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81. 发明申请

US20090122823A1 Monolithically integrated laser diode chip having a construction as a multiple beam laser diode 有权
标题翻译：具有构造为多光束激光二极管的单片集成激光二极管芯片
公开(公告)号：US20090122823A1
公开(公告)日：2009-05-14
申请号：US12217100
申请日：2008-06-30
申请人： Martin Muller , Gunther Gronninger , Alexander Behres
发明人： Martin Muller , Gunther Gronninger , Alexander Behres
IPC分类号： H01S5/026 , H01S5/323
CPC分类号： H01S5/4043 , H01S5/3095 , H01S5/3201 , H01S5/3211 , H01S5/3215 , H01S5/4018
摘要： A monolithically integrated laser diode chip having a construction as a multiple beam laser diode, which, on a semiconductor substrate (3) comprised of GaAs, has at least two laser stacks (4a, 4b, 4c) which are arranged one above another and which each contain an active zone (7). The active zone (7) is in each case arranged between waveguide layers (8). The waveguide layers (8) each adjoin a cladding layer (6) at a side remote from the active zone. At least one of the waveguide layers (8) or cladding layers (6) of at least one laser stack (4a, 4b, 4c), comprises AlxGa1-xAs, where 0≦x≦1, and at least one additional material from main group III or V, such that the lattice mismatch between the at least one waveguide layer (8) or cladding layer (6) comprising the at least one additional element and the semiconductor substrate (3) composed of GaAs is reduced. This increases the lifetime of the laser diode chip.
摘要翻译：具有构造为多光束激光二极管的单片集成激光二极管芯片，其在由GaAs构成的半导体衬底（3）上具有至少两个激光堆叠（4a，4b，4c）每个都包含活动区域（7）。有源区（7）分别布置在波导层（8）之间。每个波导层（8）在远离有源区的一侧与包层（6）相邻。至少一个激光堆叠（4a，4b，4c）的至少一个波导层（8）或覆层（6）包括Al x Ga 1-x As，其中0≤x≤1，以及至少一种附加材料来自主组III或V，使得包括至少一个附加元件的至少一个波导层（8）或包层（6）与由GaAs构成的半导体衬底（3）之间的晶格失配减小。这增加了激光二极管芯片的寿命。

82. 发明申请

US20090117641A1 Mutated Abl Kinase Domains 审中-公开
标题翻译：突变的Abl激酶结构域
公开(公告)号：US20090117641A1
公开(公告)日：2009-05-07
申请号：US12165217
申请日：2008-06-30
申请人： Christophe Barthe , Susan Bradford , Amie Corbin , Brian Jay Druker , Justus Duyster , Andreas Hochhaus , Timothy Hughes , Sebastian Kreil , Thibaut Leguay , Francios-Xavier Mahon , Gerald Marit , Martin Muller , Christian Peschel , Claude Preudhomme , Catherine Roche Lestienne , Zbigniew Rudzki
发明人： Christophe Barthe , Susan Bradford , Amie Corbin , Brian Jay Druker , Justus Duyster , Andreas Hochhaus , Timothy Hughes , Sebastian Kreil , Thibaut Leguay , Francios-Xavier Mahon , Gerald Marit , Martin Muller , Christian Peschel , Claude Preudhomme , Catherine Roche Lestienne , Zbigniew Rudzki
IPC分类号： C12N9/12
CPC分类号： C12N9/1205
摘要： The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317, Met318, Met351, Glu355, Glu359, Ile360, His361, Leu370, Asp381, Phe382, His396, Ser417, Glu459 and Phe486 is replaced by another amino acid, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.
摘要翻译：本发明涉及分离的多肽，其包含功能性激酶结构域，所述功能性激酶结构域包含天然人Abl激酶结构域的氨基酸序列或其基本相似的序列，其中至少一种选自Met244，Leu248，Gly250，Glu252，Tyr253， Val256，Glu258，Phe311，Ile313，Phe317，Met318，Met351，Glu355，Glu359，Ile360，His361，Leu370，Asp381，Phe382，His396，Ser417，Glu459和Phe486被另一个氨基酸取代，所述突变的功能性激酶结构域对通过N- [4-甲基-3-（4-吡啶-3-基 - 嘧啶-2-基氨基） - 苯基] -4-（4-甲基 - 哌嗪-1-基甲基） - 苯甲酰胺抑制其酪氨酸激酶活性或其盐使用这样的多肽筛选抑制这种多肽的酪氨酸激酶活性的化合物，编码这种多肽的核酸分子，重组载体和包含此类核酸分子的宿主细胞，以及使用其核酸分子生产这样的多肽用于筛选抑制这些多肽的酪氨酸激酶活性的化合物。

83. 发明申请

US20090099282A1 Functionalized nanoparticles 审中-公开
标题翻译：官能化纳米粒子
公开(公告)号：US20090099282A1
公开(公告)日：2009-04-16
申请号：US11920295
申请日：2006-05-17
申请人： Martin Muller , Andreas Muhlebach , Thomas Giesenberg , Didier Bauer , Thomas Ruch , Francois Rime , Leonhard Feiler , Roman Lenz , Laurent Michau
发明人： Martin Muller , Andreas Muhlebach , Thomas Giesenberg , Didier Bauer , Thomas Ruch , Francois Rime , Leonhard Feiler , Roman Lenz , Laurent Michau
IPC分类号： C08K5/5419 , C04B16/00 , C08K5/00
CPC分类号： C09B69/103 , C09B67/0097 , C09B68/20 , C09B68/443 , C09B69/10
摘要： The present invention discloses functionalized nanoparticles comprising on the surface a covalently bound radical of formula (1), wherein the nanoparticles are SiO2, Al2O3 or mixed SiO2 and Al2O3 nanoparticles, R1 and R2 are independently of each other hydrogen, nanoparticle surface-O—, or a substituent, n is 1, 2, 3, 4, 5, 6, 7 or 8, and Y is a radical of formula —B1-D1 (2a), wherein B1 is the direct bond or a bridge member, and D1 is a radical of a cationic dye, a radical of a phthalocyanine dye which carries no water-solubilizing group, or a radical of a fluorescent dye selected from the group consisting of coumarins, benzocoumarins, xanthenes, benzo[a]xanthenes, benzo[b]xanthenes, benzo[c]xanthenes, phenoxazines, benzo[a]phenoxazines, benzo[b]phenoxazines, benzo[c]phenoxazines, napthalimides, naphtholactams, azlactones, methines, oxazines, thiazines, diketopyrrolopyrroles, quinacridones, benzoxanthenes, thio-epindolines, lactamimides, diphenylmaleimides, acetoacetamides, imidazothiazines, benzanthrones, phthalimides, benzotriazoles, pyrimidines, pyrazines and triazines, or Y is a radical of formula —B2D2 (2b), wherein B2 is an organic radical comprising at least one group having a negative charge, and D2 is a cationic dye selected from the group consisting of monoazo, disazo, polyazo, methine, azamethine, diphenylmethane, triphenylmethane, triaminotriaryl methane, azine, oxazine, cyanine and anthraquinone dyes.
摘要翻译：本发明公开了在表面上包含式（1）的共价结合基团的官能化纳米颗粒，其中纳米颗粒是SiO 2，Al 2 O 3或混合的SiO 2和Al 2 O 3纳米颗粒，R 1和R 2彼此独立地是氢，纳米颗粒表面-O-，或取代基，n为1,2,3,4,5,6,7或8，并且Y为式-B1-D1（2a）的基团，其中B1为直接键或桥式构件，D1为是阳离子染料的自由基，不含水溶性基团的酞菁染料的基团，或选自香豆素，苯并香豆素，呫吨，苯并[a]呫吨，苯并[b 苯并[c]呫吨酮，苯并[c]呫吨酮，吩恶嗪，苯并[a]吩恶嗪，苯并[b]吩恶嗪，苯并[c]吩恶嗪，萘酰亚胺，萘并内酰胺，吖内酯，次甲基，恶嗪，噻嗪，二酮吡咯并吡咯，喹吖啶酮，苯并恶庚烯，硫代 - ，内酰胺，二苯基马来酰亚胺，乙酰乙酰胺，咪唑硫基吖嗪，苯并呋喃，邻苯二甲酰亚胺，苯并三唑，嘧啶，吡嗪和三嗪，或Y是式-B2D2（2b）的基团，其中B2是包含至少一个具有负电荷的基团的有机基团，并且D2是选择的阳离子染料来自由单偶氮，双偶氮，多偶氮，次甲基，氮杂酮，二苯基甲烷，三苯甲烷，三氨基三芳基甲烷，吖嗪，恶嗪，花青和蒽醌染料组成的组。

84. 发明申请

US20090029210A1 Low-Temperature Fuel-Cell Stack and Method of Operating Same 审中-公开
标题翻译：低温燃料电池堆和操作方法相同
公开(公告)号：US20090029210A1
公开(公告)日：2009-01-29
申请号：US11887815
申请日：2006-03-18
申请人： Martin Muller , Hendrik Dohle , Jurgen Mergel , Thorsten Wuster , Detlef Stolten
发明人： Martin Muller , Hendrik Dohle , Jurgen Mergel , Thorsten Wuster , Detlef Stolten
IPC分类号： H01M8/04 , H01M8/00
CPC分类号： H01M8/04201 , H01M8/04194 , H01M8/04455 , H01M8/045 , H01M8/04507 , H01M8/04731 , H01M8/04753 , H01M8/04835 , H01M8/04873 , H01M8/2465
摘要： The invention relates to a low-temperature fuel cell stack comprising a specific device for the supply of fuel. Said low-temperature fuel cell stack is characterised in that, in addition to the central fuel supply device, it comprises a supply or storage device for a liquid fuel, and a plurality of separately controllable dosing devices that lead into the central fuel supply device, especially respectively upstream of a distribution channel to the individual cells. Controllable valves, controllable piezoelectric pumps or thermally controllable supply elements are suitable as dosing devices. The invention also relates to a method for operating one such low-temperature fuel cell stack, which advantageously enables a defined concentration of fuel, or a defined humidity of the oxidation medium, to be adjusted at certain points in the fuel cell stack, especially on the inlet for the individual cells.
摘要翻译：本发明涉及一种包括用于供应燃料的特定装置的低温燃料电池堆。所述低温燃料电池堆的特征在于，除了中央燃料供应装置之外，其还包括用于液体燃料的供应或存储装置以及引导到中央燃料供应装置的多个单独可控的计量装置，特别是分配到各个单元的分配通道的上游。可控制的阀门，可控制的压电泵或热可控供应元件适合作为定量给料装置。本发明还涉及一种用于操作一种这样的低温燃料电池堆的方法，其有利地使燃料的确定浓度或氧化介质的限定湿度在燃料电池堆中的某些点被调节，特别是在单个细胞的入口。

85. 发明申请

US20090018753A1 SYSTEM AND METHOD FOR A VOLUMETRIC EFFICIENCY MODEL FOR ALL AIR INDUCTION CONFIGURATIONS 有权
标题翻译：用于所有空气感应配置的体积效率模型的系统和方法
公开(公告)号：US20090018753A1
公开(公告)日：2009-01-15
申请号：US11948297
申请日：2007-11-30
申请人： Martin Muller
发明人： Martin Muller
IPC分类号： F02D41/26 , F02D41/38
CPC分类号： F02D41/1497 , F02D41/0007 , F02D41/1448 , F02D41/2432 , F02D2200/0402 , F02D2200/0406 , F02D2200/1006
摘要： A system and method for controlling an engine involves providing a model for volumetric efficiency. The model recognizes that volumetric efficiency (VE) has stronger dependency on intake pressure than on exhaust pressure. The model allows tuning of the relative importance of intake pressure to exhaust pressure, specifically, by reducing the relative importance of the exhaust pressure to intake pressure in the composite volumetric efficiency load variable. The model provides for a calculation where the exhaust pressure term of the engine pressure ratio is de-rated through the use of an exponent less than one.
摘要翻译：用于控制发动机的系统和方法包括提供容积效率的模型。该模型认识到体积效率（VE）对进气压力的依赖性高于排气压力。该模型允许调节进气压力对排气压力的相对重要性，特别是通过降低复合容积效率负载变量中排气压力对进气压力的相对重要性。该模型提供了通过使用指数小于1的发动机压力比的排气压力项降低的计算。

86. 发明授权

US07416732B2 Papilloma virus-like particles, fusion proteins as well as processes for their production 失效
标题翻译：乳头瘤病毒样颗粒，融合蛋白以及其生产过程
公开(公告)号：US07416732B2
公开(公告)日：2008-08-26
申请号：US11358474
申请日：2006-02-21
申请人： Lutz Gissmann , Jian Zhou , Martin Muller , Jeanette Painstil
发明人： Lutz Gissmann , Jian Zhou , Martin Muller , Jeanette Painstil
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K2039/5256 , A61K2039/5258 , C07K2319/00 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
摘要： The invention relates to the recombinant production of proteins as well as VLPs which are suitable as a vaccine for therapeutic and prophylactic vaccination. The invention also relates to processes for the production and purification of recombinant papilloma virus proteins and fusion proteins.
摘要翻译：本发明涉及适合作为治疗和预防性接种疫苗的蛋白质以及VLP的重组生产。本发明还涉及生产和纯化重组乳头状瘤病毒蛋白和融合蛋白的方法。

87. 发明申请

US20080197289A1 Measuring arrangement and measuring system 有权
标题翻译：测量装置和测量系统
公开(公告)号：US20080197289A1
公开(公告)日：2008-08-21
申请号：US12011427
申请日：2008-01-25
申请人： Martin Muller
发明人： Martin Muller
IPC分类号： G01T1/24
CPC分类号： G01S17/10 , G01S7/4814 , G01S7/4818 , G01S17/58 , G01S17/87 , G01S17/936 , H01S5/005 , H01S5/0071 , H01S5/026 , H01S5/1021 , H01S5/18383 , H01S5/18397 , H01S5/3095 , H01S5/423
摘要： A measuring arrangement comprises a radiation device (SE), having at least one first surface emitting semiconductor component (1) with a vertical emission direction, a detection device (DE) for detecting reflected radiation, and an evaluation circuit (AS), set up for controlling the radiation device (SE) and the detection device (DE) and for processing a detection result of the detection device (DE). The semiconductor component (1) comprises a semiconductor body (2) with a plurality of active regions (4a, 4b) suitable for generating radiation and arranged at a distance from one another in a vertical direction. In this case, a tunnel junction (5) is monolithically integrated in the semiconductor body (2) between two active regions (4a, 4b) and the two active regions (4a, 4b) are electrically conductively connected by means of the tunnel junction during operation of the semiconductor component (1).
摘要翻译：测量装置包括具有至少一个具有垂直发射方向的第一表面发射半导体部件（1）的辐射装置（SE），用于检测反射辐射的检测装置（DE），以及评估电路（AS）用于控制辐射装置（SE）和检测装置（DE）并用于处理检测装置（DE）的检测结果。半导体部件（1）包括半导体本体（2），其具有适于产生辐射的多个有源区域（4a，4b），并且在垂直方向上彼此间隔开设置。在这种情况下，隧道结（5）在两个有源区（4a，4b）之间的半导体本体（2）中单片集成，并且两个有源区（4a，4b）通过以下方式导电连接：在半导体部件（1）的操作期间的隧道结。

88. 发明申请

US20080123710A1 Edge emitting semiconductor laser comprising a plurality of monolithically integrated laser diodes 有权
标题翻译：包括多个单片集成激光二极管的边缘发射半导体激光器
公开(公告)号：US20080123710A1
公开(公告)日：2008-05-29
申请号：US11904060
申请日：2007-09-25
申请人： Peter Brick , Johann Luft , Martin Muller , Marc Philippens
发明人： Peter Brick , Johann Luft , Martin Muller , Marc Philippens
IPC分类号： H01S5/026
CPC分类号： H01S5/4043 , B82Y20/00 , H01S5/02461 , H01S5/0421 , H01S5/2004 , H01S5/3095 , H01S5/3213 , H01S5/34 , H01S5/4018 , H01S5/4087
摘要： An edge emitting semiconductor laser containing a plurality of monolithically integrated laser diodes (1, 2, 3). Each laser diode (1, 2, 3) contains an active zone (11, 12, 13), with the active zones (11, 12, 13) being in each case arranged between waveguide layers (6), the waveguide layers (6) in each case adjoining a cladding layer (7, 8) at a side remote from the active zone (11, 12, 13). The cladding layers (7, 8) comprise inner cladding layers (7), which are arranged above a bottommost active zone (11) and below a topmost active zone (13), and outer cladding layers (8) which are arranged below the bottommost active zone (11) or above the topmost active zone (13). The inner cladding layers (7) have a smaller thickness than the outer cladding layers (8).
摘要翻译：一种边缘发射半导体激光器，包含多个单片集成的激光二极管（1,2,3）。每个激光二极管（1,2,3）包含有源区（11,12,13），其中有源区（11,12,13）各自布置在波导层（6）之间，波导层（6））在与活动区域（11,12,13）相邻的一侧邻接包层（7,8）。包覆层（7,8）包括布置在最下面的活性区域（11）的上方并位于最上面的活性区域（13）的下方的内部包层（7），以及设置在最下面的外部包层活动区域（11）或最上面的活动区域（13）之上。内包层（7）具有比外包层（8）更小的厚度。

89. 发明申请

US20080092778A1 Inorganic Bismuth-Containing Pigments 审中-公开
标题翻译：无机含铋颜料
公开(公告)号：US20080092778A1
公开(公告)日：2008-04-24
申请号：US11665628
申请日：2005-10-19
申请人： Didier Bauer , Philippe Bugnon , Robertus Hermans , Rene Kubben , Johannes Luijten , Martin Muller , Gregor Schmitt
发明人： Didier Bauer , Philippe Bugnon , Robertus Hermans , Rene Kubben , Johannes Luijten , Martin Muller , Gregor Schmitt
IPC分类号： C09C1/00 , C01G29/00
CPC分类号： C09C1/00 , C01P2002/50 , C01P2006/62 , C01P2006/65 , C01P2006/66 , C09D5/36 , C09D11/037
摘要： The invention relates to a coloured pigment of the general formula BiOIaBrbClcMdAe; wherein M is a cation of the alkaline-earth metals, a cation of the earth metals, a cation of the rare earth metals including the lanthanides or a cation of the metals Ge, Sn, Pb, Sb, Ti, Zr, Hf, Mn, Re, Fe, Ru, Os or Zn or a mixture of cations of those metals; A is a fluoride, aquoxide, hydroxide, carbonate, silicate, molybdate, tungstate, sulfate, borate or phosphate anion or a mixture of those anions; a is a number from 0.10 to 0.999; preferably from 0.50 to 0.90; b, c, d and e are numbers from 0 to 0.90; preferably from 0.10 to 0.50; a+b+c+d+e=1 and a+b+c
摘要翻译：本发明涉及以下通式的有色颜料：其中R 1，R 2，R 3， > e 其中M是碱土金属的阳离子，地球金属的阳离子，包括镧系元素的稀土金属的阳离子或金属Ge，Sn，Pb，Sb，Ti，Zr，Hf，Mn的阳离子，Re，Fe，Ru，Os或Zn或这些金属的阳离子的混合物; A是氟化物，氧化物，氢氧化物，碳酸盐，硅酸盐，钼酸盐，钨酸盐，硫酸盐，硼酸盐或磷酸盐阴离子或这些阴离子的混合物; a是从0.10到0.999的数字; 优选为0.50〜0.90; b，c，d和e是从0到0.90的数字; 优选为0.10〜0.50; a + b + c + d + e = 1，a + b + c <1; 涉及其制备方法及其在着色高分子量有机材料如表面涂料组合物，塑料和印刷油墨中的用途。

90. 发明申请

US20080058459A1 Porous Inorganic Materials Containing Polymer Additives 审中-公开
标题翻译：含有聚合物添加剂的多孔无机材料
公开(公告)号：US20080058459A1
公开(公告)日：2008-03-06
申请号：US11631551
申请日：2005-07-06
申请人： Fabien Brand , Patrice Bujard , Holger Hoppe , Martin Muller , Michael Tinkl
发明人： Fabien Brand , Patrice Bujard , Holger Hoppe , Martin Muller , Michael Tinkl
IPC分类号： B32B9/00
CPC分类号： C08K9/04 , C08K13/04 , Y10T428/2991
摘要： The present invention relates to SiOz flakes, especially porous SiOz flakes, wherein 0.70≦z≦2.0, especially 0.95≦z≦2.0, comprising a polymer additive in the pores, which provides enhanced (long term) efficacy. Further aspects of the invention are a process for their preparation and a polymer composition containing such SiOz flakes.
摘要翻译：本发明涉及SiO z薄片，特别是多孔的薄膜，其中0.70≤z≤2.0，特别是0.95≤z≤2.0，包括聚合物添加剂在孔中，其提供增强（长期）功效。本发明的其它方面是其制备方法和含有这种SiO 2薄片的聚合物组合物。

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