D structure in whole or in part with a wild-type Termamyl-like ?-amylase, e.g., a Bacillus amylase. In the hybrid, an N terminal portion of a Termamyl-like ?-amylase is replaced with sequences from an archae ? amylase. The sequence similarity between the two amylase sequences may be less than 60%. Conserving the wild-type 3D structure in the hybrid facilitates obtaining enzymatically active amylases. In one embodiment, one or both amylase sequences contribute residues to the B domain, resulting in particularly advantageous properties. For instance, replacement of the Ca2+ binding site in the B domain of the Termamyl-like ?-amylase with a B domain sequence of an archae ? amylase that does not bind Ca2+ can produce a hybrid that is fully active in the absence of Ca2+.
摘要翻译：提供杂交α-淀粉酶，其与野生型类戊酰样α-淀粉酶（例如芽孢杆菌淀粉酶）全部或部分共享保守的3D结构。在杂交体中，类戊酰样α-淀粉酶的N末端部分被来自古细菌的序列替代淀粉酶。两个淀粉酶序列之间的序列相似性可以小于60％。在杂交中保护野生型3D结构有助于获得酶活性淀粉酶。在一个实施方案中，一个或两个淀粉酶序列向B结构域贡献残基，导致特别有利的性质。例如，用具有古细菌的B结构域序列的Termamyl样α-淀粉酶的B结构域中的Ca 2+结合位点的替换不结合Ca2 +的淀粉酶可以产生在不存在Ca 2+的情况下完全活性的杂交体。

6. 发明授权

US08809032B2 Exo-specific amylase polypeptides, nucleic acids encoding those polypeptides and uses thereof 有权
标题翻译：特异性淀粉酶多肽，编码那些多肽的核酸及其用途
公开(公告)号：US08809032B2
公开(公告)日：2014-08-19
申请号：US12024324
申请日：2008-02-01
申请人： Casper Tune Berg , Kirsten Bojsen , Patrick M. F. Derkx , Carol Fioresi , Gijsbert Gerritse , Karsten Matthias Kragh , Wei Liu , Andrew Shaw , Charlotte Refdahl Thoudahl , Anja Hemmingsen Kellett-Smith
发明人： Casper Tune Berg , Kirsten Bojsen , Patrick M. F. Derkx , Carol Fioresi , Gijsbert Gerritse , Karsten Matthias Kragh , Wei Liu , Andrew Shaw , Charlotte Refdahl Thoudahl , Anja Hemmingsen Kellett-Smith
IPC分类号： C12N9/28 , C12N9/32 , A21D8/04
CPC分类号： C12N9/2417
摘要： This invention relates to amylase polypeptides, and nucleic acids encoding the polypeptides and uses thereof. The amylases of the present invention have been engineered to have more beneficial qualities. Specifically the amylases of the current invention show an altered exospecifity.
摘要翻译：本发明涉及淀粉酶多肽，以及编码多肽的核酸及其用途。本发明的淀粉酶已被设计成具有更多的有益品质。具体地说，本发明的淀粉酶表现出改变的特异性。

7. 发明授权

US08574884B2 Thermostable neutral metalloproteases 有权
标题翻译：耐热中性金属蛋白酶
公开(公告)号：US08574884B2
公开(公告)日：2013-11-05
申请号：US13345547
申请日：2012-01-06
申请人： Andrew Shaw , Louise Wallace , David A. Estell , Ronaldus W. J. Hommes , Sang-Kyu Lee , Hiroshi Oh , Eugene S. Sadlowski
发明人： Andrew Shaw , Louise Wallace , David A. Estell , Ronaldus W. J. Hommes , Sang-Kyu Lee , Hiroshi Oh , Eugene S. Sadlowski
IPC分类号： C12N9/54 , C12N9/50 , C12N1/20 , C12N15/00 , C12P21/06 , D06M16/00 , C02F3/34 , C14C1/00 , C12P1/00 , C07H21/04 , C11D3/00 , C07K1/00
CPC分类号： C12N9/54 , C11D1/02 , C11D3/386 , C11D3/38663 , C12Y304/24
摘要： The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme that has improved storage stability. In some embodiments, the neutral metalloprotease finds use in cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods and compositions comprising neutral metalloprotease(s) obtained from Bacillus sp. In some more particularly preferred embodiments, the neutral metalloprotease is obtained from B. amyloliquefaciens. In still further preferred embodiments, the neutral metalloprotease is a variant of the B. amyloliquefaciens neutral metalloprotease. In yet additional embodiments, the neutral metalloprotease is a homolog of the B. amyloliquefaciens neutral metalloprotease. The present invention finds particular use in applications including, but not limited to cleaning, bleaching and disinfecting.
摘要翻译：本发明提供包含至少一种具有改善的储存稳定性的中性金属蛋白酶的方法和组合物。在一些实施方案中，中性金属蛋白酶可用于清洁和其它应用。在一些特别优选的实施方案中，本发明提供了包含从芽孢杆菌属芽孢杆菌获得的中性金属蛋白酶的方法和组合物。在一些更特别优选的实施方案中，中性金属蛋白酶从解淀粉芽孢杆菌获得。在另外的优选实施方案中，中性金属蛋白酶是解淀粉芽孢杆菌中性金属蛋白酶的变体。在另外的实施方案中，中性金属蛋白酶是解淀粉芽孢杆菌中性金属蛋白酶的同系物。本发明特别用于包括但不限于清洁，漂白和消毒的应用。

8. 发明授权

US08318451B2 Process of obtaining ethanol without glucoamylase using Pseudomonas saccharophila G4-amylase variants thereof 失效
标题翻译：使用酿酒酵母G4-淀粉酶变体获得没有葡糖淀粉酶的乙醇的方法
公开(公告)号：US08318451B2
公开(公告)日：2012-11-27
申请号：US12318513
申请日：2008-12-30
申请人： Andrew Shaw , Regina Chin , Karsten M. Kragh
发明人： Andrew Shaw , Regina Chin , Karsten M. Kragh
IPC分类号： C12Q1/40 , C12N9/26 , C12N9/28 , C07K14/00 , C12P21/00
CPC分类号： C12N9/2417 , A21D8/042 , A23L29/35 , Y02E50/16 , Y02E50/17
摘要： Pseudomonas saccharophila G4-forming amylase (PS4), and variants thereof, advantageously can be used in an enzyme-catalyzed high temperature liquefaction step to produce ethanol from starch, e.g., cornstarch. PS4 produces significant amounts of maltotrioses, which can be utilized by S. cerevisiae in a subsequent fermentation step to produce ethanol. This property of PS4 advantageously allows ethanol to be produced from liquefacted starch in the absence of a saccharification step. PS4 variants are provided that exhibit improved properties, such as thermostability and/or altered exo-specific and endo-specific amylase activity.
摘要翻译：糖酵母（Saccharophila）G4形成淀粉酶（PS4）及其变体有利地可用于酶催化的高温液化步骤以从淀粉例如玉米淀粉生产乙醇。 PS4产生显着量的麦芽三糖，其可以在随后的发酵步骤中被酿酒酵母用于产生乙醇。 PS4的这种性质有利地允许在没有糖化步骤的情况下从液化淀粉生产乙醇。提供了PS4变体，其具有改进的性质，例如热稳定性和/或改变的外切特异性和内切特异性淀粉酶活性。

9. 发明申请

US20120009651A1 Production of Thermolysin and Variants Thereof and Use In Liquid Detergents 失效
标题翻译：生产溶血素及其变体并用于液体洗涤剂
公开(公告)号：US20120009651A1
公开(公告)日：2012-01-12
申请号：US12740782
申请日：2008-10-28
申请人： David A. Estell , Ronaldus W.J. Hommes , Amy D. Liu , Andrew Shaw
发明人： David A. Estell , Ronaldus W.J. Hommes , Amy D. Liu , Andrew Shaw
IPC分类号： C12N9/52 , C12N9/54 , D06L1/16 , C12N1/21 , C11D3/60 , C12N9/56 , C12S9/00
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38618 , C11D3/38636 , C12Y304/24027
摘要： The present invention provides methods and compositions comprising at least one thermolysin-like neutral protease enzyme with improved storage stability and/or catalytic activity. In some embodiments, the thermolysin finds use in cleaning and other applications comprising detergent. In some particularly preferred embodiments, the present invention provides methods and compositions comprising thermolysin formulated and/or engineered to resist detergent-induced inactivation.
摘要翻译：本发明提供包含至少一种具有改善的储存稳定性和/或催化活性的嗜热菌蛋白酶样中性蛋白酶的方法和组合物。在一些实施方案中，嗜热菌蛋白酶用于清洁和其它包含洗涤剂的应用。在一些特别优选的实施方案中，本发明提供包含热溶菌素的方法和组合物，其配制和/或工程化以抵抗洗涤剂诱导的失活。

10. 发明申请

US20100233780A1 Methods for Improving Protein Properties 审中-公开
标题翻译：改善蛋白质性质的方法
公开(公告)号：US20100233780A1
公开(公告)日：2010-09-16
申请号：US12602989
申请日：2008-06-06
申请人： Wolfgang Aehle , Luis Gustavo Cascao-Pereira , James T. Kellis, JR. , Andrew Shaw
发明人： Wolfgang Aehle , Luis Gustavo Cascao-Pereira , James T. Kellis, JR. , Andrew Shaw
IPC分类号： C12N9/48 , C07K14/00 , C12N9/00 , C12N9/26 , C12N9/42 , C12N9/18 , C12N9/20 , C12N9/88 , C12N9/02 , C12N9/10 , C12N9/08
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38681 , C12N9/2411 , C12N9/2417 , C12N15/1034 , C12Y302/01001 , C12Y304/21062
摘要： The present invention provides methods for engineering proteins to optimize their performance under certain environmental conditions of interest. In some embodiments, the present invention provides methods for engineering enzymes to optimize their catalytic activity under particular environmental conditions. In some preferred embodiments, the present invention provides methods for engineering enzymes to optimize their catalytic activity and/or stability under adverse environmental conditions. In some preferred embodiments, the present invention provides methods for engineering enzymes to optimize their storage stability, particularly under adverse environmental conditions. In some preferred embodiments, the present invention provides methods for altering the net surface charge and/or surface charge distribution of enzymes (e.g., metalloproteases) to obtain enzyme variants that demonstrate improved performance and/or stability in detergent formulations as compared to the starting or parent enzyme.
摘要翻译：本发明提供了在某些感兴趣的环境条件下工程化蛋白质以优化其性能的方法。在一些实施方案中，本发明提供了工程化酶以在特定环境条件下优化其催化活性的方法。在一些优选实施方案中，本发明提供了工程化酶以在不利的环境条件下优化其催化活性和/或稳定性的方法。在一些优选的实施方案中，本发明提供了工程化酶优化其储存稳定性的方法，特别是在不利的环境条件下。在一些优选的实施方案中，本发明提供了用于改变酶（例如金属蛋白酶）的净表面电荷和/或表面电荷分布以获得酶变体的方法，所述酶变体与洗涤剂配方相比起始或以后可以改善洗涤剂配方的性能和/或稳定性亲本酶。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式