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81. 发明授权

US07220865B2 Isoxazole-and isothiazole-amine compounds for the treatment of neurodegenerative disorders 失效
标题翻译：异恶唑和异噻唑胺化合物，用于治疗神经变性疾病
公开(公告)号：US07220865B2
公开(公告)日：2007-05-22
申请号：US11078862
申请日：2005-03-11
申请人： Yuhpyng L Chen , Lei Zhang
发明人： Yuhpyng L Chen , Lei Zhang
IPC分类号： C07D261/14 , A61K31/42
CPC分类号： C07D261/14
摘要： The present invention relates to compounds of the Formula I wherein R1, R3, R5, R6, R7, X and Y are as defined. Compounds of the Formula I have activity inhibiting production of Aβ-peptide. The invention also relates to pharmaceutical compositions and methods of treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
摘要翻译：本发明涉及式I化合物，其中R 1，R 3，R 5，R 6， R 7，X和Y如上所定义。式I的化合物具有抑制Abeta肽生产的活性。本发明还涉及在包含式I化合物的哺乳动物中治疗疾病和病症例如神经变性和/或神经障碍（例如阿尔茨海默氏病）的药物组合物和方法。

82. 发明申请

US20060184452A1 Electronic document management system 审中-公开
标题翻译：电子文件管理系统
公开(公告)号：US20060184452A1
公开(公告)日：2006-08-17
申请号：US10685302
申请日：2003-10-14
申请人： John Barnes , Sai Alluru , Derek Benner , Naja Buddharaju , Taj Chadha , Bonnie Kidwell , Josh Nan , Todd Safford , Xan Schmickel , Jack Sponsler , Kimberly Weaver , Bin Zhou , Peter Davies , Lei Zhang
发明人： John Barnes , Sai Alluru , Derek Benner , Naja Buddharaju , Taj Chadha , Bonnie Kidwell , Josh Nan , Todd Safford , Xan Schmickel , Jack Sponsler , Kimberly Weaver , Bin Zhou , Peter Davies , Lei Zhang
IPC分类号： G06Q99/00 , H04L9/00 , H04K1/00
CPC分类号： G06Q40/00 , H04L9/3226 , H04L9/3247 , H04L9/3268 , H04L2209/56 , H04L2209/60 , H04L2209/68
摘要： An electronic document management system. The system includes a document entry module; a document management module; and a real time digital certificate generator for effecting electronic signatures. In the preferred embodiment, the system further includes a document repository module for storing documents and for accessing documents.
摘要翻译：电子文件管理系统。该系统包括文档输入模块; 文件管理模块; 以及实现电子签名的实时数字证书发生器。在优选实施例中，系统还包括用于存储文档和访问文档的文档存储库模块。

83. 发明申请

US20060166974A1 Azabenzoxazoles for the treatment of CNS disorders 审中-公开
标题翻译：用于治疗CNS疾病的Azabenzoxazoles
公开(公告)号：US20060166974A1
公开(公告)日：2006-07-27
申请号：US11271245
申请日：2005-11-11
申请人： Bruce Rogers , Allen Duplantier , Christopher O'Donnell , Lei Zhang
发明人： Bruce Rogers , Allen Duplantier , Christopher O'Donnell , Lei Zhang
IPC分类号： A61K31/551 , C07D487/04
CPC分类号： C07D519/00
摘要： The present invention relates to α7 nicotinic receptor agonists of formula I as described herein and to a method for treating disorders of the Central Nervous System (CNS) such as cognitive deficits in schizophrenia, by administering to a mammal an α7 nicotinic receptor agonist of formula I as shown herein.
摘要翻译：本发明涉及如本文所述的式I的α7烟碱受体激动剂和通过向哺乳动物施用式I的α7烟碱受体激动剂治疗中枢神经系统（CNS）的障碍的精神分裂症认知缺陷的方法，如本文所示。

84. 发明申请

US20060160493A1 Mobile phone device having inbuilt earphone structure 审中-公开
标题翻译：具有内置耳机结构的手机设备
公开(公告)号：US20060160493A1
公开(公告)日：2006-07-20
申请号：US11147339
申请日：2005-06-08
申请人： Chengshing Lai , Lei Zhang
发明人： Chengshing Lai , Lei Zhang
IPC分类号： H04B1/38
CPC分类号： H04M1/05 , H04M1/0258 , H04M1/15 , H04M1/6058
摘要： A mobile phone having an inbuilt earphone structure comprises a main body, an earphone and a reel. The main body comprises a space. The earphone has a transmission line and is detachable attaching to the main body by the transmission line. The reel is located in the main body for rolling up the transmission line, so that the transmission line can be stored in the space.
摘要翻译：具有内置耳机结构的移动电话包括主体，耳机和卷轴。主体包括一个空间。耳机具有传输线，并且通过传输线可拆卸地连接到主体。卷轴位于主体中用于卷绕传输线，使得传输线可以存储在该空间中。

85. 发明申请

US20050277640A1 Pyrimidine derivatives for treatment of hyperproliferative disorders 失效
标题翻译：嘧啶衍生物用于治疗过度增殖性疾病
公开(公告)号：US20050277640A1
公开(公告)日：2005-12-15
申请号：US11078681
申请日：2005-03-10
申请人： Julie Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin Hentemann , Ann-Marie Bullion , Manoj Patel
发明人： Julie Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin Hentemann , Ann-Marie Bullion , Manoj Patel
IPC分类号： A61K31/506 , A61K31/5377 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D453/02 , C07D43/02
CPC分类号： C07D401/12 , C04B35/632 , C07D239/47 , C07D239/48 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D453/02
摘要： Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G′, and G″ represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.
摘要翻译：式（I）的嘧啶衍生物，其中J和Y代表芳族或杂芳族环; R 2，G，G'和G“表示取代基，R 2a表示H或卤素; L表示连接基团; 并且M代表CH或N.还公开和要求保护含有这些化合物的药物组合物，以及使用这些化合物治疗过度增殖性疾病如癌症的方法。

86. 发明申请

US20050160063A1 Method and system for distributing and updating heterogeneous resources 失效
标题翻译：分布和更新异构资源的方法和系统
公开(公告)号：US20050160063A1
公开(公告)日：2005-07-21
申请号：US10841598
申请日：2004-05-07
申请人： Yue Pan , Lei Zhang
发明人： Yue Pan , Lei Zhang
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06F17/30575 , H04L67/1006 , Y10S707/99952
摘要： Methods, systems and apparatus for distributing and updating resources. An example method comprising the steps of: a resource producer registering a resource and a resource plug-in with a first server, and submitting a resource patch thereto when a resource update occurs; a second server replicating the resource, the resource plug-in and the resource patch from the first server, and a resource consumer downloading the resource, the resource plug-in and the resource patch from the second server; and updating the resource at the resource consumer side by executing the resource plug-in to apply the resource patch on the resource, and obtaining an updated resource version. The method and system of the present invention will greatly save network bandwidth in a large scale progressive resource distribution and make the design more flexible and extensible.
摘要翻译：用于分发和更新资源的方法，系统和装置。一种示例方法，包括以下步骤：资源生成器向第一服务器注册资源和资源插件，并且在资源更新发生时向其提交资源补丁; 从第一服务器复制资源，资源插件和资源补丁的第二服务器以及从第二服务器下载资源，资源插件和资源补丁的资源使用者; 以及通过执行资源插件来更新资源消费者侧的资源，以将所述资源补丁应用于所述资源，以及获得更新的资源版本。本发明的方法和系统将大大节省大规模逐步资源分配中的网络带宽，使设计更加灵活可扩展。

87. 发明申请

US20050143613A1 Process for aromatic alkylation 有权
标题翻译：芳烃烷基化方法
公开(公告)号：US20050143613A1
公开(公告)日：2005-06-30
申请号：US10987324
申请日：2004-11-12
申请人： Jihad Dakka , John Buchanan , Robert Crane , Christine Elia , Xiaobing Feng , Larry Iaccino , Gary Mohr , Brenda Raich , Jose Santiesteban , Lei Zhang
发明人： Jihad Dakka , John Buchanan , Robert Crane , Christine Elia , Xiaobing Feng , Larry Iaccino , Gary Mohr , Brenda Raich , Jose Santiesteban , Lei Zhang
IPC分类号： B01J29/40 , B01J29/44 , B01J31/02 , C07C2/86 , C07C15/08 , C07C2/68
CPC分类号： C07C2/864 , B01J29/40 , B01J29/44 , B01J2229/12 , B01J2229/32 , B01J2229/42 , C07C2521/10 , C07C2523/42 , C07C2523/46 , C07C2527/14 , C07C2529/40 , Y02P20/52 , Y10S585/906 , C07C15/08 , C07C15/00
摘要： This invention relates to a process for the selective alkylation of toluene and/or benzene with an oxygen-containing alkylation agent. In particular, the process uses a selectivated molecular sieve which has been modified by the addition of a hydrogenation component, wherein at least one of the following conditions is met: (a) the selectivated molecular sieve has an alpha value of less than 100 prior to the addition of the hydrogenation component, or (b) the selectivated and hydrogenated catalyst has an alpha value of less than 100. The process of this invention provides high selectivity for the alkylated product while reducing catalyst degradation.
摘要翻译：本发明涉及用含氧烷基化剂选择性烷基化甲苯和/或苯的方法。特别地，该方法使用已经通过加入氢化组分进行了改性的选择性分子筛，其中符合以下条件中的至少一个：（a）选择性分子筛之前的α值小于100，氢化组分的添加，或（b）选择和氢化的催化剂具有小于100的α值。本发明的方法在减少催化剂降解的同时，对烷基化产物提供高选择性。

88. 发明申请

US20050100221A1 Systems and methods for indexing and retrieving images 失效
标题翻译：索引和检索图像的系统和方法
公开(公告)号：US20050100221A1
公开(公告)日：2005-05-12
申请号：US10703300
申请日：2003-11-07
申请人： Mingjing Li , Lei Zhang , Yan-Feng Sun , Hong-Jiang Zhang
发明人： Mingjing Li , Lei Zhang , Yan-Feng Sun , Hong-Jiang Zhang
IPC分类号： G06T7/00 , G06F17/30 , G06F19/00 , G06T7/40 , G06K9/34 , G06K9/52
CPC分类号： G06F17/30262 , G06T7/33 , G06T7/37 , G06T7/42 , G06T2207/20056
摘要： Systems and methods for indexing and retrieving images are described herein. The systems and methods analyze an image to determine its texture moments. The pixels of the image are converted to gray scale. Textural attributes of the pixels are determined. The textural attributes are associated with the local texture of the pixels and are derived from coefficients of Discrete Fourier Transform associated with the pixels. Statistical values associated with the textural attributes of the pixels are calculated. The texture moments of the image are determined from the statistical value.
摘要翻译：本文描述了索引和检索图像的系统和方法。系统和方法分析图像以确定其纹理矩。图像的像素被转换成灰度级。确定像素的纹理属性。纹理属性与像素的局部纹理相关联，并且从与像素相关联的离散傅立叶变换的系数导出。计算与像素的纹理属性相关联的统计值。根据统计值确定图像的纹理矩。

89. 发明申请

US20050054594A1 Methods for particle-assisted polynucleotide immunization using a pulsed electric field 审中-公开
标题翻译：使用脉冲电场进行颗粒辅助多核苷酸免疫的方法
公开(公告)号：US20050054594A1
公开(公告)日：2005-03-10
申请号：US10498923
申请日：2002-12-16
申请人： Lei Zhang , Georg Widera , Dietmar Rabussay
发明人： Lei Zhang , Georg Widera , Dietmar Rabussay
IPC分类号： A61N1/10 , A61B17/20 , A61K9/127 , A61K31/7088 , A61K35/76 , A61K39/00 , A61K39/29 , A61K39/39 , A61K45/06 , A61K47/02 , A61K47/04 , A61K47/24 , A61K47/30 , A61K48/00 , A61P31/04 , A61P31/12 , A61P31/20 , A61P35/00 , A61P37/04 , C12N15/87 , A61N1/30
CPC分类号： A61K39/292 , A61K31/7088 , A61K39/0011 , A61K39/12 , A61K39/39 , A61K45/06 , A61K2039/53 , A61K2039/545 , A61K2039/55555 , C12N15/87 , C12N2730/10134 , A61K2300/00
摘要： Methods are provided for enhancing an immune response induced by administration of a DNA vaccine. In the invention methods a DNA vaccine encoding an antigen and non-chemically associated adjuvant particles are injected into muscle, dermal or mucosal tissue of a subject at substantially the same time and the tissue is subjected to a pulsed electric field of sufficient strength to result in the DNA vaccine entering cells of the target tissue. The immune response to the antigen is enhanced as compared to when the DNA vaccine is administered alone or in combination with either of the electric pulses or the adjuvant particles without the other.
摘要翻译：提供了用于增强通过施用DNA疫苗诱导的免疫应答的方法。在本发明方法中，将编码抗原和非化学相关佐剂颗粒的DNA疫苗基本上同时注射到受试者的肌肉，皮肤或粘膜组织中，组织经受足够强度的脉冲电场，导致 DNA疫苗进入目标组织的细胞。与单独施用DNA疫苗或与任意一种电脉冲或佐剂颗粒组合施用时，对抗原的免疫应答增强。

90. 发明授权

US06697669B2 Skin and muscle-targeted gene therapy by pulsed electrical field 有权
公开(公告)号：US06697669B2
公开(公告)日：2004-02-24
申请号：US09352809
申请日：1999-07-13
申请人： Nagendu B. Dev , Gunter A. Hofmann , Edward Nolan , Dietmar P. Rabussay , Arnt Tonnessen , Georg Widera , Lei Zhang
发明人： Nagendu B. Dev , Gunter A. Hofmann , Edward Nolan , Dietmar P. Rabussay , Arnt Tonnessen , Georg Widera , Lei Zhang
IPC分类号： A61N130
CPC分类号： A61N1/327 , A61N1/0424 , A61N1/0452 , A61N1/306 , A61N1/325
摘要： The present invention describes an in vivo method, using pulsed electric field to deliver therapeutic agents into cells of the skin and muscle for local and systemic treatments. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.

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