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81. 发明授权

US06780591B2 Method of determining the nucleotide sequence of oligonucleotides and DNA molecules 有权
标题翻译：确定寡核苷酸和DNA分子核苷酸序列的方法
公开(公告)号：US06780591B2
公开(公告)日：2004-08-24
申请号：US09941882
申请日：2001-08-28
申请人： Peter Williams , Thomas J. Taylor , Daniel J. B. Williams , Ian Gould , Mark A. Hayes
发明人： Peter Williams , Thomas J. Taylor , Daniel J. B. Williams , Ian Gould , Mark A. Hayes
IPC分类号： C12Q168
CPC分类号： C12P19/34 , C12Q1/6816 , C12Q1/6869 , C12Q2565/629 , C12Q2533/101 , C12Q2565/301 , C12Q2563/107 , C12Q2563/103
摘要： The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.
摘要翻译：本发明涉及一种用于分析核酸序列的新方法，该方法基于DNA聚合酶催化的四个核苷酸碱基中的每一个（在微流体系统中单独提供和连续供给）中并入到包含模板系统的反应池中包含未知序列的DNA片段和寡核苷酸引物。将核苷酸碱基掺入模板系统可以通过多种方法中的任何一种检测，包括但不限于荧光和化学发光检测。或者，可以使用通过使用热电堆，热敏电阻和折射率测量将核苷酸并入扩展模板系统产生的热的微量热法测定来检测延伸反应。

82. 发明授权

US06324645B1 Risk management for public key management infrastructure using digital certificates 有权
标题翻译：使用数字证书的公钥管理基础设施的风险管理
公开(公告)号：US06324645B1
公开(公告)日：2001-11-27
申请号：US09132289
申请日：1998-08-11
申请人： Richard F Andrews , Peter Williams , Judy Lin
发明人： Richard F Andrews , Peter Williams , Judy Lin
IPC分类号： H04K100
CPC分类号： H04L9/006 , H04L9/3263 , H04L2209/56
摘要： A public key management infrastructure (104) is shared by at least two users (102). A method (300) for managing risk arising from a user's use of the shared public key management infrastructure (104) includes the following steps. The user (102) is associated (301) with a digital certificate (200) which is issued and digitally signed by a certification authority (CA). The digital certificate (200) represents that the user (102) is bound to a public key (210) corresponding to a private key held by the user (102); the public key (210) and the private key form a key pair for use in public-key cryptography. The digital certificate (200) further includes an access label (216), which may identify the domain (105) within the public key management infrastructure (104) which the user (102) is authorized to access and/or the privileges which the user (102) is authorized to exercise. The user's identity and the validity of the digital certificate (200) are established (303,305). The access label (216) is read (304) from the user's digital certificate (200), and the user's use of the public key management infrastructure (104) is controlled (306) based upon the access label (216).
摘要翻译：公共密钥管理基础设施（104）由至少两个用户共享（102）。一种用于管理由用户使用共享公钥管理基础设施（104）引起的风险的方法（300），包括以下步骤。用户（102）与由认证机构（CA）发行和数字签名的数字证书（200）相关联（301）。数字证书（200）表示用户（102）被绑定到对应于由用户（102）保存的私钥的公钥（210）; 公开密钥（210）和私钥形成用于公钥密码术的密钥对。数字证书（200）还包括访问标签（216），其可以标识用户（102）被授权访问的公共密钥管理基础设施（104）内的域（105）和/或用户（102）有权行使。建立用户身份和数字证书（200）的有效性（303,305）。从用户的数字证书（200）读取访问标签（216）（304），并且基于访问标签（216）控制用户对公钥管理基础设施（104）的使用（306）。

83. 发明申请

US20120258449A1 METHOD OF DETERMINING THE NUCLEOTIDE SEQUENCE OF OLIGONUCLEOTIDES AND DNA MOLECULES 审中-公开
公开(公告)号：US20120258449A1
公开(公告)日：2012-10-11
申请号：US13408458
申请日：2012-02-29
申请人： Peter Williams , Thomas J. Taylor , Daniel J.B. Williams , Ian Gould , Mark A. Hayes
发明人： Peter Williams , Thomas J. Taylor , Daniel J.B. Williams , Ian Gould , Mark A. Hayes
IPC分类号： G01N27/00 , G01N21/64
CPC分类号： C12Q1/6869 , C12Q1/6816 , C12Q1/6825 , C12Q2533/101 , C12Q2563/103 , C12Q2563/107 , C12Q2563/116 , C12Q2565/301 , C12Q2565/629 , G01N33/573 , G01N33/6863
摘要： The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.

84. 发明授权

US08263364B2 Method of determining the nucleotide sequence of oligonucleotides and DNA molecules 有权
标题翻译：确定寡核苷酸和DNA分子核苷酸序列的方法
公开(公告)号：US08263364B2
公开(公告)日：2012-09-11
申请号：US13008303
申请日：2011-01-18
申请人： Peter Williams , Thomas J. Taylor , Daniel J. B. Williams , Ian Gould , Mark A. Hayes
发明人： Peter Williams , Thomas J. Taylor , Daniel J. B. Williams , Ian Gould , Mark A. Hayes
IPC分类号： C12P19/34 , C12P1/68 , C07H21/00
CPC分类号： C12Q1/6869 , C12Q1/6816 , C12Q1/6825 , C12Q2533/101 , C12Q2563/103 , C12Q2563/107 , C12Q2563/116 , C12Q2565/301 , C12Q2565/629 , G01N33/573 , G01N33/6863
摘要： The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.
摘要翻译：本发明涉及一种用于分析核酸序列的新方法，该方法基于DNA聚合酶催化的四个核苷酸碱基中的每一个（在微流体系统中单独提供和连续供给）中并入到包含模板系统的反应池中包含未知序列的DNA片段和寡核苷酸引物。将核苷酸碱基掺入模板系统可以通过多种方法中的任何一种检测，包括但不限于荧光和化学发光检测。或者，可以使用通过使用热电堆，热敏电阻和折射率测量将核苷酸并入扩展模板系统产生的热的微量热法测定来检测延伸反应。

85. 发明授权

US08195526B2 Providing a personalized transactional benefit 有权
标题翻译：提供个性化的交易收益
公开(公告)号：US08195526B2
公开(公告)日：2012-06-05
申请号：US11979332
申请日：2007-11-01
申请人： Peter Williams
发明人： Peter Williams
IPC分类号： G06Q30/00
CPC分类号： G06Q30/02 , G06Q10/00 , G06Q20/20 , G06Q30/0207 , G06Q30/0222 , G06Q30/0224 , G06Q30/06 , G06Q30/0601 , G06Q30/0609 , G06Q30/0623
摘要： A mobile device is described for providing a personalized transactional benefit at a point of purchase. The mobile device includes a communications module that is configured to retrieve from a network personalized identification information associated with a consumer based on a personalized identifier uniquely associated with the consumer. The mobile device further includes a reader coupled to the communications module. The reader is configured to capture, at the point of purchase, an image representing a product identification indicia. The communications module accesses the network to identify the captured image and to retrieve from the network information associated with the captured image. Finally, the mobile device includes a visual output device coupled to the communications module. The visual output device is configured to visually output the personalized transactional benefit based on the personalized identification information associated with the consumer and the information associated with the captured image. The consumer identity is preferably shielded from a retail establishment where the product identification indicia is captured.
摘要翻译：描述了一种移动设备，用于在购买点提供个性化的交易收益。移动设备包括通信模块，其被配置为基于与消费者唯一相关联的个性化标识符从网络中检索与消费者相关联的个性化标识信息。移动设备还包括耦合到通信模块的读取器。读取器被配置为在购买时捕获表示产品识别标记的图像。通信模块访问网络以识别捕获的图像并从网络检索与捕获的图像相关联的信息。最后，移动设备包括耦合到通信模块的视觉输出设备。视觉输出设备被配置为基于与消费者相关联的个性化标识信息和与捕获图像相关联的信息来视觉地输出个性化的交易收益。消费者身份优选地与捕获产品识别标记的零售店隔离。

86. 发明授权

US08192684B2 Decontamination of enclosed space using gaseous chlorine dioxide 有权
标题翻译：使用气态二氧化氯对封闭空间进行净化
公开(公告)号：US08192684B2
公开(公告)日：2012-06-05
申请号：US12769471
申请日：2010-04-28
申请人： John Y. Mason , Peter Williams , Maggie Trabeau
发明人： John Y. Mason , Peter Williams , Maggie Trabeau
IPC分类号： C23F11/00 , G01D11/26 , A62B7/08 , A01M13/00
CPC分类号： A61L9/00 , A61L2/20 , A61L2/22 , A61L9/015 , A61L9/03 , A61L9/04 , A61L9/122 , A61L9/145 , A61L2202/25 , A61L2209/22 , B01F5/20 , C01B11/022 , F24F6/00
摘要： A method for gas phase application of chlorine dioxide within an enclosed volume that includes the steps of: climatizing the enclosed volume to achieve a relative humidity (RH) in the range of about 5% to about 56%; generating chlorine dioxide gas; and introducing the chlorine dioxide gas under specified conditions of chlorine dioxide gas concentration and contact time, the specified conditions being effective to eliminate contaminants within the closed volume, and further to mitigate corrosion within the enclosed volume during the gas phase application.
摘要翻译：一种在封闭容积内气相施用二氧化氯的方法，包括以下步骤：使封闭体积气化，以达到约5％至约56％范围内的相对湿度（RH）; 产生二氧化氯气体; 并在二氧化氯气体浓度和接触时间的规定条件下引入二氧化氯气体，规定的条件有效地消除封闭体积内的污染物，并进一步减轻在气相施加期间封闭体积内的腐蚀。

87. 发明申请

US20110183322A1 METHOD OF DETERMINING THE NUCLEOTIDE SEQUENCE OF OLIGONUCLEOTIDES AND DNA MOLECULES 有权
公开(公告)号：US20110183322A1
公开(公告)日：2011-07-28
申请号：US13008303
申请日：2011-01-18
申请人： Peter Williams , Thomas J. Taylor , Daniel J.B. Williams , Ian Gould , Mark A. Hayes
发明人： Peter Williams , Thomas J. Taylor , Daniel J.B. Williams , Ian Gould , Mark A. Hayes
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q1/6816 , C12Q1/6825 , C12Q2533/101 , C12Q2563/103 , C12Q2563/107 , C12Q2563/116 , C12Q2565/301 , C12Q2565/629 , G01N33/573 , G01N33/6863
摘要： The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.

88. 发明申请

US20100185847A1 Database outsourcing with access privacy 有权
标题翻译：数据库外包与访问隐私
公开(公告)号：US20100185847A1
公开(公告)日：2010-07-22
申请号：US12321326
申请日：2009-01-20
申请人： Dennis Shasha , Peter Williams , Radu Sion
发明人： Dennis Shasha , Peter Williams , Radu Sion
IPC分类号： H04L9/00 , G06F12/14 , G06F13/00
CPC分类号： H04L63/0435 , G06F11/1004 , G06F21/54 , G06F21/602 , G06F21/606 , G06F21/6263 , G06F2221/2101 , G06F2221/2151
摘要： This invention introduces a new paradigm for outsourcing the transaction processing backend of a multi-client database application to an untrusted service provider. Specifically, the invention enables untrusted service providers to support transaction serialization, backup and recovery for clients, with full data confidentiality and correctness. Moreover, providers learn nothing about transactions (except their size and timing), thus achieving read and write access pattern privacy.
摘要翻译：本发明引入了将多客户端数据库应用的事务处理后端外包给不可信服务提供商的新范例。具体来说，本发明使得不信任的服务提供商能够以完整的数据机密性和正确性支持客户端的事务序列化，备份和恢复。此外，提供商对事务（尺寸和时间除外）也没有学习，从而实现读写访问模式隐私。

89. 发明授权

US07459677B2 Mass spectrometer for trace gas leak detection with suppression of undesired ions 失效
标题翻译：用于痕量气体泄漏检测的质谱仪，抑制不需要的离子
公开(公告)号：US07459677B2
公开(公告)日：2008-12-02
申请号：US11354410
申请日：2006-02-15
申请人： J. Daniel Geist , Jeffrey Diep , Peter Williams , Charles W. Perkins
发明人： J. Daniel Geist , Jeffrey Diep , Peter Williams , Charles W. Perkins
IPC分类号： B01D59/44
CPC分类号： H01J49/147 , H01J49/30
摘要： Mass spectrometers for trace gas leak detection and methods for operating mass spectrometers are provided. The mass spectrometer includes an ion source to ionize trace gases, such as helium, a magnet to deflect the ions and a detector to detect the deflected ions. The ion source includes an electron source, such a filament. The method includes operating the electron source at an electron accelerating potential relative to an ionization chamber sufficient to ionize the trace gas but insufficient to form undesired ions, such as triply charged carbon.
摘要翻译：提供了用于痕量气体泄漏检测的质谱仪和操作质谱仪的方法。质谱仪包括离子源，用于电离痕量气体，例如氦气，磁体以使离子偏转和检测器以检测偏转的离子。离子源包括电子源，这种细丝。该方法包括相对于离子化室操作电子加速电位，其足以使痕量气体离子化，但不足以形成不需要的离子，例如三重充电的碳。

90. 发明授权

US07427751B2 High sensitivity slitless ion source mass spectrometer for trace gas leak detection 有权
标题翻译：高灵敏度无缝离子源质谱仪，用于痕量气体泄漏检测
公开(公告)号：US07427751B2
公开(公告)日：2008-09-23
申请号：US11354737
申请日：2006-02-15
申请人： J. Daniel Geist , Jeffrey Diep , Peter Williams , Charles W. Perkins
发明人： J. Daniel Geist , Jeffrey Diep , Peter Williams , Charles W. Perkins
IPC分类号： B01D59/44
CPC分类号： H01J49/30 , H01J37/08 , H01J49/147
摘要： A mass spectrometer includes a main magnet having spaced-apart polepieces which define a gap, the main magnet producing a magnetic field in the gap, an ion source to generate ions and to accelerate the ions into the magnetic field in the gap, the ion source located outside the gap, and an ion detector to detect a selected species of the ions generated by the ion source and deflected by the magnetic field. The ion detector is located in the gap at a natural focus point of the selected species of ions. The mass spectrometer may be used in a trace gas leak detector.
摘要翻译：质谱仪包括具有限定间隙的间隔开的极点的主磁体，主磁体在间隙中产生磁场，离子源产生离子并将离子加速到间隙中的磁场中，离子源位于间隙之外，以及离子检测器，用于检测由离子源产生的并被磁场偏转的选定种类的离子。离子检测器位于所选离子种类的自然聚焦点的间隙中。质谱仪可用于痕量气体检漏仪。

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