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81. 发明申请

US20120109235A1 CAPTURE DETECTION IN RESPONSE TO LEAD RELATED CONDITIONS 审中-公开
标题翻译：对领导相关条件的响应能力的检测
公开(公告)号：US20120109235A1
公开(公告)日：2012-05-03
申请号：US12913400
申请日：2010-10-27
申请人： Todd J. Sheldon , Bruce D. Gunderson
发明人： Todd J. Sheldon , Bruce D. Gunderson
IPC分类号： A61N1/37 , A61N1/39
CPC分类号： A61N1/371 , A61N1/3706 , A61N1/3712 , A61N1/3962 , A61N2001/083
摘要： Various techniques for detecting cardiac capture in response to a detected lead related condition are described. One example method described includes delivering a pacing therapy to a heart of a patient, periodically determining whether the pacing therapy captures the heart of the patient, detecting a lead related condition, and, in response to the detected lead related condition, increasing a frequency of determining whether the pacing therapy captures the heart.
摘要翻译：描述了响应于检测到的铅相关状况来检测心脏捕获的各种技术。所描述的一个示例性方法包括将起搏治疗递送到患者的心脏，周期性地确定起搏疗法是否捕获患者的心脏，检测引线相关状况，并且响应于检测到的引线相关状况，增加频率确定起搏治疗是否捕获心脏。

82. 发明授权

US07899538B2 Methods and apparatus for automatically tracking heart failure status 有权
标题翻译：自动跟踪心力衰竭状态的方法和装置
公开(公告)号：US07899538B2
公开(公告)日：2011-03-01
申请号：US11691266
申请日：2007-03-26
申请人： Lynn A. Davenport , Purvee P. Parikh , Todd J. Sheldon
发明人： Lynn A. Davenport , Purvee P. Parikh , Todd J. Sheldon
IPC分类号： A61N1/37
CPC分类号： A61N1/3627
摘要： Assessing symptomatic and asymptomatic physiologic changes due to chronic heart failure involves apparatus and methods for gauging degradation and possible improvement using automated measurement of inter-ventricular conduction time, both alone and in combination with other automated physiologic tests. Conduction times increase due to the greater distance a wavefront must traverse as a heart enlarges. Analysis of conduction time can be used to verify the occurrence of cardiac remodeling due to heart failure as well as beneficial reverse remodeling due to successful heart failure therapy delivery. Patient activity level(s) and presence/increase in pulmonary fluids can also be used to automatically determine changes in heart failure status and/or predict hospitalization. Conduction time is monitored between electrodes positioned in the left and right ventricles of the heart via endocardial or epicardial electrodes.
摘要翻译：评估因慢性心力衰竭引起的症状和无症状的生理变化涉及用于测量降解的设备和方法，并且可以通过自动测量心室间传导时间来单独测量并与其他自动化生理测试结合使用。由于随着心脏的扩大，波前必须穿越的距离越大，传导时间就会增加。传导时间分析可以用于验证由于心力衰竭导致的心脏重构的发生以及由于成功的心力衰竭治疗递送而导致的有益的反向重建。患者活动水平和肺流体的存在/增加也可用于自动确定心力衰竭状态的变化和/或预测住院治疗。通过心内膜或心外膜电极监测位于心脏左心室和右心室的电极之间的传导时间。

83. 发明申请

US20110040346A1 METHOD FOR SCHEDULING ATRIAL-VENTRICULAR CONDUCTION CHECKS IN MINIMUM VENTRICULAR PACING 有权
标题翻译：最小静脉血管内调节心房直肠导管检查方法
公开(公告)号：US20110040346A1
公开(公告)日：2011-02-17
申请号：US12540632
申请日：2009-08-13
申请人： Todd J. Sheldon
发明人： Todd J. Sheldon
IPC分类号： A61N1/37
CPC分类号： A61N1/368 , A61N1/3688
摘要： A medical device and associated method deliver cardiac pacing in a dual chamber pacing mode and schedule an atrial-ventricular (AV) conduction check during the dual chamber pacing mode to detect the presence of AV conduction. If AV conduction is detected during the scheduled AV conduction check, the medical device switches to an atrial pacing mode and switches back to the dual chamber pacing mode in response to an absence of AV conduction during the atrial pacing mode. The detected AV conduction is identified as a false positive detection in response to the pacing mode switch to the dual chamber pacing mode occurring within a predetermined interval of time from detecting the AV conduction.
摘要翻译：医疗设备和相关方法在双室起搏模式下提供心脏起搏，并且在双室起搏模式期间安排心房（AV）导通检查以检测AV传导的存在。如果在预定的AV导通检查期间检测到AV传导，则医疗设备切换到心房起搏模式并且响应于在心房起搏模式期间不存在AV传导而切换回双室起搏模式。检测到的AV导通被识别为响应于从检测AV传导而在预定时间间隔内发生的双室起搏模式的起搏模式切换的假阳性检测。

84. 发明申请

US20110029034A1 ALGORITHM TO MODULATE ATRIAL-VENTRICULAR DELAY AND RATE RESPONSE BASED ON AUTONOMIC FUNCTION 有权
标题翻译：基于自动功能调节心律延迟和速率响应的算法
公开(公告)号：US20110029034A1
公开(公告)日：2011-02-03
申请号：US12787058
申请日：2010-05-25
申请人： Trent M. Fischer , Douglas A. Hettrick , Todd J. Sheldon , Paul A. Belk , Thomas J. Mullen , John C. Rueter , Daniel R. Kaiser
发明人： Trent M. Fischer , Douglas A. Hettrick , Todd J. Sheldon , Paul A. Belk , Thomas J. Mullen , John C. Rueter , Daniel R. Kaiser
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/0456 , A61N1/36514 , A61N1/36542 , A61N1/36557 , A61N1/36564 , A61N1/36571 , A61N1/36578 , A61N1/36585 , A61N1/368 , A61N1/3682 , A61N1/3688
摘要： An implantable medical device and associated method provide atrial pacing and measure an atrial ventricular (AV) delay. An autonomic function index is computed using the AV delay. The autonomic function index may be compiled in a medical report. In some embodiments, the autonomic function index is used to adjust atrial pacing control parameters.
摘要翻译：可植入医疗器械和相关方法提供心房起搏并测量心房（AV）延迟。使用AV延迟计算自主功能指数。自主功能指数可以在医疗报告中编制。在一些实施例中，自主功能指数用于调节心房起搏控制参数。

85. 发明申请

US20100174334A1 SYSTEM AND METHOD FOR PROVIDING IMPROVED ATRIAL PACING BASED ON PHYSIOLOGICAL NEED 有权
标题翻译：基于生理需要提供改进的ATRIAL PACING的系统和方法
公开(公告)号：US20100174334A1
公开(公告)日：2010-07-08
申请号：US12726626
申请日：2010-03-18
申请人： Todd J. Sheldon , Robert A. Betzold , Michael O. Sweeney
发明人： Todd J. Sheldon , Robert A. Betzold , Michael O. Sweeney
IPC分类号： A61N1/368
CPC分类号： A61N1/368
摘要： An implantable medical device operates according to a ventricular pacing protocol (VPP) that precludes ventricular pacing in any cardiac cycle where a sensed ventricular event has occurred in the preceding cycle. Improved ventricular sensing, detection and classification is provided.
摘要翻译：植入式医疗装置根据心室起搏方案（VPP）进行操作，其排除在前一周期中发生感测到的心室事件的任何心动周期中的心室起搏。提供改善的心室感测，检测和分类。

86. 发明申请

US20100137935A1 LV THRESHOLD MEASUREMENT AND CAPTURE MANAGEMENT 有权
标题翻译： LV阈值测量和捕获管理
公开(公告)号：US20100137935A1
公开(公告)日：2010-06-03
申请号：US12700454
申请日：2010-02-04
申请人： Purvee P. Parikh , John C. Stroebel , Todd J. Sheldon , Karen J. Kleckner
发明人： Purvee P. Parikh , John C. Stroebel , Todd J. Sheldon , Karen J. Kleckner
IPC分类号： A61N1/08 , A61N1/362
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/371
摘要： The invention provides methods and apparatus for determining in a non-tracking pacing mode (e.g., DDI/R, VVI/R) whether a ventricular pacing stimulus is capturing a paced ventricle, including some or all of the following aspects. For example, increasing a ventricular pacing rate a nominal amount to an overdrive pacing rate higher than a most recent heart rate and evaluating a conduction interval from a first pacing ventricle to a second sensing ventricle and then continuing to monitor the underlying rate to ensure that a threshold testing pacing rate will not exceed a predetermined minimum interval and providing pacing stimulation to the first ventricle and sensing the second ventricle to determine whether the pacing stimulation to the first ventricle was one of sub-threshold and supra-threshold. The methods and apparatus are especially useful in conjunction with ensuring actual delivery of a ventricular pacing regime (e.g., cardiac resynchronization therapy or “CRT”).
摘要翻译：本发明提供了用于在非跟踪起搏模式（例如，DDI / R，VVI / R）中确定心室起搏刺激是否捕获节奏心室的方法和装置，包括以下方面中的一些或全部。例如，将心室起搏速率提高到高于最近心率的超速起搏速率的标称值，并评估从第一起搏心室到第二感测心室的传导间隔，然后继续监测潜在速率，以确保阈值测试起搏速率不会超过预定的最小间隔，并且向第一脑室提供起搏刺激并且感测第二脑室以确定对第一脑室的起搏刺激是否是子阈值和超阈值之一。所述方法和装置与确保心室起搏方案（例如，心脏再同步治疗或“CRT”）的实际递送相结合特别有用。

87. 发明授权

US07715914B2 System and method for improving ventricular sensing 有权
标题翻译：用于改善心室感觉的系统和方法
公开(公告)号：US07715914B2
公开(公告)日：2010-05-11
申请号：US11461158
申请日：2006-07-31
申请人： Todd J. Sheldon , Scott R. Stanslaski , Michael O. Sweeney , Robert A. Betzold , Douglas A. Hettrick
发明人： Todd J. Sheldon , Scott R. Stanslaski , Michael O. Sweeney , Robert A. Betzold , Douglas A. Hettrick
IPC分类号： A61N1/362
CPC分类号： A61N1/3622
摘要： An implantable medical device operates according to a ventricular pacing protocol (VPP) that precludes ventricular pacing in any cardiac cycle where a sensed ventricular event has occurred in the preceding cycle. Improved ventricular sensing, detection and classification is provided.
摘要翻译：植入式医疗装置根据心室起搏方案（VPP）进行操作，其排除在前一周期中发生感测到的心室事件的任何心动周期中的心室起搏。提供改善的心室感测，检测和分类。

88. 发明授权

US07599740B2 Ventricular event filtering for an implantable medical device 有权
标题翻译：可植入医疗器械的心室事件过滤
公开(公告)号：US07599740B2
公开(公告)日：2009-10-06
申请号：US11748659
申请日：2007-05-15
申请人： Robert A. Betzold , David A. Casavant , Paul A. Belk , Thomas J. Mullen , John C. Stroebel , Steven R. Hornberger , Todd J. Sheldon , Douglas A. Peterson
发明人： Robert A. Betzold , David A. Casavant , Paul A. Belk , Thomas J. Mullen , John C. Stroebel , Steven R. Hornberger , Todd J. Sheldon , Douglas A. Peterson
IPC分类号： A61N1/362
CPC分类号： A61N1/368 , A61N1/3688 , A61N1/3702
摘要： Pacing parameters are provided to address cross talk and intrinsic ventricular events occurring within a predefined blanking period following an atrial event. The parameters are used in conjunction with protocol for minimizing or reducing ventricular pacing, wherein ignoring intrinsic ventricular events during the blanking period might otherwise affect the performance of the protocol.
摘要翻译：提供起搏参数以解决心房事件发生后的预定义消隐期间发生的串扰和内在心室事件。这些参数与协议一起使用以最小化或减少心室起搏，其中在消隐期间忽略内部心室事件可能会影响该方案的性能。

89. 发明授权

US07502646B2 Pacing mode event classification with rate smoothing and increased ventricular sensing 有权
标题翻译：起搏模式事件分类与速率平滑和增加心室感知
公开(公告)号：US07502646B2
公开(公告)日：2009-03-10
申请号：US11461141
申请日：2006-07-31
申请人： Todd J. Sheldon , Scott R. Stanslaski , Michael O. Sweeney , Robert A. Betzold , Douglas A. Hettrick , Paul A. Belk
发明人： Todd J. Sheldon , Scott R. Stanslaski , Michael O. Sweeney , Robert A. Betzold , Douglas A. Hettrick , Paul A. Belk
IPC分类号： A61N1/362
CPC分类号： A61N1/368
摘要： An implantable medical device operates according to a ventricular pacing protocol (VPP) that precludes ventricular pacing in any cardiac cycle where a sensed ventricular event has occurred in the preceding cycle. Improved ventricular sensing, detection and classification is provided.
摘要翻译：植入式医疗装置根据心室起搏方案（VPP）进行操作，其排除在前一周期中发生感测到的心室事件的任何心动周期中的心室起搏。提供改善的心室感测，检测和分类。

90. 发明申请

US20080027492A1 Rate Smoothing Pacing Modality with Increased Ventricular Sensing 有权
标题翻译：评估平滑起搏模式，增加心室感觉
公开(公告)号：US20080027492A1
公开(公告)日：2008-01-31
申请号：US11461154
申请日：2006-07-31
申请人： Todd J. Sheldon , Scott R. Stanslaski , Michael O. Sweeney , Robert A. Betzold , Douglas A. Hettrick , Paul A. Belk
发明人： Todd J. Sheldon , Scott R. Stanslaski , Michael O. Sweeney , Robert A. Betzold , Douglas A. Hettrick , Paul A. Belk
IPC分类号： A61N1/362
CPC分类号： A61N1/368
摘要： An implantable medical device operates according to a ventricular pacing protocol (VPP) that precludes ventricular pacing in any cardiac cycle where a sensed ventricular event has occurred in the preceding cycle. Improved ventricular sensing, detection and classification is provided.
摘要翻译：植入式医疗装置根据心室起搏方案（VPP）进行操作，其排除在前一周期中发生感测到的心室事件的任何心动周期中的心室起搏。提供改善的心室感测，检测和分类。

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