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81. 发明申请

US20090105140A1 Albumin Fusion Proteins 审中-公开
公开(公告)号：US20090105140A1
公开(公告)日：2009-04-23
申请号：US12171154
申请日：2008-07-10
申请人： Craig A. Rosen , William A. Haseltine
发明人： Craig A. Rosen , William A. Haseltine
IPC分类号： A61K38/38 , C07K14/76 , C07H21/04 , C12N15/64 , C12N1/15 , A61P43/00
CPC分类号： C07K14/76 , C07K14/56 , C07K14/59 , C07K14/61 , C07K14/62 , C07K14/65 , C07K14/705 , C07K14/7151 , C07K14/765
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

82. 发明授权

US07507413B2 Albumin fusion proteins 有权
公开(公告)号：US07507413B2
公开(公告)日：2009-03-24
申请号：US10933523
申请日：2004-09-03
申请人： Craig A. Rosen , William A. Haseltine
发明人： Craig A. Rosen , William A. Haseltine
IPC分类号： A61K39/00
CPC分类号： C12N15/62 , C07K14/765
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

83. 发明授权

US07141547B2 Albumin fusion proteins comprising GLP-1 polypeptides 有权
标题翻译：包含GLP-1多肽的白蛋白融合蛋白
公开(公告)号：US07141547B2
公开(公告)日：2006-11-28
申请号：US10775204
申请日：2004-02-11
申请人： Craig A. Rosen , William A. Haseltine , David J. Ballance , Andrew J. Turner , Steven M. Ruben
发明人： Craig A. Rosen , William A. Haseltine , David J. Ballance , Andrew J. Turner , Steven M. Ruben
IPC分类号： A61K38/38 , C07K14/76 , C07K14/765
CPC分类号： C07K14/765 , A61K31/155 , A61K31/426 , A61K31/4439 , A61K31/4965 , A61K38/00 , A61K38/04 , A61K38/17 , A61K38/28 , A61K39/21 , C07K7/06 , C07K14/005 , C07K14/435 , C07K14/4713 , C07K14/4723 , C07K14/475 , C07K14/50 , C07K14/505 , C07K14/51 , C07K14/521 , C07K14/525 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/55 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/575 , C07K14/57563 , C07K14/5759 , C07K14/585 , C07K14/59 , C07K14/60 , C07K14/605 , C07K14/61 , C07K14/62 , C07K14/635 , C07K14/65 , C07K14/655 , C07K14/665 , C07K14/705 , C07K14/7151 , C07K14/82 , C07K16/00 , C07K16/241 , C07K16/26 , C07K2317/622 , C07K2317/76 , C07K2319/00 , C07K2319/20 , C07K2319/30 , C07K2319/31 , C12N7/00 , C12N9/0006 , C12N9/0008 , C12N15/62 , C12N2501/335 , C12N2740/16111 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12Y101/01105 , C12Y102/01 , C12Y207/01095
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disordrs or conditions using albumin fusion proteins of the invention.
摘要翻译：本发明包括白蛋白融合蛋白。编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，载体含有这些核酸，用这些核酸载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法酸，载体和/或宿主细胞。另外，本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗，预防或改善疾病，紊乱或病症的方法。

84. 发明授权

US06994857B2 Albumin fusion proteins 有权
公开(公告)号：US06994857B2
公开(公告)日：2006-02-07
申请号：US09833041
申请日：2001-04-12
申请人： Craig A. Rosen , William A. Haseltine
发明人： Craig A. Rosen , William A. Haseltine
IPC分类号： A61K39/00
CPC分类号： A61K38/4846 , A01K2217/05 , A61K9/0019 , A61K38/21 , A61K38/212 , A61K38/38 , A61K47/42 , A61K47/65 , A61K48/00 , A61K2039/54 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/65 , C07K14/705 , C07K14/7151 , C07K14/76 , C07K14/765 , C07K2319/00 , C07K2319/21 , C07K2319/31 , C07K2319/50 , C07K2319/75 , C12N9/96 , C12N15/62 , Y02A50/386 , Y02A50/401 , Y02A50/412
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disordrs or conditions using albumin fusion proteins of the invention.

85. 发明授权

US06653446B2 Human hypoxanthine- (guanine) phosphoribosyl transferase-2 失效
标题翻译：人类次黄嘌呤（鸟嘌呤）磷酸核糖转移酶-2
公开(公告)号：US06653446B2
公开(公告)日：2003-11-25
申请号：US09189833
申请日：1998-11-12
申请人： Daniel P. Bednarik , Craig A. Rosen , Mark D. Adams
发明人： Daniel P. Bednarik , Craig A. Rosen , Mark D. Adams
IPC分类号： C07K100
CPC分类号： C12N9/1077 , A61K38/00
摘要： A human HPRT-2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of nephrolithiasis, anemia, precocious gout, kidney stones, Lesch-Nyhan syndrome, renal failure and uricaciduria. Antagonists against such polypeptides and their use as a therapeutic to treat disorders associated with excessive purine synthesis are also disclosed. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
摘要翻译：公开了编码这种多肽的人HPRT-2多肽和DNA（RNA），以及通过重组技术产生这种多肽的方法。还公开了利用这种多肽治疗肾结石，贫血，早熟性痛风，肾结石，莱斯 - 尼汉综合征，肾衰竭和尿酸尿的方法。还公开了抗这些多肽的拮抗剂及其作为治疗用于治疗与过量嘌呤合成相关的疾病的用途。还公开了用于鉴定编码本发明多肽的核酸序列中突变和用于检测本发明多肽的改变水平的诊断测定。

86. 发明授权

US06569660B1 Human DNase 失效
标题翻译：人类DNase
公开(公告)号：US06569660B1
公开(公告)日：2003-05-27
申请号：US09662746
申请日：2000-09-15
申请人： Craig A. Rosen , Steven M. Ruben , Mark D. Adams
发明人： Craig A. Rosen , Steven M. Ruben , Mark D. Adams
IPC分类号： C12N922
CPC分类号： C12N9/22 , A61K38/00
摘要： A human DNase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating bronchopulmonary conditions. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
摘要翻译：公开了人DNase多肽和编码这种多肽的DNA（RNA），以及通过重组技术产生这种多肽的方法。还公开了利用这种多肽来预防和/或治疗支气管肺疾病的方法。还公开了用于鉴定编码本发明多肽的核酸序列中突变和用于检测本发明多肽的改变水平的诊断测定。

87. 发明授权

US5962411A Human growth hormone variants and methods of administering same 失效
标题翻译：人类生长激素变体及其施用方法
公开(公告)号：US5962411A
公开(公告)日：1999-10-05
申请号：US710324
申请日：1996-09-16
申请人： Craig A. Rosen , Timothy A. Coleman , Mark D. Adams , Jeannine D. Gocayne
发明人： Craig A. Rosen , Timothy A. Coleman , Mark D. Adams , Jeannine D. Gocayne
IPC分类号： G01N33/53 , A61K31/70 , A61K35/76 , A61K38/00 , A61K38/27 , A61K39/395 , A61K48/00 , A61P3/00 , A61P3/04 , A61P5/00 , A61P13/12 , A61P19/00 , A61P31/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P43/00 , C07H21/04 , C07K14/61 , C07K16/26 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/09 , C12N15/18 , C12P21/02 , C12R1/19 , C07K14/00 , A61K38/16
CPC分类号： C07K14/61 , A61K38/00
摘要： There is provided a DNA (or RNA) polynucleotide sequences encoding naturally occurring splice variants of human growth hormone, hGHV-2(88) and hGHV-3(53) as well as analogs and derivatives thereof, which both lack nucleotide sequences normally present in the gene which codes for wild-type hGH. The growth hormone variants of the present invention are of human origin and are useful for diagnostic preventative and therapeutic purposes with respect to certain human diseases. The present invention is also related to a method for producing the human growth hormone variants by recombinant DNA techniques. A method of generating an antibody directed against and therefore inhibiting the activity of wild-type growth hormone is also provided.
摘要翻译：提供了编码人生长激素，hGHV-2（88）和hGHV-3（53）的天然存在的剪接变体的DNA（或RNA）多核苷酸序列以及其类似物和衍生物，其缺乏通常存在于编码野生型hGH的基因。本发明的生长激素变体是人源的，并且对于某些人类疾病的诊断预防和治疗目的是有用的。本发明还涉及通过重组DNA技术生产人生长激素变体的方法。还提供了产生针对并因此抑制野生型生长激素的活性的抗体的方法。

88. 发明授权

US07364865B2 Antibodies to myeloid progenitor inhibitory factor-1 (MPIF-1) 失效
标题翻译：骨髓祖细胞抑制因子-1（MPIF-1）的抗体
公开(公告)号：US07364865B2
公开(公告)日：2008-04-29
申请号：US11381977
申请日：2006-05-05
申请人： Reiner L. Gentz , Brent L. Kreider , Jun Zhang , Michael Antonaccio , Donna Mendrick , Pablo Jimenez , Vikram Patel , Craig A. Rosen , Mark D. Adams , Haodong Li , Steven M. Ruben
发明人： Reiner L. Gentz , Brent L. Kreider , Jun Zhang , Michael Antonaccio , Donna Mendrick , Pablo Jimenez , Vikram Patel , Craig A. Rosen , Mark D. Adams , Haodong Li , Steven M. Ruben
IPC分类号： C12N5/10 , C12N5/12 , G01N33/53 , C07K16/24
CPC分类号： G01N33/6863 , A61K38/00 , A61K48/00 , C07K1/113 , C07K1/36 , C07K14/50 , C07K14/521 , C07K14/523 , C07K16/24 , C07K2319/00 , C12N15/72 , C12N2799/026 , G01N2333/52
摘要： There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine β8 (CKβ8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-γ and chemokine β1(CKβ1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.
摘要翻译：公开了使用编码人骨髓祖细胞抑制因子-1（MPIF-1）多肽（以前称为MIP-3和趋化因子β8（CKbeta8或ckb-8））的分离的核酸分子的治疗组合物和方法。人单核细胞集落抑制因子（M-CIF）多肽（以前称为MIP1-γ和趋化因子β1（CKbeta1或ckb-1））和巨噬细胞抑制蛋白-4（MIP-4）以及MPIF-1 ，M-CIF和/或MIP-4多肽本身，以及用于产生它们的载体，宿主细胞和重组方法。

89. 发明授权

US5556767A Polynucleotide encoding macrophage inflammatory protein .gamma. 失效
标题翻译：多核苷酸编码巨噬细胞炎症蛋白γ
公开(公告)号：US5556767A
公开(公告)日：1996-09-17
申请号：US173209
申请日：1993-12-22
申请人： Craig A. Rosen , Haodong Li , Steven Ruben , Mark D. Adams
发明人： Craig A. Rosen , Haodong Li , Steven Ruben , Mark D. Adams
IPC分类号： A61K38/00 , C07K14/52 , C07K16/24 , C12N15/12
CPC分类号： C07K14/523 , C07K16/24 , A61K38/00
摘要： There is disclosed a human macrophage inflammatory protein-1 .gamma. (MIP-1 .gamma.) polypeptide and DNA(RNA) encoding such polypeptide. There is also provided a procedure for producing such polypeptide by recombinant techniques and for producing an antibody against such polypeptide. Another aspect of the invention provides a combination of the polypeptide of the present invention and a suitable pharmaceutical carrier for providing a therapeutically effective amount of the polypeptide for the treatment of various associated diseases.
摘要翻译：公开了人巨噬细胞炎症蛋白-1（MIP-1γ）多肽和编码这种多肽的DNA（RNA）。还提供了通过重组技术产生这种多肽并产生针对这种多肽的抗体的方法。本发明的另一方面提供本发明的多肽和合适的药物载体的组合，用于提供治疗有效量的多肽用于治疗各种相关疾病。

90. 发明申请

US20080274109A1 Myeloid Progenitor Inhibitory Factor-1 (MPIF-1), Monocyte Colony Inhibitory Factor (M-CIF), and Macrophage Inhibitory Factor-4 (MIP-4) 失效
标题翻译：髓系祖细胞抑制因子-1（MPIF-1），单核细胞集落抑制因子（M-CIF）和巨噬细胞抑制因子-4（MIP-4）
公开(公告)号：US20080274109A1
公开(公告)日：2008-11-06
申请号：US12111079
申请日：2008-04-28
申请人： Reiner L. Gentz , Brent L. Kreider , Jun Zhang , Michael Antonaccio , Donna Mendrick , Pablo Jimenez , Vikram Patel , Craig A. Rosen , Mark D. Adams , Haodong Li , Steven M. Ruben
发明人： Reiner L. Gentz , Brent L. Kreider , Jun Zhang , Michael Antonaccio , Donna Mendrick , Pablo Jimenez , Vikram Patel , Craig A. Rosen , Mark D. Adams , Haodong Li , Steven M. Ruben
IPC分类号： A61K39/395 , C07H21/04 , C12Q1/68 , C07K14/00 , G01N33/53 , A61P43/00 , A61K38/00 , C12Q1/00 , C07K16/18
CPC分类号： G01N33/6863 , A61K38/00 , A61K48/00 , C07K1/113 , C07K1/36 , C07K14/50 , C07K14/521 , C07K14/523 , C07K16/24 , C07K2319/00 , C12N15/72 , C12N2799/026 , G01N2333/52
摘要： There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine β8 (CKβ8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-γ and chemokine β1 (CKβ1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.
摘要翻译：公开了使用编码人骨髓祖细胞抑制因子-1（MPIF-1）多肽（以前称为MIP-3和趋化因子β8（CKbeta8或ckb-8））的分离的核酸分子的治疗组合物和方法。人单核细胞集落抑制因子（M-CIF）多肽（以前称为MIP1-γ和趋化因子β1（CKbeta1或ckb-1））和巨噬细胞抑制蛋白-4（MIP-4）以及MPIF-1 ，M-CIF和/或MIP-4多肽本身，以及用于产生它们的载体，宿主细胞和重组方法。

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