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81. 发明申请

US20070026454A1 Human secreted proteins 审中-公开
标题翻译：人体分泌的蛋白质
公开(公告)号：US20070026454A1
公开(公告)日：2007-02-01
申请号：US10472965
申请日：2002-03-26
申请人： Craig Rosen , Steven Ruben
发明人： Craig Rosen , Steven Ruben
IPC分类号： C12Q1/68 , G01N33/53 , A61K38/17
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating hematopoietic and hematologic diseases, disorders, and/or conditions related thereto. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及人分泌的多肽，以及编码所述多肽的分离的核酸分子，其可用于诊断和治疗造血和血液疾病，病症和/或与之相关的病症。结合这些多肽的抗体也包括在本发明中。本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

82. 发明申请

US20070015271A1 Human secreted proteins 审中-公开
公开(公告)号：US20070015271A1
公开(公告)日：2007-01-18
申请号：US10405027
申请日：2003-04-02
申请人： Craig Rosen , Steven Ruben
发明人： Craig Rosen , Steven Ruben
IPC分类号： C12N1/12 , C12N1/20
CPC分类号： C07K14/47
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

83. 发明申请

US20060281095A1 44 human secreted proteins 审中-公开
公开(公告)号：US20060281095A1
公开(公告)日：2006-12-14
申请号：US11002754
申请日：2004-12-03
申请人： David LaFleur , Steven Ruben , Craig Rosen , Paul Moore , Yanggu Shi , Hla Kyaw , Ying-Fei Wei
发明人： David LaFleur , Steven Ruben , Craig Rosen , Paul Moore , Yanggu Shi , Hla Kyaw , Ying-Fei Wei
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/47
CPC分类号： C12Q1/6883 , A61K35/13 , A61K38/00 , C07K14/47 , G01N33/6893 , Y02A50/465
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

84. 发明申请

US20060240036A1 I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1 and CD-95 induced apoptosis 审中-公开
标题翻译： I-FLICE，一种新型的肿瘤坏死因子受体-1抑制剂和CD-95诱导的细胞凋亡
公开(公告)号：US20060240036A1
公开(公告)日：2006-10-26
申请号：US11445311
申请日：2006-06-02
申请人： Jian Ni , Craig Rosen , Vishva Dixit , Reiner Gentz , Joseph Kenny
发明人： Jian Ni , Craig Rosen , Vishva Dixit , Reiner Gentz , Joseph Kenny
IPC分类号： A61K39/00 , C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06
CPC分类号： C12N9/6475 , A61K38/00
摘要： The present invention relates to a novel I-FLICE-1 or I-FLICE-2 protein which is a novel inhibitor of TNFR-1 and CD-95 induced apoptosis. In particular, isolated nucleic acid molecules are provided encoding the human I-FLICE-1 or I-FLICE-2 protein. I-FLICE-1 or I-FLICE-2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of I-FLICE-1 or I-FLICE-2 activity. Also provided are therapeutic methods for treating diseases and disorders associated with apoptosis.
摘要翻译：本发明涉及一种新型的I-FLICE-1或I-FLICE-2蛋白，其是TNFR-1和CD-95诱导的细胞凋亡的新型抑制剂。特别地，提供编码人I-FLICE-1或I-FLICE-2蛋白的分离的核酸分子。还提供I-FLICE-1或I-FLICE-2多肽，载体，宿主细胞和用于制备它的重组方法。本发明还涉及用于鉴定I-FLICE-1或I-FLICE-2活性的激动剂和拮抗剂的筛选方法。还提供了用于治疗与凋亡相关的疾病和病症的治疗方法。

85. 发明申请

US20060233749A1 Interleukin-19 审中-公开
标题翻译：白细胞介素-19
公开(公告)号：US20060233749A1
公开(公告)日：2006-10-19
申请号：US11400219
申请日：2006-04-10
申请人： Craig Rosen , Joseph Kenny
发明人： Craig Rosen , Joseph Kenny
IPC分类号： A61K38/20 , C07K14/54 , C07H21/04 , C12P21/04
CPC分类号： C07K14/54 , A61K38/00 , Y02A50/41
摘要： The present invention concerns a novel human cytokine. In particular, isolated nucleic acid molecules are provided encoding interleukin-19 (IL-19). IL-19 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The IL-19 polypeptides of the present invention can also be used to raise polyclonal and monoclonal antibodies. The invention further concerns therapeutic methods for modulating cytokine production.
摘要翻译：本发明涉及一种新的人细胞因子。特别地，提供编码白细胞介素-19（IL-19）的分离的核酸分子。还提供了IL-19多肽，载体，宿主细胞以及用于制备它们的重组方法。本发明的IL-19多肽也可用于产生多克隆和单克隆抗体。本发明还涉及调节细胞因子产生的治疗方法。

86. 发明申请

US20060147421A1 Methods and compositions for treating and preventing infection using human interferon regulatory factor 3 审中-公开
公开(公告)号：US20060147421A1
公开(公告)日：2006-07-06
申请号：US11358007
申请日：2006-02-22
申请人： Paul Moore , Paula Pitha Rowe , Craig Rosen
发明人： Paul Moore , Paula Pitha Rowe , Craig Rosen
IPC分类号： C07K14/715 , C07H21/04 , C12P21/06 , A61K48/00 , C12N15/867
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/47 , C12N2799/027
摘要： The present invention relates to IRF3 polypeptides. In particular, isolated nucleic acid molecules are provided encoding human IRF3 protein. IRF3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods of gene therapy using polynucleotides encoding IRF3 polypeptides, fragments or variants to treat, prevent or ameliorate infectious diseases.

87. 发明申请

US20060068474A1 Endothelial-monocyte activating polypeptide III 失效
公开(公告)号：US20060068474A1
公开(公告)日：2006-03-30
申请号：US11272757
申请日：2005-11-15
申请人： Timothy Coleman , Craig Rosen
发明人： Timothy Coleman , Craig Rosen
IPC分类号： C07K14/52 , C07H21/04 , C12P21/02
CPC分类号： C07K14/52
摘要： A human EMAP III polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating neoplasia. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.

88. 发明申请

US20060008882A1 Antibodies to Chemokine Alpha-5 失效
标题翻译：趋化因子α-5抗体
公开(公告)号：US20060008882A1
公开(公告)日：2006-01-12
申请号：US11224076
申请日：2005-09-13
申请人： Ying-Fei Wei , Yi Li , Jian Ni , Craig Rosen , Steven Ruben
发明人： Ying-Fei Wei , Yi Li , Jian Ni , Craig Rosen , Steven Ruben
IPC分类号： C12P21/02 , C07H21/04 , C07K14/52 , C07K16/24
CPC分类号： C07K14/521 , A61K38/00 , C07K14/522 , C07K2319/00 , C12N2799/026 , Y02A50/423 , Y10T436/143333
摘要： The present invention relates to a novel CKα-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-5 protein. CKα-5 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Antibodies and fragments thereof that specifically bind to CKα-5 polypeptides are also disclosed, as are compositions and methods for making such antibodies. The invention further relates to screening methods for identifying agonists and antagonists of CKα-5 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及作为α趋化因子家族成员的新型CKalpha-5蛋白。特别地，提供编码人CKalpha-5蛋白的分离的核酸分子。还提供了CKalpha-5多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。还公开了特异性结合CKalpha-5多肽的抗体及其片段，以及制备这种抗体的组合物和方法。本发明还涉及鉴定CKalpha-5活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

89. 发明申请

US20050232921A1 Vascular endothelial growth factor 2 审中-公开
标题翻译：血管内皮生长因子2
公开(公告)号：US20050232921A1
公开(公告)日：2005-10-20
申请号：US10992195
申请日：2004-11-19
申请人： Craig Rosen , Vivian Albert , Steven Ruben , Ruth Wager
发明人： Craig Rosen , Vivian Albert , Steven Ruben , Ruth Wager
IPC分类号： A61K39/395 , C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/73
摘要： Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention also relates to methods and compositions for preventing, treating or ameliorating a disease or disorder comprising administering to an animal, preferably a human, an effective amount of one or more VEGF-2 antibodies or fragments or variants thereof.
摘要翻译：公开了人VEGF-2抗体，抗体片段或其变体。还提供了产生这种抗体的方法。本发明还涉及用于预防，治疗或改善疾病或病症的方法和组合物，其包括向动物，优选人类施用有效量的一种或多种VEGF-2抗体或其片段或变体。

90. 发明申请

US20050215775A1 70 human secreted proteins 审中-公开
公开(公告)号：US20050215775A1
公开(公告)日：2005-09-29
申请号：US10979111
申请日：2004-11-02
申请人： Steven Ruben , Craig Rosen , Carrie Fischer , Daniel Soppet , Kenneth Carter , Daniel Bednarik , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul Young , John Greene , Ann Ferrie , D. Duan , Jing-Shan Hu , Kimberly Florence , Henrik Olsen , Reinhard Ebner , Laurie Brewer , Yanggu Shi
发明人： Steven Ruben , Craig Rosen , Carrie Fischer , Daniel Soppet , Kenneth Carter , Daniel Bednarik , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul Young , John Greene , Ann Ferrie , D. Duan , Jing-Shan Hu , Kimberly Florence , Henrik Olsen , Reinhard Ebner , Laurie Brewer , Yanggu Shi
IPC分类号： C07H21/04 , C07K14/47 , C12N9/00 , C12P21/06 , C12Q1/68
CPC分类号： C07K14/47 , Y10T436/143333
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

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