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81. 发明授权

US08124392B2 Crystal structure of Aurora-2 protein and binding pockets thereof 失效
标题翻译： Aurora-2蛋白的晶体结构及其结合口袋
公开(公告)号：US08124392B2
公开(公告)日：2012-02-28
申请号：US12890826
申请日：2010-09-27
申请人： Graham Cheetham , Ronald Knegtel , Lovorka Swenson , Joyce T. Coll , Suzanne Renwick , Peter Weber
发明人： Graham Cheetham , Ronald Knegtel , Lovorka Swenson , Joyce T. Coll , Suzanne Renwick , Peter Weber
IPC分类号： C12N9/12 , G01N31/00
CPC分类号： C12N9/1205 , C07K2299/00
摘要： The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2. The present invention also relates to a computer comprising a data storage medium encoded with the structural coordinates of Aurora-2 binding pockets and methods of using a computer to evaluate the ability of a compound to bind to the molecule or molecular complex. This invention also provides methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention provides methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to Aurora-2 or homologues thereof.
摘要翻译：本发明提供包含Aurora-2或其同系物的结合口袋的结晶分子或分子复合物。本发明还提供了包含Aurora-2的晶体。本发明还涉及包含用Aurora-2结合口袋的结构座标编码的数据存储介质的计算机，以及使用计算机评价化合物结合分子或分子复合物的能力的方法。本发明还提供了使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。此外，本发明提供了使用结构坐标筛选和设计结合Aurora-2或其同系物的化合物（包括抑制性化合物）的方法。

82. 外观设计

USD643411S1 Audio mixing board 有权
公开(公告)号：USD643411S1
公开(公告)日：2011-08-16
申请号：US29365932
申请日：2010-07-16
申请人： Andreas Siegrist , Werner Stauffacher , Rene Wussler , Meinrad Lienert , Peter Weber
设计人： Andreas Siegrist , Werner Stauffacher , Rene Wussler , Meinrad Lienert , Peter Weber

83. 发明授权

US07960398B2 Regulation of TNF-alpha 失效
标题翻译：调节TNF-α
公开(公告)号：US07960398B2
公开(公告)日：2011-06-14
申请号：US10419327
申请日：2003-04-17
申请人： Karen Miller , Anita Diu-Hercend , Thierry Hercend , Paul Lang , Peter Weber , Julian Golec , Michael Mortimore
发明人： Karen Miller , Anita Diu-Hercend , Thierry Hercend , Paul Lang , Peter Weber , Julian Golec , Michael Mortimore
IPC分类号： A61K31/517
CPC分类号： C07D235/24 , A61K38/00 , C07C233/64 , C07C233/83 , C07C235/52 , C07C237/22 , C07C237/42 , C07C255/57 , C07C271/22 , C07C271/28 , C07C2601/14 , C07D209/42 , C07D209/86 , C07D211/60 , C07D217/24 , C07D233/90 , C07D239/90 , C07D401/06 , C07D405/12 , C07D409/06 , C07D417/06 , C07D455/04 , C07D487/04 , C07F9/3264 , C07F9/65128 , C07K5/0202 , G01N33/6863 , G01N2333/525 , G01N2500/04 , Y02A50/411
摘要： The present invention relates to methods for identifying compounds useful for regulating TNF-alpha levels and/or activity. The invention also relates to methods for decreasing TNF-alpha levels and/or activity. Compounds and compositions according to this invention are useful for treating TNF-mediated diseases. The invention also relates to kits comprising the compounds and compositions herein and a tool for measuring TNF-alpha activity and/or levels.
摘要翻译：本发明涉及用于鉴定可用于调节TNF-α水平和/或活性的化合物的方法。本发明还涉及降低TNF-α水平和/或活性的方法。根据本发明的化合物和组合物可用于治疗TNF介导的疾病。本发明还涉及包含本文的化合物和组合物的试剂盒以及用于测量TNF-α活性和/或水平的工具。

84. 发明授权

US07807659B2 Caspase inhibitors and uses thereof 有权
标题翻译：胱天蛋白酶抑制剂及其用途
公开(公告)号：US07807659B2
公开(公告)日：2010-10-05
申请号：US11522375
申请日：2006-09-14
申请人： Anita Diu-Hercend , Julian Golec , Thierry Hercend , Ronald Knegtel , Paul Lang , Andrew Miller , Karen Miller , Michael Mortimore , Peter Weber
发明人： Anita Diu-Hercend , Julian Golec , Thierry Hercend , Ronald Knegtel , Paul Lang , Andrew Miller , Karen Miller , Michael Mortimore , Peter Weber
IPC分类号： A61K31/675 , A01N57/00
CPC分类号： C07D401/06 , C07D211/60 , C07D405/06 , C07D409/06 , C07D417/06
摘要： The present invention relates to novel classes of compounds of formula I which are caspase and TNF-alpha inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting caspase and TNF-alpha activity and consequently, can be advantageously used as agents against caspase-, interleukin-1-(“IL-1”), apoptosis-, interferon-γ inducing factor-(IGIF), interferon-γ-(“IFN-γ”), or TNF-alpha mediated diseases, including inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, and degenerative diseases. This invention also relates to processes for preparing the compounds of this invention. This invention also relates to methods for inhibiting caspase and TNF-alpha activity and decreasing IGIF production and IFN-γ production and methods for treating caspase-, interleukin-1, apoptosis-, and interferon-γ-, and TNF-alpha mediated diseases using the compounds and compositions of this invention.
摘要翻译：本发明涉及新型的式I化合物，其为半胱天冬酶和TNF-α抑制剂。本发明还涉及包含这些化合物的药物组合物。本发明的化合物和药物组合物特别适用于抑制半胱天冬酶和TNF-α活性，因此可有利地用作抗半胱天冬酶，白细胞介素-1（“IL-1”），细胞凋亡 - 干扰素 - γ诱导因子（IGIF），干扰素-γ-（“IFN-γ”）或TNF-α介导的疾病，包括炎性疾病，自身免疫性疾病，破坏性骨病，增殖性疾病，感染性疾病和退行性疾病。本发明还涉及制备本发明化合物的方法。本发明还涉及用于抑制半胱天冬酶和TNF-α活性并减少IGIF产生和IFN-γ产生的方法以及用于治疗半胱天冬酶，白细胞介素-1，细胞凋亡和干扰素-γ以及TNF-α介导的疾病的方法本发明的化合物和组合物。

85. 发明申请

US20100040512A1 METHOD AND PLANT FOR THE HEAT TREATMENT OF SOLIDS CONTAINING IRON OXIDE 有权
标题翻译：用于处理含氧化铁的固体的方法和设备
公开(公告)号：US20100040512A1
公开(公告)日：2010-02-18
申请号：US12603852
申请日：2009-10-22
申请人： Andreas Orth , Martin Hirsch , Peter Weber , Stuart Sneyd , Dirk Nuber , Michael Stroeder
发明人： Andreas Orth , Martin Hirsch , Peter Weber , Stuart Sneyd , Dirk Nuber , Michael Stroeder
IPC分类号： B01J8/18 , B01J8/24
CPC分类号： B01J8/18 , B01J8/1863 , B01J8/30 , B01J8/44 , B01J2208/00061 , C22B1/10 , C22B5/14 , F27B15/02 , F27B15/08 , F27B15/10
摘要： A plant for the heat treatment of solids containing iron oxide. The plant includes a reactor including a fluidized bed reactor. The reactor includes a gas supply system disposed in the reactor, a stationary annular fluidized bed which at least partly surrounds the gas supply system, and a mixing chamber. The gas supply system is configured so that gas flowing through the gas supply system entrains solids from the stationary annular fluidized bed into the mixing chamber.
摘要翻译：用于热处理含有氧化铁的固体的设备。该设备包括一个包括流化床反应器的反应器。反应器包括设置在反应器中的气体供应系统，至少部分地围绕气体供应系统的固定环形流化床和混合室。气体供应系统被配置为使得流过气体供应系统的气体将固体从固定的环形流化床引入混合室。

86. 发明授权

US07625422B2 Method and plant for the heat treatment of solids containing iron oxide using a fluidized bed reactor 有权
标题翻译：使用流化床反应器对含有氧化铁的固体进行热处理的方法和设备
公开(公告)号：US07625422B2
公开(公告)日：2009-12-01
申请号：US10540435
申请日：2003-12-01
申请人： Andreas Orth , Martin Hirsch , Peter Weber , Stuart Sneyd , Dirk Nuber , Michael Ströder
发明人： Andreas Orth , Martin Hirsch , Peter Weber , Stuart Sneyd , Dirk Nuber , Michael Ströder
IPC分类号： B01J8/24 , C22B1/10 , C22B5/14
CPC分类号： B01J8/18 , B01J8/1863 , B01J8/30 , B01J8/44 , B01J2208/00061 , C22B1/10 , C22B5/14 , F27B15/02 , F27B15/08 , F27B15/10
摘要： The present invention relates to a method and a plant for the heat treatment of solids containing iron oxide, in which fine-grained solids are heated to a temperature of 700 to 1150° C. in a fluidized bed reactor (8). To improve the utilization of energy, it is proposed to introduce a first gas or gas mixture from below through at least one gas supply tube (9) into a mixing chamber region (15) of the reactor (8), the gas supply tube (9) being at least partly surrounded by a stationary annular fluidized bed (12) which is fluidized by supplying fluidizing gas. The gas velocities of the first gas or gas mixture and of the fluidizing gas for the annular fluidized bed (12) are adjusted such that the Particle-Froude-Numbers in the gas supply tube (9) are between 1 and 100, in the annular fluidized bed (12) between 0.02 and 2, and in the mixing chamber (15) between 0.3 and 30.
摘要翻译：本发明涉及用于热处理包含氧化铁的固体的方法和设备，其中在流化床反应器（8）中将细粒固体加热至700至1150℃的温度。为了提高能量的利用率，建议从下方通过至少一个气体供给管（9）将第一气体或气体混合物引入反应器（8）的混合室区域（15），气体供给管 9）至少部分地被固定的环形流化床（12）包围，所述静止环形流化床通过供应流化气体而被流化。第一气体或气体混合物以及用于环形流化床（12）的流化气体的气体速度被调整为使得气体供应管（9）中的“微粒 - 弗劳德数”在1和100之间，在环形流化床（12）在0.02和2之间，在混合室（15）中在0.3和30之间。

87. 发明申请

US20090289535A1 CUPBOARD INSTALLATION PART WITH STORAGE COMPARTMENTS, WHICH PART IS INSERTABLE IN AN UPPER CUPBOARD 失效
标题翻译：带有存储舱的银联安装部分，其中一部分是在上一杯子中插入的
公开(公告)号：US20090289535A1
公开(公告)日：2009-11-26
申请号：US12126525
申请日：2008-05-23
申请人： Peter Weber
发明人： Peter Weber
IPC分类号： A47B88/18
CPC分类号： A47B46/005 , A47B51/00
摘要： A cupboard installation part with storage compartments is insertable in an upper cupboard and is pivotable from an upper position, moved into the upper cupboard, into a position moved out of the upper cupboard and displaced downward. The cupboard installation part comprises pivot levers aligned parallel, which, on the one hand, are coupled to the cupboard installation part, and, on the other hand, are able to be coupled to the upper cupboard. A supporting element is insertable and mountable in the upper cupboard, on which supporting element a first pivot lever and a second pivot lever are pivotably borne, in each case in a first pivot bearing. The two pivot levers are each pivotably connected to a support part via a second pivot bearing, on which support part the storage compartments are mountable, at least on one side. An easily mountable cupboard installation part is thereby obtained which has a very stable construction and is usable in diverse ways.
摘要翻译：具有存储隔间的橱柜安装部分可插入上部橱柜中，并且可从上部位置移动到上部橱柜中的上部位置转动到从上部橱柜移出并向下移位的位置。橱柜安装部分包括平行排列的枢转杆，一方面，它连接到橱柜安装部分，另一方面，能够联接到上部橱柜。支撑元件可插入并安装在上部橱柜中，支撑元件上的第一枢转杆和第二枢转杆可枢转地承载在每个壳体中的第一枢转轴承中。所述两个枢轴杆通过第二枢转轴承枢转地连接到支撑部分，所述第二枢轴支承件至少在一侧上可在其上安装所述储存隔间的支撑部分。从而获得了一种易于安装的橱柜安装部件，其具有非常稳定的结构并且可以以各种方式使用。

88. 发明申请

US20070137435A1 Method and plant for the heat treatment of solids containing iron oxide using a fluidized bed reactor 有权
标题翻译：使用流化床反应器对含有氧化铁的固体进行热处理的方法和设备
公开(公告)号：US20070137435A1
公开(公告)日：2007-06-21
申请号：US10540435
申请日：2003-12-01
申请人： Andreas Orth , Martin Hirsch , Peter Weber , Stuart Sneyd , Dirk Nuber , Michael Stroder
发明人： Andreas Orth , Martin Hirsch , Peter Weber , Stuart Sneyd , Dirk Nuber , Michael Stroder
IPC分类号： C21B13/00
CPC分类号： B01J8/18 , B01J8/1863 , B01J8/30 , B01J8/44 , B01J2208/00061 , C22B1/10 , C22B5/14 , F27B15/02 , F27B15/08 , F27B15/10
摘要： The present invention relates to a method and a plant for the heat treatment of solids containing iron oxide, in which fine-grained solids are heated to a temperature of 700 to 1150° C. in a fluidized bed reactor (8). To improve the utilization of energy, it is proposed to introduce a first gas or gas mixture from below through at least one gas supply tube (9) into a mixing chamber region (15) of the reactor (8), the gas supply tube (9) being at least partly surrounded by a stationary annular fluidized bed (12) which is fluidized by supplying fluidizing gas. The gas velocities of the first gas or gas mixture and of the fluidizing gas for the annular fluidized bed (12) are adjusted such that the Particle-Froude-Numbers in the gas supply tube (9) are between 1 and 100, in the annular fluidized bed (12) between 0.02 and 2, and in the mixing chamber (15) between 0.3 and 30.
摘要翻译：本发明涉及用于热处理包含氧化铁的固体的方法和设备，其中在流化床反应器（8）中将细粒固体加热至700至1150℃的温度。为了提高能量的利用率，建议从下方通过至少一个气体供给管（9）将第一气体或气体混合物引入反应器（8）的混合室区域（15），气体供给管 9）至少部分地被固定的环形流化床（12）包围，所述静止环形流化床通过供应流化气体而被流化。第一气体或气体混合物以及用于环形流化床（12）的流化气体的气体速度被调整为使得气体供应管（9）中的“微粒 - 弗劳德数”在1和100之间，在环形流化床（12）在0.02和2之间，在混合室（15）中在0.3和30之间。

89. 发明申请

US20060247485A1 SYSTEM AND METHOD FOR TREATING INFECTIOUS WASTE MATTER 有权
标题翻译：用于处理感染性废物的系统和方法
公开(公告)号：US20060247485A1
公开(公告)日：2006-11-02
申请号：US11457342
申请日：2006-07-13
申请人： Joseph Wilson , Gordon Kaye , Robert Hahn , Peter Weber , Kevin Morris
发明人： Joseph Wilson , Gordon Kaye , Robert Hahn , Peter Weber , Kevin Morris
IPC分类号： A62D3/00 , A61L2/18 , A61L2/00
CPC分类号： A62D3/35 , A61L2/04 , A61L2/18 , A61L2/24 , A61L11/00 , A62D2101/02 , A62D2101/04 , A62D2101/20 , A62D2101/28 , A62D2203/10 , B09B3/00 , B09B3/0075 , B09B3/0083 , G21F9/34
摘要： In accordance with the present invention, a system and method is provided for producing a safely disposable end product from waste matter containing undesirable materials, such as infectious, biohazardous, hazardous, or radioactive elements. The method comprises the steps of providing a highly basic solvent, immersing the waste matter containing the undesirable materials within the highly basic solvent, and heating the solvent. The waste matter containing the undesirable materials is allowed to remain within the solvent until digested, thereby forming a solution void of any infectious or biohazardous elements and/or containing a concentration of radioisotope below the maximum permissible concentration (MPC) for release to a sanitary sewer as defined in applicable federal regulations. The invention further provides a system for producing a safely disposable end product void of any infectious or biohazardous elements and/or containing only a concentration of radioisotope below the MPC for release to a sanitary sewer as defined in applicable federal regulations from waste matter containing such materials. The system comprises a tank or vessel capable of containing a highly basic solvent during a closed digestion reaction, heating means for heating the solvent within the vessel, filtering means, and means for removing the post-digestion aqueous solution and solid waste materials from within the vessel. The post-digestion product in both aqueous and solid form can then by disposed of by conventional means.
摘要翻译：根据本发明，提供了一种系统和方法，用于从含有不希望的材料（例如感染性，生物危害性的，危险的或放射性的）元素的废物中产生安全的一次性最终产品。该方法包括提供高碱性溶剂，将含有不需要的物质的废物浸入高碱性溶剂中并加热溶剂的步骤。允许含有不需要的材料的废物保留在溶剂中直到消化，从而形成无法感染或生物危害的元素的溶液和/或含有低于最大允许浓度（MPC）的放射性同位素浓度以释放到卫生污水管如适用的联邦法规所定义。本发明还提供了一种用于生产无任何传染性或生物危害元素的安全的一次性终端产品和/或仅在MPC下方仅含有放射性同位素浓度的系统，用于根据适用的联邦法规从含有这种材料的废物中定义的卫生下水道。该系统包括能够在封闭的消化反应期间容纳高碱性溶剂的罐或容器，用于加热容器内的溶剂的加热装置，过滤装置和用于从消化反应器内部除去消化后水溶液和固体废物的装置船只。然后可以通过常规方法处理水和固体形式的消化后产物。

90. 发明申请

US20060222574A1 Apparatus and method for chemically reducing waste materials 审中-公开
公开(公告)号：US20060222574A1
公开(公告)日：2006-10-05
申请号：US11096330
申请日：2005-04-02
申请人： Gordon Kaye , Peter Weber , Kevin Morris , Joseph Wilson , Robert Hahn
发明人： Gordon Kaye , Peter Weber , Kevin Morris , Joseph Wilson , Robert Hahn
IPC分类号： A62D3/00 , B09B3/00
CPC分类号： B09B3/00 , A61L11/00 , B01J4/002 , B01J19/26 , B01J2208/00814 , B09B3/0075 , B09B3/0083
摘要： In accordance with the present invention, a system, method and apparatus is provided for chemically reducing waste. The apparatus includes a substantially alkaline-resistant vessel having a temperature sensor positioned in thermal communication therewith, a heater in thermal communication with the vessel, a substantially alkaline-resistant magnetic stir rod adapted to be positioned within the vessel, and a magnetic stirrer adapted to produce a rotating magnetic field within the vessel capable of spinning a magnetic stir rod positioned therein. The apparatus further includes a water inlet valve operationally connected to the vessel and a water outlet valve operationally connected to the vessel. An electronic controller is connected in electric communication to the heater, to the magnetic stirrer, to the water inlet valve, to the water outlet valve, and to the temperature sensor and is adapted to maintain the temperature of the substantially alkaline resistant vessel substantially at a predetermined value.

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